QDPR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	QDPR
Entrez Gene ID	5860
Full Name	quinoid dihydropteridine reductase
Synonyms	DHPR,PKU2,SDR33C1
General protein information	Preferred Names quinoid dihydropteridine reductase Names dihydropteridine reductase 6,7-dihydropteridine reductase HDHPR short chain dehydrogenase/reductase family 33C member 1 testis secretory sperm-binding protein Li 236P
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p15.32
Summary	This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008].
Disorder MIM:	612676
Disorder Html:	Hyperphenylalaninemia, BH4-deficient, C, 261630 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001306140.1	NP_001293069.1	dihydropteridine reductase isoform 2
NM_000320.3	NP_000311.2	dihydropteridine reductase isoform 1
NM_000320.2	NP_000311.2	dihydropteridine reductase isoform 1

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	qdpr-1	NP_499760.1
Homo sapiens (human)	QDPR	NP_000311.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002534	XP_312404.2
Pan troglodytes (chimpanzee)	QDPR	XP_001161997.1
Canis lupus familiaris (dog)	QDPR	XP_536229.2
Bos taurus (cattle)	QDPR	NP_001069960.1
Mus musculus (house mouse)	Qdpr	NP_077198.1
Rattus norvegicus (Norway rat)	Qdpr	NP_071785.1
Drosophila melanogaster (fruit fly)	Dhpr	NP_001014579.1
	LOC714966	XP_001102244.1
Gallus gallus (chicken)	QDPR	NP_001006566.1
Danio rerio (zebrafish)	qdprb1	NP_001018534.1
Xenopus tropicalis (tropical clawed frog)	qdpr	NP_001011492.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and Purification of Quinine Dihydro Pteridine Reductase from astrocytes and its significance in the astrocyte pathology.
Chandrashekaran S, Karthikeyan S, Balakrishnan A, Nair S, Kumaran Madathiparambil SK, Vattathara JJ, Menon KN
International journal of biological macromolecules(2018 Jan)

A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling.
Si Q, Sun S, Gu Y
Acta biochimica et biophysica Sinica49(8)706-712(2017 Aug)

Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.
Zahra C, Tabone C, Camilleri G, Felice AE, Farrugia R, Bezzina Wettinger S
BMC medical genetics17(1)65(2016 09)

QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency.
Lu DY, Ye J, Han LS, Qiu WJ, Zhang HW, Zhou JD, Bao PZ, Zhang YF, Gu XF
World journal of pediatrics : WJP10(3)219-26(2014 Aug)

Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
Golini L, Chouabe C, Berthier C, Cusimano V, Fornaro M, Bonvallet R, Formoso L, Giacomello E, Jacquemond V, Sorrentino V
The Journal of biological chemistry286(51)43717-25(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The allele frequencies for the QDPR c.68G > A(0.3%) polymorphism is not a major cause of Parkinson's disease in the Maltese.
Title: Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.

The mutation spectrum of the QDPR gene is different in the Chinese population. Most mutations are related to severe phenotype.
Title: QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency.

JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery
Title: Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.

the electrostatic regulatory interaction between the SPRY2 F loop residues (that bind to imperatoxin A) and the ASI/basic residues of RyR1 does not influence bi-directional DHPR-RyR1 signaling during skeletal EC coupling
Title: The elusive role of the SPRY2 domain in RyR1.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following QDPR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the QDPR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21788	NM_000320.3 Latest version!	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu60151	NM_001306140.1 Latest version!	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu21788	NM_000320.2	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

QDPR ( NM_000320.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000311.2 Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21788
Clone ID Related Accession (Same CDS sequence)	NM_000320.3 , NM_000320.2
Accession Version	NM_000320.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	dihydropteridine reductase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM762805.1, BC000576.2, AC093600.3 and AW104747.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000320.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.736743.1, SRR3476690.840895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000281243.10/ ENSP00000281243.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGTGGGT TGCCAGCGTT 
GATGTGGTGG AGAATGAAGA GGCCAGCGCT AGCATCATTG TTAAAATGAC AGACTCGTTC 
ACTGAGCAGG CTGACCAGGT GACTGCTGAG GTTGGAAAGC TCTTGGGTGA AGAGAAGGTG 
GATGCAATTC TTTGCGTTGC TGGAGGATGG GCCGGGGGCA ATGCCAAATC CAAGTCTCTC 
TTTAAGAACT GTGACCTGAT GTGGAAGCAG AGCATATGGA CATCGACCAT CTCCAGCCAT 
CTGGCTACCA AGCATCTCAA GGAAGGAGGC CTCCTGACCT TGGCTGGCGC AAAGGCTGCC 
CTGGATGGGA CTCCTGGTAT GATCGGGTAC GGCATGGCCA AGGGTGCTGT TCACCAGCTC 
TGCCAGAGCC TGGCTGGGAA GAACAGCGGC ATGCCGCCCG GGGCAGCCGC CATCGCTGTG 
CTCCCGGTTA CCCTGGATAC CCCGATGAAC AGGAAATCAA TGCCTGAGGC TGACTTCAGC 
TCCTGGACAC CCTTAGAATT CCTAGTTGAA ACTTTCCATG ACTGGATCAC AGGGAAAAAC 
CGACCGAGCT CAGGAAGCCT AATCCAGGTG GTAACCACAG AAGGAAGGAC GGAACTCACC 
CCAGCATATT TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000311.2
CDS	37..771
Translation	MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF

Target ORF information:

RefSeq Version	NM_000320.3
Organism	Homo sapiens(human)
Definition	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000320.3

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGTGGGT TGCCAGCGTT 
GATGTGGTGG AGAATGAAGA GGCCAGCGCT AGCATCATTG TTAAAATGAC AGACTCGTTC 
ACTGAGCAGG CTGACCAGGT GACTGCTGAG GTTGGAAAGC TCTTGGGTGA AGAGAAGGTG 
GATGCAATTC TTTGCGTTGC TGGAGGATGG GCCGGGGGCA ATGCCAAATC CAAGTCTCTC 
TTTAAGAACT GTGACCTGAT GTGGAAGCAG AGCATATGGA CATCGACCAT CTCCAGCCAT 
CTGGCTACCA AGCATCTCAA GGAAGGAGGC CTCCTGACCT TGGCTGGCGC AAAGGCTGCC 
CTGGATGGGA CTCCTGGTAT GATCGGGTAC GGCATGGCCA AGGGTGCTGT TCACCAGCTC 
TGCCAGAGCC TGGCTGGGAA GAACAGCGGC ATGCCGCCCG GGGCAGCCGC CATCGCTGTG 
CTCCCGGTTA CCCTGGATAC CCCGATGAAC AGGAAATCAA TGCCTGAGGC TGACTTCAGC 
TCCTGGACAC CCTTAGAATT CCTAGTTGAA ACTTTCCATG ACTGGATCAC AGGGAAAAAC 
CGACCGAGCT CAGGAAGCCT AATCCAGGTG GTAACCACAG AAGGAAGGAC GGAACTCACC 
CCAGCATATT TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QDPR ( NM_000320.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000311.2 Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21788
Clone ID Related Accession (Same CDS sequence)	NM_000320.3 , NM_000320.2
Accession Version	NM_000320.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	dihydropteridine reductase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM762805.1, BC000576.2, AC093600.3 and AW104747.1. This sequence is a reference standard in the RefSeqGene project. On Oct 8, 2008 this sequence version replaced NM_000320.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005649.1, SRR1803612.186471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGTGGGT TGCCAGCGTT 
GATGTGGTGG AGAATGAAGA GGCCAGCGCT AGCATCATTG TTAAAATGAC AGACTCGTTC 
ACTGAGCAGG CTGACCAGGT GACTGCTGAG GTTGGAAAGC TCTTGGGTGA AGAGAAGGTG 
GATGCAATTC TTTGCGTTGC TGGAGGATGG GCCGGGGGCA ATGCCAAATC CAAGTCTCTC 
TTTAAGAACT GTGACCTGAT GTGGAAGCAG AGCATATGGA CATCGACCAT CTCCAGCCAT 
CTGGCTACCA AGCATCTCAA GGAAGGAGGC CTCCTGACCT TGGCTGGCGC AAAGGCTGCC 
CTGGATGGGA CTCCTGGTAT GATCGGGTAC GGCATGGCCA AGGGTGCTGT TCACCAGCTC 
TGCCAGAGCC TGGCTGGGAA GAACAGCGGC ATGCCGCCCG GGGCAGCCGC CATCGCTGTG 
CTCCCGGTTA CCCTGGATAC CCCGATGAAC AGGAAATCAA TGCCTGAGGC TGACTTCAGC 
TCCTGGACAC CCTTAGAATT CCTAGTTGAA ACTTTCCATG ACTGGATCAC AGGGAAAAAC 
CGACCGAGCT CAGGAAGCCT AATCCAGGTG GTAACCACAG AAGGAAGGAC GGAACTCACC 
CCAGCATATT TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000311.2
CDS	181..915
Translation	MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF

Target ORF information:

RefSeq Version	NM_000320.2
Organism	Homo sapiens(human)
Definition	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000320.2

