PREX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PREX1
Entrez Gene ID	57580
Full Name	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Synonyms	P-REX1
General protein information	Preferred Names phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Names phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein PIP3 dependent Rac exchange factor 1 ptdIns(3,4,5)-dependent Rac exchanger 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.13
Summary	The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008].
Disorder MIM:	606905

mRNA and Protein(s)

mRNA	Protein	Name
NM_020820.3	NP_065871.2	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
XM_011528934.2	XP_011527236.1	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
NM_020820.4	NP_065871.3	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PREX1	NP_065871.2
Bos taurus (cattle)	PREX1	XP_002692397.3
Canis lupus familiaris (dog)	PREX1	XP_543041.3
Gallus gallus (chicken)	PREX1	XP_004947127.1
Danio rerio (zebrafish)	prex1	XP_699627.3
Pan troglodytes (chimpanzee)	PREX1	XP_003953812.1
	PREX1	XP_002798174.1
Rattus norvegicus (Norway rat)	Prex1	NP_001129190.1
Mus musculus (house mouse)	Prex1	NP_808450.2
Xenopus tropicalis (tropical clawed frog)	prex1	XP_002933203.1

Gene Ontology
Bibliography

Related articles in PubMed

TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.
Kremer KN, Dinkel BA, Sterner RM, Osborne DG, Jevremovic D, Hedin KE
Blood130(8)982-994(2017 08)

P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA
Biochemical Society transactions45(4)963-77(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4, and IL-10 messenger RNA (mRNA) transcripts.
Title: TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.

Data suggest that PREX1 and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 is altered in many cancers. [REVIEW]
Title: P-Rex1 and P-Rex2 RacGEFs and cancer.

data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways
Title: PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).

PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen.
Title: PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.

An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib.
Title: P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

The following PREX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PREX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25757	NM_020820.3 Latest version!	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
OHu70657	XM_011528934.2 Latest version!	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
OHu107314	NM_020820.4 Latest version!	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PREX1 ( NM_020820.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065871.2 Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.

Price & Availability↑

CloneID	OHu25757
Clone ID Related Accession (Same CDS sequence)	NM_020820.3
Accession Version	NM_020820.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ320261.1, BC053616.1 and AB037836.2. On Aug 18, 2006 this sequence version replaced NM_020820.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB037836.2, AJ320261.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGC CCAGCGGCAG CGAGCCCGGC GGCGACGGGG CCGGGGACTG CGCCCACCCG 
GACCCCCGGG CCCCTGGCGC CGCGGCGCCC AGCTCCGGCC CCGGCCCGTG CGCGGCCGCC 
CGGGAGTCCG AGCGCCAGCT GCGCCTCCGC CTCTGCGTCC TCAACGAGAT CTTGGGCACC 
GAGAGGGACT ACGTGGGCAC CTTGCGCTTC TTGCAGTCGG CATTCCTGCA TCGCATCCGG 
CAGAACGTGG CCGACTCAGT GGAGAAGGGC CTCACGGAGG AGAATGTCAA GGTCCTGTTC 
TCGAACATCG AAGACATCCT GGAAGTTCAT AAGGATTTCT TGGCCGCCTT GGAGTATTGT 
TTACACCCGG AGCCGCAGTC TCAGCATGAA CTTGGGAATG TTTTCTTAAA ATTCAAGGAC 
AAGTTCTGCG TGTACGAGGA GTATTGCAGC AACCATGAGA AAGCCCTGAG GCTGCTGGTG 
GAGCTGAACA AGATCCCTAC CGTGCGCGCC TTCCTTTTGA GCTGCATGCT TCTGGGAGGC 
CGGAAGACCA CGGACATCCC TTTGGAAGGC TACCTGTTGT CTCCGATCCA GAGGATCTGC 
AAGTACCCGC TCCTCCTTAA GGAGCTGGCC AAGAGGACTC CCGGCAAGCA CCCAGACCAC 
CCCGCGGTCC AGAGTGCCCT GCAGGCCATG AAGACCGTTT GCTCCAACAT CAATGAGACC 
AAGCGGCAGA TGGAGAAGCT GGAAGCCCTG GAGCAGCTGC AGTCCCACAT CGAAGGCTGG 
GAGGGTTCCA ACCTCACAGA CATCTGCACT CAGCTCCTCC TGCAAGGGAC TTTGTTAAAG 
ATCTCTGCGG GCAACATCCA GGAAAGGGCC TTCTTCCTCT TCGACAACCT TCTCGTCTAC 
TGCAAGCGGA AATCCAGGGT CACCGGGAGC AAGAAGTCCA CCAAGAGGAC CAAATCCATC 
AACGGCTCCC TCTACATCTT CAGGGGTCGA ATCAACACTG AAGTCATGGA GGTGGAGAAT 
GTGGAAGATG GGACAGCGGA TTACCATAGC AACGGCTATA CCGTCACCAA CGGCTGGAAG 
ATCCACAACA CGGCCAAGAA TAAGTGGTTT GTCTGCATGG CCAAGACGGC AGAGGAGAAG 
CAGAAGTGGC TGGATGCCAT CATCCGCGAG CGGGAGCAGC GCGAGAGCCT GAAGCTGGGC 
ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCGAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065871.2
CDS	24..5003
Translation	MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL

Target ORF information:

RefSeq Version	NM_020820.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020820.3

ORF Insert Sequence:

ATGGAGGCGC CCAGCGGCAG CGAGCCCGGC GGCGACGGGG CCGGGGACTG CGCCCACCCG 
GACCCCCGGG CCCCTGGCGC CGCGGCGCCC AGCTCCGGCC CCGGCCCGTG CGCGGCCGCC 
CGGGAGTCCG AGCGCCAGCT GCGCCTCCGC CTCTGCGTCC TCAACGAGAT CTTGGGCACC 
GAGAGGGACT ACGTGGGCAC CTTGCGCTTC TTGCAGTCGG CATTCCTGCA TCGCATCCGG 
CAGAACGTGG CCGACTCAGT GGAGAAGGGC CTCACGGAGG AGAATGTCAA GGTCCTGTTC 
TCGAACATCG AAGACATCCT GGAAGTTCAT AAGGATTTCT TGGCCGCCTT GGAGTATTGT 
TTACACCCGG AGCCGCAGTC TCAGCATGAA CTTGGGAATG TTTTCTTAAA ATTCAAGGAC 
AAGTTCTGCG TGTACGAGGA GTATTGCAGC AACCATGAGA AAGCCCTGAG GCTGCTGGTG 
GAGCTGAACA AGATCCCTAC CGTGCGCGCC TTCCTTTTGA GCTGCATGCT TCTGGGAGGC 
CGGAAGACCA CGGACATCCC TTTGGAAGGC TACCTGTTGT CTCCGATCCA GAGGATCTGC 
AAGTACCCGC TCCTCCTTAA GGAGCTGGCC AAGAGGACTC CCGGCAAGCA CCCAGACCAC 
CCCGCGGTCC AGAGTGCCCT GCAGGCCATG AAGACCGTTT GCTCCAACAT CAATGAGACC 
AAGCGGCAGA TGGAGAAGCT GGAAGCCCTG GAGCAGCTGC AGTCCCACAT CGAAGGCTGG 
GAGGGTTCCA ACCTCACAGA CATCTGCACT CAGCTCCTCC TGCAAGGGAC TTTGTTAAAG 
ATCTCTGCGG GCAACATCCA GGAAAGGGCC TTCTTCCTCT TCGACAACCT TCTCGTCTAC 
TGCAAGCGGA AATCCAGGGT CACCGGGAGC AAGAAGTCCA CCAAGAGGAC CAAATCCATC 
AACGGCTCCC TCTACATCTT CAGGGGTCGA ATCAACACTG AAGTCATGGA GGTGGAGAAT 
GTGGAAGATG GGACAGCGGA TTACCATAGC AACGGCTATA CCGTCACCAA CGGCTGGAAG 
ATCCACAACA CGGCCAAGAA TAAGTGGTTT GTCTGCATGG CCAAGACGGC AGAGGAGAAG 
CAGAAGTGGC TGGATGCCAT CATCCGCGAG CGGGAGCAGC GCGAGAGCCT GAAGCTGGGC 
ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCGAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PREX1 ( XM_011528934.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527236.1 Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), transcript variant X1, mRNA.

