HCN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HCN3
Entrez Gene ID	57657
Full Name	hyperpolarization activated cyclic nucleotide gated potassium channel 3
General protein information	Preferred Names hyperpolarization activated cyclic nucleotide gated potassium channel 3 Names potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder MIM:	609973

mRNA and Protein(s)

mRNA	Protein	Name
NM_020897.3	NP_065948.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
XM_011509817.2	XP_011508119.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2
XM_011509816.3	XP_011508118.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1
XM_011509816.2	XP_011508118.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1
XM_011509818.2	XP_011508120.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3
XM_017001918.1	XP_016857407.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3
NM_020897.2	NP_065948.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HCN3	XP_513856.3
	HCN3	XP_001115891.1
Canis lupus familiaris (dog)	HCN3	XP_547548.2
Mus musculus (house mouse)	Hcn3	NP_032253.1
Homo sapiens (human)	HCN3	NP_065948.1
Rattus norvegicus (Norway rat)	Hcn3	NP_446137.1
Bos taurus (cattle)	HCN3	NP_001179207.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002150	XP_003436040.1

Gene Ontology
Bibliography

Related articles in PubMed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.
Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, S?dhof TC
Science (New York, N.Y.)352(6286)aaf2669(2016 May)

Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
O'Donnell AM, Coyle D, Puri P
World journal of gastroenterology21(18)5635-40(2015 May)

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
Cao-Ehlker X, Zong X, Hammelmann V, Gruner C, Fenske S, Michalakis S, Wahl-Schott C, Biel M
The Journal of biological chemistry288(11)7580-9(2013 Mar)

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.
Xue L, Li Y, Han X, Yao L, Yuan J, Qin W, Liu F, Wang H
Urology80(1)224.e13-8(2012 Jul)

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.
Tu E, Waterhouse L, Duflou J, Bagnall RD, Semsarian C
Brain pathology (Zurich, Switzerland)21(6)692-8(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reduced HCN3 expression in aganglionic bowel suggests its potential role in Hirschsprung's disease pathophysiology.
Title: Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.

KCTD3 is an accessory subunit of native HCN3 complexes
Title: Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4.
Title: Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

human HCN3 is not modulated by intracellular cAMP, in contrast to other HCN subtypes
Title: Functional expression of the human HCN3 channel.

The following HCN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HCN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu70808	XM_011509818.2 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu70808	XM_017001918.1 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu15115	NM_020897.3 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
OHu70806	XM_011509816.3 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu70807	XM_011509817.2 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu70806	XM_011509816.2	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu15115	NM_020897.2	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HCN3 ( XM_011509818.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508120.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu70808
Clone ID Related Accession (Same CDS sequence)	XM_011509818.2 , XM_017001918.1
Accession Version	XM_011509818.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509818.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTATG ACCTGGCCAG TGCTGTGGTT CGCATCTTCA ACCTCATTGG GATGATGCTG 
CTGCTATGTC ACTGGGATGG CTGTCTGCAG TTCCTGGTGC CCATGCTGCA GGACTTCCCT 
CCCGACTGCT GGGTCTCCAT CAACCACATG GTGAACCACT CGTGGGGCCG CCAGTATTCC 
CATGCCCTGT TCAAGGCCAT GAGCCACATG CTGTGCATTG GCTATGGGCA GCAGGCACCT 
GTAGGCATGC CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTAGGTGC CACATGCTAC 
GCCATGTTCA TCGGCCATGC CACGGCACTC ATCCAGTCCC TGGACTCTTC CCGGCGTCAG 
TACCAGGAGA AGTACAAGCA GGTGGAGCAG TACATGTCCT TCCACAAGCT GCCAGCAGAC 
ACGCGGCAGC GCATCCACGA GTACTATGAG CACCGCTACC AGGGCAAGAT GTTCGATGAG 
GAAAGCATCC TGGGCGAGCT GAGCGAGCCG CTTCGCGAGG AGATCATTAA CTTCACCTGT 
CGGGGCCTGG TGGCCCACAT GCCGCTGTTT GCCCATGCCG ACCCCAGCTT CGTCACTGCA 
GTTCTCACCA AGCTGCGCTT TGAGGTCTTC CAGCCGGGGG ATCTCGTGGT GCGTGAGGGC 
TCCGTGGGGA GGAAGATGTA CTTCATCCAG CATGGGCTGC TCAGTGTGCT GGCCCGCGGC 
GCCCGGGACA CACGCCTCAC CGATGGATCC TACTTTGGGG AGATCTGCCT GCTAACTAGG 
GGCCGGCGCA CAGCCAGTGT TCGGGCTGAC ACCTACTGCC GCCTTTACTC ACTCAGCGTG 
GACCATTTCA ATGCTGTGCT TGAGGAGTTC CCCATGATGC GCCGGGCCTT TGAGACTGTG 
GCCATGGATC GGCTGCTCCG CATCGGCAAG AAGAATTCCA TACTGCAGCG GAAGCGCTCC 
GAGCCAAGTC CAGGCAGCAG TGGTGGCATC ATGGAGCAGC ACTTGGTGCA ACATGACAGA 
GACATGGCTC GGGGTGTTCG GGGTCGGGCC CCGAGCACAG GAGCTCAGCT TAGTGGAAAG 
CCAGTACTGT GGGAGCCACT GGTACATGCG CCCCTTCAGG CAGCTGCTGT GACCTCCAAT 
GTGGCCATTG CCCTGACTCA TCAGCGGGGC CCTCTGCCCC TCTCCCCTGA CTCTCCAGCC 
ACCCTCCTTG CTCGCTCTGC TTGGCGCTCA GCAGGCTCTC CAGCTTCCCC GCTGGTGCCC 
GTCCGAGCTG GCCCATGGGC ATCCACCTCC CGCCTGCCCG CCCCACCTGC CCGAACCCTG 
CACGCCAGCC TATCCCGGGC AGGGCGCTCC CAGGTCTCCC TGCTGGGTCC CCCTCCAGGA 
GGAGGTGGAC GGCGGCTAGG ACCTCGGGGC CGCCCACTCT CAGCCTCCCA ACCCTCTCTG 
CCTCAGCGGG CAACAGGCGA TGGCTCTCCT GGGCGTAAGG GATCAGGAAG TGAGCGGCTG 
CCTCCCTCAG GGCTCCTGGC CAAACCTCCA AGGACAGCCC AGCCCCCCAG GCCACCAGTG 
CCTGAGCCAG CCACACCCCG GGGTCTCCAG CTTTCTGCCA ACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508120.1
CDS	112..1719
Translation	MTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	XM_011509818.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509818.2

ORF Insert Sequence:

ATGACCTATG ACCTGGCCAG TGCTGTGGTT CGCATCTTCA ACCTCATTGG GATGATGCTG 
CTGCTATGTC ACTGGGATGG CTGTCTGCAG TTCCTGGTGC CCATGCTGCA GGACTTCCCT 
CCCGACTGCT GGGTCTCCAT CAACCACATG GTGAACCACT CGTGGGGCCG CCAGTATTCC 
CATGCCCTGT TCAAGGCCAT GAGCCACATG CTGTGCATTG GCTATGGGCA GCAGGCACCT 
GTAGGCATGC CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTAGGTGC CACATGCTAC 
GCCATGTTCA TCGGCCATGC CACGGCACTC ATCCAGTCCC TGGACTCTTC CCGGCGTCAG 
TACCAGGAGA AGTACAAGCA GGTGGAGCAG TACATGTCCT TCCACAAGCT GCCAGCAGAC 
ACGCGGCAGC GCATCCACGA GTACTATGAG CACCGCTACC AGGGCAAGAT GTTCGATGAG 
GAAAGCATCC TGGGCGAGCT GAGCGAGCCG CTTCGCGAGG AGATCATTAA CTTCACCTGT 
CGGGGCCTGG TGGCCCACAT GCCGCTGTTT GCCCATGCCG ACCCCAGCTT CGTCACTGCA 
GTTCTCACCA AGCTGCGCTT TGAGGTCTTC CAGCCGGGGG ATCTCGTGGT GCGTGAGGGC 
TCCGTGGGGA GGAAGATGTA CTTCATCCAG CATGGGCTGC TCAGTGTGCT GGCCCGCGGC 
GCCCGGGACA CACGCCTCAC CGATGGATCC TACTTTGGGG AGATCTGCCT GCTAACTAGG 
GGCCGGCGCA CAGCCAGTGT TCGGGCTGAC ACCTACTGCC GCCTTTACTC ACTCAGCGTG 
GACCATTTCA ATGCTGTGCT TGAGGAGTTC CCCATGATGC GCCGGGCCTT TGAGACTGTG 
GCCATGGATC GGCTGCTCCG CATCGGCAAG AAGAATTCCA TACTGCAGCG GAAGCGCTCC 
GAGCCAAGTC CAGGCAGCAG TGGTGGCATC ATGGAGCAGC ACTTGGTGCA ACATGACAGA 
GACATGGCTC GGGGTGTTCG GGGTCGGGCC CCGAGCACAG GAGCTCAGCT TAGTGGAAAG 
CCAGTACTGT GGGAGCCACT GGTACATGCG CCCCTTCAGG CAGCTGCTGT GACCTCCAAT 
GTGGCCATTG CCCTGACTCA TCAGCGGGGC CCTCTGCCCC TCTCCCCTGA CTCTCCAGCC 
ACCCTCCTTG CTCGCTCTGC TTGGCGCTCA GCAGGCTCTC CAGCTTCCCC GCTGGTGCCC 
GTCCGAGCTG GCCCATGGGC ATCCACCTCC CGCCTGCCCG CCCCACCTGC CCGAACCCTG 
CACGCCAGCC TATCCCGGGC AGGGCGCTCC CAGGTCTCCC TGCTGGGTCC CCCTCCAGGA 
GGAGGTGGAC GGCGGCTAGG ACCTCGGGGC CGCCCACTCT CAGCCTCCCA ACCCTCTCTG 
CCTCAGCGGG CAACAGGCGA TGGCTCTCCT GGGCGTAAGG GATCAGGAAG TGAGCGGCTG 
CCTCCCTCAG GGCTCCTGGC CAAACCTCCA AGGACAGCCC AGCCCCCCAG GCCACCAGTG 
CCTGAGCCAG CCACACCCCG GGGTCTCCAG CTTTCTGCCA ACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( XM_017001918.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857407.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X7, mRNA.

Price & Availability↑

CloneID	OHu70808
Clone ID Related Accession (Same CDS sequence)	XM_011509818.2 , XM_017001918.1
Accession Version	XM_017001918.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTATG ACCTGGCCAG TGCTGTGGTT CGCATCTTCA ACCTCATTGG GATGATGCTG 
CTGCTATGTC ACTGGGATGG CTGTCTGCAG TTCCTGGTGC CCATGCTGCA GGACTTCCCT 
CCCGACTGCT GGGTCTCCAT CAACCACATG GTGAACCACT CGTGGGGCCG CCAGTATTCC 
CATGCCCTGT TCAAGGCCAT GAGCCACATG CTGTGCATTG GCTATGGGCA GCAGGCACCT 
GTAGGCATGC CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTAGGTGC CACATGCTAC 
GCCATGTTCA TCGGCCATGC CACGGCACTC ATCCAGTCCC TGGACTCTTC CCGGCGTCAG 
TACCAGGAGA AGTACAAGCA GGTGGAGCAG TACATGTCCT TCCACAAGCT GCCAGCAGAC 
ACGCGGCAGC GCATCCACGA GTACTATGAG CACCGCTACC AGGGCAAGAT GTTCGATGAG 
GAAAGCATCC TGGGCGAGCT GAGCGAGCCG CTTCGCGAGG AGATCATTAA CTTCACCTGT 
CGGGGCCTGG TGGCCCACAT GCCGCTGTTT GCCCATGCCG ACCCCAGCTT CGTCACTGCA 
GTTCTCACCA AGCTGCGCTT TGAGGTCTTC CAGCCGGGGG ATCTCGTGGT GCGTGAGGGC 
TCCGTGGGGA GGAAGATGTA CTTCATCCAG CATGGGCTGC TCAGTGTGCT GGCCCGCGGC 
GCCCGGGACA CACGCCTCAC CGATGGATCC TACTTTGGGG AGATCTGCCT GCTAACTAGG 
GGCCGGCGCA CAGCCAGTGT TCGGGCTGAC ACCTACTGCC GCCTTTACTC ACTCAGCGTG 
GACCATTTCA ATGCTGTGCT TGAGGAGTTC CCCATGATGC GCCGGGCCTT TGAGACTGTG 
GCCATGGATC GGCTGCTCCG CATCGGCAAG AAGAATTCCA TACTGCAGCG GAAGCGCTCC 
GAGCCAAGTC CAGGCAGCAG TGGTGGCATC ATGGAGCAGC ACTTGGTGCA ACATGACAGA 
GACATGGCTC GGGGTGTTCG GGGTCGGGCC CCGAGCACAG GAGCTCAGCT TAGTGGAAAG 
CCAGTACTGT GGGAGCCACT GGTACATGCG CCCCTTCAGG CAGCTGCTGT GACCTCCAAT 
GTGGCCATTG CCCTGACTCA TCAGCGGGGC CCTCTGCCCC TCTCCCCTGA CTCTCCAGCC 
ACCCTCCTTG CTCGCTCTGC TTGGCGCTCA GCAGGCTCTC CAGCTTCCCC GCTGGTGCCC 
GTCCGAGCTG GCCCATGGGC ATCCACCTCC CGCCTGCCCG CCCCACCTGC CCGAACCCTG 
CACGCCAGCC TATCCCGGGC AGGGCGCTCC CAGGTCTCCC TGCTGGGTCC CCCTCCAGGA 
GGAGGTGGAC GGCGGCTAGG ACCTCGGGGC CGCCCACTCT CAGCCTCCCA ACCCTCTCTG 
CCTCAGCGGG CAACAGGCGA TGGCTCTCCT GGGCGTAAGG GATCAGGAAG TGAGCGGCTG 
CCTCCCTCAG GGCTCCTGGC CAAACCTCCA AGGACAGCCC AGCCCCCCAG GCCACCAGTG 
CCTGAGCCAG CCACACCCCG GGGTCTCCAG CTTTCTGCCA ACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857407.1
CDS	94..1701
Translation	MTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	XM_017001918.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001918.1

ORF Insert Sequence:

ATGACCTATG ACCTGGCCAG TGCTGTGGTT CGCATCTTCA ACCTCATTGG GATGATGCTG 
CTGCTATGTC ACTGGGATGG CTGTCTGCAG TTCCTGGTGC CCATGCTGCA GGACTTCCCT 
CCCGACTGCT GGGTCTCCAT CAACCACATG GTGAACCACT CGTGGGGCCG CCAGTATTCC 
CATGCCCTGT TCAAGGCCAT GAGCCACATG CTGTGCATTG GCTATGGGCA GCAGGCACCT 
GTAGGCATGC CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTAGGTGC CACATGCTAC 
GCCATGTTCA TCGGCCATGC CACGGCACTC ATCCAGTCCC TGGACTCTTC CCGGCGTCAG 
TACCAGGAGA AGTACAAGCA GGTGGAGCAG TACATGTCCT TCCACAAGCT GCCAGCAGAC 
ACGCGGCAGC GCATCCACGA GTACTATGAG CACCGCTACC AGGGCAAGAT GTTCGATGAG 
GAAAGCATCC TGGGCGAGCT GAGCGAGCCG CTTCGCGAGG AGATCATTAA CTTCACCTGT 
CGGGGCCTGG TGGCCCACAT GCCGCTGTTT GCCCATGCCG ACCCCAGCTT CGTCACTGCA 
GTTCTCACCA AGCTGCGCTT TGAGGTCTTC CAGCCGGGGG ATCTCGTGGT GCGTGAGGGC 
TCCGTGGGGA GGAAGATGTA CTTCATCCAG CATGGGCTGC TCAGTGTGCT GGCCCGCGGC 
GCCCGGGACA CACGCCTCAC CGATGGATCC TACTTTGGGG AGATCTGCCT GCTAACTAGG 
GGCCGGCGCA CAGCCAGTGT TCGGGCTGAC ACCTACTGCC GCCTTTACTC ACTCAGCGTG 
GACCATTTCA ATGCTGTGCT TGAGGAGTTC CCCATGATGC GCCGGGCCTT TGAGACTGTG 
GCCATGGATC GGCTGCTCCG CATCGGCAAG AAGAATTCCA TACTGCAGCG GAAGCGCTCC 
GAGCCAAGTC CAGGCAGCAG TGGTGGCATC ATGGAGCAGC ACTTGGTGCA ACATGACAGA 
GACATGGCTC GGGGTGTTCG GGGTCGGGCC CCGAGCACAG GAGCTCAGCT TAGTGGAAAG 
CCAGTACTGT GGGAGCCACT GGTACATGCG CCCCTTCAGG CAGCTGCTGT GACCTCCAAT 
GTGGCCATTG CCCTGACTCA TCAGCGGGGC CCTCTGCCCC TCTCCCCTGA CTCTCCAGCC 
ACCCTCCTTG CTCGCTCTGC TTGGCGCTCA GCAGGCTCTC CAGCTTCCCC GCTGGTGCCC 
GTCCGAGCTG GCCCATGGGC ATCCACCTCC CGCCTGCCCG CCCCACCTGC CCGAACCCTG 
CACGCCAGCC TATCCCGGGC AGGGCGCTCC CAGGTCTCCC TGCTGGGTCC CCCTCCAGGA 
GGAGGTGGAC GGCGGCTAGG ACCTCGGGGC CGCCCACTCT CAGCCTCCCA ACCCTCTCTG 
CCTCAGCGGG CAACAGGCGA TGGCTCTCCT GGGCGTAAGG GATCAGGAAG TGAGCGGCTG 
CCTCCCTCAG GGCTCCTGGC CAAACCTCCA AGGACAGCCC AGCCCCCCAG GCCACCAGTG 
CCTGAGCCAG CCACACCCCG GGGTCTCCAG CTTTCTGCCA ACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( NM_020897.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065948.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15115
Clone ID Related Accession (Same CDS sequence)	NM_020897.3 , NM_020897.2
Accession Version	NM_020897.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2325bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA127524.1, AB040968.2, AL713999.28 and BC028024.1. On Nov 23, 2018 this sequence version replaced NM_020897.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.115093.1, AB040968.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368358.4/ ENSP00000357342.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAT CTTTCACATG 
ACCTATGACC TGGCCAGTGC TGTGGTTCGC ATCTTCAACC TCATTGGGAT GATGCTGCTG 
CTATGTCACT GGGATGGCTG TCTGCAGTTC CTGGTGCCCA TGCTGCAGGA CTTCCCTCCC 
GACTGCTGGG TCTCCATCAA CCACATGGTG AACCACTCGT GGGGCCGCCA GTATTCCCAT 
GCCCTGTTCA AGGCCATGAG CCACATGCTG TGCATTGGCT ATGGGCAGCA GGCACCTGTA 
GGCATGCCCG ACGTCTGGCT CACCATGCTC AGCATGATCG TAGGTGCCAC ATGCTACGCC 
ATGTTCATCG GCCATGCCAC GGCACTCATC CAGTCCCTGG ACTCTTCCCG GCGTCAGTAC 
CAGGAGAAGT ACAAGCAGGT GGAGCAGTAC ATGTCCTTCC ACAAGCTGCC AGCAGACACG 
CGGCAGCGCA TCCACGAGTA CTATGAGCAC CGCTACCAGG GCAAGATGTT CGATGAGGAA 
AGCATCCTGG GCGAGCTGAG CGAGCCGCTT CGCGAGGAGA TCATTAACTT CACCTGTCGG 
GGCCTGGTGG CCCACATGCC GCTGTTTGCC CATGCCGACC CCAGCTTCGT CACTGCAGTT 
CTCACCAAGC TGCGCTTTGA GGTCTTCCAG CCGGGGGATC TCGTGGTGCG TGAGGGCTCC 
GTGGGGAGGA AGATGTACTT CATCCAGCAT GGGCTGCTCA GTGTGCTGGC CCGCGGCGCC 
CGGGACACAC GCCTCACCGA TGGATCCTAC TTTGGGGAGA TCTGCCTGCT AACTAGGGGC 
CGGCGCACAG CCAGTGTTCG GGCTGACACC TACTGCCGCC TTTACTCACT CAGCGTGGAC 
CATTTCAATG CTGTGCTTGA GGAGTTCCCC ATGATGCGCC GGGCCTTTGA GACTGTGGCC 
ATGGATCGGC TGCTCCGCAT CGGCAAGAAG AATTCCATAC TGCAGCGGAA GCGCTCCGAG 
CCAAGTCCAG GCAGCAGTGG TGGCATCATG GAGCAGCACT TGGTGCAACA TGACAGAGAC 
ATGGCTCGGG GTGTTCGGGG TCGGGCCCCG AGCACAGGAG CTCAGCTTAG TGGAAAGCCA 
GTACTGTGGG AGCCACTGGT ACATGCGCCC CTTCAGGCAG CTGCTGTGAC CTCCAATGTG 
GCCATTGCCC TGACTCATCA GCGGGGCCCT CTGCCCCTCT CCCCTGACTC TCCAGCCACC 
CTCCTTGCTC GCTCTGCTTG GCGCTCAGCA GGCTCTCCAG CTTCCCCGCT GGTGCCCGTC 
CGAGCTGGCC CATGGGCATC CACCTCCCGC CTGCCCGCCC CACCTGCCCG AACCCTGCAC 
GCCAGCCTAT CCCGGGCAGG GCGCTCCCAG GTCTCCCTGC TGGGTCCCCC TCCAGGAGGA 
GGTGGACGGC GGCTAGGACC TCGGGGCCGC CCACTCTCAG CCTCCCAACC CTCTCTGCCT 
CAGCGGGCAA CAGGCGATGG CTCTCCTGGG CGTAAGGGAT CAGGAAGTGA GCGGCTGCCT 
CCCTCAGGGC TCCTGGCCAA ACCTCCAAGG ACAGCCCAGC CCCCCAGGCC ACCAGTGCCT 
GAGCCAGCCA CACCCCGGGG TCTCCAGCTT TCTGCCAACA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065948.1
CDS	129..2453
Translation	MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	NM_020897.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020897.3

ORF Insert Sequence:

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAT CTTTCACATG 
ACCTATGACC TGGCCAGTGC TGTGGTTCGC ATCTTCAACC TCATTGGGAT GATGCTGCTG 
CTATGTCACT GGGATGGCTG TCTGCAGTTC CTGGTGCCCA TGCTGCAGGA CTTCCCTCCC 
GACTGCTGGG TCTCCATCAA CCACATGGTG AACCACTCGT GGGGCCGCCA GTATTCCCAT 
GCCCTGTTCA AGGCCATGAG CCACATGCTG TGCATTGGCT ATGGGCAGCA GGCACCTGTA 
GGCATGCCCG ACGTCTGGCT CACCATGCTC AGCATGATCG TAGGTGCCAC ATGCTACGCC 
ATGTTCATCG GCCATGCCAC GGCACTCATC CAGTCCCTGG ACTCTTCCCG GCGTCAGTAC 
CAGGAGAAGT ACAAGCAGGT GGAGCAGTAC ATGTCCTTCC ACAAGCTGCC AGCAGACACG 
CGGCAGCGCA TCCACGAGTA CTATGAGCAC CGCTACCAGG GCAAGATGTT CGATGAGGAA 
AGCATCCTGG GCGAGCTGAG CGAGCCGCTT CGCGAGGAGA TCATTAACTT CACCTGTCGG 
GGCCTGGTGG CCCACATGCC GCTGTTTGCC CATGCCGACC CCAGCTTCGT CACTGCAGTT 
CTCACCAAGC TGCGCTTTGA GGTCTTCCAG CCGGGGGATC TCGTGGTGCG TGAGGGCTCC 
GTGGGGAGGA AGATGTACTT CATCCAGCAT GGGCTGCTCA GTGTGCTGGC CCGCGGCGCC 
CGGGACACAC GCCTCACCGA TGGATCCTAC TTTGGGGAGA TCTGCCTGCT AACTAGGGGC 
CGGCGCACAG CCAGTGTTCG GGCTGACACC TACTGCCGCC TTTACTCACT CAGCGTGGAC 
CATTTCAATG CTGTGCTTGA GGAGTTCCCC ATGATGCGCC GGGCCTTTGA GACTGTGGCC 
ATGGATCGGC TGCTCCGCAT CGGCAAGAAG AATTCCATAC TGCAGCGGAA GCGCTCCGAG 
CCAAGTCCAG GCAGCAGTGG TGGCATCATG GAGCAGCACT TGGTGCAACA TGACAGAGAC 
ATGGCTCGGG GTGTTCGGGG TCGGGCCCCG AGCACAGGAG CTCAGCTTAG TGGAAAGCCA 
GTACTGTGGG AGCCACTGGT ACATGCGCCC CTTCAGGCAG CTGCTGTGAC CTCCAATGTG 
GCCATTGCCC TGACTCATCA GCGGGGCCCT CTGCCCCTCT CCCCTGACTC TCCAGCCACC 
CTCCTTGCTC GCTCTGCTTG GCGCTCAGCA GGCTCTCCAG CTTCCCCGCT GGTGCCCGTC 
CGAGCTGGCC CATGGGCATC CACCTCCCGC CTGCCCGCCC CACCTGCCCG AACCCTGCAC 
GCCAGCCTAT CCCGGGCAGG GCGCTCCCAG GTCTCCCTGC TGGGTCCCCC TCCAGGAGGA 
GGTGGACGGC GGCTAGGACC TCGGGGCCGC CCACTCTCAG CCTCCCAACC CTCTCTGCCT 
CAGCGGGCAA CAGGCGATGG CTCTCCTGGG CGTAAGGGAT CAGGAAGTGA GCGGCTGCCT 
CCCTCAGGGC TCCTGGCCAA ACCTCCAAGG ACAGCCCAGC CCCCCAGGCC ACCAGTGCCT 
GAGCCAGCCA CACCCCGGGG TCTCCAGCTT TCTGCCAACA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( NM_020897.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065948.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.

