MARK4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MARK4
Entrez Gene ID	57787
Full Name	microtubule affinity regulating kinase 4
Synonyms	MARK4L,MARK4S,MARKL1,MARKL1L,PAR-1D
General protein information	Preferred Names microtubule affinity regulating kinase 4 Names MAP/microtubule affinity-regulating kinase 4 MAP/microtubule affinity-regulating kinase like 1 MARK4 serine/threonine protein kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	606495

mRNA and Protein(s)

mRNA	Protein	Name
XM_006723307.3	XP_006723370.1	MAP/microtubule affinity-regulating kinase 4 isoform X1
NM_001199867.2	NP_001186796.1	MAP/microtubule affinity-regulating kinase 4 isoform 1
NM_001199867.1	NP_001186796.1	MAP/microtubule affinity-regulating kinase 4 isoform 1
NM_031417.3	NP_113605.2	MAP/microtubule affinity-regulating kinase 4 isoform 2
XM_006723307.4	XP_006723370.1	MAP/microtubule affinity-regulating kinase 4 isoform X1
NM_031417.4	NP_113605.2	MAP/microtubule affinity-regulating kinase 4 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MARK4	XP_541564.4
Danio rerio (zebrafish)	mark4a	XP_005165425.1
Danio rerio (zebrafish)	si:dkey-31m14.7	XP_005157656.1
Homo sapiens (human)	MARK4	NP_001186796.1
	MARK4	XP_001105523.2
Xenopus tropicalis (tropical clawed frog)	mark4	XP_002932682.1
Pan troglodytes (chimpanzee)	MARK4	XP_512745.3
Mus musculus (house mouse)	Mark4	NP_758483.1
Rattus norvegicus (Norway rat)	Mark4	NP_001178000.1
Bos taurus (cattle)	MARK4	NP_001030436.1

Gene Ontology
Bibliography

Related articles in PubMed

Roles of tau protein in health and disease.
Guo T, Noble W, Hanger DP
Acta neuropathologica133(5)665-704(2017 May)

MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells.
Heidary Arash E, Shiban A, Song S, Attisano L
EMBO reports18(3)420-436(2017 03)

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment.
Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim KM, Tang H, Ashford JW, Rajadas J
Scientific reports634784(2016 Oct)

miR-515-5p controls cancer cell migration through MARK4 regulation.
Pardo OE, Castellano L, Munro CE, Hu Y, Mauri F, Krell J, Lara R, Pinho FG, Choudhury T, Frampton AE, Pellegrino L, Pshezhetskiy D, Wang Y, Waxman J, Seckl MJ, Stebbing J
EMBO reports17(4)570-84(2016 04)

Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.
Naz F, Islam A, Ahmad F, Hassan MI
Molecular and cellular biochemistry410(1-2)223-8(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP/TAZ activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells.
Title: MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells.

data demonstrate that miR-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types
Title: miR-515-5p controls cancer cell migration through MARK4 regulation.

Atypical PKC phosphorylates serine-threonine residues of MARK4.
Title: Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.

Suggest role for polypyrimidine-tract binding protein in regulating alternative splicing of MARK4 in gliomas.
Title: Suggestive evidence on the involvement of polypyrimidine-tract binding protein in regulating alternative splicing of MAP/microtubule affinity-regulating kinase 4 in glioma.

MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition.
Title: Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics.

The following MARK4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MARK4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16911	NM_001199867.1 Latest version!	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu16698	NM_031417.3 Latest version!	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$482.30 $689.00
OHu52400	XM_006723307.4 Latest version!	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu107230	NM_001199867.2 Latest version!	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu108699	NM_031417.4 Latest version!	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu52400	XM_006723307.3	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MARK4 ( NM_001199867.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186796.1 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16911
Clone ID Related Accession (Same CDS sequence)	NM_001199867.1
Accession Version	NM_001199867.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB100014.1, AB049127.1, AY120867.1 and AB058763.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB088047.1, AY057448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGCGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CGCAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGCCCTCCT GAGGCCCTGA TGGCAGCTCT GCGCCAGGCC 
ACAGCAGCCG CCCGCTGCCG CTGCCGCCAG CCACAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CACTTCGAAG TGGAGGTCTG CCAGCTGCCC 
CGGCCAGGCT TGCGGGGAGT TCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186796.1
CDS	332..2590
Translation	MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	NM_001199867.1
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199867.1

