RAB13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB13
Entrez Gene ID	5872
Full Name	RAB13, member RAS oncogene family
Synonyms	GIG4
General protein information	Preferred Names RAB13, member RAS oncogene family Names ras-related protein Rab-13 RAS-associated protein RAB13 cell growth-inhibiting gene 4 protein growth-inhibiting gene 4 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013].
Disorder MIM:	602672

mRNA and Protein(s)

mRNA	Protein	Name
XM_017001959.1	XP_016857448.1	ras-related protein Rab-13 isoform X1
NM_002870.3	NP_002861.1	ras-related protein Rab-13 isoform 1
NM_001272038.1	NP_001258967.1	ras-related protein Rab-13 isoform 2
NM_002870.5	NP_002861.1	ras-related protein Rab-13 isoform 1
NM_002870.4	NP_002861.1	ras-related protein Rab-13 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RAB13	XP_005622856.1
Mus musculus (house mouse)	Rab13	NP_080953.1
Rattus norvegicus (Norway rat)	Rab13	NP_112354.1
Homo sapiens (human)	RAB13	NP_002861.1
Pan troglodytes (chimpanzee)	RAB13	XP_522433.3
Xenopus tropicalis (tropical clawed frog)	MGC97787	NP_001025679.1
	RAB13	XP_001112675.1
Bos taurus (cattle)	RAB13	NP_001019711.1
Danio rerio (zebrafish)	rab13	NP_958486.1

Gene Ontology
Bibliography

Related articles in PubMed

Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells.
Zhang L, Dai F, Cui L, Zhou B, Guo Y
Biochimica et biophysica acta1864(4)613-624(2017 04)

Regulation of Cancer Cell Behavior by the Small GTPase Rab13.
Ioannou MS, McPherson PS
The Journal of biological chemistry291(19)9929-37(2016 May)

Rab13 Traffics on Vesicles Independent of Prenylation.
Ioannou MS, Girard M, McPherson PS
The Journal of biological chemistry291(20)10726-35(2016 May)

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
Lai YC, Kondapalli C, Lehneck R, Procter JB, Dill BD, Woodroof HI, Gourlay R, Peggie M, Macartney TJ, Corti O, Corvol JC, Campbell DG, Itzen A, Trost M, Muqit MM
The EMBO journal34(22)2840-61(2015 Nov)

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.
Ioannou MS, Bell ES, Girard M, Chaineau M, Hamlin JN, Daubaras M, Monast A, Park M, Hodgson L, McPherson PS
The Journal of cell biology208(5)629-48(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rab13 activated the downstream AMPK and blocked mTOR signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
Title: Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells.

the role of Rab13 as a potent driver of cancer progression.
Title: Regulation of Cancer Cell Behavior by the Small GTPase Rab13.

Inactive Rab13 appears to associate with vesicles via protein-protein interactions. Only following activation does Rab13 associate with the plasma membrane, presumably with insertion of the C-terminal prenyl group into the membrane.
Title: Rab13 Traffics on Vesicles Independent of Prenylation.

Rab8A GTPase Ser(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin at Ser(65).
Title: Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Disruption of Rab13-mediated trafficking dramatically limits the invasive behavior of epithelial cells in vitro and the growth and migration of highly invasive cancer cells in vivo.
Title: DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.

The following RAB13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09711	NM_001272038.1 Latest version!	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu09711	XM_017001959.1 Latest version!	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu09950	NM_002870.5 Latest version!	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu09950	NM_002870.3	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu09950	NM_002870.4	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB13 ( NM_002870.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002861.1 Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09950
Clone ID Related Accession (Same CDS sequence)	NM_002870.3 , NM_002870.5 , NM_002870.4
Accession Version	NM_002870.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ras-related protein Rab-13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BJ997167.1, BC094846.1, BC000799.1 and AK291580.1. On Jan 4, 2013 this sequence version replaced NM_002870.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291580.1, SRR1163655.277213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002861.1
CDS	142..753
Translation	MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG

Target ORF information:

RefSeq Version	NM_002870.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002870.3