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CloneID	OHu15115
Clone ID Related Accession (Same CDS sequence)	NM_020897.3 , NM_020897.2
Accession Version	NM_020897.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2325bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA127524.1, AB040968.2, AL713999.28 and BC028024.1. On Aug 8, 2012 this sequence version replaced NM_020897.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.115093.1, AB040968.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAT CTTTCACATG 
ACCTATGACC TGGCCAGTGC TGTGGTTCGC ATCTTCAACC TCATTGGGAT GATGCTGCTG 
CTATGTCACT GGGATGGCTG TCTGCAGTTC CTGGTGCCCA TGCTGCAGGA CTTCCCTCCC 
GACTGCTGGG TCTCCATCAA CCACATGGTG AACCACTCGT GGGGCCGCCA GTATTCCCAT 
GCCCTGTTCA AGGCCATGAG CCACATGCTG TGCATTGGCT ATGGGCAGCA GGCACCTGTA 
GGCATGCCCG ACGTCTGGCT CACCATGCTC AGCATGATCG TAGGTGCCAC ATGCTACGCC 
ATGTTCATCG GCCATGCCAC GGCACTCATC CAGTCCCTGG ACTCTTCCCG GCGTCAGTAC 
CAGGAGAAGT ACAAGCAGGT GGAGCAGTAC ATGTCCTTCC ACAAGCTGCC AGCAGACACG 
CGGCAGCGCA TCCACGAGTA CTATGAGCAC CGCTACCAGG GCAAGATGTT CGATGAGGAA 
AGCATCCTGG GCGAGCTGAG CGAGCCGCTT CGCGAGGAGA TCATTAACTT CACCTGTCGG 
GGCCTGGTGG CCCACATGCC GCTGTTTGCC CATGCCGACC CCAGCTTCGT CACTGCAGTT 
CTCACCAAGC TGCGCTTTGA GGTCTTCCAG CCGGGGGATC TCGTGGTGCG TGAGGGCTCC 
GTGGGGAGGA AGATGTACTT CATCCAGCAT GGGCTGCTCA GTGTGCTGGC CCGCGGCGCC 
CGGGACACAC GCCTCACCGA TGGATCCTAC TTTGGGGAGA TCTGCCTGCT AACTAGGGGC 
CGGCGCACAG CCAGTGTTCG GGCTGACACC TACTGCCGCC TTTACTCACT CAGCGTGGAC 
CATTTCAATG CTGTGCTTGA GGAGTTCCCC ATGATGCGCC GGGCCTTTGA GACTGTGGCC 
ATGGATCGGC TGCTCCGCAT CGGCAAGAAG AATTCCATAC TGCAGCGGAA GCGCTCCGAG 
CCAAGTCCAG GCAGCAGTGG TGGCATCATG GAGCAGCACT TGGTGCAACA TGACAGAGAC 
ATGGCTCGGG GTGTTCGGGG TCGGGCCCCG AGCACAGGAG CTCAGCTTAG TGGAAAGCCA 
GTACTGTGGG AGCCACTGGT ACATGCGCCC CTTCAGGCAG CTGCTGTGAC CTCCAATGTG 
GCCATTGCCC TGACTCATCA GCGGGGCCCT CTGCCCCTCT CCCCTGACTC TCCAGCCACC 
CTCCTTGCTC GCTCTGCTTG GCGCTCAGCA GGCTCTCCAG CTTCCCCGCT GGTGCCCGTC 
CGAGCTGGCC CATGGGCATC CACCTCCCGC CTGCCCGCCC CACCTGCCCG AACCCTGCAC 
GCCAGCCTAT CCCGGGCAGG GCGCTCCCAG GTCTCCCTGC TGGGTCCCCC TCCAGGAGGA 
GGTGGACGGC GGCTAGGACC TCGGGGCCGC CCACTCTCAG CCTCCCAACC CTCTCTGCCT 
CAGCGGGCAA CAGGCGATGG CTCTCCTGGG CGTAAGGGAT CAGGAAGTGA GCGGCTGCCT 
CCCTCAGGGC TCCTGGCCAA ACCTCCAAGG ACAGCCCAGC CCCCCAGGCC ACCAGTGCCT 
GAGCCAGCCA CACCCCGGGG TCTCCAGCTT TCTGCCAACA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065948.1
CDS	165..2489
Translation	MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	NM_020897.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020897.2

ORF Insert Sequence:

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAT CTTTCACATG 
ACCTATGACC TGGCCAGTGC TGTGGTTCGC ATCTTCAACC TCATTGGGAT GATGCTGCTG 
CTATGTCACT GGGATGGCTG TCTGCAGTTC CTGGTGCCCA TGCTGCAGGA CTTCCCTCCC 
GACTGCTGGG TCTCCATCAA CCACATGGTG AACCACTCGT GGGGCCGCCA GTATTCCCAT 
GCCCTGTTCA AGGCCATGAG CCACATGCTG TGCATTGGCT ATGGGCAGCA GGCACCTGTA 
GGCATGCCCG ACGTCTGGCT CACCATGCTC AGCATGATCG TAGGTGCCAC ATGCTACGCC 
ATGTTCATCG GCCATGCCAC GGCACTCATC CAGTCCCTGG ACTCTTCCCG GCGTCAGTAC 
CAGGAGAAGT ACAAGCAGGT GGAGCAGTAC ATGTCCTTCC ACAAGCTGCC AGCAGACACG 
CGGCAGCGCA TCCACGAGTA CTATGAGCAC CGCTACCAGG GCAAGATGTT CGATGAGGAA 
AGCATCCTGG GCGAGCTGAG CGAGCCGCTT CGCGAGGAGA TCATTAACTT CACCTGTCGG 
GGCCTGGTGG CCCACATGCC GCTGTTTGCC CATGCCGACC CCAGCTTCGT CACTGCAGTT 
CTCACCAAGC TGCGCTTTGA GGTCTTCCAG CCGGGGGATC TCGTGGTGCG TGAGGGCTCC 
GTGGGGAGGA AGATGTACTT CATCCAGCAT GGGCTGCTCA GTGTGCTGGC CCGCGGCGCC 
CGGGACACAC GCCTCACCGA TGGATCCTAC TTTGGGGAGA TCTGCCTGCT AACTAGGGGC 
CGGCGCACAG CCAGTGTTCG GGCTGACACC TACTGCCGCC TTTACTCACT CAGCGTGGAC 
CATTTCAATG CTGTGCTTGA GGAGTTCCCC ATGATGCGCC GGGCCTTTGA GACTGTGGCC 
ATGGATCGGC TGCTCCGCAT CGGCAAGAAG AATTCCATAC TGCAGCGGAA GCGCTCCGAG 
CCAAGTCCAG GCAGCAGTGG TGGCATCATG GAGCAGCACT TGGTGCAACA TGACAGAGAC 
ATGGCTCGGG GTGTTCGGGG TCGGGCCCCG AGCACAGGAG CTCAGCTTAG TGGAAAGCCA 
GTACTGTGGG AGCCACTGGT ACATGCGCCC CTTCAGGCAG CTGCTGTGAC CTCCAATGTG 
GCCATTGCCC TGACTCATCA GCGGGGCCCT CTGCCCCTCT CCCCTGACTC TCCAGCCACC 
CTCCTTGCTC GCTCTGCTTG GCGCTCAGCA GGCTCTCCAG CTTCCCCGCT GGTGCCCGTC 
CGAGCTGGCC CATGGGCATC CACCTCCCGC CTGCCCGCCC CACCTGCCCG AACCCTGCAC 
GCCAGCCTAT CCCGGGCAGG GCGCTCCCAG GTCTCCCTGC TGGGTCCCCC TCCAGGAGGA 
GGTGGACGGC GGCTAGGACC TCGGGGCCGC CCACTCTCAG CCTCCCAACC CTCTCTGCCT 
CAGCGGGCAA CAGGCGATGG CTCTCCTGGG CGTAAGGGAT CAGGAAGTGA GCGGCTGCCT 
CCCTCAGGGC TCCTGGCCAA ACCTCCAAGG ACAGCCCAGC CCCCCAGGCC ACCAGTGCCT 
GAGCCAGCCA CACCCCGGGG TCTCCAGCTT TCTGCCAACA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( XM_011509816.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508118.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.