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CloneID	OHu70657
Clone ID Related Accession (Same CDS sequence)	XM_011528934.2
Accession Version	XM_011528934.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528934.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCAAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527236.1
CDS	126..3905
Translation	MERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL

Target ORF information:

RefSeq Version	XM_011528934.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528934.2

ORF Insert Sequence:

ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCAAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PREX1 ( NM_020820.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065871.3 Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.

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CloneID	OHu107314
Clone ID Related Accession (Same CDS sequence)	NM_020820.4
Accession Version	NM_020820.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL133342.14, AL035106.28 and AL445192.3. On Nov 23, 2018 this sequence version replaced NM_020820.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB037836.2, AJ320261.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371941.4/ ENSP00000361009.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCGC CCAGCGGCAG CGAGCCCGGC GGCGACGGGG CCGGGGACTG CGCCCACCCG 
GACCCCCGGG CCCCTGGCGC CGCGGCGCCC AGCTCCGGCC CCGGCCCGTG CGCGGCCGCC 
CGGGAGTCCG AGCGCCAGCT GCGCCTCCGC CTCTGCGTCC TCAACGAGAT CTTGGGCACC 
GAGAGGGACT ACGTGGGCAC CTTGCGCTTC TTGCAGTCGG CATTCCTGCA TCGCATCCGG 
CAGAACGTGG CCGACTCAGT GGAGAAGGGC CTCACGGAGG AGAATGTCAA GGTCCTGTTC 
TCGAACATCG AAGACATCCT GGAAGTTCAT AAGGATTTCT TGGCCGCCTT GGAGTATTGT 
TTACACCCGG AGCCGCAGTC TCAGCATGAA CTTGGGAATG TTTTCTTAAA ATTCAAGGAC 
AAGTTCTGCG TGTACGAGGA GTATTGCAGC AACCATGAGA AAGCCCTGAG GCTGCTGGTG 
GAGCTGAACA AGATCCCTAC CGTGCGCGCC TTCCTTTTGA GCTGCATGCT TCTGGGAGGC 
CGGAAGACCA CGGACATCCC TTTGGAAGGC TACCTGTTGT CTCCGATCCA GAGGATCTGC 
AAGTACCCGC TCCTCCTTAA GGAGCTGGCC AAGAGGACTC CCGGCAAGCA CCCAGACCAC 
CCCGCGGTCC AGAGTGCCCT GCAGGCCATG AAGACCGTTT GCTCCAACAT CAATGAGACC 
AAGCGGCAGA TGGAGAAGCT GGAAGCCCTG GAGCAGCTGC AGTCCCACAT CGAAGGCTGG 
GAGGGTTCCA ACCTCACAGA CATCTGCACT CAGCTCCTCC TGCAAGGGAC TTTGTTAAAG 
ATCTCTGCGG GCAACATCCA GGAAAGGGCC TTCTTCCTCT TCGACAACCT TCTCGTCTAC 
TGCAAGCGGA AATCCAGGGT CACCGGGAGC AAGAAGTCCA CCAAGAGGAC CAAATCCATC 
AACGGCTCCC TCTACATCTT CAGGGGTCGA ATCAACACTG AAGTCATGGA GGTGGAGAAT 
GTGGAAGATG GGACAGCGGA TTACCATAGC AACGGCTATA CCGTCACCAA CGGCTGGAAG 
ATCCACAACA CGGCCAAGAA TAAGTGGTTT GTCTGCATGG CCAAGACGGC AGAGGAGAAG 
CAGAAGTGGC TGGATGCCAT CATCCGCGAG CGGGAGCAGC GCGAGAGCCT GAAGCTGGGC 
ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCAAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065871.3
CDS	140..5119
Translation	MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL

Target ORF information:

RefSeq Version	NM_020820.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020820.4

ORF Insert Sequence:

ATGGAGGCGC CCAGCGGCAG CGAGCCCGGC GGCGACGGGG CCGGGGACTG CGCCCACCCG 
GACCCCCGGG CCCCTGGCGC CGCGGCGCCC AGCTCCGGCC CCGGCCCGTG CGCGGCCGCC 
CGGGAGTCCG AGCGCCAGCT GCGCCTCCGC CTCTGCGTCC TCAACGAGAT CTTGGGCACC 
GAGAGGGACT ACGTGGGCAC CTTGCGCTTC TTGCAGTCGG CATTCCTGCA TCGCATCCGG 
CAGAACGTGG CCGACTCAGT GGAGAAGGGC CTCACGGAGG AGAATGTCAA GGTCCTGTTC 
TCGAACATCG AAGACATCCT GGAAGTTCAT AAGGATTTCT TGGCCGCCTT GGAGTATTGT 
TTACACCCGG AGCCGCAGTC TCAGCATGAA CTTGGGAATG TTTTCTTAAA ATTCAAGGAC 
AAGTTCTGCG TGTACGAGGA GTATTGCAGC AACCATGAGA AAGCCCTGAG GCTGCTGGTG 
GAGCTGAACA AGATCCCTAC CGTGCGCGCC TTCCTTTTGA GCTGCATGCT TCTGGGAGGC 
CGGAAGACCA CGGACATCCC TTTGGAAGGC TACCTGTTGT CTCCGATCCA GAGGATCTGC 
AAGTACCCGC TCCTCCTTAA GGAGCTGGCC AAGAGGACTC CCGGCAAGCA CCCAGACCAC 
CCCGCGGTCC AGAGTGCCCT GCAGGCCATG AAGACCGTTT GCTCCAACAT CAATGAGACC 
AAGCGGCAGA TGGAGAAGCT GGAAGCCCTG GAGCAGCTGC AGTCCCACAT CGAAGGCTGG 
GAGGGTTCCA ACCTCACAGA CATCTGCACT CAGCTCCTCC TGCAAGGGAC TTTGTTAAAG 
ATCTCTGCGG GCAACATCCA GGAAAGGGCC TTCTTCCTCT TCGACAACCT TCTCGTCTAC 
TGCAAGCGGA AATCCAGGGT CACCGGGAGC AAGAAGTCCA CCAAGAGGAC CAAATCCATC 
AACGGCTCCC TCTACATCTT CAGGGGTCGA ATCAACACTG AAGTCATGGA GGTGGAGAAT 
GTGGAAGATG GGACAGCGGA TTACCATAGC AACGGCTATA CCGTCACCAA CGGCTGGAAG 
ATCCACAACA CGGCCAAGAA TAAGTGGTTT GTCTGCATGG CCAAGACGGC AGAGGAGAAG 
CAGAAGTGGC TGGATGCCAT CATCCGCGAG CGGGAGCAGC GCGAGAGCCT GAAGCTGGGC 
ATGGAGCGTG ATGCCTACGT CATGATTGCG GAGAAGGGGG AGAAGCTGTA CCACATGATG 
ATGAACAAGA AGGTGAACCT CATCAAGGAC CGCCGGAGAA AGCTGAGCAC TGTCCCCAAG 
TGCTTTCTTG GCAATGAGTT CGTTGCCTGG CTCCTAGAAA TTGGTGAAAT CAGCAAGACG 
GAAGAAGGAG TCAACTTGGG CCAAGCCCTG TTGGAGAATG GCATCATCCA CCATGTTTCC 
GACAAGCACC AGTTCAAGAA TGAGCAGGTG ATGTATCGCT TCCGCTACGA CGATGGCACC 
TACAAGGCCC GAAGTGAGCT GGAGGACATC ATGTCCAAGG GTGTGAGGCT TTACTGCCGT 
CTTCACAGCC TCTACACCCC GGTGATCAAA GACCGTGATT ACCACCTGAA GACCTACAAG 
TCAGTGCTTC CCGGGAGCAA GCTGGTGGAC TGGCTGCTGG CTCAGGGAGA CTGCCAGACT 
CGGGAGGAGG CAGTGGCGCT CGGCGTGGGT CTGTGCAACA ATGGCTTCAT GCACCACGTG 
CTGGAGAAGA GCGAGTTCAG GGATGAGTCC CAGTACTTCC GCTTTCATGC TGACGAGGAG 