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGCGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CGCAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGCCCTCCT GAGGCCCTGA TGGCAGCTCT GCGCCAGGCC 
ACAGCAGCCG CCCGCTGCCG CTGCCGCCAG CCACAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CACTTCGAAG TGGAGGTCTG CCAGCTGCCC 
CGGCCAGGCT TGCGGGGAGT TCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARK4 ( NM_031417.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_113605.2 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16698
Clone ID Related Accession (Same CDS sequence)	NM_031417.3
Accession Version	NM_031417.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB100014.1, AB049127.1 and AB058763.1. On Dec 24, 2010 this sequence version replaced NM_031417.2. Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB058763.1, AB049127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGCGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTTTCGGGCG CCTCTCTGCC CCAGGGATCC AAGATCAGGT CGCAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113605.2
CDS	332..2398
Translation	MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIKRKPPPGCSDSPGV

Target ORF information:

RefSeq Version	NM_031417.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031417.3

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGCGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTTTCGGGCG CCTCTCTGCC CCAGGGATCC AAGATCAGGT CGCAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARK4 ( XM_006723307.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723370.1 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.

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CloneID	OHu52400
Clone ID Related Accession (Same CDS sequence)	XM_006723307.3 , XM_006723307.4
Accession Version	XM_006723307.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723307.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GGTTGCCATC 
AAGATTATCG ACAAAACCCA GCTGAATCCC AGCAGCCTGC AGAAGCTGTT CCGAGAAGTC 
CGCATCATGA AGGGCCTAAA CCACCCCAAC ATCGTGAAGC TCTTTGAGGT GATTGAGACT 
GAGAAGACGC TGTACCTGGT GATGGAGTAC GCAAGTGCTG GAGAAGTGTT TGACTACCTC 
GTGTCGCATG GCCGCATGAA GGAGAAGGAA GCTCGAGCCA AGTTCCGACA GATTGTTTCG 