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CloneID	OHu70806
Clone ID Related Accession (Same CDS sequence)	XM_011509816.3 , XM_011509816.2
Accession Version	XM_011509816.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011509816.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGGCTT CACACAGTTC CCTCTTGACC TCTTCTTTCC ACGGTGTCTG CCACAGCAAT 
GTCACTCACC CCTGCCCATG CCTCTGCCTG TGCTCAGCCA GAGTCCCAGT GGACACAGGG 
AGGCCAGAGG AGGAAAGGTT TTACTGGGAC CTGATCATGC TGCTGCTGAT GGTGGGGAAC 
CTCATCGTCC TGCCTGTGGG CATCACCTTC TTCAAGGAGG AGAACTCCCC GCCTTGGATC 
GTCTTCAACG TATTGTCTGA TACTTTCTTC CTACTGGATC TGGTGCTCAA CTTCCGAACG 
GGCATCGTGG TGGAGGAGGG TGCTGAGATC CTGCTGGCAC CGCGGGCCAT CCGCACGCGC 
TACCTGCGCA CCTGGTTCCT GGTTGACCTC ATCTCTTCTA TCCCTGTGGA TTACATCTTC 
CTAGTGGTGG AGCTGGAGCC ACGGTTGGAC GCTGAGGTCT ACAAAACGGC ACGGGCCCTA 
CGCATCGTTC GCTTCACCAA GATCCTAAGC CTGCTGAGGC TGCTCCGCCT CTCCCGCCTC 
ATCCGCTACA TACACCAGTG GGAGGAGATC TTTCACATGA CCTATGACCT GGCCAGTGCT 
GTGGTTCGCA TCTTCAACCT CATTGGGATG ATGCTGCTGC TATGTCACTG GGATGGCTGT 
CTGCAGTTCC TGGTGCCCAT GCTGCAGGAC TTCCCTCCCG ACTGCTGGGT CTCCATCAAC 
CACATGGTGA ACCACTCGTG GGGCCGCCAG TATTCCCATG CCCTGTTCAA GGCCATGAGC 
CACATGCTGT GCATTGGCTA TGGGCAGCAG GCACCTGTAG GCATGCCCGA CGTCTGGCTC 
ACCATGCTCA GCATGATCGT AGGTGCCACA TGCTACGCCA TGTTCATCGG CCATGCCACG 
GCACTCATCC AGTCCCTGGA CTCTTCCCGG CGTCAGTACC AGGAGAAGTA CAAGCAGGTG 
GAGCAGTACA TGTCCTTCCA CAAGCTGCCA GCAGACACGC GGCAGCGCAT CCACGAGTAC 
TATGAGCACC GCTACCAGGG CAAGATGTTC GATGAGGAAA GCATCCTGGG CGAGCTGAGC 
GAGCCGCTTC GCGAGGAGAT CATTAACTTC ACCTGTCGGG GCCTGGTGGC CCACATGCCG 
CTGTTTGCCC ATGCCGACCC CAGCTTCGTC ACTGCAGTTC TCACCAAGCT GCGCTTTGAG 
GTCTTCCAGC CGGGGGATCT CGTGGTGCGT GAGGGCTCCG TGGGGAGGAA GATGTACTTC 
ATCCAGCATG GGCTGCTCAG TGTGCTGGCC CGCGGCGCCC GGGACACACG CCTCACCGAT 
GGATCCTACT TTGGGGAGAT CTGCCTGCTA ACTAGGGGCC GGCGCACAGC CAGTGTTCGG 
GCTGACACCT ACTGCCGCCT TTACTCACTC AGCGTGGACC ATTTCAATGC TGTGCTTGAG 
GAGTTCCCCA TGATGCGCCG GGCCTTTGAG ACTGTGGCCA TGGATCGGCT GCTCCGCATC 
GGCAAGAAGA ATTCCATACT GCAGCGGAAG CGCTCCGAGC CAAGTCCAGG CAGCAGTGGT 
GGCATCATGG AGCAGCACTT GGTGCAACAT GACAGAGACA TGGCTCGGGG TGTTCGGGGT 
CGGGCCCCGA GCACAGGAGC TCAGCTTAGT GGAAAGCCAG TACTGTGGGA GCCACTGGTA 
CATGCGCCCC TTCAGGCAGC TGCTGTGACC TCCAATGTGG CCATTGCCCT GACTCATCAG 
CGGGGCCCTC TGCCCCTCTC CCCTGACTCT CCAGCCACCC TCCTTGCTCG CTCTGCTTGG 
CGCTCAGCAG GCTCTCCAGC TTCCCCGCTG GTGCCCGTCC GAGCTGGCCC ATGGGCATCC 
ACCTCCCGCC TGCCCGCCCC ACCTGCCCGA ACCCTGCACG CCAGCCTATC CCGGGCAGGG 
CGCTCCCAGG TCTCCCTGCT GGGTCCCCCT CCAGGAGGAG GTGGACGGCG GCTAGGACCT 
CGGGGCCGCC CACTCTCAGC CTCCCAACCC TCTCTGCCTC AGCGGGCAAC AGGCGATGGC 
TCTCCTGGGC GTAAGGGATC AGGAAGTGAG CGGCTGCCTC CCTCAGGGCT CCTGGCCAAA 
CCTCCAAGGA CAGCCCAGCC CCCCAGGCCA CCAGTGCCTG AGCCAGCCAC ACCCCGGGGT 
CTCCAGCTTT CTGCCAACAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508118.1
CDS	871..3054
Translation	MRASHSSLLTSSFHGVCHSNVTHPCPCLCLCSARVPVDTGRPEEERFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	XM_011509816.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509816.3

ORF Insert Sequence:

ATGAGGGCTT CACACAGTTC CCTCTTGACC TCTTCTTTCC ACGGTGTCTG CCACAGCAAT 
GTCACTCACC CCTGCCCATG CCTCTGCCTG TGCTCAGCCA GAGTCCCAGT GGACACAGGG 
AGGCCAGAGG AGGAAAGGTT TTACTGGGAC CTGATCATGC TGCTGCTGAT GGTGGGGAAC 
CTCATCGTCC TGCCTGTGGG CATCACCTTC TTCAAGGAGG AGAACTCCCC GCCTTGGATC 
GTCTTCAACG TATTGTCTGA TACTTTCTTC CTACTGGATC TGGTGCTCAA CTTCCGAACG 
GGCATCGTGG TGGAGGAGGG TGCTGAGATC CTGCTGGCAC CGCGGGCCAT CCGCACGCGC 
TACCTGCGCA CCTGGTTCCT GGTTGACCTC ATCTCTTCTA TCCCTGTGGA TTACATCTTC 
CTAGTGGTGG AGCTGGAGCC ACGGTTGGAC GCTGAGGTCT ACAAAACGGC ACGGGCCCTA 
CGCATCGTTC GCTTCACCAA GATCCTAAGC CTGCTGAGGC TGCTCCGCCT CTCCCGCCTC 
ATCCGCTACA TACACCAGTG GGAGGAGATC TTTCACATGA CCTATGACCT GGCCAGTGCT 
GTGGTTCGCA TCTTCAACCT CATTGGGATG ATGCTGCTGC TATGTCACTG GGATGGCTGT 
CTGCAGTTCC TGGTGCCCAT GCTGCAGGAC TTCCCTCCCG ACTGCTGGGT CTCCATCAAC 
CACATGGTGA ACCACTCGTG GGGCCGCCAG TATTCCCATG CCCTGTTCAA GGCCATGAGC 
CACATGCTGT GCATTGGCTA TGGGCAGCAG GCACCTGTAG GCATGCCCGA CGTCTGGCTC 
ACCATGCTCA GCATGATCGT AGGTGCCACA TGCTACGCCA TGTTCATCGG CCATGCCACG 
GCACTCATCC AGTCCCTGGA CTCTTCCCGG CGTCAGTACC AGGAGAAGTA CAAGCAGGTG 
GAGCAGTACA TGTCCTTCCA CAAGCTGCCA GCAGACACGC GGCAGCGCAT CCACGAGTAC 
TATGAGCACC GCTACCAGGG CAAGATGTTC GATGAGGAAA GCATCCTGGG CGAGCTGAGC 
GAGCCGCTTC GCGAGGAGAT CATTAACTTC ACCTGTCGGG GCCTGGTGGC CCACATGCCG 
CTGTTTGCCC ATGCCGACCC CAGCTTCGTC ACTGCAGTTC TCACCAAGCT GCGCTTTGAG 
GTCTTCCAGC CGGGGGATCT CGTGGTGCGT GAGGGCTCCG TGGGGAGGAA GATGTACTTC 
ATCCAGCATG GGCTGCTCAG TGTGCTGGCC CGCGGCGCCC GGGACACACG CCTCACCGAT 
GGATCCTACT TTGGGGAGAT CTGCCTGCTA ACTAGGGGCC GGCGCACAGC CAGTGTTCGG 
GCTGACACCT ACTGCCGCCT TTACTCACTC AGCGTGGACC ATTTCAATGC TGTGCTTGAG 
GAGTTCCCCA TGATGCGCCG GGCCTTTGAG ACTGTGGCCA TGGATCGGCT GCTCCGCATC 
GGCAAGAAGA ATTCCATACT GCAGCGGAAG CGCTCCGAGC CAAGTCCAGG CAGCAGTGGT 
GGCATCATGG AGCAGCACTT GGTGCAACAT GACAGAGACA TGGCTCGGGG TGTTCGGGGT 
CGGGCCCCGA GCACAGGAGC TCAGCTTAGT GGAAAGCCAG TACTGTGGGA GCCACTGGTA 
CATGCGCCCC TTCAGGCAGC TGCTGTGACC TCCAATGTGG CCATTGCCCT GACTCATCAG 
CGGGGCCCTC TGCCCCTCTC CCCTGACTCT CCAGCCACCC TCCTTGCTCG CTCTGCTTGG 
CGCTCAGCAG GCTCTCCAGC TTCCCCGCTG GTGCCCGTCC GAGCTGGCCC ATGGGCATCC 
ACCTCCCGCC TGCCCGCCCC ACCTGCCCGA ACCCTGCACG CCAGCCTATC CCGGGCAGGG 
CGCTCCCAGG TCTCCCTGCT GGGTCCCCCT CCAGGAGGAG GTGGACGGCG GCTAGGACCT 
CGGGGCCGCC CACTCTCAGC CTCCCAACCC TCTCTGCCTC AGCGGGCAAC AGGCGATGGC 
TCTCCTGGGC GTAAGGGATC AGGAAGTGAG CGGCTGCCTC CCTCAGGGCT CCTGGCCAAA 
CCTCCAAGGA CAGCCCAGCC CCCCAGGCCA CCAGTGCCTG AGCCAGCCAC ACCCCGGGGT 
CTCCAGCTTT CTGCCAACAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( XM_011509816.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508118.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu70806
Clone ID Related Accession (Same CDS sequence)	XM_011509816.3 , XM_011509816.2
Accession Version	XM_011509816.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509816.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGGCTT CACACAGTTC CCTCTTGACC TCTTCTTTCC ACGGTGTCTG CCACAGCAAT 
GTCACTCACC CCTGCCCATG CCTCTGCCTG TGCTCAGCCA GAGTCCCAGT GGACACAGGG 
AGGCCAGAGG AGGAAAGGTT TTACTGGGAC CTGATCATGC TGCTGCTGAT GGTGGGGAAC 
CTCATCGTCC TGCCTGTGGG CATCACCTTC TTCAAGGAGG AGAACTCCCC GCCTTGGATC 
GTCTTCAACG TATTGTCTGA TACTTTCTTC CTACTGGATC TGGTGCTCAA CTTCCGAACG 
GGCATCGTGG TGGAGGAGGG TGCTGAGATC CTGCTGGCAC CGCGGGCCAT CCGCACGCGC 
TACCTGCGCA CCTGGTTCCT GGTTGACCTC ATCTCTTCTA TCCCTGTGGA TTACATCTTC 
CTAGTGGTGG AGCTGGAGCC ACGGTTGGAC GCTGAGGTCT ACAAAACGGC ACGGGCCCTA 
CGCATCGTTC GCTTCACCAA GATCCTAAGC CTGCTGAGGC TGCTCCGCCT CTCCCGCCTC 
ATCCGCTACA TACACCAGTG GGAGGAGATC TTTCACATGA CCTATGACCT GGCCAGTGCT 
GTGGTTCGCA TCTTCAACCT CATTGGGATG ATGCTGCTGC TATGTCACTG GGATGGCTGT 
CTGCAGTTCC TGGTGCCCAT GCTGCAGGAC TTCCCTCCCG ACTGCTGGGT CTCCATCAAC 
CACATGGTGA ACCACTCGTG GGGCCGCCAG TATTCCCATG CCCTGTTCAA GGCCATGAGC 
CACATGCTGT GCATTGGCTA TGGGCAGCAG GCACCTGTAG GCATGCCCGA CGTCTGGCTC 
ACCATGCTCA GCATGATCGT AGGTGCCACA TGCTACGCCA TGTTCATCGG CCATGCCACG 
GCACTCATCC AGTCCCTGGA CTCTTCCCGG CGTCAGTACC AGGAGAAGTA CAAGCAGGTG 
GAGCAGTACA TGTCCTTCCA CAAGCTGCCA GCAGACACGC GGCAGCGCAT CCACGAGTAC 
TATGAGCACC GCTACCAGGG CAAGATGTTC GATGAGGAAA GCATCCTGGG CGAGCTGAGC 
GAGCCGCTTC GCGAGGAGAT CATTAACTTC ACCTGTCGGG GCCTGGTGGC CCACATGCCG 
CTGTTTGCCC ATGCCGACCC CAGCTTCGTC ACTGCAGTTC TCACCAAGCT GCGCTTTGAG 
GTCTTCCAGC CGGGGGATCT CGTGGTGCGT GAGGGCTCCG TGGGGAGGAA GATGTACTTC 
ATCCAGCATG GGCTGCTCAG TGTGCTGGCC CGCGGCGCCC GGGACACACG CCTCACCGAT 
GGATCCTACT TTGGGGAGAT CTGCCTGCTA ACTAGGGGCC GGCGCACAGC CAGTGTTCGG 
GCTGACACCT ACTGCCGCCT TTACTCACTC AGCGTGGACC ATTTCAATGC TGTGCTTGAG 
GAGTTCCCCA TGATGCGCCG GGCCTTTGAG ACTGTGGCCA TGGATCGGCT GCTCCGCATC 
GGCAAGAAGA ATTCCATACT GCAGCGGAAG CGCTCCGAGC CAAGTCCAGG CAGCAGTGGT 
GGCATCATGG AGCAGCACTT GGTGCAACAT GACAGAGACA TGGCTCGGGG TGTTCGGGGT 
CGGGCCCCGA GCACAGGAGC TCAGCTTAGT GGAAAGCCAG TACTGTGGGA GCCACTGGTA 
CATGCGCCCC TTCAGGCAGC TGCTGTGACC TCCAATGTGG CCATTGCCCT GACTCATCAG 
CGGGGCCCTC TGCCCCTCTC CCCTGACTCT CCAGCCACCC TCCTTGCTCG CTCTGCTTGG 
CGCTCAGCAG GCTCTCCAGC TTCCCCGCTG GTGCCCGTCC GAGCTGGCCC ATGGGCATCC 
ACCTCCCGCC TGCCCGCCCC ACCTGCCCGA ACCCTGCACG CCAGCCTATC CCGGGCAGGG 
CGCTCCCAGG TCTCCCTGCT GGGTCCCCCT CCAGGAGGAG GTGGACGGCG GCTAGGACCT 
CGGGGCCGCC CACTCTCAGC CTCCCAACCC TCTCTGCCTC AGCGGGCAAC AGGCGATGGC 
TCTCCTGGGC GTAAGGGATC AGGAAGTGAG CGGCTGCCTC CCTCAGGGCT CCTGGCCAAA 
CCTCCAAGGA CAGCCCAGCC CCCCAGGCCA CCAGTGCCTG AGCCAGCCAC ACCCCGGGGT 
CTCCAGCTTT CTGCCAACAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508118.1
CDS	824..3007
Translation	MRASHSSLLTSSFHGVCHSNVTHPCPCLCLCSARVPVDTGRPEEERFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	XM_011509816.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509816.2

