SLC7A14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC7A14
Entrez Gene ID	57709
Full Name	solute carrier family 7 member 14
Synonyms	PPP1R142
General protein information	Preferred Names solute carrier family 7 member 14 Names probable cationic amino acid transporter protein phosphatase 1, regulatory subunit 142 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 solute carrier family 7 (orphan transporter), member 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q26.2
Summary	This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014].
Disorder MIM:	615720
Disorder Html:	Retinitis pigmentosa 68, 615725 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020949.3	NP_066000.2	probable cationic amino acid transporter
NM_020949.2	NP_066000.2	probable cationic amino acid transporter

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC566270	XP_005163464.1
Drosophila melanogaster (fruit fly)	CG12531	NP_608350.2
Canis lupus familiaris (dog)	SLC7A14	XP_545285.2
Rattus norvegicus (Norway rat)	Slc7a14	NP_001128087.1
Xenopus tropicalis (tropical clawed frog)	slc7a14	XP_002931595.1
Gallus gallus (chicken)	SLC7A14	XP_422796.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001265	XP_321887.4
Homo sapiens (human)	SLC7A14	NP_066000.2
Pan troglodytes (chimpanzee)	SLC7A14	XP_526378.2
	SLC7A14	XP_001088713.1
Bos taurus (cattle)	SLC7A14	NP_001071460.1
Mus musculus (house mouse)	Slc7a14	NP_766449.1

Gene Ontology
Bibliography

Related articles in PubMed

Screening for SLC7A14 gene mutations in patients with autosomal recessive or sporadic retinitis pigmentosa.
Sugahara M, Oishi M, Oishi A, Ogino K, Morooka S, Gotoh N, Kang I, Yoshimura N
Ophthalmic genetics38(1)70-73(2017 Jan-Feb)

SLC7A14 linked to autosomal recessive retinitis pigmentosa.
Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen J, Huang C, Wu J, Lu F, Qu J
Nature communications53517(2014 Mar)

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
Jaenecke I, Boissel JP, Lemke M, Rupp J, Gasnier B, Closs EI
The Journal of biological chemistry287(36)30853-60(2012 Aug)

Docking motif-guided mapping of the interactome of protein phosphatase-1.
Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M
Chemistry & biology16(4)365-71(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The four SLC7A14 mutations detected herein were unlikely to be pathogenic in this Japanese cohort. The frequency and pathogenicity of SLC7A14 mutations may vary depending on ethnicity, and these mutations may be rare in Japanese patients.
Title: Screening for SLC7A14 gene mutations in patients with autosomal recessive or sporadic retinitis pigmentosa.

Data suggests that cationic transporter SLC7A14 has an important role in retinal development and visual function.
Title: SLC7A14 linked to autosomal recessive retinitis pigmentosa.

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
Title: A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following SLC7A14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC7A14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28179	NM_020949.3 Latest version!	Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
View Old Accession Versions >>
OHu28179	NM_020949.2	Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC7A14 ( NM_020949.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066000.2 Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.