GCTGTGCACT ATTGTCACCA GAAAAATATT GTACACAGGG ACCTGAAGGC TGAGAACCTC 
TTGCTGGATG CCGAGGCCAA CATCAAGATT GCTGACTTTG GCTTCAGCAA CGAGTTCACG 
CTGGGATCGA AGCTGGACAC GTTCTGCGGG AGCCCCCCAT ATGCCGCCCC GGAGCTGTTT 
CAGGGCAAGA AGTACGACGG GCCGGAGGTG GACATCTGGA GCCTGGGAGT CATCCTGTAC 
ACCCTCGTCA GCGGCTCCCT GCCCTTCGAC GGGCACAACC TCAAGGAGCT GCGGGAGCGA 
GTACTCAGAG GGAAGTACCG GGTCCCTTTC TACATGTCAA CAGACTGTGA GAGCATCCTG 
CGGAGATTTT TGGTGCTGAA CCCAGCTAAA CGCTGTACTC TCGAGCAAAT CATGAAAGAC 
AAATGGATCA ACATCGGCTA TGAGGGTGAG GAGTTGAAGC CATACACAGA GCCCGAGGAG 
GACTTCGGGG ACACCAAGAG AATTGAGGTG ATGGTGGGTA TGGGCTACAC ACGGGAAGAA 
ATCAAAGAGT CCTTGACCAG CCAGAAGTAC AACGAAGTGA CCGCCACCTA CCTCCTGCTG 
GGCAGGAAGA CTGAGGAGGG TGGGGACCGG GGCGCCCCAG GGCTGGCCCT GGCACGGGTG 
CGGGCGCCCA GCGACACCAC CAACGGAACA AGTTCCAGCA AAGGCACCAG CCACAGCAAA 
GGGCAGCGGA GTTCCTCTTC CACCTACCAC CGCCAGCGCA GGCATAGCGA TTTCTGTGGC 
CCATCCCCTG CACCCCTGCA CCCCAAACGC AGCCCGACGA GCACGGGGGA GGCGGAGCTG 
AAGGAGGAGC GGCTGCCAGG CCGGAAGGCG AGCTGCAGCA CCGCGGGGAG TGGGAGTCGA 
GGGCTGCCCC CCTCCAGCCC CATGGTCAGC AGCGCCCACA ACCCCAACAA GGCAGAGATC 
CCAGAGCGGC GGAAGGACAG CACGAGCACC CCCAACAACC TCCCTCCTAG CATGATGACC 
CGCAGAAACA CCTACGTTTG CACAGAACGC CCGGGGGCTG AGCGCCCGTC ACTGTTGCCA 
AATGGGAAAG AAAACAGCTC AGGCACCCCA CGGGTGCCCC CTGCCTCCCC CTCCAGTCAC 
AGCCTGGCAC CCCCATCAGG GGAGCGGAGC CGCCTGGCAC GTGGTTCCAC CATCCGCAGC 
ACCTTCCATG GTGGCCAGGT CCGGGACCGG CGGGCAGGGG GTGGGGGTGG TGGGGGTGTG 
CAGAATGGGC CCCCTGCCTC TCCCACACTG GCCCATGAGG CTGCACCCCT GCCCGCCGGG 
CGGCCCCGCC CCACCACCAA CCTCTTCACC AAGCTGACCT CCAAACTGAC CCGAAGGGTC 
GCAGACGAAC CTGAGAGAAT CGGGGGACCT GAGGTCACAA GTTGCCATCT ACCTTGGGAT 
CAAACGGAAA CCGCCCCCCG GCTGCTCCGA TTCCCCTGGA GTGTGAAGCT GACCAGCTCG 
CGCCCTCCTG AGGCCCTGAT GGCAGCTCTG CGCCAGGCCA CAGCAGCCGC CCGCTGCCGC 
TGCCGCCAGC CACAGCCGTT CCTGCTGGCC TGCCTGCACG GGGGTGCGGG CGGGCCCGAG 
CCCCTGTCCC ACTTCGAAGT GGAGGTCTGC CAGCTGCCCC GGCCAGGCTT GCGGGGAGTT 
CTCTTCCGCC GTGTGGCGGG CACCGCCCTG GCCTTCCGCA CCCTCGTCAC CCGCATCTCC 
AACGACCTCG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723370.1
CDS	224..2281
Translation	MSSRTVLAPGNDRNSDTVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	XM_006723307.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723307.3

