PTPN9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTPN9
Entrez Gene ID	5780
Full Name	protein tyrosine phosphatase, non-receptor type 9
Synonyms	MEG2,PTPMEG2
General protein information	Preferred Names protein tyrosine phosphatase, non-receptor type 9 Names tyrosine-protein phosphatase non-receptor type 9 PTPase-MEG2 protein-tyrosine phosphatase MEG2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	600768

mRNA and Protein(s)

mRNA	Protein	Name
NM_002833.3	NP_002824.1	tyrosine-protein phosphatase non-receptor type 9
NM_002833.4	NP_002824.1	tyrosine-protein phosphatase non-receptor type 9

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTPN9	NP_002824.1
Canis lupus familiaris (dog)	PTPN9	XP_005638697.1
Gallus gallus (chicken)	PTPN9	XP_413696.3
	PTPN9	XP_002804927.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001109	XP_322055.4
Pan troglodytes (chimpanzee)	PTPN9	XP_001144390.2
Bos taurus (cattle)	PTPN9	NP_001178983.1
Mus musculus (house mouse)	Ptpn9	NP_062625.2
Rattus norvegicus (Norway rat)	Ptpn9	NP_001013058.1
Danio rerio (zebrafish)	ptpn9a	XP_003201442.1

Gene Ontology
Bibliography

Related articles in PubMed

MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells.
Liu Z, Sun F, Hong Y, Liu Y, Fen M, Yin K, Ge X, Wang F, Chen X, Guan W
Molecular cancer16(1)133(2017 Jul)

The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G
The Journal of biological chemistry291(46)23895-23905(2016 Nov)

miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
Hong Y, Liang H, Uzair-Ur-Rehman, Wang Y, Zhang W, Zhou Y, Chen S, Yu M, Cui S, Liu M, Wang N, Ye C, Zhao C, Liu Y, Fan Q, Zhang CY, Sang J, Zen K, Chen X
Scientific reports637421(2016 Nov)

Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.
Hu B, Yan X, Liu F, Zhu C, Zhou H, Chen Y, Liu J, Gu X, Ni R, Zhang T
Pathology oncology research : POR22(3)555-65(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTPN9 inhibited cell proliferation in HepG2 cells.
Title: Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.

This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells.
Title: Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells.

PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development.
Title: Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer.

data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation
Title: Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells.

the N terminus of PTPMEG2 is necessary for the targeting of this phosphatase to the secretory vesicle compartment by association with other proteins involved in intracellular transport.
Title: Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins.

The following PTPN9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTPN9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10891	NM_002833.4 Latest version!	Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu10891	NM_002833.3	Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTPN9 ( NM_002833.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002824.1 Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.