Price & Availability↑

CloneID	OHu28179
Clone ID Related Accession (Same CDS sequence)	NM_020949.3 , NM_020949.2
Accession Version	NM_020949.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2316bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	probable cationic amino acid transporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008041.5, DA475001.1, AK122655.1, AB046833.1 and N64525.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_020949.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.185681.1, SRR1660805.215668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231706.6/ ENSP00000231706.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGGCT TCTTCACCTC GCTGGACCCC CGGCGGGTGC AGTGGGGAGC TGCCTGGTAT 
GCAATGCACT CCAGGATCCT ACGCACCAAA CCAGTGGAGT CCATGCTAGA GGGAACTGGG 
ACCACCACGG CACATGGAAC TAAGCTAGCC CAGGTACTCA CCACAGTGGA CCTCATCTCT 
CTTGGCGTTG GCAGCTGTGT GGGCACTGGC ATGTATGTGG TCTCTGGCCT GGTGGCCAAG 
GAAATGGCAG GACCTGGTGT CATTGTGTCC TTCATCATTG CAGCCGTCGC ATCCATATTA 
TCAGGCGTCT GCTATGCAGA GTTTGGAGTT CGAGTCCCCA AGACCACAGG ATCTGCCTAC 
ACCTACAGCT ATGTCACTGT TGGGGAATTT GTGGCATTTT TCATTGGCTG GAACCTGATC 
CTGGAGTACC TGATTGGCAC TGCGGCCGGA GCCAGTGCTC TGAGCAGCAT GTTTGACTCA 
CTAGCCAACC ACACCATCAG CCGCTGGATG GCGGACAGCG TGGGAACCCT CAATGGCCTG 
GGGAAAGGTG AAGAATCATA CCCAGACCTT CTGGCTCTGT TGATCGCGGT CATCGTGACC 
ATCATTGTTG CTCTGGGGGT GAAGAATTCC ATAGGCTTCA ACAATGTTCT CAATGTGCTG 
AACCTGGCAG TATGGGTGTT CATCATGATC GCAGGCCTCT TCTTCATCAA TGGGAAATAC 
TGGGCGGAGG GCCAGTTCTT GCCCCACGGC TGGTCAGGGG TGCTGCAAGG AGCAGCAACA 
TGCTTCTACG CTTTCATTGG CTTTGACATC ATCGCCACCA CTGGAGAGGA AGCCAAGAAT 
CCCAACACGT CCATCCCTTA TGCTATCACT GCCTCCCTGG TCATCTGCCT GACAGCATAT 
