DNASE2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNASE2B
Entrez Gene ID	58511
Full Name	deoxyribonuclease 2 beta
Synonyms	DLAD
General protein information	Preferred Names deoxyribonuclease 2 beta Names deoxyribonuclease-2-beta DNase II beta DNase II-like acid DNase DNase2-like acid DNase deoxyribonuclease II beta endonuclease DLAD lysosomal DNase II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.1-p22.3
Summary	The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	608057

mRNA and Protein(s)

mRNA	Protein	Name
NM_021233.2	NP_067056.2	deoxyribonuclease-2-beta isoform 1 precursor
XM_011541878.2	XP_011540180.1	deoxyribonuclease-2-beta isoform X1
NM_058248.1	NP_490649.1	deoxyribonuclease-2-beta isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DNASE2B	NP_001032927.1
	DNASE2B	XP_001106353.1
Danio rerio (zebrafish)	LOC562996	XP_691451.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003295	XP_319521.5
Pan troglodytes (chimpanzee)	DNASE2B	XP_524754.3
Canis lupus familiaris (dog)	DNASE2B	XP_537097.2
Bos taurus (cattle)	DNASE2B	NP_001069333.1
Rattus norvegicus (Norway rat)	Dnase2b	NP_067696.1
Caenorhabditis elegans (roundworm)	crn-6	NP_499062.1
Caenorhabditis elegans (roundworm)	nuc-1	NP_509604.1
Xenopus tropicalis (tropical clawed frog)	dnase2b	NP_001011305.1
Homo sapiens (human)	DNASE2B	NP_067056.2
Mus musculus (house mouse)	Dnase2b	NP_064341.3
Drosophila melanogaster (fruit fly)	DNaseII	NP_650672.1

Gene Ontology
Bibliography

Related articles in PubMed

HSF4 regulates DLAD expression and promotes lens de-nucleation.
Cui X, Wang L, Zhang J, Du R, Liao S, Li D, Li C, Ke T, Li DW, Huang H, Yin Z, Tang Z, Liu M
Biochimica et biophysica acta1832(8)1167-72(2013 Aug)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)

Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
Lange CM, Kutalik Z, Morikawa K, Bibert S, Cerny A, Dollenmaier G, Dufour JF, Gerlach TJ, Heim MH, Malinverni R, M?llhaupt B, Negro F, Moradpour D, Bochud PY,
Hepatology (Baltimore, Md.)55(4)1038-47(2012 Apr)

DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
Fischer H, Scherz J, Szabo S, Mildner M, Benarafa C, Torriglia A, Tschachler E, Eckhart L
PloS one6(3)e17581(2011 Mar)

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HSF4 exerts its function on lens differentiation via positive regulation of DLAD expression.
Title: HSF4 regulates DLAD expression and promotes lens de-nucleation.

These data identify DNase 2 as the predominant DNase on the mammalian skin surface and indicate that its activity is primarily targeted to exogenous DNA.
Title: DNase 2 is the main DNA-degrading enzyme of the stratum corneum.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of alcohol dependence implicates a region on chromosome 11.

gene lie head-to-head with the urate oxidase gene
Title: Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.

