ACTA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACTA2
Entrez Gene ID	59
Full Name	actin, alpha 2, smooth muscle, aorta
Synonyms	ACTSA
General protein information	Preferred Names actin, alpha 2, smooth muscle, aorta Names actin, aortic smooth muscle alpha-cardiac actin cell growth-inhibiting gene 46 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.31
Summary	This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017].
Disorder MIM:	102620
Disorder Html:	Aortic aneurysm, familial thoracic 6, 611788 (3); Multisystemic smooth muscle dysfunction syndrome, 613834 (3); Moyamoya disease 5, 614042 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011540016.1	XP_011538318.1	actin, aortic smooth muscle isoform X1
NM_001613.3	NP_001604.1	actin, aortic smooth muscle
NM_001613.2	NP_001604.1	actin, aortic smooth muscle
NM_001613.4	NP_001604.1	actin, aortic smooth muscle
NM_001141945.1	NP_001135417.1	actin, aortic smooth muscle
NM_001320855.1	NP_001307784.1	actin, aortic smooth muscle
NM_001141945.2	NP_001135417.1	actin, aortic smooth muscle

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Acta2	NP_112266.1
Gallus gallus (chicken)	ACTA2	NP_001026400.1
Xenopus tropicalis (tropical clawed frog)	acta1	NP_001006709.1
Homo sapiens (human)	ACTA2	NP_001604.1
Canis lupus familiaris (dog)	ACTA2	XP_534781.2
Bos taurus (cattle)	ACTA2	NP_001029674.1
	ACTA2	XP_002805789.1
Danio rerio (zebrafish)	acta1a	NP_001017750.1
Oryza sativa (rice)	Os12g0163700	NP_001066233.1
Xenopus tropicalis (tropical clawed frog)	MGC75582	NP_989355.1
Pan troglodytes (chimpanzee)	ACTA2	XP_001142014.1
Mus musculus (house mouse)	Acta2	NP_031418.1

Gene Ontology
Bibliography

Related articles in PubMed

ACTA2 mutation and postpartum hemorrhage: a case report.
Cooper K, Brown S
BMC medical genetics18(1)143(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We present a young woman whose ACTA2 mutation was ascertained during pregnancy because of her father's history of dissecting aneurysms. She was delivered at full term by cesarean section and subsequently had severe uterine hemorrhage due to uterine atony. Targeted analysis of the patient's ACTA2 gene revealed she had inherited the N117S variant from her father.
Title: ACTA2 mutation and postpartum hemorrhage: a case report.

Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 and VE-cadherin, and a significant increase in that of alpha-SMA and collagen I.
Title: High glucose induced endothelial to mesenchymal transition in human umbilical vein endothelial cell.

ACTA2 is the isoform of contractile protein alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4
Title: Management of Bilateral Axillary Aneurysms, Threatened Limb, and Diffuse Vasculopathy in a Patient With ACTA2 Mutation.

Two unrelated patients with the heterozygous R189H mutation in ACTA2 and complex congenital heart defects expands the cardiac phenotype of multisystemic smooth muscle dysfunction syndrome.
Title: Two patients with the heterozygous R189H mutation in ACTA2 and Complex congenital heart defects expands the cardiac phenotype of multisystemic smooth muscle dysfunction syndrome.

During transition from the pluripotent stage towards the neural developmental stage, ACTA2 is differentially expressed in bipolar patient derived cells compared to control derived cells.
Title: Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2 inflammasome gene distinctly differentiates between patients and healthy controls in the transition between iPS cell and neural stem cell stages.

The following ACTA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16443	NM_001141945.2 Latest version!	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16443	NM_001320855.1 Latest version!	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16443	NM_001613.4 Latest version!	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16443	XM_011540016.1 Latest version!	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu16443	NM_001613.2	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16443	NM_001613.3	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16443	NM_001141945.1	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACTA2 ( NM_001613.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001604.1 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001613.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	actin, aortic smooth muscle
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP320140.1, BC093052.1 and BQ029841.1. On Sep 13, 2017 this sequence version replaced NM_001613.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279874.1584.1, BC093052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001604.1
CDS	171..1304
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001613.3
Organism	Homo sapiens(human)
Definition	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001613.3

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( NM_001613.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001604.1 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001613.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-05
Organism	Homo sapiens(Human)
Product	actin, aortic smooth muscle
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP379410.1, BC093052.1 and BQ029841.1. This sequence is a reference standard in the RefSeqGene project. On Nov 21, 2008 this sequence version replaced NM_001613.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279874.1584.1, BC093052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001604.1
CDS	117..1250
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001613.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001613.2