GTGTCTGTGA GCGTGATCTT AACTCTGATG GTGCCATATT ATACCATTGA CACGGAATCC 
CCACTCATGG AGATGTTTGT GGCTCATGGG TTCTATGCTG CCAAATTCGT AGTGGCCATT 
GGGTCGGTTG CAGGACTGAC AGTCAGCTTG CTGGGGTCCC TCTTCCCGAT GCCGAGGGTC 
ATTTATGCCA TGGCTGGTGA CGGGCTCCTT TTCAGGTTCC TGGCTCACGT CAGCTCCTAC 
ACAGAGACAC CAGTGGTGGC CTGCATCGTG TCGGGGTTCC TGGCAGCGCT CCTCGCACTG 
TTGGTCAGCT TGAGAGACCT GATAGAGATG ATGTCTATCG GCACGCTCCT GGCCTACACC 
TTGGTCTCTG TCTGTGTCTT GCTCCTTCGA TACCAACCTG AGAGTGACAT TGATGGTTTT 
GTCAAGTTCT TGTCTGAGGA GCACACCAAG AAGAAGGAGG GCATTCTGGC TGACTGTGAG 
AAGGAAGCTT GTTCTCCTGT GAGTGAGGGG GATGAGTTTT CTGGCCCAGC CACCAACACA 
TGTGGGGCCA AGAACTTACC ATCCTTGGGA GACAATGAGA TGCTCATAGG GAAATCAGAC 
AAGTCAACCT ACAACGTCAA CCACCCCAAT TACGGCACCG TGGACATGAC CACAGGCATA 
GAAGCTGATG AATCCGAAAA TATTTATCTC ATCAAGTTAA AGAAGCTGAT TGGGCCTCAT 
TATTACACCA TGAGAATCCG GCTGGGCCTT CCAGGCAAAA TGGACCGGCC CACAGCAGCG 
ACGGGGCACA CGGTGACCAT CTGCGTGCTC CTGCTCTTCA TCCTCATGTT CATCTTCTGC 
TCCTTCATCA TCTTTGGTTC TGACTACATC TCAGAGCAGA GCTGGTGGGC CATCCTTCTG 
GTTGTTCTGA TGGTGCTGCT GATCAGCACC CTGGTGTTTG TGATCCTGCA GCAGCCAGAG 
AACCCCAAGA AGCTGCCCTA CATGGCCCCT TGCCTCCCCT TTGTGCCTGC CTTTGCCATG 
CTGGTGAACA TCTATCTCAT GCTAAAGCTC TCCACCATCA CATGGATCCG GTTTGCGGTC 
TGGTGCTTTG TGGGTCTGCT CATTTATTTT GGATATGGCA TCTGGAACAG CACCCTGGAA 
ATCAGCGCTC GAGAAGAGGC CCTGCACCAA AGCACGTACC AACGCTACGA CGTGGATGAC 
CCCTTCTCAG TGGAGGAGGG TTTCTCCTAC GCCACAGAGG GCGAGAGCCA GGAGGACTGG 
GGCGGGCCCA CTGAAGACAA AGGCTTCTAT TACCAACAGA TGTCAGATGC GAAGGCAAAC 
GGCCGGACAA GTAGCAAAGC GAAGAGCAAA AGCAAACACA AACAGAACTC AGAGGCCCTG 
ATTGCAAATG ATGAGTTAGA TTACTCTCCA GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066000.2
CDS	318..2633
Translation	MSGFFTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELDYSPE

Target ORF information:

RefSeq Version	NM_020949.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020949.3

ORF Insert Sequence:

ATGAGTGGCT TCTTCACCTC GCTGGACCCC CGGCGGGTGC AGTGGGGAGC TGCCTGGTAT 
GCAATGCACT CCAGGATCCT ACGCACCAAA CCAGTGGAGT CCATGCTAGA GGGAACTGGG 
ACCACCACGG CACATGGAAC TAAGCTAGCC CAGGTACTCA CCACAGTGGA CCTCATCTCT 
CTTGGCGTTG GCAGCTGTGT GGGCACTGGC ATGTATGTGG TCTCTGGCCT GGTGGCCAAG 
GAAATGGCAG GACCTGGTGT CATTGTGTCC TTCATCATTG CAGCCGTCGC ATCCATATTA 
TCAGGCGTCT GCTATGCAGA GTTTGGAGTT CGAGTCCCCA AGACCACAGG ATCTGCCTAC 
ACCTACAGCT ATGTCACTGT TGGGGAATTT GTGGCATTTT TCATTGGCTG GAACCTGATC 
CTGGAGTACC TGATTGGCAC TGCGGCCGGA GCCAGTGCTC TGAGCAGCAT GTTTGACTCA 
CTAGCCAACC ACACCATCAG CCGCTGGATG GCGGACAGCG TGGGAACCCT CAATGGCCTG 
GGGAAAGGTG AAGAATCATA CCCAGACCTT CTGGCTCTGT TGATCGCGGT CATCGTGACC 
ATCATTGTTG CTCTGGGGGT GAAGAATTCC ATAGGCTTCA ACAATGTTCT CAATGTGCTG 
AACCTGGCAG TATGGGTGTT CATCATGATC GCAGGCCTCT TCTTCATCAA TGGGAAATAC 
TGGGCGGAGG GCCAGTTCTT GCCCCACGGC TGGTCAGGGG TGCTGCAAGG AGCAGCAACA 
TGCTTCTACG CTTTCATTGG CTTTGACATC ATCGCCACCA CTGGAGAGGA AGCCAAGAAT 
CCCAACACGT CCATCCCTTA TGCTATCACT GCCTCCCTGG TCATCTGCCT GACAGCATAT 
GTGTCTGTGA GCGTGATCTT AACTCTGATG GTGCCATATT ATACCATTGA CACGGAATCC 
CCACTCATGG AGATGTTTGT GGCTCATGGG TTCTATGCTG CCAAATTCGT AGTGGCCATT 
GGGTCGGTTG CAGGACTGAC AGTCAGCTTG CTGGGGTCCC TCTTCCCGAT GCCGAGGGTC 
ATTTATGCCA TGGCTGGTGA CGGGCTCCTT TTCAGGTTCC TGGCTCACGT CAGCTCCTAC 
ACAGAGACAC CAGTGGTGGC CTGCATCGTG TCGGGGTTCC TGGCAGCGCT CCTCGCACTG 
TTGGTCAGCT TGAGAGACCT GATAGAGATG ATGTCTATCG GCACGCTCCT GGCCTACACC 
TTGGTCTCTG TCTGTGTCTT GCTCCTTCGA TACCAACCTG AGAGTGACAT TGATGGTTTT 
GTCAAGTTCT TGTCTGAGGA GCACACCAAG AAGAAGGAGG GCATTCTGGC TGACTGTGAG 
AAGGAAGCTT GTTCTCCTGT GAGTGAGGGG GATGAGTTTT CTGGCCCAGC CACCAACACA 
TGTGGGGCCA AGAACTTACC ATCCTTGGGA GACAATGAGA TGCTCATAGG GAAATCAGAC 
AAGTCAACCT ACAACGTCAA CCACCCCAAT TACGGCACCG TGGACATGAC CACAGGCATA 
GAAGCTGATG AATCCGAAAA TATTTATCTC ATCAAGTTAA AGAAGCTGAT TGGGCCTCAT 
TATTACACCA TGAGAATCCG GCTGGGCCTT CCAGGCAAAA TGGACCGGCC CACAGCAGCG 
ACGGGGCACA CGGTGACCAT CTGCGTGCTC CTGCTCTTCA TCCTCATGTT CATCTTCTGC 
TCCTTCATCA TCTTTGGTTC TGACTACATC TCAGAGCAGA GCTGGTGGGC CATCCTTCTG 
GTTGTTCTGA TGGTGCTGCT GATCAGCACC CTGGTGTTTG TGATCCTGCA GCAGCCAGAG 
AACCCCAAGA AGCTGCCCTA CATGGCCCCT TGCCTCCCCT TTGTGCCTGC CTTTGCCATG 
CTGGTGAACA TCTATCTCAT GCTAAAGCTC TCCACCATCA CATGGATCCG GTTTGCGGTC 
TGGTGCTTTG TGGGTCTGCT CATTTATTTT GGATATGGCA TCTGGAACAG CACCCTGGAA 
ATCAGCGCTC GAGAAGAGGC CCTGCACCAA AGCACGTACC AACGCTACGA CGTGGATGAC 
CCCTTCTCAG TGGAGGAGGG TTTCTCCTAC GCCACAGAGG GCGAGAGCCA GGAGGACTGG 
GGCGGGCCCA CTGAAGACAA AGGCTTCTAT TACCAACAGA TGTCAGATGC GAAGGCAAAC 
GGCCGGACAA GTAGCAAAGC GAAGAGCAAA AGCAAACACA AACAGAACTC AGAGGCCCTG 
ATTGCAAATG ATGAGTTAGA TTACTCTCCA GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC7A14 ( NM_020949.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066000.2 Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.