The following DNASE2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNASE2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31513	NM_021233.2 Latest version!	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30355	NM_058248.1 Latest version!	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu30355	XM_011541878.2 Latest version!	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNASE2B ( NM_021233.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_067056.2 Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31513
Clone ID Related Accession (Same CDS sequence)	NM_021233.2
Accession Version	NM_021233.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	deoxyribonuclease-2-beta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF274571.1, BC080621.1, BC065182.1 and AF333389.1. On Dec 7, 2001 this sequence version replaced NM_021233.1. Transcript Variant: This variant (1) is the full-length transcript and encodes the longer isoform (1), which is more highly expressed in the salivary gland. ##Evidence-Data-START## Transcript exon combination :: AF274571.1, BC126136.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACAGA AAATGATGGC AAGACTGCTA AGAACATCCT TTGCTTTGCT CTTCCTTGGC 
CTCTTTGGGG TGCTGGGGGC AGCAACAATT TCATGCAGAA ATGAAGAAGG GAAAGCTGTG 
GACTGGTTTA CTTTTTATAA GTTACCTAAA AGACAAAACA AGGAAAGTGG AGAGACTGGG 
TTAGAGTACC TGTACCTAGA CTCTACAACT AGAAGCTGGA GGAAGAGTGA GCAACTAATG 
AATGACACCA AGAGTGTTTT GGGAAGGACA TTACAACAGC TATATGAAGC ATATGCCTCT 
AAGAGTAACA ACACAGCCTA TCTAATATAC AATGATGGAG TCCCTAAACC TGTGAATTAC 
AGCAGAAAGT ATGGACACAC CAAAGGTTTA CTGCTGTGGA ACAGAGTTCA AGGGTTCTGG 
CTGATTCATT CCATCCCTCA GTTTCCTCCA ATTCCGGAAG AAGGCTATGA TTATCCACCC 
ACAGGGAGAC GAAATGGACA AAGTGGCATC TGCATAACTT TCAAGTACAA CCAGTATGAG 
GCAATAGATT CTCAGCTCTT GGTCTGCAAC CCCAACGTCT ATAGCTGCTC CATCCCAGCC 
ACCTTTCACC AGGAGCTCAT TCACATGCCC CAGCTGTGCA CCAGGGCCAG CTCATCAGAG 
ATTCCTGGCA GGCTCCTCAC CACACTTCAG TCGGCCCAGG GACAAAAATT CCTCCATTTT 
GCAAAGTCGG ATTCTTTTCT TGACGACATC TTTGCAGCCT GGATGGCTCA ACGGCTGAAG 
ACACACTTGT TAACAGAAAC CTGGCAGCGA AAAAGACAAG AGCTTCCTTC AAACTGCTCC 
CTTCCTTACC ATGTCTACAA TATAAAAGCA ATTAAATTAT CACGACACTC TTATTTCAGT 
TCTTATCAAG ATCATGCCAA GTGGTGTATT TCCCAAAAGG GCACCAAAAA TCGCTGGACA 
TGTATTGGAG ACCTAAATCG GAGTCCACAC CAAGCCTTCA GAAGTGGAGG ATTCATTTGT 
ACCCAGAATT GGCAAATTTA CCAAGCATTT CAAGGATTAG TATTATACTA TGAAAGCTGT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067056.2
CDS	34..1119
Translation	MKQKMMARLLRTSFALLFLGLFGVLGAATISCRNEEGKAVDWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSCSIPATFHQELIHMPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK

Target ORF information:

RefSeq Version	NM_021233.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021233.2

ORF Insert Sequence:

ATGAAACAGA AAATGATGGC AAGACTGCTA AGAACATCCT TTGCTTTGCT CTTCCTTGGC 
CTCTTTGGGG TGCTGGGGGC AGCAACAATT TCATGCAGAA ATGAAGAAGG GAAAGCTGTG 
GACTGGTTTA CTTTTTATAA GTTACCTAAA AGACAAAACA AGGAAAGTGG AGAGACTGGG 
TTAGAGTACC TGTACCTAGA CTCTACAACT AGAAGCTGGA GGAAGAGTGA GCAACTAATG 
AATGACACCA AGAGTGTTTT GGGAAGGACA TTACAACAGC TATATGAAGC ATATGCCTCT 
AAGAGTAACA ACACAGCCTA TCTAATATAC AATGATGGAG TCCCTAAACC TGTGAATTAC 
AGCAGAAAGT ATGGACACAC CAAAGGTTTA CTGCTGTGGA ACAGAGTTCA AGGGTTCTGG 
CTGATTCATT CCATCCCTCA GTTTCCTCCA ATTCCGGAAG AAGGCTATGA TTATCCACCC 
ACAGGGAGAC GAAATGGACA AAGTGGCATC TGCATAACTT TCAAGTACAA CCAGTATGAG 
GCAATAGATT CTCAGCTCTT GGTCTGCAAC CCCAACGTCT ATAGCTGCTC CATCCCAGCC 
ACCTTTCACC AGGAGCTCAT TCACATGCCC CAGCTGTGCA CCAGGGCCAG CTCATCAGAG 
ATTCCTGGCA GGCTCCTCAC CACACTTCAG TCGGCCCAGG GACAAAAATT CCTCCATTTT 
GCAAAGTCGG ATTCTTTTCT TGACGACATC TTTGCAGCCT GGATGGCTCA ACGGCTGAAG 
ACACACTTGT TAACAGAAAC CTGGCAGCGA AAAAGACAAG AGCTTCCTTC AAACTGCTCC 
CTTCCTTACC ATGTCTACAA TATAAAAGCA ATTAAATTAT CACGACACTC TTATTTCAGT 
TCTTATCAAG ATCATGCCAA GTGGTGTATT TCCCAAAAGG GCACCAAAAA TCGCTGGACA 
TGTATTGGAG ACCTAAATCG GAGTCCACAC CAAGCCTTCA GAAGTGGAGG ATTCATTTGT 
ACCCAGAATT GGCAAATTTA CCAAGCATTT CAAGGATTAG TATTATACTA TGAAAGCTGT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE2B ( NM_058248.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_490649.1 Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30355
Clone ID Related Accession (Same CDS sequence)	XM_011541878.2 , NM_058248.1
Accession Version	NM_058248.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	deoxyribonuclease-2-beta isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF333389.1. Transcript Variant: This variant (2) lacks the first two exons present in transcript variant 1. However, it maintains the same reading frame and encodes an isoform (2) which is truncated at the N-terminus compared to isoform 1. Isoform 2 is specifically expressed in the lungs. ##Evidence-Data-START## Transcript exon combination :: AF333389.1, BC080621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCCAGC TGTGCACCAG GGCCAGCTCA TCAGAGATTC CTGGCAGGCT CCTCACCACA 
CTTCAGTCGG CCCAGGGACA AAAATTCCTC CATTTTGCAA AGTCGGATTC TTTTCTTGAC 
GACATCTTTG CAGCCTGGAT GGCTCAACGG CTGAAGACAC ACTTGTTAAC AGAAACCTGG 
CAGCGAAAAA GACAAGAGCT TCCTTCAAAC TGCTCCCTTC CTTACCATGT CTACAATATA 
AAAGCAATTA AATTATCACG ACACTCTTAT TTCAGTTCTT ATCAAGATCA TGCCAAGTGG 
TGTATTTCCC AAAAGGGCAC CAAAAATCGC TGGACATGTA TTGGAGACCT AAATCGGAGT 
CCACACCAAG CCTTCAGAAG TGGAGGATTC ATTTGTACCC AGAATTGGCA AATTTACCAA 
GCATTTCAAG GATTAGTATT ATACTATGAA AGCTGTAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_490649.1
CDS	408..869
Translation	MPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK

Target ORF information:

RefSeq Version	NM_058248.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058248.1

ORF Insert Sequence:

ATGCCCCAGC TGTGCACCAG GGCCAGCTCA TCAGAGATTC CTGGCAGGCT CCTCACCACA 
CTTCAGTCGG CCCAGGGACA AAAATTCCTC CATTTTGCAA AGTCGGATTC TTTTCTTGAC 
GACATCTTTG CAGCCTGGAT GGCTCAACGG CTGAAGACAC ACTTGTTAAC AGAAACCTGG 
CAGCGAAAAA GACAAGAGCT TCCTTCAAAC TGCTCCCTTC CTTACCATGT CTACAATATA 
AAAGCAATTA AATTATCACG ACACTCTTAT TTCAGTTCTT ATCAAGATCA TGCCAAGTGG 
TGTATTTCCC AAAAGGGCAC CAAAAATCGC TGGACATGTA TTGGAGACCT AAATCGGAGT 
CCACACCAAG CCTTCAGAAG TGGAGGATTC ATTTGTACCC AGAATTGGCA AATTTACCAA 
GCATTTCAAG GATTAGTATT ATACTATGAA AGCTGTAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE2B ( XM_011541878.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540180.1 Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30355
Clone ID Related Accession (Same CDS sequence)	XM_011541878.2 , NM_058248.1
Accession Version	XM_011541878.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	deoxyribonuclease-2-beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011541878.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCAGC TGTGCACCAG GGCCAGCTCA TCAGAGATTC CTGGCAGGCT CCTCACCACA 
CTTCAGTCGG CCCAGGGACA AAAATTCCTC CATTTTGCAA AGTCGGATTC TTTTCTTGAC 
GACATCTTTG CAGCCTGGAT GGCTCAACGG CTGAAGACAC ACTTGTTAAC AGAAACCTGG 
CAGCGAAAAA GACAAGAGCT TCCTTCAAAC TGCTCCCTTC CTTACCATGT CTACAATATA 
AAAGCAATTA AATTATCACG ACACTCTTAT TTCAGTTCTT ATCAAGATCA TGCCAAGTGG 
TGTATTTCCC AAAAGGGCAC CAAAAATCGC TGGACATGTA TTGGAGACCT AAATCGGAGT 
CCACACCAAG CCTTCAGAAG TGGAGGATTC ATTTGTACCC AGAATTGGCA AATTTACCAA 
GCATTTCAAG GATTAGTATT ATACTATGAA AGCTGTAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540180.1
CDS	560..1021
Translation	MPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK

Target ORF information:

RefSeq Version	XM_011541878.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 2 beta (DNASE2B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011541878.2

ORF Insert Sequence:

ATGCCCCAGC TGTGCACCAG GGCCAGCTCA TCAGAGATTC CTGGCAGGCT CCTCACCACA 
CTTCAGTCGG CCCAGGGACA AAAATTCCTC CATTTTGCAA AGTCGGATTC TTTTCTTGAC 
GACATCTTTG CAGCCTGGAT GGCTCAACGG CTGAAGACAC ACTTGTTAAC AGAAACCTGG 
CAGCGAAAAA GACAAGAGCT TCCTTCAAAC TGCTCCCTTC CTTACCATGT CTACAATATA 
AAAGCAATTA AATTATCACG ACACTCTTAT TTCAGTTCTT ATCAAGATCA TGCCAAGTGG 
TGTATTTCCC AAAAGGGCAC CAAAAATCGC TGGACATGTA TTGGAGACCT AAATCGGAGT 
CCACACCAAG CCTTCAGAAG TGGAGGATTC ATTTGTACCC AGAATTGGCA AATTTACCAA 
GCATTTCAAG GATTAGTATT ATACTATGAA AGCTGTAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HSF4 regulates DLAD expression and promotes lens de-nucleation.
Biochimica et biophysica acta1832(8)1167-72(2013 Aug)
Cui X,Wang L,Zhang J,Du R,Liao S,Li D,Li C,Ke T,Li DW,Huang H,Yin Z,Tang Z,Liu M

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics9(1)e1003225(2013)
Lauc G,Huffman JE,Pu?i? M,Zgaga L,Adamczyk B,Mu?ini? A,Novokmet M,Pola?ek O,Gornik O,Kri?ti? J,Keser T,Vitart V,Scheijen B,Uh HW,Molokhia M,Patrick AL,McKeigue P,Kol?i? I,Luki? IK,Swann O,van Leeuwen FN,Ruhaak LR,Houwing-Duistermaat JJ,Slagboom PE,Beekman M,de Craen AJ,Deelder AM,Zeng Q,Wang W,Hastie ND,Gyllensten U,Wilson JF,Wuhrer M,Wright AF,Rudd PM,Hayward C,Aulchenko Y,Campbell H,Rudan I

Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
Hepatology (Baltimore, Md.)55(4)1038-47(2012 Apr)
Lange CM,Kutalik Z,Morikawa K,Bibert S,Cerny A,Dollenmaier G,Dufour JF,Gerlach TJ,Heim MH,Malinverni R,M?llhaupt B,Negro F,Moradpour D,Bochud PY,

DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
PloS one6(3)e17581(2011 Mar)
Fischer H,Scherz J,Szabo S,Mildner M,Benarafa C,Torriglia A,Tschachler E,Eckhart L

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research694(1-2)13-9(2010 Dec)
Flachsbart F,Franke A,Kleindorp R,Caliebe A,Blanch? H,Schreiber S,Nebel A

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DNASE2B cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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