Gene Symbol | TRIB3 |
Entrez Gene ID | 57761 |
Full Name | tribbles pseudokinase 3 |
Synonyms | C20orf97,NIPK,SINK,SKIP3,TRB3 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]. |
Disorder MIM: |