Price & Availability↑

CloneID	OHu28179
Clone ID Related Accession (Same CDS sequence)	NM_020949.3 , NM_020949.2
Accession Version	NM_020949.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2316bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	probable cationic amino acid transporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA475001.1, AK122655.1, AB046833.1, AC008041.5 and N64525.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2008 this sequence version replaced NM_020949.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.49193.1, SRR1660809.185681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGCT TCTTCACCTC GCTGGACCCC CGGCGGGTGC AGTGGGGAGC TGCCTGGTAT 
GCAATGCACT CCAGGATCCT ACGCACCAAA CCAGTGGAGT CCATGCTAGA GGGAACTGGG 
ACCACCACGG CACATGGAAC TAAGCTAGCC CAGGTACTCA CCACAGTGGA CCTCATCTCT 
CTTGGCGTTG GCAGCTGTGT GGGCACTGGC ATGTATGTGG TCTCTGGCCT GGTGGCCAAG 
GAAATGGCAG GACCTGGTGT CATTGTGTCC TTCATCATTG CAGCCGTCGC ATCCATATTA 
TCAGGCGTCT GCTATGCAGA GTTTGGAGTT CGAGTCCCCA AGACCACAGG ATCTGCCTAC 
ACCTACAGCT ATGTCACTGT TGGGGAATTT GTGGCATTTT TCATTGGCTG GAACCTGATC 
CTGGAGTACC TGATTGGCAC TGCGGCCGGA GCCAGTGCTC TGAGCAGCAT GTTTGACTCA 
CTAGCCAACC ACACCATCAG CCGCTGGATG GCGGACAGCG TGGGAACCCT CAATGGCCTG 
GGGAAAGGTG AAGAATCATA CCCAGACCTT CTGGCTCTGT TGATCGCGGT CATCGTGACC 
ATCATTGTTG CTCTGGGGGT GAAGAATTCC ATAGGCTTCA ACAATGTTCT CAATGTGCTG 
AACCTGGCAG TATGGGTGTT CATCATGATC GCAGGCCTCT TCTTCATCAA TGGGAAATAC 
TGGGCGGAGG GCCAGTTCTT GCCCCACGGC TGGTCAGGGG TGCTGCAAGG AGCAGCAACA 
TGCTTCTACG CTTTCATTGG CTTTGACATC ATCGCCACCA CTGGAGAGGA AGCCAAGAAT 
CCCAACACGT CCATCCCTTA TGCTATCACT GCCTCCCTGG TCATCTGCCT GACAGCATAT 
GTGTCTGTGA GCGTGATCTT AACTCTGATG GTGCCATATT ATACCATTGA CACGGAATCC 
CCACTCATGG AGATGTTTGT GGCTCATGGG TTCTATGCTG CCAAATTCGT AGTGGCCATT 
GGGTCGGTTG CAGGACTGAC AGTCAGCTTG CTGGGGTCCC TCTTCCCGAT GCCGAGGGTC 
ATTTATGCCA TGGCTGGTGA CGGGCTCCTT TTCAGGTTCC TGGCTCACGT CAGCTCCTAC 
ACAGAGACAC CAGTGGTGGC CTGCATCGTG TCGGGGTTCC TGGCAGCGCT CCTCGCACTG 
TTGGTCAGCT TGAGAGACCT GATAGAGATG ATGTCTATCG GCACGCTCCT GGCCTACACC 
TTGGTCTCTG TCTGTGTCTT GCTCCTTCGA TACCAACCTG AGAGTGACAT TGATGGTTTT 
GTCAAGTTCT TGTCTGAGGA GCACACCAAG AAGAAGGAGG GCATTCTGGC TGACTGTGAG 
AAGGAAGCTT GTTCTCCTGT GAGTGAGGGG GATGAGTTTT CTGGCCCAGC CACCAACACA 
TGTGGGGCCA AGAACTTACC ATCCTTGGGA GACAATGAGA TGCTCATAGG GAAATCAGAC 
AAGTCAACCT ACAACGTCAA CCACCCCAAT TACGGCACCG TGGACATGAC CACAGGCATA 
GAAGCTGATG AATCCGAAAA TATTTATCTC ATCAAGTTAA AGAAGCTGAT TGGGCCTCAT 
TATTACACCA TGAGAATCCG GCTGGGCCTT CCAGGCAAAA TGGACCGGCC CACAGCAGCG 
ACGGGGCACA CGGTGACCAT CTGCGTGCTC CTGCTCTTCA TCCTCATGTT CATCTTCTGC 
TCCTTCATCA TCTTTGGTTC TGACTACATC TCAGAGCAGA GCTGGTGGGC CATCCTTCTG 
GTTGTTCTGA TGGTGCTGCT GATCAGCACC CTGGTGTTTG TGATCCTGCA GCAGCCAGAG 
AACCCCAAGA AGCTGCCCTA CATGGCCCCT TGCCTCCCCT TTGTGCCTGC CTTTGCCATG 
CTGGTGAACA TCTATCTCAT GCTAAAGCTC TCCACCATCA CATGGATCCG GTTTGCGGTC 
TGGTGCTTTG TGGGTCTGCT CATTTATTTT GGATATGGCA TCTGGAACAG CACCCTGGAA 
ATCAGCGCTC GAGAAGAGGC CCTGCACCAA AGCACGTACC AACGCTACGA CGTGGATGAC 
CCCTTCTCAG TGGAGGAGGG TTTCTCCTAC GCCACAGAGG GCGAGAGCCA GGAGGACTGG 
GGCGGGCCCA CTGAAGACAA AGGCTTCTAT TACCAACAGA TGTCAGATGC GAAGGCAAAC 
GGCCGGACAA GTAGCAAAGC GAAGAGCAAA AGCAAACACA AACAGAACTC AGAGGCCCTG 
ATTGCAAATG ATGAGTTAGA TTACTCTCCA GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066000.2
CDS	317..2632
Translation	MSGFFTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELDYSPE

Target ORF information:

RefSeq Version	NM_020949.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 7 member 14 (SLC7A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020949.2

ORF Insert Sequence:

ATGAGTGGCT TCTTCACCTC GCTGGACCCC CGGCGGGTGC AGTGGGGAGC TGCCTGGTAT 
GCAATGCACT CCAGGATCCT ACGCACCAAA CCAGTGGAGT CCATGCTAGA GGGAACTGGG 
ACCACCACGG CACATGGAAC TAAGCTAGCC CAGGTACTCA CCACAGTGGA CCTCATCTCT 
CTTGGCGTTG GCAGCTGTGT GGGCACTGGC ATGTATGTGG TCTCTGGCCT GGTGGCCAAG 
GAAATGGCAG GACCTGGTGT CATTGTGTCC TTCATCATTG CAGCCGTCGC ATCCATATTA 
TCAGGCGTCT GCTATGCAGA GTTTGGAGTT CGAGTCCCCA AGACCACAGG ATCTGCCTAC 
ACCTACAGCT ATGTCACTGT TGGGGAATTT GTGGCATTTT TCATTGGCTG GAACCTGATC 
CTGGAGTACC TGATTGGCAC TGCGGCCGGA GCCAGTGCTC TGAGCAGCAT GTTTGACTCA 
CTAGCCAACC ACACCATCAG CCGCTGGATG GCGGACAGCG TGGGAACCCT CAATGGCCTG 
GGGAAAGGTG AAGAATCATA CCCAGACCTT CTGGCTCTGT TGATCGCGGT CATCGTGACC 
ATCATTGTTG CTCTGGGGGT GAAGAATTCC ATAGGCTTCA ACAATGTTCT CAATGTGCTG 
AACCTGGCAG TATGGGTGTT CATCATGATC GCAGGCCTCT TCTTCATCAA TGGGAAATAC 
TGGGCGGAGG GCCAGTTCTT GCCCCACGGC TGGTCAGGGG TGCTGCAAGG AGCAGCAACA 
TGCTTCTACG CTTTCATTGG CTTTGACATC ATCGCCACCA CTGGAGAGGA AGCCAAGAAT 
CCCAACACGT CCATCCCTTA TGCTATCACT GCCTCCCTGG TCATCTGCCT GACAGCATAT 
GTGTCTGTGA GCGTGATCTT AACTCTGATG GTGCCATATT ATACCATTGA CACGGAATCC 
CCACTCATGG AGATGTTTGT GGCTCATGGG TTCTATGCTG CCAAATTCGT AGTGGCCATT 
GGGTCGGTTG CAGGACTGAC AGTCAGCTTG CTGGGGTCCC TCTTCCCGAT GCCGAGGGTC 
ATTTATGCCA TGGCTGGTGA CGGGCTCCTT TTCAGGTTCC TGGCTCACGT CAGCTCCTAC 
ACAGAGACAC CAGTGGTGGC CTGCATCGTG TCGGGGTTCC TGGCAGCGCT CCTCGCACTG 
TTGGTCAGCT TGAGAGACCT GATAGAGATG ATGTCTATCG GCACGCTCCT GGCCTACACC 
TTGGTCTCTG TCTGTGTCTT GCTCCTTCGA TACCAACCTG AGAGTGACAT TGATGGTTTT 
GTCAAGTTCT TGTCTGAGGA GCACACCAAG AAGAAGGAGG GCATTCTGGC TGACTGTGAG 
AAGGAAGCTT GTTCTCCTGT GAGTGAGGGG GATGAGTTTT CTGGCCCAGC CACCAACACA 
TGTGGGGCCA AGAACTTACC ATCCTTGGGA GACAATGAGA TGCTCATAGG GAAATCAGAC 