ATGGAGGGGA CCAGCAGCAA GAACAAACAG CTTCGCAACG ACTTCAAGCT GGTGGAGAAC 
ATTCTGGCCA AGCGCCTGCT GATCCTGCCC CAGGAGGAGG ACTATGGCTT TGACATCGAG 
GAGAAGAACA AGGCTGTGGT GGTGAAGTCC GTCCAGAGGG GCTCGCTGGC TGAGGTGGCT 
GGCCTGCAGG TGGGGAGGAA GATCTACTCC ATCAATGAGG ACCTGGTGTT CCTGCGGCCG 
TTTTCAGAGG TGGAGTCCAT CCTCAACCAG TCCTTCTGCT CCCGCCGCCC TCTGCGCCTC 
CTGGTGGCCA CGAAGGCCAA AGAGATCATC AAAATCCCCG ACCAGCCGGA CACACTGTGC 
TTCCAGATTC GTGGAGCTGC CCCACCGTAC GTCTATGCTG TGGGGAGAGG CTCTGAGGCC 
ATGGCTGCAG GGCTCTGTGC TGGTCAGTGC ATTCTGAAGG TCAATGGCAG CAACGTGATG 
AACGATGGTG CCCCTGAGGT CCTGGAGCAC TTCCAGGCAT TCCGGAGTCG GCGCGAAGAG 
GCCCTGGGCC TGTACCAGTG GATCTACCAC ACCCATGAGG ATGCCCAGGA AGCACGAGCC 
AGTCAGGAGG CCTCCACTGA GGACCCCAGT GGCGAGCAGG CCCAGGAGGA AGACCAGGCT 
GATTCAGCCT TCCCACTGCT GTCCCTGGGT CCCCGGCTGA GCCTGTGTGA GGACAGCCCC 
ATGGTCACCC TGACTGTGGA CAACGTGCAC CTGGAACACG GCGTGGTGTA TGAGTATGTG 
AGCACGGCAG GCGTCAGGTG CCATGTGCTG GAGAAGATCG TGGAGCCCCG CGGCTGCTTC 
GGCCTCACCG CCAAGATCCT CGAGGCCTTT GCTGCCAATG ACAGCGTCTT CGTGGAGAAC 
TGCAGGCGGC TCATGGCCCT GAGCAGCGCC ATCGTGACCA TGCCCCACTT TGAGTTCCGC 
AACATCTGTG ACACCAAGCT GGAGAGCATT GGCCAGAGGA TTGCCTGCTA CCAGGAGTTT 
GCAGCCCAAC TGAAGAGCAG GGTCAGCCCA CCCTTCAAAC AAGCCCCCCT GGAGCCCCAC 
CCGCTGTGTG GCCTGGACTT CTGCCCCACC AATTGCCACA TCAACCTCAT GGAAGTGTCC 
TACCCCAAGA CCACCCCCTC AGTGGGCAGG TCCTTCAGCA TCCGCTTTGG ACGCAAACCC 
TCCCTCATCG GCCTTGACCC GGAGCAAGGC CACCTGAACC CCATGTCGTA CACCCAGCAC 
TGCATCACCA CCATGGCTGC TCCCTCCTGG AAGTGCTTGC CTGCTGCAGA GGGTGATCCC 
CAAGGCCAGG GTCTCCATGA TGGCAGCTTC GGGCCAGCCA GTGGGACCCT TGGTCAGGAA 
GACCGGGGCC TCAGCTTCCT ACTCAAGCAG GAGGACCGTG AGATCCAGGA TGCCTACCTG 
CAGCTCTTCA CCAAGCTGGA TGTGGCCCTG AAGGAGATGA AGCAATATGT CACCCAGATC 
AACAGGCTGC TGTCCACCAT CACAGAGCCC ACCTCGGGTG GGTCCTGCGA CGCATCCTTG 
GCTGAGGAGG CCTCCTCCCT GCCCCTGGTC AGTGAAGAGA GCGAGATGGA CAGGAGTGAC 
CATGGGGGCA TCAAGAAGGT GTGCTTCAAG GTGGCCGAGG AGGACCAGGA GGACTCAGGC 
CACGACACCA TGAGTTATCG CGACTCCTAC AGCGAGTGTA ACAGCAATCG AGACTCGGTC 
CTGTCCTACA CCAGCGTGAG AAGTAACAGC TCCTACTTGG GCAGCGACGA GATGGGGTCT 
