Gene Symbol | MKL1 |
Entrez Gene ID | 57591 |
Full Name | megakaryoblastic leukemia (translocation) 1 |
Synonyms | BSAC,MAL,MKL,MRTF-A |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. |
Disorder MIM: | |
Disorder Html: | Megakaryoblastic leukemia, acute (3) |