AAGTCAACCT ACAACGTCAA CCACCCCAAT TACGGCACCG TGGACATGAC CACAGGCATA 
GAAGCTGATG AATCCGAAAA TATTTATCTC ATCAAGTTAA AGAAGCTGAT TGGGCCTCAT 
TATTACACCA TGAGAATCCG GCTGGGCCTT CCAGGCAAAA TGGACCGGCC CACAGCAGCG 
ACGGGGCACA CGGTGACCAT CTGCGTGCTC CTGCTCTTCA TCCTCATGTT CATCTTCTGC 
TCCTTCATCA TCTTTGGTTC TGACTACATC TCAGAGCAGA GCTGGTGGGC CATCCTTCTG 
GTTGTTCTGA TGGTGCTGCT GATCAGCACC CTGGTGTTTG TGATCCTGCA GCAGCCAGAG 
AACCCCAAGA AGCTGCCCTA CATGGCCCCT TGCCTCCCCT TTGTGCCTGC CTTTGCCATG 
CTGGTGAACA TCTATCTCAT GCTAAAGCTC TCCACCATCA CATGGATCCG GTTTGCGGTC 
TGGTGCTTTG TGGGTCTGCT CATTTATTTT GGATATGGCA TCTGGAACAG CACCCTGGAA 
ATCAGCGCTC GAGAAGAGGC CCTGCACCAA AGCACGTACC AACGCTACGA CGTGGATGAC 
CCCTTCTCAG TGGAGGAGGG TTTCTCCTAC GCCACAGAGG GCGAGAGCCA GGAGGACTGG 
GGCGGGCCCA CTGAAGACAA AGGCTTCTAT TACCAACAGA TGTCAGATGC GAAGGCAAAC 
GGCCGGACAA GTAGCAAAGC GAAGAGCAAA AGCAAACACA AACAGAACTC AGAGGCCCTG 
ATTGCAAATG ATGAGTTAGA TTACTCTCCA GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Screening for SLC7A14 gene mutations in patients with autosomal recessive or sporadic retinitis pigmentosa.
Ophthalmic genetics38(1)70-73(2017 Jan-Feb)
Sugahara M,Oishi M,Oishi A,Ogino K,Morooka S,Gotoh N,Kang I,Yoshimura N

SLC7A14 linked to autosomal recessive retinitis pigmentosa.
Nature communications53517(2014 Mar)
Jin ZB,Huang XF,Lv JN,Xiang L,Li DQ,Chen J,Huang C,Wu J,Lu F,Qu J

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
The Journal of biological chemistry287(36)30853-60(2012 Aug)
Jaenecke I,Boissel JP,Lemke M,Rupp J,Gasnier B,Closs EI

Docking motif-guided mapping of the interactome of protein phosphatase-1.
Chemistry & biology16(4)365-71(2009 Apr)
Hendrickx A,Beullens M,Ceulemans H,Den Abt T,Van Eynde A,Nicolaescu E,Lesage B,Bollen M

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SLC7A14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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