RABGGTB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RABGGTB
Entrez Gene ID	5876
Full Name	Rab geranylgeranyltransferase beta subunit
Synonyms	GGTB
General protein information	Preferred Names Rab geranylgeranyltransferase beta subunit Names geranylgeranyl transferase type-2 subunit beta GGTase-II-beta rab GG transferase beta rab GGTase beta type II protein geranyl-geranyltransferase subunit beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.1
Summary	This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013].
Disorder MIM:	179080

mRNA and Protein(s)

mRNA	Protein	Name
NM_004582.4	NP_004573.2	geranylgeranyl transferase type-2 subunit beta
NM_004582.3	NP_004573.2	geranylgeranyl transferase type-2 subunit beta

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RABGGTB	XP_005622111.1
Saccharomyces cerevisiae (baker's yeast)	BET2	NP_015502.1
Schizosaccharomyces pombe (fission yeast)	ptb1	NP_593383.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013277	XP_003435802.1
Eremothecium gossypii	AGOS_AEL268W	NP_984592.1
Magnaporthe oryzae (rice blast fungus)	MGG_09304	XP_003709954.1
Oryza sativa (rice)	Os08g0512300	NP_001062217.1
Pan troglodytes (chimpanzee)	RABGGTB	XP_003308209.1
	RABGGTB	XP_001101556.1
Bos taurus (cattle)	RABGGTB	NP_001015646.1
Drosophila melanogaster (fruit fly)	betaggt-II	NP_524894.1
Caenorhabditis elegans (roundworm)	ggtb-1	NP_498559.1
Kluyveromyces lactis	KLLA0E04797g	XP_454162.1
Arabidopsis thaliana (thale cress)	RGTB1	NP_568259.1
Arabidopsis thaliana (thale cress)	RGTB2	NP_850567.1
Homo sapiens (human)	RABGGTB	NP_004573.2
Gallus gallus (chicken)	RABGGTB	XP_422548.2
Danio rerio (zebrafish)	rabggtb	NP_998277.2
Mus musculus (house mouse)	Rabggtb	NP_001156950.1
Rattus norvegicus (Norway rat)	Rabggtb	NP_619715.1
Neurospora crassa	NCU07509	XP_965056.1
Xenopus tropicalis (tropical clawed frog)	rabggtb	NP_001106636.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Regulation of ?2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.
Lachance V, Cartier A, G?nier S, Munger S, Germain P, Labrecque P, Parent JL
The Journal of biological chemistry286(47)40802-13(2011 Nov)

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer prevention research (Philadelphia, Pa.)3(5)597-603(2010 May)

Membrane targeting of Rab GTPases is influenced by the prenylation motif.
Gomes AQ, Ali BR, Ramalho JS, Godfrey RF, Barral DC, Hume AN, Seabra MC
Molecular biology of the cell14(5)1882-99(2003 May)

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Yuryev A, Wennogle LP
Genomics81(2)112-25(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an interaction between a transmembrane receptor and RGGTA
Title: Regulation of ?2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.

The following RABGGTB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RABGGTB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11348	NM_004582.4 Latest version!	Homo sapiens Rab geranylgeranyltransferase subunit beta (RABGGTB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu11348	NM_004582.3	Homo sapiens Rab geranylgeranyltransferase beta subunit (RABGGTB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RABGGTB ( NM_004582.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004573.2 Homo sapiens Rab geranylgeranyltransferase subunit beta (RABGGTB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11348
Clone ID Related Accession (Same CDS sequence)	NM_004582.4 , NM_004582.3
Accession Version	NM_004582.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	geranylgeranyl transferase type-2 subunit beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020790.1, AL357314.11 and BQ773824.1. On Nov 22, 2018 this sequence version replaced NM_004582.3. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.140872.1, SRR5189661.109385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319942.8/ ENSP00000317473.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCACTC CACAGAAGGA TGTTATTATC AAGTCAGATG CACCGGACAC TTTGTTATTG 
GAGAAACATG CAGATTATAT CGCATCCTAT GGCTCAAAGA AAGATGATTA TGAATACTGT 
ATGTCTGAGT ATTTGAGAAT GAGTGGCATC TATTGGGGTC TGACAGTAAT GGATCTCATG 
GGACAACTTC ATCGCATGAA TAGAGAAGAG ATTCTGGCAT TTATTAAGTC TTGCCAACAT 
GAATGTGGTG GAATAAGTGC TAGTATCGGA CATGATCCTC ATCTTTTATA CACTCTTAGT 
GCTGTCCAGA TTCTTACGCT GTATGACAGT ATTAATGTTA TTGACGTAAA TAAAGTTGTG 
GAATATGTTA AAGGTCTACA GAAAGAAGAT GGTTCTTTTG CTGGAGATAT TTGGGGAGAA 
ATTGACACAA GATTCTCTTT TTGTGCGGTG GCAACTTTGG CTTTGTTGGG GAAGCTTGAT 
GCTATTAATG TGGAAAAGGC AATCGAATTT GTTTTATCCT GTATGAACTT TGACGGTGGA 
TTTGGTTGCA GACCAGGTTC TGAATCCCAT GCTGGGCAGA TCTATTGTTG CACAGGATTT 
CTGGCAATTA CAAGTCAGTT GCATCAAGTA AATTCTGATT TACTTGGCTG GTGGCTTTGT 
GAACGACAAT TACCCTCAGG CGGGCTCAAT GGAAGGCCGG AGAAGTTACC AGATGTATGC 
TACTCATGGT GGGTCCTGGC TTCCCTAAAG ATAATTGGAA GACTTCATTG GATTGATAGA 
GAGAAACTGC GTAATTTCAT TTTAGCATGT CAAGATGAAG AAACGGGGGG ATTTGCAGAC 
AGGCCAGGAG ATATGGTGGA TCCTTTTCAT ACCTTATTTG GAATTGCTGG ATTGTCACTT 
TTGGGAGAAG AACAGATTAA ACCTGTTAAT CCTGTCTTTT GCATGCCTGA AGAAGTGCTT 
CAGAGAGTGA ATGTTCAGCC TGAGCTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004573.2
CDS	17..1012
Translation	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS

Target ORF information:

RefSeq Version	NM_004582.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rab geranylgeranyltransferase subunit beta (RABGGTB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004582.4

ORF Insert Sequence:

ATGGGCACTC CACAGAAGGA TGTTATTATC AAGTCAGATG CACCGGACAC TTTGTTATTG 
GAGAAACATG CAGATTATAT CGCATCCTAT GGCTCAAAGA AAGATGATTA TGAATACTGT 
ATGTCTGAGT ATTTGAGAAT GAGTGGCATC TATTGGGGTC TGACAGTAAT GGATCTCATG 
GGACAACTTC ATCGCATGAA TAGAGAAGAG ATTCTGGCAT TTATTAAGTC TTGCCAACAT 
GAATGTGGTG GAATAAGTGC TAGTATCGGA CATGATCCTC ATCTTTTATA CACTCTTAGT 
GCTGTCCAGA TTCTTACGCT GTATGACAGT ATTAATGTTA TTGACGTAAA TAAAGTTGTG 
GAATATGTTA AAGGTCTACA GAAAGAAGAT GGTTCTTTTG CTGGAGATAT TTGGGGAGAA 
ATTGACACAA GATTCTCTTT TTGTGCGGTG GCAACTTTGG CTTTGTTGGG GAAGCTTGAT 
GCTATTAATG TGGAAAAGGC AATCGAATTT GTTTTATCCT GTATGAACTT TGACGGTGGA 
TTTGGTTGCA GACCAGGTTC TGAATCCCAT GCTGGGCAGA TCTATTGTTG CACAGGATTT 
CTGGCAATTA CAAGTCAGTT GCATCAAGTA AATTCTGATT TACTTGGCTG GTGGCTTTGT 
GAACGACAAT TACCCTCAGG CGGGCTCAAT GGAAGGCCGG AGAAGTTACC AGATGTATGC 
TACTCATGGT GGGTCCTGGC TTCCCTAAAG ATAATTGGAA GACTTCATTG GATTGATAGA 
GAGAAACTGC GTAATTTCAT TTTAGCATGT CAAGATGAAG AAACGGGGGG ATTTGCAGAC 
AGGCCAGGAG ATATGGTGGA TCCTTTTCAT ACCTTATTTG GAATTGCTGG ATTGTCACTT 
TTGGGAGAAG AACAGATTAA ACCTGTTAAT CCTGTCTTTT GCATGCCTGA AGAAGTGCTT 
CAGAGAGTGA ATGTTCAGCC TGAGCTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RABGGTB ( NM_004582.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004573.2 Homo sapiens Rab geranylgeranyltransferase beta subunit (RABGGTB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11348
Clone ID Related Accession (Same CDS sequence)	NM_004582.4 , NM_004582.3
Accession Version	NM_004582.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	geranylgeranyl transferase type-2 subunit beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293057.1, BC020790.1, AL357314.11 and BQ773824.1. On Jan 10, 2013 this sequence version replaced NM_004582.2. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020790.1, SRR1660807.266730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACTC CACAGAAGGA TGTTATTATC AAGTCAGATG CACCGGACAC TTTGTTATTG 
GAGAAACATG CAGATTATAT CGCATCCTAT GGCTCAAAGA AAGATGATTA TGAATACTGT 
ATGTCTGAGT ATTTGAGAAT GAGTGGCATC TATTGGGGTC TGACAGTAAT GGATCTCATG 
GGACAACTTC ATCGCATGAA TAGAGAAGAG ATTCTGGCAT TTATTAAGTC TTGCCAACAT 
GAATGTGGTG GAATAAGTGC TAGTATCGGA CATGATCCTC ATCTTTTATA CACTCTTAGT 
GCTGTCCAGA TTCTTACGCT GTATGACAGT ATTAATGTTA TTGACGTAAA TAAAGTTGTG 
GAATATGTTA AAGGTCTACA GAAAGAAGAT GGTTCTTTTG CTGGAGATAT TTGGGGAGAA 
ATTGACACAA GATTCTCTTT TTGTGCGGTG GCAACTTTGG CTTTGTTGGG GAAGCTTGAT 
GCTATTAATG TGGAAAAGGC AATCGAATTT GTTTTATCCT GTATGAACTT TGACGGTGGA 
TTTGGTTGCA GACCAGGTTC TGAATCCCAT GCTGGGCAGA TCTATTGTTG CACAGGATTT 
CTGGCAATTA CAAGTCAGTT GCATCAAGTA AATTCTGATT TACTTGGCTG GTGGCTTTGT 
GAACGACAAT TACCCTCAGG CGGGCTCAAT GGAAGGCCGG AGAAGTTACC AGATGTATGC 
TACTCATGGT GGGTCCTGGC TTCCCTAAAG ATAATTGGAA GACTTCATTG GATTGATAGA 
GAGAAACTGC GTAATTTCAT TTTAGCATGT CAAGATGAAG AAACGGGGGG ATTTGCAGAC 
AGGCCAGGAG ATATGGTGGA TCCTTTTCAT ACCTTATTTG GAATTGCTGG ATTGTCACTT 
TTGGGAGAAG AACAGATTAA ACCTGTTAAT CCTGTCTTTT GCATGCCTGA AGAAGTGCTT 
CAGAGAGTGA ATGTTCAGCC TGAGCTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004573.2
CDS	79..1074
Translation	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS

Target ORF information:

RefSeq Version	NM_004582.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rab geranylgeranyltransferase beta subunit (RABGGTB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004582.3

ORF Insert Sequence:

ATGGGCACTC CACAGAAGGA TGTTATTATC AAGTCAGATG CACCGGACAC TTTGTTATTG 
GAGAAACATG CAGATTATAT CGCATCCTAT GGCTCAAAGA AAGATGATTA TGAATACTGT 
ATGTCTGAGT ATTTGAGAAT GAGTGGCATC TATTGGGGTC TGACAGTAAT GGATCTCATG 
GGACAACTTC ATCGCATGAA TAGAGAAGAG ATTCTGGCAT TTATTAAGTC TTGCCAACAT 
GAATGTGGTG GAATAAGTGC TAGTATCGGA CATGATCCTC ATCTTTTATA CACTCTTAGT 
GCTGTCCAGA TTCTTACGCT GTATGACAGT ATTAATGTTA TTGACGTAAA TAAAGTTGTG 
GAATATGTTA AAGGTCTACA GAAAGAAGAT GGTTCTTTTG CTGGAGATAT TTGGGGAGAA 
ATTGACACAA GATTCTCTTT TTGTGCGGTG GCAACTTTGG CTTTGTTGGG GAAGCTTGAT 
GCTATTAATG TGGAAAAGGC AATCGAATTT GTTTTATCCT GTATGAACTT TGACGGTGGA 
TTTGGTTGCA GACCAGGTTC TGAATCCCAT GCTGGGCAGA TCTATTGTTG CACAGGATTT 
CTGGCAATTA CAAGTCAGTT GCATCAAGTA AATTCTGATT TACTTGGCTG GTGGCTTTGT 
GAACGACAAT TACCCTCAGG CGGGCTCAAT GGAAGGCCGG AGAAGTTACC AGATGTATGC 
TACTCATGGT GGGTCCTGGC TTCCCTAAAG ATAATTGGAA GACTTCATTG GATTGATAGA 
GAGAAACTGC GTAATTTCAT TTTAGCATGT CAAGATGAAG AAACGGGGGG ATTTGCAGAC 
AGGCCAGGAG ATATGGTGGA TCCTTTTCAT ACCTTATTTG GAATTGCTGG ATTGTCACTT 
TTGGGAGAAG AACAGATTAA ACCTGTTAAT CCTGTCTTTT GCATGCCTGA AGAAGTGCTT 
CAGAGAGTGA ATGTTCAGCC TGAGCTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Regulation of ?2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.
The Journal of biological chemistry286(47)40802-13(2011 Nov)
Lachance V,Cartier A,G?nier S,Munger S,Germain P,Labrecque P,Parent JL

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Cancer prevention research (Philadelphia, Pa.)3(5)597-603(2010 May)
Lipkin SM,Chao EC,Moreno V,Rozek LS,Rennert H,Pinchev M,Dizon D,Rennert G,Kopelovich L,Gruber SB

Membrane targeting of Rab GTPases is influenced by the prenylation motif.
Molecular biology of the cell14(5)1882-99(2003 May)
Gomes AQ,Ali BR,Ramalho JS,Godfrey RF,Barral DC,Hume AN,Seabra MC

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Genomics81(2)112-25(2003 Feb)
Yuryev A,Wennogle LP

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RABGGTB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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