LSM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM2
Entrez Gene ID	57819
Full Name	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	C6orf28,G7B,YBL026W,snRNP
General protein information	Preferred Names LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm2 LSM2 U6 small nuclear RNA and mRNA degradation associated LSM2 homolog, U6 small nuclear RNA associated protein G7b small nuclear ribonuclear protein D homolog snRNP core Sm-like protein Sm-x5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011].
Disorder MIM:	607282

mRNA and Protein(s)

mRNA	Protein	Name
NM_021177.4	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2
NM_021177.5	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LSM2	XP_518362.3
Rattus norvegicus (Norway rat)	Lsm2	NP_001004073.1
Caenorhabditis elegans (roundworm)	gut-2	NP_001256511.1
Neurospora crassa	NCU07382	XP_958875.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005136	XP_314020.2
Saccharomyces cerevisiae (baker's yeast)	LSM2	NP_009527.1
Schizosaccharomyces pombe (fission yeast)	lsm2	NP_588459.1
Magnaporthe oryzae (rice blast fungus)	MGG_00355	XP_003718727.1
Homo sapiens (human)	LSM2	NP_067000.1
	LSM2	XP_001105870.1
Danio rerio (zebrafish)	smx5	NP_571571.1
Kluyveromyces lactis	KLLA0F09207g	XP_455499.1
Canis lupus familiaris (dog)	LOC474849	XP_532081.3
Mus musculus (house mouse)	Lsm2	NP_085100.1
Drosophila melanogaster (fruit fly)	CG10418	NP_648570.1
Eremothecium gossypii	AGOS_AFR182C	NP_985729.1
Arabidopsis thaliana (thale cress)	AT1G03330	NP_563682.1
Bos taurus (cattle)	LSM2	NP_001094647.1
Oryza sativa (rice)	Os08g0154700	NP_001061016.2
Xenopus tropicalis (tropical clawed frog)	lsm2	NP_001016402.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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Title: Small nuclear ribonucleoprotein associated polypeptide N accelerates cell proliferation in pancreatic adenocarcinoma.

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Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

The following LSM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03672	NM_021177.5 Latest version!	Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03672	NM_021177.4	Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM2 ( NM_021177.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067000.1 Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.

Price & Availability↑

CloneID	OHu03672
Clone ID Related Accession (Same CDS sequence)	NM_021177.4 , NM_021177.5
Accession Version	NM_021177.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP203102.1, BU189898.1, AF136977.1 and AI570628.1. On Nov 5, 2011 this sequence version replaced NM_021177.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.127504.1, SRR1163658.430761.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCTTCT ATTCTTTTTT CAAGTCCCTT GTGGGCAAGG ATGTGGTCGT GGAACTAAAG 
AATGACCTGA GCATCTGTGG AACCCTCCAT TCTGTGGATC AGTATCTCAA CATCAAACTA 
ACTGACATCA GTGTCACAGA CCCTGAGAAA TACCCTCACA TGTTATCAGT GAAGAACTGC 
TTCATTCGGG GCTCAGTGGT CCGATACGTG CAGCTGCCAG CAGATGAGGT CGACACACAG 
TTGCTACAGG ATGCGGCAAG GAAGGAAGCC CTGCAGCAGA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067000.1
CDS	228..515
Translation	MLFYSFFKSLVGKDVVVELKNDLSICGTLHSVDQYLNIKLTDISVTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ

Target ORF information:

RefSeq Version	NM_021177.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021177.4

ORF Insert Sequence:

ATGCTCTTCT ATTCTTTTTT CAAGTCCCTT GTGGGCAAGG ATGTGGTCGT GGAACTAAAG 
AATGACCTGA GCATCTGTGG AACCCTCCAT TCTGTGGATC AGTATCTCAA CATCAAACTA 
ACTGACATCA GTGTCACAGA CCCTGAGAAA TACCCTCACA TGTTATCAGT GAAGAACTGC 
TTCATTCGGG GCTCAGTGGT CCGATACGTG CAGCTGCCAG CAGATGAGGT CGACACACAG 
TTGCTACAGG ATGCGGCAAG GAAGGAAGCC CTGCAGCAGA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM2 ( NM_021177.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_067000.1 Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.

Price & Availability↑

CloneID	OHu03672
Clone ID Related Accession (Same CDS sequence)	NM_021177.4 , NM_021177.5
Accession Version	NM_021177.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU189898.1 and AF136977.1. On Nov 22, 2018 this sequence version replaced NM_021177.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009192.2, SRR1163655.277720.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375661.6/ ENSP00000364813.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCTTCT ATTCTTTTTT CAAGTCCCTT GTGGGCAAGG ATGTGGTCGT GGAACTAAAG 
AATGACCTGA GCATCTGTGG AACCCTCCAT TCTGTGGATC AGTATCTCAA CATCAAACTA 
ACTGACATCA GTGTCACAGA CCCTGAGAAA TACCCTCACA TGTTATCAGT GAAGAACTGC 
TTCATTCGGG GCTCAGTGGT CCGATACGTG CAGCTGCCAG CAGATGAGGT CGACACACAG 
TTGCTACAGG ATGCGGCAAG GAAGGAAGCC CTGCAGCAGA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067000.1
CDS	210..497
Translation	MLFYSFFKSLVGKDVVVELKNDLSICGTLHSVDQYLNIKLTDISVTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ

Target ORF information:

RefSeq Version	NM_021177.5
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021177.5

ORF Insert Sequence:

ATGCTCTTCT ATTCTTTTTT CAAGTCCCTT GTGGGCAAGG ATGTGGTCGT GGAACTAAAG 
AATGACCTGA GCATCTGTGG AACCCTCCAT TCTGTGGATC AGTATCTCAA CATCAAACTA 
ACTGACATCA GTGTCACAGA CCCTGAGAAA TACCCTCACA TGTTATCAGT GAAGAACTGC 
TTCATTCGGG GCTCAGTGGT CCGATACGTG CAGCTGCCAG CAGATGAGGT CGACACACAG 
TTGCTACAGG ATGCGGCAAG GAAGGAAGCC CTGCAGCAGA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

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LSM2 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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