GGAGATGAGC TGCCCTGTGA CATGCGGATC CCATCTGACA AGCAGGACAA GCTTCATGGC 
TGCCTGGAGC ACCTCTTTAA CCAGGTGGAC TCCATCAATG CTCTCCTCAA GGGGCCAGTC 
ATGAGCCGGG CTTTCGAAGA GACCAAGCAT TTCCCTATGA ACCACAGCTT ACAAGAGTTT 
AAACAGAAAG AAGAGTGTAC AATCCGTGGC CGGAGCCTGA TCCAGATTAG CATCCAGGAG 
GACCCCTGGA ACCTCCCCAA CTCCATCAAG ACCCTGGTGG ACAACATTCA GAGATATGTG 
GAAGATGGGA AGAACCAGCT GCTCCTGGCC TTGCTGAAGT GCACAGACAC GGAGCTGCAG 
CTGCGCAGAG ACGCGATCTT CTGCCAGGCC CTGGTGGCCG CCGTGTGCAC CTTCTCCAAG 
CAGCTGCTGG CGGCCCTGGG CTACCGCTAC AACAACAATG GCGAGTACGA GGAGAGCAGC 
CGCGACGCCA GCCGCAAGTG GCTGGAGCAG GTGGCGGCCA CGGGCGTCCT GCTGCACTGC 
CAGTCCCTGC TCTCGCCAGC CACAGTGAAG GAGGAACGGA CCATGCTGGA GGACATCTGG 
GTGACGCTGT CAGAGCTGGA CAATGTCACC TTCTCCTTTA AGCAGCTGGA CGAGAACTAT 
GTGGCCAACA CCAACGTCTT CTACCACATT GAGGGCAGCC GGCAGGCGCT GAAGGTCATC 
TTCTACCTCG ACAGCTACCA CTTCTCCAAG CTGCCCTCCC GCCTGGAGGG TGGGGCCAGC 
CTGAGGCTGC ACACAGCGCT GTTCACGAAA GTGCTGGAGA ACGTGGAGGG GCTGCCTTCT 
CCAGGCAGCC AGGCCGCGGA GGATTTGCAG CAGGACATCA ACGCGCAGTC CCTGGAGAAA 
GTTCAGCAGT ATTACCGCAA ACTCAGGGCA TTTTACCTGG AGCGGTCTAA CCTGCCCACG 
GATGCCAGCA CCACGGCGGT AAAGATAGAC CAGCTGATCC GCCCCATCAA TGCCCTGGAT 
GAGCTCTGCC GCCTCATGAA GTCCTTTGTC CACCCAAAGC CTGGTGCTGC TGGGAGTGTG 
GGCGCCGGCC TCATCCCCAT CTCCTCGGAG CTCTGCTACC GCCTGGGGGC CTGCCAGATG 
GTCATGTGTG GCACAGGCAT GCAGAGGAGC ACCCTGAGCG TGTCCCTGGA GCAGGCGGCC 
ATCTTGGCAC GGAGCCACGG GTTGCTGCCC AAGTGCATCA TGCAGGCCAC GGACATCATG 
CGGAAGCAGG GCCCAAGGGT GGAGATTCTG GCCAAAAACC TGCGAGTCAA GGACCAGATG 
CCCCAGGGTG CTCCGCGCCT CTACCGCCTC TGCCAGCCGC CGGTGGATGG GGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.
Blood130(8)982-994(2017 08)
Kremer KN,Dinkel BA,Sterner RM,Osborne DG,Jevremovic D,Hedin KE

P-Rex1 and P-Rex2 RacGEFs and cancer.
Biochemical Society transactions45(4)963-77(2017 08)
Srijakotre N,Man J,Ooms LM,Lucato CM,Ellisdon AM,Mitchell CA

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PREX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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