SLC4A5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC4A5
Entrez Gene ID	57835
Full Name	solute carrier family 4 member 5
Synonyms	NBC4,NBCe2
General protein information	Preferred Names solute carrier family 4 member 5 Names electrogenic sodium bicarbonate cotransporter 4 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	606757

mRNA and Protein(s)

mRNA	Protein	Name
NM_133478.3	NP_597812.1	electrogenic sodium bicarbonate cotransporter 4 isoform c
NM_133478.2	NP_597812.1	electrogenic sodium bicarbonate cotransporter 4 isoform c
NM_021196.3	NP_067019.3	electrogenic sodium bicarbonate cotransporter 4 isoform a

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC4A5	XP_005212529.1
Mus musculus (house mouse)	Slc4a5	NP_001159539.1
Danio rerio (zebrafish)	si:ch211-48m9.1	XP_687688.6
Pan troglodytes (chimpanzee)	SLC4A5	XP_001154954.1
	SLC4A5	XP_002799360.1
Rattus norvegicus (Norway rat)	Slc4a5	NP_997677.1
Homo sapiens (human)	SLC4A5	NP_067019.3
Canis lupus familiaris (dog)	SLC4A5	XP_005630605.1
Xenopus tropicalis (tropical clawed frog)	slc4a5	XP_002933018.2

Gene Ontology
Bibliography

Related articles in PubMed

The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.
Gildea JJ, Xu P, Carlson JM, Gaglione RT, Bigler Wang D, Kemp BA, Reyes CM, McGrath HE, Carey RM, Jose PA, Felder RA
American journal of physiology. Regulatory, integrative and comparative physiology309(11)R1447-59(2015 Dec)

Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.
Wen D, Sansom SC
American journal of physiology. Renal physiology309(6)F489-91(2015 Sep)

Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
Xie P, Kranzler HR, Yang C, Zhao H, Farrer LA, Gelernter J
Biological psychiatry74(9)656-63(2013 Nov)

Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.
Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, Park MJ, Sobota RS, Underwood PC, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins PN, Adler GK, Williams SM, Jose PA, Felder RA
Hypertension (Dallas, Tex. : 1979)60(5)1359-66(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions.
Title: The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.

we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW}
Title: Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.

Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes.
Title: Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.

The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153).
Title: Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Genetic and environmental risks for high blood pressure among African American mothers and daughters.

The following SLC4A5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC4A5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18627	NM_021196.3 Latest version!	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$804.30 $1149.00
OHu29914	NM_133478.3 Latest version!	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$790.30 $1129.00
View Old Accession Versions >>
OHu29914	NM_133478.2	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$790.30 $1129.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC4A5 ( NM_021196.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067019.3 Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu18627
Clone ID Related Accession (Same CDS sequence)	NM_021196.3
Accession Version	NM_021196.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-26
Organism	Homo sapiens(human)
Product	electrogenic sodium bicarbonate cotransporter 4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF293337.2 and AF243499.2. On Feb 16, 2007 this sequence version replaced NM_021196.2. Transcript Variant: This variant (a) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF243499.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGATGG GGACCGGAGG GTCAGAATTC 
AAAATCCAGA AGAAGCTGAC TCCATTCTGG GAACGCTGCA AGCTCTTCCT GATGCCAGCC 
AAGCACCAGC CGGACCATGC CTTCCTGCGG CACGTGCCGC TGCGCCGGAT CCACCTCTTC 
ACCCTGGTGC AGATCCTCTG CCTGGCGGTG CTCTGGATCC TCAAATCCAC GGTGGCTGCC 
ATCATCTTCC CGGTCATGAT CCTGGGCCTC ATCATCGTTC GAAGGCTTCT GGATTTCATC 
TTTTCCCAGC ACGACCTGGC CTGGATTGAC AACATCCTCC CAGAGAAGGA AAAAAAGGAG 
ACAGACAAGA AGAGGAAGAG AAAAAAAGGG GCCCACGAGG ACTGTGATGA GGAGCCCCAG 
TTCCCTCCTC CCTCGGTTAT AAAGATTCCC ATGGAAAGTG TCCAATCAGA TCCCCAAAAC 
GGTATCCACT GCATTGCCAG AAAAAGATCT TCCAGTTGGA GTTACTCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067019.3
CDS	3..3416
Translation	MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL

Target ORF information:

RefSeq Version	NM_021196.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021196.3

ORF Insert Sequence:

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGATGG GGACCGGAGG GTCAGAATTC 
AAAATCCAGA AGAAGCTGAC TCCATTCTGG GAACGCTGCA AGCTCTTCCT GATGCCAGCC 
AAGCACCAGC CGGACCATGC CTTCCTGCGG CACGTGCCGC TGCGCCGGAT CCACCTCTTC 
ACCCTGGTGC AGATCCTCTG CCTGGCGGTG CTCTGGATCC TCAAATCCAC GGTGGCTGCC 
ATCATCTTCC CGGTCATGAT CCTGGGCCTC ATCATCGTTC GAAGGCTTCT GGATTTCATC 
TTTTCCCAGC ACGACCTGGC CTGGATTGAC AACATCCTCC CAGAGAAGGA AAAAAAGGAG 
ACAGACAAGA AGAGGAAGAG AAAAAAAGGG GCCCACGAGG ACTGTGATGA GGAGCCCCAG 
TTCCCTCCTC CCTCGGTTAT AAAGATTCCC ATGGAAAGTG TCCAATCAGA TCCCCAAAAC 
GGTATCCACT GCATTGCCAG AAAAAGATCT TCCAGTTGGA GTTACTCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC4A5 ( NM_133478.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_597812.1 Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.

Price & Availability↑

CloneID	OHu29914
Clone ID Related Accession (Same CDS sequence)	NM_133478.3 , NM_133478.2
Accession Version	NM_133478.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-26
Organism	Homo sapiens(human)
Product	electrogenic sodium bicarbonate cotransporter 4 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006030.2, DB455137.2 and AF293337.2. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_133478.2. Transcript Variant: This variant (c) lacks an internal exon in the coding region as compared to variant a. Variant c encodes a protein that lacks a 16 aa internal segment. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGTTCT GGGAACGCTG CAAGCTCTTC 
CTGATGCCAG CCAAGCACCA GCCGGACCAT GCCTTCCTGC GGCACGTGCC GCTGCGCCGG 
ATCCACCTCT TCACCCTGGT GCAGATCCTC TGCCTGGCGG TGCTCTGGAT CCTCAAATCC 
ACGGTGGCTG CCATCATCTT CCCGGTCATG ATCCTGGGCC TCATCATCGT TCGAAGGCTT 
CTGGATTTCA TCTTTTCCCA GCACGACCTG GCCTGGATTG ACAACATCCT CCCAGAGAAG 
GAAAAAAAGG AGACAGACAA GAAGAGGAAG AGAAAAAAAG GGGCCCACGA GGACTGTGAT 
GAGGAGCCCC AGTTCCCTCC TCCCTCGGTT ATAAAGATTC CCATGGAAAG TGTCCAATCA 
GATCCCCAAA ACGGTATCCA CTGCATTGCC AGAAAAAGAT CTTCCAGTTG GAGTTACTCA 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597812.1
CDS	408..3773
Translation	MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL

Target ORF information:

RefSeq Version	NM_133478.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133478.3

ORF Insert Sequence:

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGTTCT GGGAACGCTG CAAGCTCTTC 
CTGATGCCAG CCAAGCACCA GCCGGACCAT GCCTTCCTGC GGCACGTGCC GCTGCGCCGG 
ATCCACCTCT TCACCCTGGT GCAGATCCTC TGCCTGGCGG TGCTCTGGAT CCTCAAATCC 
ACGGTGGCTG CCATCATCTT CCCGGTCATG ATCCTGGGCC TCATCATCGT TCGAAGGCTT 
CTGGATTTCA TCTTTTCCCA GCACGACCTG GCCTGGATTG ACAACATCCT CCCAGAGAAG 
GAAAAAAAGG AGACAGACAA GAAGAGGAAG AGAAAAAAAG GGGCCCACGA GGACTGTGAT 
GAGGAGCCCC AGTTCCCTCC TCCCTCGGTT ATAAAGATTC CCATGGAAAG TGTCCAATCA 
GATCCCCAAA ACGGTATCCA CTGCATTGCC AGAAAAAGAT CTTCCAGTTG GAGTTACTCA 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC4A5 ( NM_133478.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_597812.1 Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.

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CloneID	OHu29914
Clone ID Related Accession (Same CDS sequence)	NM_133478.3 , NM_133478.2
Accession Version	NM_133478.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-08
Organism	Homo sapiens(human)
Product	electrogenic sodium bicarbonate cotransporter 4 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB455137.2 and AF293337.2. On or before Aug 31, 2013 this sequence version replaced XM_005264465.1, NM_133478.1. Transcript Variant: This variant (c) lacks an internal exon in the coding region as compared to variant a. Variant c encodes a protein that lacks a 16 aa internal segment. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF293337.2 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGTTCT GGGAACGCTG CAAGCTCTTC 
CTGATGCCAG CCAAGCACCA GCCGGACCAT GCCTTCCTGC GGCACGTGCC GCTGCGCCGG 
ATCCACCTCT TCACCCTGGT GCAGATCCTC TGCCTGGCGG TGCTCTGGAT CCTCAAATCC 
ACGGTGGCTG CCATCATCTT CCCGGTCATG ATCCTGGGCC TCATCATCGT TCGAAGGCTT 
CTGGATTTCA TCTTTTCCCA GCACGACCTG GCCTGGATTG ACAACATCCT CCCAGAGAAG 
GAAAAAAAGG AGACAGACAA GAAGAGGAAG AGAAAAAAAG GGGCCCACGA GGACTGTGAT 
GAGGAGCCCC AGTTCCCTCC TCCCTCGGTT ATAAAGATTC CCATGGAAAG TGTCCAATCA 
GATCCCCAAA ACGGTATCCA CTGCATTGCC AGAAAAAGAT CTTCCAGTTG GAGTTACTCA 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597812.1
CDS	399..3764
Translation	MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL

Target ORF information:

RefSeq Version	NM_133478.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 4 member 5 (SLC4A5), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133478.2

ORF Insert Sequence:

ATGAAGGTGA AGGAGGAGAA GGCTGGGGTA GGAAAGCTGG ACCACACTAA CCACAGGAGG 
AGATTTCCGG ATCAGAAAGA ATGCCCTCCT ATCCACATTG GGCTTCCAGT ACCCACTTAC 
CCTCAAAGAA AAACTGACCA GAAGGGACAT CTTTCAGGCC TGCAAAAAGT CCACTGGGGC 
CTGCGGCCAG ACCAGCCACA GCAGGAACTG ACTGGCCCAG GGAGTGGGGC AAGCAGCCAG 
GACAGCAGCA TGGATCTTAT CAGCAGGACT CGGTCCCCAG CTGCTGAGCA GCTCCAGGAC 
ATCCTGGGGG AGGAAGATGA GGCTCCCAAC CCCACCCTCT TTACAGAGAT GGATACTCTG 
CAGCATGACG GAGACCAGAT GGAGTGGAAG GAGTCAGCCA GGTGGATAAA GTTTGAAGAA 
AAGGTAGAGG AAGGCGGCGA ACGCTGGAGC AAGCCCCACG TGTCCACACT ATCCCTGCAC 
AGCCTCTTCG AGCTCCGTAC CTGCCTGCAG ACGGGGACGG TGCTGCTGGA TTTGGACAGT 
GGCTCCTTAC CACAGATCAT AGATGATGTC ATTGAGAAGC AGATTGAGGA TGGTCTCCTG 
CGGCCAGAGC TCCGGGAGAG GGTCAGTTAC GTCCTCCTGA GGAGGCACCG CCACCAAACC 
AAGAAGCCCA TCCACCGCTC CTTAGCTGAC ATTGGGAAGT CAGTCTCCAC CACAAATCGC 
AGTCCTGCCC GGAGCCCTGG TGCTGGCCCG AGTCTACACC ACTCCACGGA AGACCTGCGG 
ATGCGGCAGA GTGCAAATTA CGGACGTCTG TGTCATGCCC AGAGCAGAAG CATGAATGAC 
ATTTCTCTCA CCCCAAACAC AGACCAGCGG AAAAACAAAT TCATGAAGAA GATCCCCAAG 
GACTCAGAAG CGTCCAACGT GCTCGTGGGC GAGGTGGACT TCCTAGACCA GCCATTCATC 
GCGTTCGTGC GCCTCATCCA GTCGGCCATG CTGGGAGGAG TGACCGAGGT GCCTGTCCCC 
ACCAGATTTC TGTTTATACT ACTGGGACCT TCTGGGAGAG CAAAATCCTA CAATGAAATT 
GGCCGTGCCA TTGCAACCCT CATGGTAGAT GATCTCTTCA GTGACGTGGC CTACAAAGCC 
CGCAATCGGG AAGATCTGAT CGCAGGAATT GATGAATTTC TGGATGAGGT CATCGTCCTT 
CCTCCTGGAG AATGGGACCC AAATATCCGG ATTGAGCCCC CCAAGAAGGT GCCCTCTGCT 
GACAAGAGGA AATCTGTGTT CTCCCTAGCA GAGCTGGGCC AGATGAATGG CTCTGTGGGA 
GGAGGCGGCG GAGCTCCTGG AGGAGGCAAT GGAGGTGGTG GTGGTGGTGG CAGTGGCGGC 
GGGGCTGGCA GTGGCGGGGC CGGCGGAACA AGCAGCGGGG ATGATGGAGA GATGCCAGCC 
ATGCATGAAA TCGGGGAGGA ACTTATCTGG ACAGGAAGGT TCTTCGGTGG CCTGTGTCTG 
GATATCAAGA GGAAGTTGCC CTGGTTCCCA AGTGACTTCT ATGATGGCTT CCACATTCAG 
TCCATCTCTG CCATCCTATT CATCTACCTC GGCTGTATCA CCAACGCGAT CACCTTTGGT 
GGGCTTCTGG GGGATGCCAC CGACAATTAT CAGGGAGTGA TGGAGAGCTT CCTGGGCACT 
GCCATGGCTG GCTCCTTGTT CTGCCTCTTC TCGGGACAGC CTCTCATCAT TCTCAGCAGC 
ACGGGGCCCA TCCTCATCTT TGAGAAGCTC CTCTTCGACT TCAGCAAAGG CAATGGCCTG 
GACTACATGG AGTTCCGCCT CTGGATTGGC CTACACTCAG CTGTCCAGTG CCTTATCCTA 
GTGGCCACAG ATGCCAGCTT TATCATCAAA TATATCACCC GCTTCACCGA GGAGGGCTTC 
TCCACCCTTA TCAGCTTCAT CTTCATCTAC GATGCCATCA AGAAGATGAT CGGTGCCTTC 
AAGTACTACC CTATCAATAT GGACTTCAAG CCAAACTTCA TCACTACCTA CAAGTGCGAG 
TGTGTCGCCC CTGACACAGT GAATACAACC GTGTTCAATG CTTCAGCCCC ATTGGCACCA 
GACACCAACG CTTCTCTGTA CAACCTCCTT AACCTCACAG CGTTGGACTG GTCCCTGCTG 