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GGTTGCCATC 
AAGATTATCG ACAAAACCCA GCTGAATCCC AGCAGCCTGC AGAAGCTGTT CCGAGAAGTC 
CGCATCATGA AGGGCCTAAA CCACCCCAAC ATCGTGAAGC TCTTTGAGGT GATTGAGACT 
GAGAAGACGC TGTACCTGGT GATGGAGTAC GCAAGTGCTG GAGAAGTGTT TGACTACCTC 
GTGTCGCATG GCCGCATGAA GGAGAAGGAA GCTCGAGCCA AGTTCCGACA GATTGTTTCG 
GCTGTGCACT ATTGTCACCA GAAAAATATT GTACACAGGG ACCTGAAGGC TGAGAACCTC 
TTGCTGGATG CCGAGGCCAA CATCAAGATT GCTGACTTTG GCTTCAGCAA CGAGTTCACG 
CTGGGATCGA AGCTGGACAC GTTCTGCGGG AGCCCCCCAT ATGCCGCCCC GGAGCTGTTT 
CAGGGCAAGA AGTACGACGG GCCGGAGGTG GACATCTGGA GCCTGGGAGT CATCCTGTAC 
ACCCTCGTCA GCGGCTCCCT GCCCTTCGAC GGGCACAACC TCAAGGAGCT GCGGGAGCGA 
GTACTCAGAG GGAAGTACCG GGTCCCTTTC TACATGTCAA CAGACTGTGA GAGCATCCTG 
CGGAGATTTT TGGTGCTGAA CCCAGCTAAA CGCTGTACTC TCGAGCAAAT CATGAAAGAC 
AAATGGATCA ACATCGGCTA TGAGGGTGAG GAGTTGAAGC CATACACAGA GCCCGAGGAG 
GACTTCGGGG ACACCAAGAG AATTGAGGTG ATGGTGGGTA TGGGCTACAC ACGGGAAGAA 
ATCAAAGAGT CCTTGACCAG CCAGAAGTAC AACGAAGTGA CCGCCACCTA CCTCCTGCTG 
GGCAGGAAGA CTGAGGAGGG TGGGGACCGG GGCGCCCCAG GGCTGGCCCT GGCACGGGTG 
CGGGCGCCCA GCGACACCAC CAACGGAACA AGTTCCAGCA AAGGCACCAG CCACAGCAAA 
GGGCAGCGGA GTTCCTCTTC CACCTACCAC CGCCAGCGCA GGCATAGCGA TTTCTGTGGC 
CCATCCCCTG CACCCCTGCA CCCCAAACGC AGCCCGACGA GCACGGGGGA GGCGGAGCTG 
AAGGAGGAGC GGCTGCCAGG CCGGAAGGCG AGCTGCAGCA CCGCGGGGAG TGGGAGTCGA 
GGGCTGCCCC CCTCCAGCCC CATGGTCAGC AGCGCCCACA ACCCCAACAA GGCAGAGATC 
CCAGAGCGGC GGAAGGACAG CACGAGCACC CCCAACAACC TCCCTCCTAG CATGATGACC 
CGCAGAAACA CCTACGTTTG CACAGAACGC CCGGGGGCTG AGCGCCCGTC ACTGTTGCCA 
AATGGGAAAG AAAACAGCTC AGGCACCCCA CGGGTGCCCC CTGCCTCCCC CTCCAGTCAC 
AGCCTGGCAC CCCCATCAGG GGAGCGGAGC CGCCTGGCAC GTGGTTCCAC CATCCGCAGC 
ACCTTCCATG GTGGCCAGGT CCGGGACCGG CGGGCAGGGG GTGGGGGTGG TGGGGGTGTG 
CAGAATGGGC CCCCTGCCTC TCCCACACTG GCCCATGAGG CTGCACCCCT GCCCGCCGGG 
CGGCCCCGCC CCACCACCAA CCTCTTCACC AAGCTGACCT CCAAACTGAC CCGAAGGGTC 
GCAGACGAAC CTGAGAGAAT CGGGGGACCT GAGGTCACAA GTTGCCATCT ACCTTGGGAT 
CAAACGGAAA CCGCCCCCCG GCTGCTCCGA TTCCCCTGGA GTGTGAAGCT GACCAGCTCG 
CGCCCTCCTG AGGCCCTGAT GGCAGCTCTG CGCCAGGCCA CAGCAGCCGC CCGCTGCCGC 
TGCCGCCAGC CACAGCCGTT CCTGCTGGCC TGCCTGCACG GGGGTGCGGG CGGGCCCGAG 
CCCCTGTCCC ACTTCGAAGT GGAGGTCTGC CAGCTGCCCC GGCCAGGCTT GCGGGGAGTT 
CTCTTCCGCC GTGTGGCGGG CACCGCCCTG GCCTTCCGCA CCCTCGTCAC CCGCATCTCC 
AACGACCTCG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARK4 ( XM_006723307.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723370.1 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.