Price & Availability↑

CloneID	OHu10891
Clone ID Related Accession (Same CDS sequence)	NM_002833.3 , NM_002833.4
Accession Version	NM_002833.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	tyrosine-protein phosphatase non-receptor type 9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105036.14, M83738.1, BC071574.1 and AC105137.18. On Sep 11, 2013 this sequence version replaced NM_002833.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M83738.1, SRR1660805.8874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCG CGACCGCGCC CCGGCCCGAC ATGGCGCCGG AGCTGACCCC GGAGGAGGAG 
CAGGCTACCA AGCAGTTTCT CGAAGAGATT AACAAGTGGA CAGTTCAGTA CAATGTTTCC 
CCGCTGTCTT GGAATGTGGC TGTCAAGTTC CTCATGGCAA GGAAGTTTGA TGTGCTCCGT 
GCCATAGAAT TGTTCCACTC CTACAGAGAA ACTCGAAGGA AGGAAGGCAT TGTAAAGCTG 
AAACCTCATG AGGAACCTCT TCGTTCTGAG ATCCTCAGTG GAAAATTCAC CATCTTAAAT 
GTTCGGGACC CAACAGGAGC CTCCATTGCC CTCTTTACTG CCAGGTTGCA TCATCCCCAC 
AAGTCAGTCC AACATGTGGT ACTTCAGGCT CTGTTTTACT TGCTAGACAG AGCTGTGGAT 
AGCTTTGAAA CTCAGAGGAA TGGACTGGTG TTTATCTATG ACATGTGTGG TTCTAATTAT 
GCCAACTTTG AGCTGGATCT TGGCAAGAAA GTCCTAAACC TGCTGAAGGG AGCATTTCCA 
GCTCGTTTGA AGAAGGTGCT GATTGTGGGG GCACCCATAT GGTTCCGAGT GCCCTATTCC 
ATCATCAGTC TCCTCCTGAA GGACAAAGTC CGGGAGAGGA TTCAAATATT AAAGACATCT 
GAGGTCACGC AGCATCTGCC CAGGGAGTGT CTTCCAGAAA ACCTGGGTGG GTACGTCAAA 
ATTGATCTCG CCACTTGGAA TTTCCAGTTC CTACCCCAGG TGAACGGCCA CCCAGATCCC 
TTCGATGAGA TCATCCTGTT CTCCCTCCCT CCTGCCTTAG ACTGGGACTC AGTACATGTT 
CCAGGTCCCC ATGCTATGAC CATCCAAGAG TTGGTGGACT ATGTTAATGC CAGGCAAAAG 
CAAGGAATCT ATGAGGAATA TGAAGACATT CGTCGTGAGA ACCCTGTTGG CACTTTCCAC 
TGTTCCATGT CTCCAGGAAA CCTAGAGAAA AACCGTTATG GGGATGTACC CTGCCTGGAC 
CAAACTAGAG TGAAGCTAAC AAAGCGAAGT GGCCATACTC AGACAGATTA CATCAATGCC 
AGTTTCATGG ATGGCTACAA GCAGAAGAAT GCTTACATTG GCACACAAGG TCCTTTGGAG 
AATACCTATC GTGATTTCTG GCTCATGGTA TGGGAGCAAA AAGTCTTGGT GATTGTCATG 
ACCACCCGCT TTGAGGAAGG CGGCAGGAGA AAGTGTGGCC AGTACTGGCC TTTAGAAAAA 
GACTCTCGGA TCCGATTTGG CTTCCTCACA GTGACCAATC TAGGCGTGGA GAACATGAAT 
CATTATAAGA AAACAACGCT AGAAATTCAC AACACAGAGG AACGGCAGAA ACGCCAGGTG 
ACCCACTTCC AGTTCTTGAG CTGGCCAGAC TATGGTGTCC CTTCCTCAGC AGCTTCCCTC 
ATTGACTTCT TGAGAGTGGT CAGAAACCAG CAGAGTCTGG CTGTGAGCAA CATGGGAGCA 
CGCTCCAAAG GGCAGTGCCC TGAGCCACCC ATTGTGGTCC ATTGCAGTGC AGGCATTGGC 
AGGACAGGTA CCTTCTGCTC ACTGGACATC TGCCTGGCAC AGCTGGAGGA GCTTGGCACC 
CTTAATGTGT TCCAGACGGT GTCACGCATG AGGACCCAGA GGGCCTTCAG CATCCAGACC 
CCTGAGCAGT ACTATTTTTG CTACAAGGCC ATCCTGGAGT TCGCAGAGAA GGAGGGCATG 
GTATCCTCTG GCCAAAACCT GCTGGCCGTG GAGAGTCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002824.1
CDS	516..2297
Translation	MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ

Target ORF information:

RefSeq Version	NM_002833.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002833.3

ORF Insert Sequence:

ATGGAGCCCG CGACCGCGCC CCGGCCCGAC ATGGCGCCGG AGCTGACCCC GGAGGAGGAG 
CAGGCTACCA AGCAGTTTCT CGAAGAGATT AACAAGTGGA CAGTTCAGTA CAATGTTTCC 
CCGCTGTCTT GGAATGTGGC TGTCAAGTTC CTCATGGCAA GGAAGTTTGA TGTGCTCCGT 
GCCATAGAAT TGTTCCACTC CTACAGAGAA ACTCGAAGGA AGGAAGGCAT TGTAAAGCTG 
AAACCTCATG AGGAACCTCT TCGTTCTGAG ATCCTCAGTG GAAAATTCAC CATCTTAAAT 
GTTCGGGACC CAACAGGAGC CTCCATTGCC CTCTTTACTG CCAGGTTGCA TCATCCCCAC 
AAGTCAGTCC AACATGTGGT ACTTCAGGCT CTGTTTTACT TGCTAGACAG AGCTGTGGAT 
AGCTTTGAAA CTCAGAGGAA TGGACTGGTG TTTATCTATG ACATGTGTGG TTCTAATTAT 
GCCAACTTTG AGCTGGATCT TGGCAAGAAA GTCCTAAACC TGCTGAAGGG AGCATTTCCA 
GCTCGTTTGA AGAAGGTGCT GATTGTGGGG GCACCCATAT GGTTCCGAGT GCCCTATTCC 
ATCATCAGTC TCCTCCTGAA GGACAAAGTC CGGGAGAGGA TTCAAATATT AAAGACATCT 
GAGGTCACGC AGCATCTGCC CAGGGAGTGT CTTCCAGAAA ACCTGGGTGG GTACGTCAAA 
ATTGATCTCG CCACTTGGAA TTTCCAGTTC CTACCCCAGG TGAACGGCCA CCCAGATCCC 
TTCGATGAGA TCATCCTGTT CTCCCTCCCT CCTGCCTTAG ACTGGGACTC AGTACATGTT 
CCAGGTCCCC ATGCTATGAC CATCCAAGAG TTGGTGGACT ATGTTAATGC CAGGCAAAAG 
CAAGGAATCT ATGAGGAATA TGAAGACATT CGTCGTGAGA ACCCTGTTGG CACTTTCCAC 
TGTTCCATGT CTCCAGGAAA CCTAGAGAAA AACCGTTATG GGGATGTACC CTGCCTGGAC 
CAAACTAGAG TGAAGCTAAC AAAGCGAAGT GGCCATACTC AGACAGATTA CATCAATGCC 
AGTTTCATGG ATGGCTACAA GCAGAAGAAT GCTTACATTG GCACACAAGG TCCTTTGGAG 
AATACCTATC GTGATTTCTG GCTCATGGTA TGGGAGCAAA AAGTCTTGGT GATTGTCATG 
ACCACCCGCT TTGAGGAAGG CGGCAGGAGA AAGTGTGGCC AGTACTGGCC TTTAGAAAAA 
GACTCTCGGA TCCGATTTGG CTTCCTCACA GTGACCAATC TAGGCGTGGA GAACATGAAT 
CATTATAAGA AAACAACGCT AGAAATTCAC AACACAGAGG AACGGCAGAA ACGCCAGGTG 
ACCCACTTCC AGTTCTTGAG CTGGCCAGAC TATGGTGTCC CTTCCTCAGC AGCTTCCCTC 
ATTGACTTCT TGAGAGTGGT CAGAAACCAG CAGAGTCTGG CTGTGAGCAA CATGGGAGCA 
CGCTCCAAAG GGCAGTGCCC TGAGCCACCC ATTGTGGTCC ATTGCAGTGC AGGCATTGGC 
AGGACAGGTA CCTTCTGCTC ACTGGACATC TGCCTGGCAC AGCTGGAGGA GCTTGGCACC 
CTTAATGTGT TCCAGACGGT GTCACGCATG AGGACCCAGA GGGCCTTCAG CATCCAGACC 
CCTGAGCAGT ACTATTTTTG CTACAAGGCC ATCCTGGAGT TCGCAGAGAA GGAGGGCATG 
GTATCCTCTG GCCAAAACCT GCTGGCCGTG GAGAGTCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTPN9 ( NM_002833.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002824.1 Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.