AGCAAGAAGG AGTGTCTGAG CTACGGCGGG CGCCTGCTTG GGAATTCCTG CAAGTTTATC 
CCAGACCTGG CGCTCATGTC CTTCATCCTT TTCTTTGGGA CATACTCCAT GACCCTGACC 
CTGAAGAAGT TCAAATTCAG CCGCTATTTT CCTACCAAGG TCCGGGCCCT GGTGGCTGAC 
TTTTCCATTG TTTTCTCCAT CCTGATGTTC TGTGGAATCG ATGCCTGTTT TGGCCTAGAA 
ACTCCCAAGC TGCATGTGCC CAGTGTCATC AAGCCAACGC GGCCTGACCG AGGCTGGTTC 
GTGGCCCCCT TTGGGAAGAA CCCGTGGTGG GTATACCCAG CAAGCATCCT GCCCGCCCTG 
CTGGTGACCA TCCTGATCTT CATGGACCAG CAGATCACTG CCGTCATTGT CAACCGGAAG 
GAGAACAAAC TGAAGAAGGC TGCCGGCTAC CATCTGGACC TGTTCTGGGT GGGCATCCTC 
ATGGCTTTGT GCTCCTTTAT GGGGCTCCCC TGGTACGTGG CTGCCACGGT CATCTCCATC 
GCCCACATCG ACAGCCTCAA GATGGAGACA GAGACCAGTG CCCCTGGGGA GCAGCCCCAG 
TTTCTGGGAG TCAGGGAACA GAGAGTAACC GGCATCATCG TCTTCATCCT GACGGGAATC 
TCTGTCTTCC TGGCTCCCAT CCTAAAGTGT ATCCCCCTGC CGGTGCTGTA CGGAGTCTTC 
CTCTACATGG GCGTGGCCTC CCTGAATGGC ATCCAGTTCT GGGAACGCTG CAAGCTCTTC 
CTGATGCCAG CCAAGCACCA GCCGGACCAT GCCTTCCTGC GGCACGTGCC GCTGCGCCGG 
ATCCACCTCT TCACCCTGGT GCAGATCCTC TGCCTGGCGG TGCTCTGGAT CCTCAAATCC 
ACGGTGGCTG CCATCATCTT CCCGGTCATG ATCCTGGGCC TCATCATCGT TCGAAGGCTT 
CTGGATTTCA TCTTTTCCCA GCACGACCTG GCCTGGATTG ACAACATCCT CCCAGAGAAG 
GAAAAAAAGG AGACAGACAA GAAGAGGAAG AGAAAAAAAG GGGCCCACGA GGACTGTGAT 
GAGGAGCCCC AGTTCCCTCC TCCCTCGGTT ATAAAGATTC CCATGGAAAG TGTCCAATCA 
GATCCCCAAA ACGGTATCCA CTGCATTGCC AGAAAAAGAT CTTCCAGTTG GAGTTACTCA 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.
American journal of physiology. Regulatory, integrative and comparative physiology309(11)R1447-59(2015 Dec)
Gildea JJ,Xu P,Carlson JM,Gaglione RT,Bigler Wang D,Kemp BA,Reyes CM,McGrath HE,Carey RM,Jose PA,Felder RA

Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.
American journal of physiology. Renal physiology309(6)F489-91(2015 Sep)
Wen D,Sansom SC

Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
Biological psychiatry74(9)656-63(2013 Nov)
Xie P,Kranzler HR,Yang C,Zhao H,Farrer LA,Gelernter J

Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.
Hypertension (Dallas, Tex. : 1979)60(5)1359-66(2012 Nov)
Carey RM,Schoeffel CD,Gildea JJ,Jones JE,McGrath HE,Gordon LN,Park MJ,Sobota RS,Underwood PC,Williams J,Sun B,Raby B,Lasky-Su J,Hopkins PN,Adler GK,Williams SM,Jose PA,Felder RA

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SLC4A5 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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