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CloneID	OHu52400
Clone ID Related Accession (Same CDS sequence)	XM_006723307.3 , XM_006723307.4
Accession Version	XM_006723307.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006723307.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GGTTGCCATC 
AAGATTATCG ACAAAACCCA GCTGAATCCC AGCAGCCTGC AGAAGCTGTT CCGAGAAGTC 
CGCATCATGA AGGGCCTAAA CCACCCCAAC ATCGTGAAGC TCTTTGAGGT GATTGAGACT 
GAGAAGACGC TGTACCTGGT GATGGAGTAC GCAAGTGCTG GAGAAGTGTT TGACTACCTC 
GTGTCGCATG GCCGCATGAA GGAGAAGGAA GCTCGAGCCA AGTTCCGACA GATTGTTTCG 
GCTGTGCACT ATTGTCACCA GAAAAATATT GTACACAGGG ACCTGAAGGC TGAGAACCTC 
TTGCTGGATG CCGAGGCCAA CATCAAGATT GCTGACTTTG GCTTCAGCAA CGAGTTCACG 
CTGGGATCGA AGCTGGACAC GTTCTGCGGG AGCCCCCCAT ATGCCGCCCC GGAGCTGTTT 
CAGGGCAAGA AGTACGACGG GCCGGAGGTG GACATCTGGA GCCTGGGAGT CATCCTGTAC 
ACCCTCGTCA GCGGCTCCCT GCCCTTCGAC GGGCACAACC TCAAGGAGCT GCGGGAGCGA 
GTACTCAGAG GGAAGTACCG GGTCCCTTTC TACATGTCAA CAGACTGTGA GAGCATCCTG 
CGGAGATTTT TGGTGCTGAA CCCAGCTAAA CGCTGTACTC TCGAGCAAAT CATGAAAGAC 
AAATGGATCA ACATCGGCTA TGAGGGTGAG GAGTTGAAGC CATACACAGA GCCCGAGGAG 
GACTTCGGGG ACACCAAGAG AATTGAGGTG ATGGTGGGTA TGGGCTACAC ACGGGAAGAA 
ATCAAAGAGT CCTTGACCAG CCAGAAGTAC AACGAAGTGA CCGCCACCTA CCTCCTGCTG 
GGCAGGAAGA CTGAGGAGGG TGGGGACCGG GGCGCCCCAG GGCTGGCCCT GGCACGGGTG 
CGGGCGCCCA GCGACACCAC CAACGGAACA AGTTCCAGCA AAGGCACCAG CCACAGCAAA 
GGGCAGCGGA GTTCCTCTTC CACCTACCAC CGCCAGCGCA GGCATAGCGA TTTCTGTGGC 
CCATCCCCTG CACCCCTGCA CCCCAAACGC AGCCCGACGA GCACGGGGGA GGCGGAGCTG 
AAGGAGGAGC GGCTGCCAGG CCGGAAGGCG AGCTGCAGCA CCGCGGGGAG TGGGAGTCGA 
GGGCTGCCCC CCTCCAGCCC CATGGTCAGC AGCGCCCACA ACCCCAACAA GGCAGAGATC 
CCAGAGCGGC GGAAGGACAG CACGAGCACC CCCAACAACC TCCCTCCTAG CATGATGACC 
CGCAGAAACA CCTACGTTTG CACAGAACGC CCGGGGGCTG AGCGCCCGTC ACTGTTGCCA 
AATGGGAAAG AAAACAGCTC AGGCACCCCA CGGGTGCCCC CTGCCTCCCC CTCCAGTCAC 
AGCCTGGCAC CCCCATCAGG GGAGCGGAGC CGCCTGGCAC GTGGTTCCAC CATCCGCAGC 
ACCTTCCATG GTGGCCAGGT CCGGGACCGG CGGGCAGGGG GTGGGGGTGG TGGGGGTGTG 
CAGAATGGGC CCCCTGCCTC TCCCACACTG GCCCATGAGG CTGCACCCCT GCCCGCCGGG 
CGGCCCCGCC CCACCACCAA CCTCTTCACC AAGCTGACCT CCAAACTGAC CCGAAGGGTC 
GCAGACGAAC CTGAGAGAAT CGGGGGACCT GAGGTCACAA GTTGCCATCT ACCTTGGGAT 
CAAACGGAAA CCGCCCCCCG GCTGCTCCGA TTCCCCTGGA GTGTGAAGCT GACCAGCTCG 
CGCCCTCCTG AGGCCCTGAT GGCAGCTCTG CGCCAGGCCA CAGCAGCCGC CCGCTGCCGC 
TGCCGCCAGC CACAGCCGTT CCTGCTGGCC TGCCTGCACG GGGGTGCGGG CGGGCCCGAG 
CCCCTGTCCC ACTTCGAAGT GGAGGTCTGC CAGCTGCCCC GGCCAGGCTT GCGGGGAGTT 
CTCTTCCGCC GTGTGGCGGG CACCGCCCTG GCCTTCCGCA CCCTCGTCAC CCGCATCTCC 
AACGACCTCG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723370.1
CDS	300..2357
Translation	MSSRTVLAPGNDRNSDTVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	XM_006723307.4
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723307.4