ORF Insert Sequence:

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB13 ( NM_002870.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002861.1 Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09950
Clone ID Related Accession (Same CDS sequence)	NM_002870.3 , NM_002870.5 , NM_002870.4
Accession Version	NM_002870.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	ras-related protein Rab-13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC094846.1, BC000799.1, AK291580.1 and AL358472.54. On May 17, 2019 this sequence version replaced NM_002870.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.110528.1, SRR7346977.83454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002861.1
CDS	104..715
Translation	MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG

Target ORF information:

RefSeq Version	NM_002870.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002870.4

ORF Insert Sequence:

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB13 ( NM_001272038.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258967.1 Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09711
Clone ID Related Accession (Same CDS sequence)	XM_017001959.1 , NM_001272038.1
Accession Version	NM_001272038.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	ras-related protein Rab-13 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN396084.1, BC009227.2 and AK291580.1. Transcript Variant: This variant (2) contains a novel 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1163657.455707.1, SRR5189667.247518.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCATTA TCCTAGTATA CGACATCACG GATGAGAAAT CTTTCGAGAA TATTCAGAAC 
TGGATGAAAA GCATCAAGGA GAATGCCTCG GCTGGGGTGG AGCGCCTCTT GCTGGGGAAC 
AAATGTGACA TGGAGGCCAA GAGGAAGGTG CAGAAGGAGC AGGCCGATAA GTTGGCTCGA 
GAGCATGGAA TCCGATTTTT CGAAACTAGT GCTAAATCCA GTATGAATGT GGATGAGGCT 
TTTAGTTCCC TGGCCCGGGA CATCTTGCTC AAGTCAGGAG GCCGGAGATC AGGAAACGGC 
AACAAGCCTC CCAGTACTGA CCTGAAAACT TGTGACAAGA AGAACACCAA CAAGTGCTCC 
CTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258967.1
CDS	503..871
Translation	MGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG

Target ORF information:

RefSeq Version	NM_001272038.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272038.1

ORF Insert Sequence:

ATGGGCATTA TCCTAGTATA CGACATCACG GATGAGAAAT CTTTCGAGAA TATTCAGAAC 
TGGATGAAAA GCATCAAGGA GAATGCCTCG GCTGGGGTGG AGCGCCTCTT GCTGGGGAAC 
AAATGTGACA TGGAGGCCAA GAGGAAGGTG CAGAAGGAGC AGGCCGATAA GTTGGCTCGA 
GAGCATGGAA TCCGATTTTT CGAAACTAGT GCTAAATCCA GTATGAATGT GGATGAGGCT 
TTTAGTTCCC TGGCCCGGGA CATCTTGCTC AAGTCAGGAG GCCGGAGATC AGGAAACGGC 
AACAAGCCTC CCAGTACTGA CCTGAAAACT TGTGACAAGA AGAACACCAA CAAGTGCTCC 
CTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB13 ( XM_017001959.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857448.1 Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09711
Clone ID Related Accession (Same CDS sequence)	XM_017001959.1 , NM_001272038.1
Accession Version	XM_017001959.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ras-related protein Rab-13 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCATTA TCCTAGTATA CGACATCACG GATGAGAAAT CTTTCGAGAA TATTCAGAAC 
TGGATGAAAA GCATCAAGGA GAATGCCTCG GCTGGGGTGG AGCGCCTCTT GCTGGGGAAC 
AAATGTGACA TGGAGGCCAA GAGGAAGGTG CAGAAGGAGC AGGCCGATAA GTTGGCTCGA 
GAGCATGGAA TCCGATTTTT CGAAACTAGT GCTAAATCCA GTATGAATGT GGATGAGGCT 
TTTAGTTCCC TGGCCCGGGA CATCTTGCTC AAGTCAGGAG GCCGGAGATC AGGAAACGGC 
AACAAGCCTC CCAGTACTGA CCTGAAAACT TGTGACAAGA AGAACACCAA CAAGTGCTCC 
CTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857448.1
CDS	138..506
Translation	MGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG

Target ORF information:

RefSeq Version	XM_017001959.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001959.1

ORF Insert Sequence:

ATGGGCATTA TCCTAGTATA CGACATCACG GATGAGAAAT CTTTCGAGAA TATTCAGAAC 
TGGATGAAAA GCATCAAGGA GAATGCCTCG GCTGGGGTGG AGCGCCTCTT GCTGGGGAAC 
AAATGTGACA TGGAGGCCAA GAGGAAGGTG CAGAAGGAGC AGGCCGATAA GTTGGCTCGA 
GAGCATGGAA TCCGATTTTT CGAAACTAGT GCTAAATCCA GTATGAATGT GGATGAGGCT 
TTTAGTTCCC TGGCCCGGGA CATCTTGCTC AAGTCAGGAG GCCGGAGATC AGGAAACGGC 
AACAAGCCTC CCAGTACTGA CCTGAAAACT TGTGACAAGA AGAACACCAA CAAGTGCTCC 
CTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB13 ( NM_002870.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002861.1 Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09950
Clone ID Related Accession (Same CDS sequence)	NM_002870.3 , NM_002870.5 , NM_002870.4
Accession Version	NM_002870.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	ras-related protein Rab-13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC094846.1, BC000799.1 and AK291580.1. On Aug 31, 2019 this sequence version replaced NM_002870.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000799.1, AK291580.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002861.1
CDS	104..715
Translation	MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG

Target ORF information:

RefSeq Version	NM_002870.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002870.5

ORF Insert Sequence:

ATGGCCAAAG CCTACGACCA CCTCTTCAAG TTGCTGCTGA TCGGGGACTC GGGGGTGGGC 
AAGACTTGTC TGATCATTCG CTTTGCAGAG GACAACTTCA ACAACACTTA CATCTCCACC 
ATCGGAATTG ATTTCAAGAT CCGCACTGTG GATATAGAGG GGAAGAAGAT CAAACTACAA 
GTCTGGGACA CGGCTGGCCA AGAGCGGTTC AAGACAATAA CTACTGCCTA CTACCGTGGA 
GCCATGGGCA TTATCCTAGT ATACGACATC ACGGATGAGA AATCTTTCGA GAATATTCAG 
AACTGGATGA AAAGCATCAA GGAGAATGCC TCGGCTGGGG TGGAGCGCCT CTTGCTGGGG 
AACAAATGTG ACATGGAGGC CAAGAGGAAG GTGCAGAAGG AGCAGGCCGA TAAGTTGGCT 
CGAGAGCATG GAATCCGATT TTTCGAAACT AGTGCTAAAT CCAGTATGAA TGTGGATGAG 
GCTTTTAGTT CCCTGGCCCG GGACATCTTG CTCAAGTCAG GAGGCCGGAG ATCAGGAAAC 
GGCAACAAGC CTCCCAGTAC TGACCTGAAA ACTTGTGACA AGAAGAACAC CAACAAGTGC 
TCCCTGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells.
Biochimica et biophysica acta1864(4)613-624(2017 04)
Zhang L,Dai F,Cui L,Zhou B,Guo Y

Regulation of Cancer Cell Behavior by the Small GTPase Rab13.
The Journal of biological chemistry291(19)9929-37(2016 May)
Ioannou MS,McPherson PS

Rab13 Traffics on Vesicles Independent of Prenylation.
The Journal of biological chemistry291(20)10726-35(2016 May)
Ioannou MS,Girard M,McPherson PS

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
The EMBO journal34(22)2840-61(2015 Nov)
Lai YC,Kondapalli C,Lehneck R,Procter JB,Dill BD,Woodroof HI,Gourlay R,Peggie M,Macartney TJ,Corti O,Corvol JC,Campbell DG,Itzen A,Trost M,Muqit MM

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.
The Journal of cell biology208(5)629-48(2015 Mar)
Ioannou MS,Bell ES,Girard M,Chaineau M,Hamlin JN,Daubaras M,Monast A,Park M,Hodgson L,McPherson PS

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RAB13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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