Price & Availability↑

CloneID	OHu10891
Clone ID Related Accession (Same CDS sequence)	NM_002833.3 , NM_002833.4
Accession Version	NM_002833.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	tyrosine-protein phosphatase non-receptor type 9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105036.14, M83738.1, BC071574.1 and AC105137.18. On May 17, 2019 this sequence version replaced NM_002833.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M83738.1, SRR1803613.3838.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000618819.5/ ENSP00000482732.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCG CGACCGCGCC CCGGCCCGAC ATGGCGCCGG AGCTGACCCC GGAGGAGGAG 
CAGGCTACCA AGCAGTTTCT CGAAGAGATT AACAAGTGGA CAGTTCAGTA CAATGTTTCC 
CCGCTGTCTT GGAATGTGGC TGTCAAGTTC CTCATGGCAA GGAAGTTTGA TGTGCTCCGT 
GCCATAGAAT TGTTCCACTC CTACAGAGAA ACTCGAAGGA AGGAAGGCAT TGTAAAGCTG 
AAACCTCATG AGGAACCTCT TCGTTCTGAG ATCCTCAGTG GAAAATTCAC CATCTTAAAT 
GTTCGGGACC CAACAGGAGC CTCCATTGCC CTCTTTACTG CCAGGTTGCA TCATCCCCAC 
AAGTCAGTCC AACATGTGGT ACTTCAGGCT CTGTTTTACT TGCTAGACAG AGCTGTGGAT 
AGCTTTGAAA CTCAGAGGAA TGGACTGGTG TTTATCTATG ACATGTGTGG TTCTAATTAT 
GCCAACTTTG AGCTGGATCT TGGCAAGAAA GTCCTAAACC TGCTGAAGGG AGCATTTCCA 
GCTCGTTTGA AGAAGGTGCT GATTGTGGGG GCACCCATAT GGTTCCGAGT GCCCTATTCC 
ATCATCAGTC TCCTCCTGAA GGACAAAGTC CGGGAGAGGA TTCAAATATT AAAGACATCT 
GAGGTCACGC AGCATCTGCC CAGGGAGTGT CTTCCAGAAA ACCTGGGTGG GTACGTCAAA 
ATTGATCTCG CCACTTGGAA TTTCCAGTTC CTACCCCAGG TGAACGGCCA CCCAGATCCC 
TTCGATGAGA TCATCCTGTT CTCCCTCCCT CCTGCCTTAG ACTGGGACTC AGTACATGTT 
CCAGGTCCCC ATGCTATGAC CATCCAAGAG TTGGTGGACT ATGTTAATGC CAGGCAAAAG 
CAAGGAATCT ATGAGGAATA TGAAGACATT CGTCGTGAGA ACCCTGTTGG CACTTTCCAC 
TGTTCCATGT CTCCAGGAAA CCTAGAGAAA AACCGTTATG GGGATGTACC CTGCCTGGAC 
CAAACTAGAG TGAAGCTAAC AAAGCGAAGT GGCCATACTC AGACAGATTA CATCAATGCC 
AGTTTCATGG ATGGCTACAA GCAGAAGAAT GCTTACATTG GCACACAAGG TCCTTTGGAG 
AATACCTATC GTGATTTCTG GCTCATGGTA TGGGAGCAAA AAGTCTTGGT GATTGTCATG 
ACCACCCGCT TTGAGGAAGG CGGCAGGAGA AAGTGTGGCC AGTACTGGCC TTTAGAAAAA 
GACTCTCGGA TCCGATTTGG CTTCCTCACA GTGACCAATC TAGGCGTGGA GAACATGAAT 
CATTATAAGA AAACAACGCT AGAAATTCAC AACACAGAGG AACGGCAGAA ACGCCAGGTG 
ACCCACTTCC AGTTCTTGAG CTGGCCAGAC TATGGTGTCC CTTCCTCAGC AGCTTCCCTC 
ATTGACTTCT TGAGAGTGGT CAGAAACCAG CAGAGTCTGG CTGTGAGCAA CATGGGAGCA 
CGCTCCAAAG GGCAGTGCCC TGAGCCACCC ATTGTGGTCC ATTGCAGTGC AGGCATTGGC 
AGGACAGGTA CCTTCTGCTC ACTGGACATC TGCCTGGCAC AGCTGGAGGA GCTTGGCACC 
CTTAATGTGT TCCAGACGGT GTCACGCATG AGGACCCAGA GGGCCTTCAG CATCCAGACC 
CCTGAGCAGT ACTATTTTTG CTACAAGGCC ATCCTGGAGT TCGCAGAGAA GGAGGGCATG 
GTATCCTCTG GCCAAAACCT GCTGGCCGTG GAGAGTCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002824.1
CDS	540..2321
Translation	MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ

Target ORF information:

RefSeq Version	NM_002833.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase non-receptor type 9 (PTPN9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002833.4

ORF Insert Sequence:

ATGGAGCCCG CGACCGCGCC CCGGCCCGAC ATGGCGCCGG AGCTGACCCC GGAGGAGGAG 
CAGGCTACCA AGCAGTTTCT CGAAGAGATT AACAAGTGGA CAGTTCAGTA CAATGTTTCC 
CCGCTGTCTT GGAATGTGGC TGTCAAGTTC CTCATGGCAA GGAAGTTTGA TGTGCTCCGT 
GCCATAGAAT TGTTCCACTC CTACAGAGAA ACTCGAAGGA AGGAAGGCAT TGTAAAGCTG 
AAACCTCATG AGGAACCTCT TCGTTCTGAG ATCCTCAGTG GAAAATTCAC CATCTTAAAT 
GTTCGGGACC CAACAGGAGC CTCCATTGCC CTCTTTACTG CCAGGTTGCA TCATCCCCAC 
AAGTCAGTCC AACATGTGGT ACTTCAGGCT CTGTTTTACT TGCTAGACAG AGCTGTGGAT 
AGCTTTGAAA CTCAGAGGAA TGGACTGGTG TTTATCTATG ACATGTGTGG TTCTAATTAT 
GCCAACTTTG AGCTGGATCT TGGCAAGAAA GTCCTAAACC TGCTGAAGGG AGCATTTCCA 
GCTCGTTTGA AGAAGGTGCT GATTGTGGGG GCACCCATAT GGTTCCGAGT GCCCTATTCC 
ATCATCAGTC TCCTCCTGAA GGACAAAGTC CGGGAGAGGA TTCAAATATT AAAGACATCT 
GAGGTCACGC AGCATCTGCC CAGGGAGTGT CTTCCAGAAA ACCTGGGTGG GTACGTCAAA 
ATTGATCTCG CCACTTGGAA TTTCCAGTTC CTACCCCAGG TGAACGGCCA CCCAGATCCC 
TTCGATGAGA TCATCCTGTT CTCCCTCCCT CCTGCCTTAG ACTGGGACTC AGTACATGTT 
CCAGGTCCCC ATGCTATGAC CATCCAAGAG TTGGTGGACT ATGTTAATGC CAGGCAAAAG 
CAAGGAATCT ATGAGGAATA TGAAGACATT CGTCGTGAGA ACCCTGTTGG CACTTTCCAC 
TGTTCCATGT CTCCAGGAAA CCTAGAGAAA AACCGTTATG GGGATGTACC CTGCCTGGAC 
CAAACTAGAG TGAAGCTAAC AAAGCGAAGT GGCCATACTC AGACAGATTA CATCAATGCC 
AGTTTCATGG ATGGCTACAA GCAGAAGAAT GCTTACATTG GCACACAAGG TCCTTTGGAG 
AATACCTATC GTGATTTCTG GCTCATGGTA TGGGAGCAAA AAGTCTTGGT GATTGTCATG 
ACCACCCGCT TTGAGGAAGG CGGCAGGAGA AAGTGTGGCC AGTACTGGCC TTTAGAAAAA 
GACTCTCGGA TCCGATTTGG CTTCCTCACA GTGACCAATC TAGGCGTGGA GAACATGAAT 
CATTATAAGA AAACAACGCT AGAAATTCAC AACACAGAGG AACGGCAGAA ACGCCAGGTG 
ACCCACTTCC AGTTCTTGAG CTGGCCAGAC TATGGTGTCC CTTCCTCAGC AGCTTCCCTC 
ATTGACTTCT TGAGAGTGGT CAGAAACCAG CAGAGTCTGG CTGTGAGCAA CATGGGAGCA 
CGCTCCAAAG GGCAGTGCCC TGAGCCACCC ATTGTGGTCC ATTGCAGTGC AGGCATTGGC 
AGGACAGGTA CCTTCTGCTC ACTGGACATC TGCCTGGCAC AGCTGGAGGA GCTTGGCACC 
CTTAATGTGT TCCAGACGGT GTCACGCATG AGGACCCAGA GGGCCTTCAG CATCCAGACC 
CCTGAGCAGT ACTATTTTTG CTACAAGGCC ATCCTGGAGT TCGCAGAGAA GGAGGGCATG 
GTATCCTCTG GCCAAAACCT GCTGGCCGTG GAGAGTCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells.
Molecular cancer16(1)133(2017 Jul)
Liu Z,Sun F,Hong Y,Liu Y,Fen M,Yin K,Ge X,Wang F,Chen X,Guan W

The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
The Journal of biological chemistry291(46)23895-23905(2016 Nov)
Zhang D,Marlin MC,Liang Z,Ahmad M,Ashpole NM,Sonntag WE,Zhao ZJ,Li G

miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
Scientific reports637421(2016 Nov)
Hong Y,Liang H,Uzair-Ur-Rehman,Wang Y,Zhang W,Zhou Y,Chen S,Yu M,Cui S,Liu M,Wang N,Ye C,Zhao C,Liu Y,Fan Q,Zhang CY,Sang J,Zen K,Chen X

Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.
Pathology oncology research : POR22(3)555-65(2016 Jul)
Hu B,Yan X,Liu F,Zhu C,Zhou H,Chen Y,Liu J,Gu X,Ni R,Zhang T

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PTPN9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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