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GGTTGCCATC 
AAGATTATCG ACAAAACCCA GCTGAATCCC AGCAGCCTGC AGAAGCTGTT CCGAGAAGTC 
CGCATCATGA AGGGCCTAAA CCACCCCAAC ATCGTGAAGC TCTTTGAGGT GATTGAGACT 
GAGAAGACGC TGTACCTGGT GATGGAGTAC GCAAGTGCTG GAGAAGTGTT TGACTACCTC 
GTGTCGCATG GCCGCATGAA GGAGAAGGAA GCTCGAGCCA AGTTCCGACA GATTGTTTCG 
GCTGTGCACT ATTGTCACCA GAAAAATATT GTACACAGGG ACCTGAAGGC TGAGAACCTC 
TTGCTGGATG CCGAGGCCAA CATCAAGATT GCTGACTTTG GCTTCAGCAA CGAGTTCACG 
CTGGGATCGA AGCTGGACAC GTTCTGCGGG AGCCCCCCAT ATGCCGCCCC GGAGCTGTTT 
CAGGGCAAGA AGTACGACGG GCCGGAGGTG GACATCTGGA GCCTGGGAGT CATCCTGTAC 
ACCCTCGTCA GCGGCTCCCT GCCCTTCGAC GGGCACAACC TCAAGGAGCT GCGGGAGCGA 
GTACTCAGAG GGAAGTACCG GGTCCCTTTC TACATGTCAA CAGACTGTGA GAGCATCCTG 
CGGAGATTTT TGGTGCTGAA CCCAGCTAAA CGCTGTACTC TCGAGCAAAT CATGAAAGAC 
AAATGGATCA ACATCGGCTA TGAGGGTGAG GAGTTGAAGC CATACACAGA GCCCGAGGAG 
GACTTCGGGG ACACCAAGAG AATTGAGGTG ATGGTGGGTA TGGGCTACAC ACGGGAAGAA 
ATCAAAGAGT CCTTGACCAG CCAGAAGTAC AACGAAGTGA CCGCCACCTA CCTCCTGCTG 
GGCAGGAAGA CTGAGGAGGG TGGGGACCGG GGCGCCCCAG GGCTGGCCCT GGCACGGGTG 
CGGGCGCCCA GCGACACCAC CAACGGAACA AGTTCCAGCA AAGGCACCAG CCACAGCAAA 
GGGCAGCGGA GTTCCTCTTC CACCTACCAC CGCCAGCGCA GGCATAGCGA TTTCTGTGGC 
CCATCCCCTG CACCCCTGCA CCCCAAACGC AGCCCGACGA GCACGGGGGA GGCGGAGCTG 
AAGGAGGAGC GGCTGCCAGG CCGGAAGGCG AGCTGCAGCA CCGCGGGGAG TGGGAGTCGA 
GGGCTGCCCC CCTCCAGCCC CATGGTCAGC AGCGCCCACA ACCCCAACAA GGCAGAGATC 
CCAGAGCGGC GGAAGGACAG CACGAGCACC CCCAACAACC TCCCTCCTAG CATGATGACC 
CGCAGAAACA CCTACGTTTG CACAGAACGC CCGGGGGCTG AGCGCCCGTC ACTGTTGCCA 
AATGGGAAAG AAAACAGCTC AGGCACCCCA CGGGTGCCCC CTGCCTCCCC CTCCAGTCAC 
AGCCTGGCAC CCCCATCAGG GGAGCGGAGC CGCCTGGCAC GTGGTTCCAC CATCCGCAGC 
ACCTTCCATG GTGGCCAGGT CCGGGACCGG CGGGCAGGGG GTGGGGGTGG TGGGGGTGTG 
CAGAATGGGC CCCCTGCCTC TCCCACACTG GCCCATGAGG CTGCACCCCT GCCCGCCGGG 
CGGCCCCGCC CCACCACCAA CCTCTTCACC AAGCTGACCT CCAAACTGAC CCGAAGGGTC 
GCAGACGAAC CTGAGAGAAT CGGGGGACCT GAGGTCACAA GTTGCCATCT ACCTTGGGAT 
CAAACGGAAA CCGCCCCCCG GCTGCTCCGA TTCCCCTGGA GTGTGAAGCT GACCAGCTCG 
CGCCCTCCTG AGGCCCTGAT GGCAGCTCTG CGCCAGGCCA CAGCAGCCGC CCGCTGCCGC 
TGCCGCCAGC CACAGCCGTT CCTGCTGGCC TGCCTGCACG GGGGTGCGGG CGGGCCCGAG 
CCCCTGTCCC ACTTCGAAGT GGAGGTCTGC CAGCTGCCCC GGCCAGGCTT GCGGGGAGTT 
CTCTTCCGCC GTGTGGCGGG CACCGCCCTG GCCTTCCGCA CCCTCGTCAC CCGCATCTCC 
AACGACCTCG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARK4 ( NM_001199867.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186796.1 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.