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( NM_001613.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001604.1 Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001613.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	actin, aortic smooth muscle
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP320140.1, BC093052.1 and BQ029841.1. On Nov 22, 2018 this sequence version replaced NM_001613.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.142831.1, SRR5189652.195477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000224784.10/ ENSP00000224784.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001604.1
CDS	67..1200
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001613.4
Organism	Homo sapiens(human)
Definition	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001613.4

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( NM_001141945.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135417.1 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001141945.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	actin, aortic smooth muscle
Comment

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135417.1
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001141945.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001141945.1

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( NM_001320855.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307784.1 Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001320855.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	actin, aortic smooth muscle
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC359878.1, DC354672.1, BP248338.1 and AY692464.1. On Mar 9, 2016 this sequence version replaced XM_011540016.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.537357.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307784.1
CDS	400..1533
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001320855.1
Organism	Homo sapiens(human)
Definition	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320855.1

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( NM_001141945.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135417.1 Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	NM_001141945.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	actin, aortic smooth muscle
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC359878.1, DC354672.1, DC385559.1 and AY692464.1. On Mar 9, 2016 this sequence version replaced NM_001141945.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY692464.1, SRR1163655.382717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135417.1
CDS	483..1616
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	NM_001141945.2
Organism	Homo sapiens(human)
Definition	Homo sapiens actin alpha 2, smooth muscle (ACTA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001141945.2

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTA2 ( XM_011540016.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538318.1 Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu16443
Clone ID Related Accession (Same CDS sequence)	XM_011540016.1 , NM_001613.3 , NM_001613.2 , NM_001613.4 , NM_001141945.1 , NM_001320855.1 , NM_001141945.2
Accession Version	XM_011540016.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	actin, aortic smooth muscle isoform X1
Comment

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538318.1
Translation	MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Target ORF information:

RefSeq Version	XM_011540016.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540016.1

ORF Insert Sequence:

ATGTGTGAAG AAGAGGACAG CACTGCCTTG GTGTGTGACA ATGGCTCTGG GCTCTGTAAG 
GCCGGCTTTG CTGGGGACGA TGCTCCCAGG GCTGTTTTCC CATCCATTGT GGGACGTCCC 
AGACATCAGG GGGTGATGGT GGGAATGGGA CAAAAAGACA GCTACGTGGG TGACGAAGCA 
CAGAGCAAAA GAGGAATCCT GACCCTGAAG TACCCGATAG AACATGGCAT CATCACCAAC 
TGGGACGACA TGGAAAAGAT CTGGCACCAC TCTTTCTACA ATGAGCTTCG TGTTGCCCCT 
GAAGAGCATC CCACCCTGCT CACGGAGGCA CCCCTGAACC CCAAGGCCAA CCGGGAGAAA 
ATGACTCAAA TTATGTTTGA GACTTTCAAT GTCCCAGCCA TGTATGTGGC TATCCAGGCG 
GTGCTGTCTC TCTATGCCTC TGGACGCACA ACTGGCATCG TGCTGGACTC TGGAGATGGT 
GTCACCCACA ATGTCCCCAT CTATGAGGGC TATGCCTTGC CCCATGCCAT CATGCGTCTG 
GATCTGGCTG GCCGAGATCT CACTGACTAC CTCATGAAGA TCCTGACTGA GCGTGGCTAT 
TCCTTCGTTA CTACTGCTGA GCGTGAGATT GTCCGGGACA TCAAGGAGAA ACTGTGTTAT 
GTAGCTCTGG ACTTTGAAAA TGAGATGGCC ACTGCCGCAT CCTCATCCTC CCTTGAGAAG 
AGTTACGAGT TGCCTGATGG GCAAGTGATC ACCATCGGAA ATGAACGTTT CCGCTGCCCA 
GAGACCCTGT TCCAGCCATC CTTCATCGGG ATGGAGTCTG CTGGCATCCA TGAAACCACC 
TACAACAGCA TCATGAAGTG TGATATTGAC ATCAGGAAGG ACCTCTATGC TAACAATGTC 
CTATCAGGGG GCACCACTAT GTACCCTGGC ATTGCCGACC GAATGCAGAA GGAGATCACG 
GCCCTAGCAC CCAGCACCAT GAAGATCAAG ATCATTGCCC CTCCGGAGCG CAAATACTCT 
GTCTGGATCG GTGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAGAT GTGGATCAGC 
AAACAGGAAT ACGATGAAGC CGGGCCTTCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ACTA2 mutation and postpartum hemorrhage: a case report.
BMC medical genetics18(1)143(2017 12)
Cooper K,Brown S

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ACTA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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