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGTGGGT TGCCAGCGTT 
GATGTGGTGG AGAATGAAGA GGCCAGCGCT AGCATCATTG TTAAAATGAC AGACTCGTTC 
ACTGAGCAGG CTGACCAGGT GACTGCTGAG GTTGGAAAGC TCTTGGGTGA AGAGAAGGTG 
GATGCAATTC TTTGCGTTGC TGGAGGATGG GCCGGGGGCA ATGCCAAATC CAAGTCTCTC 
TTTAAGAACT GTGACCTGAT GTGGAAGCAG AGCATATGGA CATCGACCAT CTCCAGCCAT 
CTGGCTACCA AGCATCTCAA GGAAGGAGGC CTCCTGACCT TGGCTGGCGC AAAGGCTGCC 
CTGGATGGGA CTCCTGGTAT GATCGGGTAC GGCATGGCCA AGGGTGCTGT TCACCAGCTC 
TGCCAGAGCC TGGCTGGGAA GAACAGCGGC ATGCCGCCCG GGGCAGCCGC CATCGCTGTG 
CTCCCGGTTA CCCTGGATAC CCCGATGAAC AGGAAATCAA TGCCTGAGGC TGACTTCAGC 
TCCTGGACAC CCTTAGAATT CCTAGTTGAA ACTTTCCATG ACTGGATCAC AGGGAAAAAC 
CGACCGAGCT CAGGAAGCCT AATCCAGGTG GTAACCACAG AAGGAAGGAC GGAACTCACC 
CCAGCATATT TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QDPR ( NM_001306140.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001293069.1 Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu60151
Clone ID Related Accession (Same CDS sequence)	NM_001306140.1
Accession Version	NM_001306140.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	dihydropteridine reductase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM760507.1, AK124382.1 and AW104747.1. On Apr 15, 2015 this sequence version replaced XM_011513875.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.217671.1, SRR1803613.278851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGGTGAC TGCTGAGGTT 
GGAAAGCTCT TGGGTGAAGA GAAGGTGGAT GCAATTCTTT GCGTTGCTGG AGGATGGGCC 
GGGGGCAATG CCAAATCCAA GTCTCTCTTT AAGAACTGTG ACCTGATGTG GAAGCAGAGC 
ATATGGACAT CGACCATCTC CAGCCATCTG GCTACCAAGC ATCTCAAGGA AGGAGGCCTC 
CTGACCTTGG CTGGCGCAAA GGCTGCCCTG GATGGGACTC CTGGTATGAT CGGGTACGGC 
ATGGCCAAGG GTGCTGTTCA CCAGCTCTGC CAGAGCCTGG CTGGGAAGAA CAGCGGCATG 
CCGCCCGGGG CAGCCGCCAT CGCTGTGCTC CCGGTTACCC TGGATACCCC GATGAACAGG 
AAATCAATGC CTGAGGCTGA CTTCAGCTCC TGGACACCCT TAGAATTCCT AGTTGAAACT 
TTCCATGACT GGATCACAGG GAAAAACCGA CCGAGCTCAG GAAGCCTAAT CCAGGTGGTA 
ACCACAGAAG GAAGGACGGA ACTCACCCCA GCATATTTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293069.1
CDS	181..822
Translation	MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF

Target ORF information:

RefSeq Version	NM_001306140.1
Organism	Homo sapiens(human)
Definition	Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001306140.1

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCTGC AGGCGAGGCG CGCCGGGTGC TGGTGTACGG CGGCAGGGGC 
GCTCTGGGTT CTCGATGCGT GCAGGCTTTT CGGGCCCGCA ACTGGGTGAC TGCTGAGGTT 
GGAAAGCTCT TGGGTGAAGA GAAGGTGGAT GCAATTCTTT GCGTTGCTGG AGGATGGGCC 
GGGGGCAATG CCAAATCCAA GTCTCTCTTT AAGAACTGTG ACCTGATGTG GAAGCAGAGC 
ATATGGACAT CGACCATCTC CAGCCATCTG GCTACCAAGC ATCTCAAGGA AGGAGGCCTC 
CTGACCTTGG CTGGCGCAAA GGCTGCCCTG GATGGGACTC CTGGTATGAT CGGGTACGGC 
ATGGCCAAGG GTGCTGTTCA CCAGCTCTGC CAGAGCCTGG CTGGGAAGAA CAGCGGCATG 
CCGCCCGGGG CAGCCGCCAT CGCTGTGCTC CCGGTTACCC TGGATACCCC GATGAACAGG 
AAATCAATGC CTGAGGCTGA CTTCAGCTCC TGGACACCCT TAGAATTCCT AGTTGAAACT 
TTCCATGACT GGATCACAGG GAAAAACCGA CCGAGCTCAG GAAGCCTAAT CCAGGTGGTA 
ACCACAGAAG GAAGGACGGA ACTCACCCCA GCATATTTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and Purification of Quinine Dihydro Pteridine Reductase from astrocytes and its significance in the astrocyte pathology.
International journal of biological macromolecules(2018 Jan)
Chandrashekaran S,Karthikeyan S,Balakrishnan A,Nair S,Kumaran Madathiparambil SK,Vattathara JJ,Menon KN

A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling.
Acta biochimica et biophysica Sinica49(8)706-712(2017 Aug)
Si Q,Sun S,Gu Y

Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.
BMC medical genetics17(1)65(2016 09)
Zahra C,Tabone C,Camilleri G,Felice AE,Farrugia R,Bezzina Wettinger S

QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency.
World journal of pediatrics : WJP10(3)219-26(2014 Aug)
Lu DY,Ye J,Han LS,Qiu WJ,Zhang HW,Zhou JD,Bao PZ,Zhang YF,Gu XF

Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
The Journal of biological chemistry286(51)43717-25(2011 Dec)
Golini L,Chouabe C,Berthier C,Cusimano V,Fornaro M,Bonvallet R,Formoso L,Giacomello E,Jacquemond V,Sorrentino V

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QDPR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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