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CloneID	OHu107230
Clone ID Related Accession (Same CDS sequence)	NM_001199867.2
Accession Version	NM_001199867.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006126.1, AC005581.1 and AC005781.1. On Nov 22, 2018 this sequence version replaced NM_001199867.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB088047.1, AY057448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262891.9/ ENSP00000262891.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGTGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CGCAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGCCCTCCT GAGGCCCTGA TGGCAGCTCT GCGCCAGGCC 
ACAGCAGCCG CCCGCTGCCG CTGCCGCCAG CCACAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CACTTCGAAG TGGAGGTCTG CCAGCTGCCC 
CGGCCAGGCT TGCGGGGAGT TCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186796.1
CDS	319..2577
Translation	MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Target ORF information:

RefSeq Version	NM_001199867.2
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199867.2

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGTGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT CGCAGACGAA CCTGAGAGAA TCGGGGGACC TGAGGTCACA 
AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC GGCTGCTCCG ATTCCCCTGG 
AGTGTGAAGC TGACCAGCTC GCGCCCTCCT GAGGCCCTGA TGGCAGCTCT GCGCCAGGCC 
ACAGCAGCCG CCCGCTGCCG CTGCCGCCAG CCACAGCCGT TCCTGCTGGC CTGCCTGCAC 
GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CACTTCGAAG TGGAGGTCTG CCAGCTGCCC 
CGGCCAGGCT TGCGGGGAGT TCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 
ACCCTCGTCA CCCGCATCTC CAACGACCTC GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARK4 ( NM_031417.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_113605.2 Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.

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CloneID	OHu108699
Clone ID Related Accession (Same CDS sequence)	NM_031417.4
Accession Version	NM_031417.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	MAP/microtubule affinity-regulating kinase 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006126.1, AC005581.1 and AC005781.1. On May 31, 2019 this sequence version replaced NM_031417.3. Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB058763.1, AB049127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGTGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTTTCGGGCG CCTCTCTGCC CCAGGGATCC AAGATCAGGT CGCAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113605.2
CDS	319..2385
Translation	MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIKRKPPPGCSDSPGV

Target ORF information:

RefSeq Version	NM_031417.4
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule affinity regulating kinase 4 (MARK4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031417.4

ORF Insert Sequence:

ATGTCTTCGC GGACGGTGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 
TTGGGCAGTG GCCGCTCCTC GGACAAAGGC CCGTCCTGGT CCAGCCGCTC ACTGGGTGCC 
CGTTGCCGGA ACTCCATCGC CTCCTGTCCC GAGGAGCAGC CCCACGTGGG CAACTACCGC 
CTGCTGAGGA CCATTGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 
ACTGGTCGGG AGGTTGCCAT CAAGATTATC GACAAAACCC AGCTGAATCC CAGCAGCCTG 
CAGAAGCTGT TCCGAGAAGT CCGCATCATG AAGGGCCTAA ACCACCCCAA CATCGTGAAG 
CTCTTTGAGG TGATTGAGAC TGAGAAGACG CTGTACCTGG TGATGGAGTA CGCAAGTGCT 
GGAGAAGTGT TTGACTACCT CGTGTCGCAT GGCCGCATGA AGGAGAAGGA AGCTCGAGCC 
AAGTTCCGAC AGATTGTTTC GGCTGTGCAC TATTGTCACC AGAAAAATAT TGTACACAGG 
GACCTGAAGG CTGAGAACCT CTTGCTGGAT GCCGAGGCCA ACATCAAGAT TGCTGACTTT 
GGCTTCAGCA ACGAGTTCAC GCTGGGATCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 
TATGCCGCCC CGGAGCTGTT TCAGGGCAAG AAGTACGACG GGCCGGAGGT GGACATCTGG 
AGCCTGGGAG TCATCCTGTA CACCCTCGTC AGCGGCTCCC TGCCCTTCGA CGGGCACAAC 
CTCAAGGAGC TGCGGGAGCG AGTACTCAGA GGGAAGTACC GGGTCCCTTT CTACATGTCA 
ACAGACTGTG AGAGCATCCT GCGGAGATTT TTGGTGCTGA ACCCAGCTAA ACGCTGTACT 
CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGTTGAAG 
CCATACACAG AGCCCGAGGA GGACTTCGGG GACACCAAGA GAATTGAGGT GATGGTGGGT 
ATGGGCTACA CACGGGAAGA AATCAAAGAG TCCTTGACCA GCCAGAAGTA CAACGAAGTG 
ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCGCCCCA 
GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAACGGAAC AAGTTCCAGC 
AAAGGCACCA GCCACAGCAA AGGGCAGCGG AGTTCCTCTT CCACCTACCA CCGCCAGCGC 
AGGCATAGCG ATTTCTGTGG CCCATCCCCT GCACCCCTGC ACCCCAAACG CAGCCCGACG 
AGCACGGGGG AGGCGGAGCT GAAGGAGGAG CGGCTGCCAG GCCGGAAGGC GAGCTGCAGC 
ACCGCGGGGA GTGGGAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 
AACCCCAACA AGGCAGAGAT CCCAGAGCGG CGGAAGGACA GCACGAGCAC CCCCAACAAC 
CTCCCTCCTA GCATGATGAC CCGCAGAAAC ACCTACGTTT GCACAGAACG CCCGGGGGCT 
GAGCGCCCGT CACTGTTGCC AAATGGGAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 
CCTGCCTCCC CCTCCAGTCA CAGCCTGGCA CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 
CGTGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 
GGTGGGGGTG GTGGGGGTGT GCAGAATGGG CCCCCTGCCT CTCCCACACT GGCCCATGAG 
GCTGCACCCC TGCCCGCCGG GCGGCCCCGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 
TCCAAACTGA CCCGAAGGGT TACCCTCGAT CCCTCTAAAC GGCAGAACTC TAACCGCTGT 
GTTTCGGGCG CCTCTCTGCC CCAGGGATCC AAGATCAGGT CGCAGACGAA CCTGAGAGAA 
TCGGGGGACC TGAGGTCACA AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC 
GGCTGCTCCG ATTCCCCTGG AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Roles of tau protein in health and disease.
Acta neuropathologica133(5)665-704(2017 May)
Guo T,Noble W,Hanger DP

MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells.
EMBO reports18(3)420-436(2017 03)
Heidary Arash E,Shiban A,Song S,Attisano L

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment.
Scientific reports634784(2016 Oct)
Sun W,Lee S,Huang X,Liu S,Inayathullah M,Kim KM,Tang H,Ashford JW,Rajadas J

miR-515-5p controls cancer cell migration through MARK4 regulation.
EMBO reports17(4)570-84(2016 04)
Pardo OE,Castellano L,Munro CE,Hu Y,Mauri F,Krell J,Lara R,Pinho FG,Choudhury T,Frampton AE,Pellegrino L,Pshezhetskiy D,Wang Y,Waxman J,Seckl MJ,Stebbing J

Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.
Molecular and cellular biochemistry410(1-2)223-8(2015 Dec)
Naz F,Islam A,Ahmad F,Hassan MI

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MARK4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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