ORF Insert Sequence:

ATGAGGGCTT CACACAGTTC CCTCTTGACC TCTTCTTTCC ACGGTGTCTG CCACAGCAAT 
GTCACTCACC CCTGCCCATG CCTCTGCCTG TGCTCAGCCA GAGTCCCAGT GGACACAGGG 
AGGCCAGAGG AGGAAAGGTT TTACTGGGAC CTGATCATGC TGCTGCTGAT GGTGGGGAAC 
CTCATCGTCC TGCCTGTGGG CATCACCTTC TTCAAGGAGG AGAACTCCCC GCCTTGGATC 
GTCTTCAACG TATTGTCTGA TACTTTCTTC CTACTGGATC TGGTGCTCAA CTTCCGAACG 
GGCATCGTGG TGGAGGAGGG TGCTGAGATC CTGCTGGCAC CGCGGGCCAT CCGCACGCGC 
TACCTGCGCA CCTGGTTCCT GGTTGACCTC ATCTCTTCTA TCCCTGTGGA TTACATCTTC 
CTAGTGGTGG AGCTGGAGCC ACGGTTGGAC GCTGAGGTCT ACAAAACGGC ACGGGCCCTA 
CGCATCGTTC GCTTCACCAA GATCCTAAGC CTGCTGAGGC TGCTCCGCCT CTCCCGCCTC 
ATCCGCTACA TACACCAGTG GGAGGAGATC TTTCACATGA CCTATGACCT GGCCAGTGCT 
GTGGTTCGCA TCTTCAACCT CATTGGGATG ATGCTGCTGC TATGTCACTG GGATGGCTGT 
CTGCAGTTCC TGGTGCCCAT GCTGCAGGAC TTCCCTCCCG ACTGCTGGGT CTCCATCAAC 
CACATGGTGA ACCACTCGTG GGGCCGCCAG TATTCCCATG CCCTGTTCAA GGCCATGAGC 
CACATGCTGT GCATTGGCTA TGGGCAGCAG GCACCTGTAG GCATGCCCGA CGTCTGGCTC 
ACCATGCTCA GCATGATCGT AGGTGCCACA TGCTACGCCA TGTTCATCGG CCATGCCACG 
GCACTCATCC AGTCCCTGGA CTCTTCCCGG CGTCAGTACC AGGAGAAGTA CAAGCAGGTG 
GAGCAGTACA TGTCCTTCCA CAAGCTGCCA GCAGACACGC GGCAGCGCAT CCACGAGTAC 
TATGAGCACC GCTACCAGGG CAAGATGTTC GATGAGGAAA GCATCCTGGG CGAGCTGAGC 
GAGCCGCTTC GCGAGGAGAT CATTAACTTC ACCTGTCGGG GCCTGGTGGC CCACATGCCG 
CTGTTTGCCC ATGCCGACCC CAGCTTCGTC ACTGCAGTTC TCACCAAGCT GCGCTTTGAG 
GTCTTCCAGC CGGGGGATCT CGTGGTGCGT GAGGGCTCCG TGGGGAGGAA GATGTACTTC 
ATCCAGCATG GGCTGCTCAG TGTGCTGGCC CGCGGCGCCC GGGACACACG CCTCACCGAT 
GGATCCTACT TTGGGGAGAT CTGCCTGCTA ACTAGGGGCC GGCGCACAGC CAGTGTTCGG 
GCTGACACCT ACTGCCGCCT TTACTCACTC AGCGTGGACC ATTTCAATGC TGTGCTTGAG 
GAGTTCCCCA TGATGCGCCG GGCCTTTGAG ACTGTGGCCA TGGATCGGCT GCTCCGCATC 
GGCAAGAAGA ATTCCATACT GCAGCGGAAG CGCTCCGAGC CAAGTCCAGG CAGCAGTGGT 
GGCATCATGG AGCAGCACTT GGTGCAACAT GACAGAGACA TGGCTCGGGG TGTTCGGGGT 
CGGGCCCCGA GCACAGGAGC TCAGCTTAGT GGAAAGCCAG TACTGTGGGA GCCACTGGTA 
CATGCGCCCC TTCAGGCAGC TGCTGTGACC TCCAATGTGG CCATTGCCCT GACTCATCAG 
CGGGGCCCTC TGCCCCTCTC CCCTGACTCT CCAGCCACCC TCCTTGCTCG CTCTGCTTGG 
CGCTCAGCAG GCTCTCCAGC TTCCCCGCTG GTGCCCGTCC GAGCTGGCCC ATGGGCATCC 
ACCTCCCGCC TGCCCGCCCC ACCTGCCCGA ACCCTGCACG CCAGCCTATC CCGGGCAGGG 
CGCTCCCAGG TCTCCCTGCT GGGTCCCCCT CCAGGAGGAG GTGGACGGCG GCTAGGACCT 
CGGGGCCGCC CACTCTCAGC CTCCCAACCC TCTCTGCCTC AGCGGGCAAC AGGCGATGGC 
TCTCCTGGGC GTAAGGGATC AGGAAGTGAG CGGCTGCCTC CCTCAGGGCT CCTGGCCAAA 
CCTCCAAGGA CAGCCCAGCC CCCCAGGCCA CCAGTGCCTG AGCCAGCCAC ACCCCGGGGT 
CTCCAGCTTT CTGCCAACAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN3 ( XM_011509817.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508119.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu70807
Clone ID Related Accession (Same CDS sequence)	XM_011509817.2
Accession Version	XM_011509817.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509817.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAA CCACTCGTGG 
GGCCGCCAGT ATTCCCATGC CCTGTTCAAG GCCATGAGCC ACATGCTGTG CATTGGCTAT 
GGGCAGCAGG CACCTGTAGG CATGCCCGAC GTCTGGCTCA CCATGCTCAG CATGATCGTA 
GGTGCCACAT GCTACGCCAT GTTCATCGGC CATGCCACGG CACTCATCCA GTCCCTGGAC 
TCTTCCCGGC GTCAGTACCA GGAGAAGTAC AAGCAGGTGG AGCAGTACAT GTCCTTCCAC 
AAGCTGCCAG CAGACACGCG GCAGCGCATC CACGAGTACT ATGAGCACCG CTACCAGGGC 
AAGATGTTCG ATGAGGAAAG CATCCTGGGC GAGCTGAGCG AGCCGCTTCG CGAGGAGATC 
ATTAACTTCA CCTGTCGGGG CCTGGTGGCC CACATGCCGC TGTTTGCCCA TGCCGACCCC 
AGCTTCGTCA CTGCAGTTCT CACCAAGCTG CGCTTTGAGG TCTTCCAGCC GGGGGATCTC 
GTGGTGCGTG AGGGCTCCGT GGGGAGGAAG ATGTACTTCA TCCAGCATGG GCTGCTCAGT 
GTGCTGGCCC GCGGCGCCCG GGACACACGC CTCACCGATG GATCCTACTT TGGGGAGATC 
TGCCTGCTAA CTAGGGGCCG GCGCACAGCC AGTGTTCGGG CTGACACCTA CTGCCGCCTT 
TACTCACTCA GCGTGGACCA TTTCAATGCT GTGCTTGAGG AGTTCCCCAT GATGCGCCGG 
GCCTTTGAGA CTGTGGCCAT GGATCGGCTG CTCCGCATCG GCAAGAAGAA TTCCATACTG 
CAGCGGAAGC GCTCCGAGCC AAGTCCAGGC AGCAGTGGTG GCATCATGGA GCAGCACTTG 
GTGCAACATG ACAGAGACAT GGCTCGGGGT GTTCGGGGTC GGGCCCCGAG CACAGGAGCT 
CAGCTTAGTG GAAAGCCAGT ACTGTGGGAG CCACTGGTAC ATGCGCCCCT TCAGGCAGCT 
GCTGTGACCT CCAATGTGGC CATTGCCCTG ACTCATCAGC GGGGCCCTCT GCCCCTCTCC 
CCTGACTCTC CAGCCACCCT CCTTGCTCGC TCTGCTTGGC GCTCAGCAGG CTCTCCAGCT 
TCCCCGCTGG TGCCCGTCCG AGCTGGCCCA TGGGCATCCA CCTCCCGCCT GCCCGCCCCA 
CCTGCCCGAA CCCTGCACGC CAGCCTATCC CGGGCAGGGC GCTCCCAGGT CTCCCTGCTG 
GGTCCCCCTC CAGGAGGAGG TGGACGGCGG CTAGGACCTC GGGGCCGCCC ACTCTCAGCC 
TCCCAACCCT CTCTGCCTCA GCGGGCAACA GGCGATGGCT CTCCTGGGCG TAAGGGATCA 
GGAAGTGAGC GGCTGCCTCC CTCAGGGCTC CTGGCCAAAC CTCCAAGGAC AGCCCAGCCC 
CCCAGGCCAC CAGTGCCTGA GCCAGCCACA CCCCGGGGTC TCCAGCTTTC TGCCAACATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508119.1
CDS	165..2327
Translation	MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEENHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Target ORF information:

RefSeq Version	XM_011509817.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HCN3), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509817.2

ORF Insert Sequence:

ATGGAGGCAG AGCAGCGGCC GGCGGCGGGG GCCAGCGAAG GGGCGACCCC TGGACTGGAG 
GCGGTGCCTC CCGTTGCTCC CCCGCCTGCG ACCGCGGCCT CAGGTCCGAT CCCCAAATCT 
GGGCCTGAGC CTAAGAGGAG GCACCTTGGG ACGCTGCTCC AGCCTACGGT CAACAAGTTC 
TCCCTTCGGG TGTTCGGCAG CCACAAAGCA GTGGAAATCG AGCAGGAGCG GGTGAAGTCA 
GCGGGGGCCT GGATCATCCA CCCCTACAGC GACTTCCGGT TTTACTGGGA CCTGATCATG 
CTGCTGCTGA TGGTGGGGAA CCTCATCGTC CTGCCTGTGG GCATCACCTT CTTCAAGGAG 
GAGAACTCCC CGCCTTGGAT CGTCTTCAAC GTATTGTCTG ATACTTTCTT CCTACTGGAT 
CTGGTGCTCA ACTTCCGAAC GGGCATCGTG GTGGAGGAGG GTGCTGAGAT CCTGCTGGCA 
CCGCGGGCCA TCCGCACGCG CTACCTGCGC ACCTGGTTCC TGGTTGACCT CATCTCTTCT 
ATCCCTGTGG ATTACATCTT CCTAGTGGTG GAGCTGGAGC CACGGTTGGA CGCTGAGGTC 
TACAAAACGG CACGGGCCCT ACGCATCGTT CGCTTCACCA AGATCCTAAG CCTGCTGAGG 
CTGCTCCGCC TCTCCCGCCT CATCCGCTAC ATACACCAGT GGGAGGAGAA CCACTCGTGG 
GGCCGCCAGT ATTCCCATGC CCTGTTCAAG GCCATGAGCC ACATGCTGTG CATTGGCTAT 
GGGCAGCAGG CACCTGTAGG CATGCCCGAC GTCTGGCTCA CCATGCTCAG CATGATCGTA 
GGTGCCACAT GCTACGCCAT GTTCATCGGC CATGCCACGG CACTCATCCA GTCCCTGGAC 
TCTTCCCGGC GTCAGTACCA GGAGAAGTAC AAGCAGGTGG AGCAGTACAT GTCCTTCCAC 
AAGCTGCCAG CAGACACGCG GCAGCGCATC CACGAGTACT ATGAGCACCG CTACCAGGGC 
AAGATGTTCG ATGAGGAAAG CATCCTGGGC GAGCTGAGCG AGCCGCTTCG CGAGGAGATC 
ATTAACTTCA CCTGTCGGGG CCTGGTGGCC CACATGCCGC TGTTTGCCCA TGCCGACCCC 
AGCTTCGTCA CTGCAGTTCT CACCAAGCTG CGCTTTGAGG TCTTCCAGCC GGGGGATCTC 
GTGGTGCGTG AGGGCTCCGT GGGGAGGAAG ATGTACTTCA TCCAGCATGG GCTGCTCAGT 
GTGCTGGCCC GCGGCGCCCG GGACACACGC CTCACCGATG GATCCTACTT TGGGGAGATC 
TGCCTGCTAA CTAGGGGCCG GCGCACAGCC AGTGTTCGGG CTGACACCTA CTGCCGCCTT 
TACTCACTCA GCGTGGACCA TTTCAATGCT GTGCTTGAGG AGTTCCCCAT GATGCGCCGG 
GCCTTTGAGA CTGTGGCCAT GGATCGGCTG CTCCGCATCG GCAAGAAGAA TTCCATACTG 
CAGCGGAAGC GCTCCGAGCC AAGTCCAGGC AGCAGTGGTG GCATCATGGA GCAGCACTTG 
GTGCAACATG ACAGAGACAT GGCTCGGGGT GTTCGGGGTC GGGCCCCGAG CACAGGAGCT 
CAGCTTAGTG GAAAGCCAGT ACTGTGGGAG CCACTGGTAC ATGCGCCCCT TCAGGCAGCT 
GCTGTGACCT CCAATGTGGC CATTGCCCTG ACTCATCAGC GGGGCCCTCT GCCCCTCTCC 
CCTGACTCTC CAGCCACCCT CCTTGCTCGC TCTGCTTGGC GCTCAGCAGG CTCTCCAGCT 
TCCCCGCTGG TGCCCGTCCG AGCTGGCCCA TGGGCATCCA CCTCCCGCCT GCCCGCCCCA 
CCTGCCCGAA CCCTGCACGC CAGCCTATCC CGGGCAGGGC GCTCCCAGGT CTCCCTGCTG 
GGTCCCCCTC CAGGAGGAGG TGGACGGCGG CTAGGACCTC GGGGCCGCCC ACTCTCAGCC 
TCCCAACCCT CTCTGCCTCA GCGGGCAACA GGCGATGGCT CTCCTGGGCG TAAGGGATCA 
GGAAGTGAGC GGCTGCCTCC CTCAGGGCTC CTGGCCAAAC CTCCAAGGAC AGCCCAGCCC 
CCCAGGCCAC CAGTGCCTGA GCCAGCCACA CCCCGGGGTC TCCAGCTTTC TGCCAACATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.
Science (New York, N.Y.)352(6286)aaf2669(2016 May)
Yi F,Danko T,Botelho SC,Patzke C,Pak C,Wernig M,S?dhof TC

Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World journal of gastroenterology21(18)5635-40(2015 May)
O'Donnell AM,Coyle D,Puri P

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
The Journal of biological chemistry288(11)7580-9(2013 Mar)
Cao-Ehlker X,Zong X,Hammelmann V,Gruner C,Fenske S,Michalakis S,Wahl-Schott C,Biel M

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.
Urology80(1)224.e13-8(2012 Jul)
Xue L,Li Y,Han X,Yao L,Yuan J,Qin W,Liu F,Wang H

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.
Brain pathology (Zurich, Switzerland)21(6)692-8(2011 Nov)
Tu E,Waterhouse L,Duflou J,Bagnall RD,Semsarian C

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HCN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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