Gene Symbol | MIB1 |
Entrez Gene ID | 57534 |
Full Name | mindbomb E3 ubiquitin protein ligase 1 |
Synonyms | DIP-1,DIP1,LVNC7,MIB,ZZANK2,ZZZ6 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]. |
Disorder MIM: | |
Disorder Html: | Left ventricular noncompaction 7, 615092 (3) |