AARS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AARS2
Entrez Gene ID	57505
Full Name	alanyl-tRNA synthetase 2, mitochondrial
Synonyms	AARSL,COXPD8,LKENP,MT-ALARS,MTALARS
General protein information	Preferred Names alanyl-tRNA synthetase 2, mitochondrial Names alanine--tRNA ligase, mitochondrial alanine tRNA ligase 2, mitochondrial (putative) alanyl-tRNA synthetase 2, mitochondrial (putative) alanyl-tRNA synthetase like probable alanyl-tRNA synthetase, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.1
Summary	The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011].
Disorder MIM:	612035
Disorder Html:	Combined oxidative phosphorylation deficiency 8, 614096 (3); Leukoencephalopathy, progressive, with ovarian failure, 615889 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020745.4	NP_065796.2	alanine--tRNA ligase, mitochondrial
XM_011514764.2	XP_011513066.1	alanine--tRNA ligase, mitochondrial isoform X1
XM_017011112.1	XP_016866601.1	alanine--tRNA ligase, mitochondrial isoform X3
NM_020745.3	NP_065796.1	alanine--tRNA ligase, mitochondrial
XM_005249245.3	XP_005249302.1	alanine--tRNA ligase, mitochondrial isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AARS2	XP_518510.2
Mus musculus (house mouse)	Aars2	NP_941010.2
Homo sapiens (human)	AARS2	NP_065796.1
Rattus norvegicus (Norway rat)	Aars2	NP_001100361.1
Gallus gallus (chicken)	AARS2	NP_001026227.1
	AARS2	XP_001099647.1
Canis lupus familiaris (dog)	AARS2	XP_532155.2
Danio rerio (zebrafish)	aars2	XP_001332388.5
Bos taurus (cattle)	AARS2	NP_001178140.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia.
Lynch DS, Zhang WJ, Lakshmanan R, Kinsella JA, Uzun GA, Karbay M, T?fek?ioglu Z, Hanagasi H, Burke G, Foulds N, Hammans SR, Bhattacharjee A, Wilson H, Adams M, Walker M, Nicoll JA, Chataway J, Fox N, Davagnanam I, Phadke R, Houlden H
JAMA neurology73(12)1433-1439(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This paper documented a new, nonsense AARS2 gene mutation (c.578T>G, p.Leu193*) and a known missense mutation (c.595C>T, p.Arg199Cys) associated with leukoencephalopathy in a male patient.
Title: Novel AARS2 gene mutation producing leukodystrophy: a case report.

Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia.
Title: Analysis of Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia.

we describe a Japanese woman with novel compound heterozygous mutations in AARS2, the first report of leukodystrophy caused by AARS2 mutations in Asia.
Title: The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations.

A new phenotype caused by AARS2 mutations is characterized by leukoencephalopathy and ovarian failure in female patients, indicating that the phenotypic spectrum associated with AARS2 variants is much wider than previously reported.
Title: Novel (ovario) leukodystrophy related to AARS2 mutations.

Mutations in AARS2 found in lethal mitochondrial myopathy
Title: Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.

The following AARS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AARS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20431	NM_020745.3 Latest version!	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$469.50-$657.30 $939.00
OHu40392	XM_005249245.3 Latest version!	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu70539	XM_011514764.2 Latest version!	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu107874	NM_020745.4 Latest version!	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu96712	XM_017011112.1 Latest version!	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AARS2 ( NM_020745.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065796.1 Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.

Price & Availability↑

CloneID	OHu20431
Clone ID Related Accession (Same CDS sequence)	NM_020745.3
Accession Version	NM_020745.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2958bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	alanine--tRNA ligase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC131728.1, CN343332.1, AL536467.3 and AL353588.25. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2011 this sequence version replaced NM_020745.2. ##Evidence-Data-START## Transcript exon combination :: BC131728.1, SRR1803613.100991.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCGTCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGGTGCCA TGCCCACCTT CACAGCAGAG 
GCCTGGGCAC TGGCAGTGTG CAGCCACATG GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG 
GCCCAAGGCA CCGGAAGCAC TACTGACCTG GAAGCTGCCC TCAGTATAGC CCAAACCTAT 
GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065796.1
CDS	4..2961
Translation	MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPPYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGVFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL

Target ORF information:

RefSeq Version	NM_020745.3
Organism	Homo sapiens(human)
Definition	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020745.3

ORF Insert Sequence:

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCGTCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGGTGCCA TGCCCACCTT CACAGCAGAG 
GCCTGGGCAC TGGCAGTGTG CAGCCACATG GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG 
GCCCAAGGCA CCGGAAGCAC TACTGACCTG GAAGCTGCCC TCAGTATAGC CCAAACCTAT 
GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AARS2 ( XM_005249245.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249302.1 Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu40392
Clone ID Related Accession (Same CDS sequence)	XM_005249245.3
Accession Version	XM_005249245.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alanine--tRNA ligase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005249245.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGG CTGGTTCTTC GTCGGATCCT GCGTCGAGCT 
GTGCGTTTCT CCATGGAGAT CTTAAAGGCA CCACCTGGCT TCCTAGGCAG CCTGGTACCT 
GTAGTGGTGG AGACACTGGG AGATGCTTAT CCAGAACTGC AAAGGAACTC AGCCCAGATC 
GCCAACCTGG TGTCAGAGGA CGAGGCAGCC TTCCTGGCCT CCCTGGAGCG GGGTAGGCGG 
ATCATTGATC GGACTCTGAG GACCCTGGGG CCTTCAGATA TGTTCCCTGC TGAAGTGGCC 
TGGTCCTTGT CACTGTGTGG AGACCTGGGA CTCCCCTTGG ACATGGTAGA GCTGATGCTG 
GAGGAGAAAG GGGTCCAGCT AGACTCCGCT GGACTGGAGC GGTTGGCCCA AGAGGAGGCC 
CAGCACCGGG CACGGCAGGC TGAGCCAGTT CAGAAGCAGG GATTGTGGCT TGATGTCCAT 
GCGCTTGGGG AGCTGCAGCG CCAAGGAGTG CCCCCAACTG ACGACAGCCC CAAGTACAAC 
TACTCCCTGC GACCCAGCGG AAGTTATGAG TTCGGCACCT GTGAGGCCCA GGTGTTGCAA 
CTGTATACAG AGGACGGGAC AGCAGTGGCC TCCGTGGGGA AAGGCCAGCG CTGTGGCCTC 
CTCTTGGACA GGACCAACTT CTACGCAGAA CAGGGGGGCC AGGCTTCAGA CCGTGGCTAC 
CTGGTGCGGG CAGGGCAAGA GGACGTGCTG TTCCCAGTAG CCCGGGCCCA GGTCTGTGGA 
GGTTTCATCC TGCATGAGGC AGTAGCCCCT GAGTGCCTGC GGTTAGGGGA CCAGGTGCAG 
CTGCATGTGG ATGAGGCCTG GCGTCTAGGC TGCATGGCGA AGCATACGGC CACCCACCTG 
CTGAACTGGG CACTGAGGCA GACCCTGGGC CCTGGCACAG AGCAGCAGGG CTCCCATCTC 
AATCCTGAGC AGCTGCGCTT GGATGTGACC ACCCAGACCC CATTGACCCC AGAGCAGCTC 
CGGGCAGTGG AGAACACTGT GCAGGAGGCC GTGGGGCAGG ATGAGGCTGT GTACATGGAG 
GAGGTGCCCC TGGCGCTCAC TGCCCAGGTC CCTGGCCTGC GCTCTCTGGA TGAGGTTTAC 
CCAGACCCTG TGCGGGTGGT ATCAGTGGGG GTGCCCGTGG CCCATGCATT GGACCCAGCC 
TCCCAAGCCG CACTGCAGAC CTCTGTGGAG CTATGCTGTG GGACGCACCT GTTACGTACT 
GGGGCTGTAG GGGACCTGGT TATCATCGGG GACCGCCAGC TTTCCAAGGG CACTACCCGC 
CTGCTGGCCG TCACTGGGGA GCAGGCCCAG CAGGCCCGAG AGCTAGGCCA GAGCCTGGCC 
CAGGAAGTGA AAGCGGCCAC TGAGCGGCTG AGTCTGGGGA GCCGGGATGT GGCGGAGGCA 
CTGAGGCTGT CCAAGGACAT AGGACGACTC ATTGAAGCTG TGGAAACTGC TGTGATGCCC 
CAGTGGCAGC GGCGGGAGCT GCTGGCCACA GTGAAGATGC TGCAGCGGCG TGCCAACACT 
GCCATCCGTA AGCTGCAAAT GGGACAGGCT GCAAAGAAAA CTCAGGAGCT GCTGGAGCGG 
CACTCGAAGG GGCCTCTGAT TGTGGACACA GTCTCTGCTG AGTCTCTCTC AGTGCTGGTG 
AAGGTGGTAC GGCAGCTGTG TGAGCAGGCC CCCAGCACGT CTGTGCTCCT ACTCAGCCCC 
CAGCCCATGG GGAAGGTGCT GTGTGCCTGT CAGGTGGCCC AGGGTGCCAT GCCCACCTTC 
ACAGCAGAGG CCTGGGCACT GGCAGTGTGC AGCCACATGG GGGGCAAGGC GTGGGGCTCA 
CGAGTGGTGG CCCAAGGCAC CGGAAGCACT ACTGACCTGG AAGCTGCCCT CAGTATAGCC 
CAAACCTATG CCCTCAGCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249302.1
CDS	36..2702
Translation	MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNRLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL

Target ORF information:

RefSeq Version	XM_005249245.3
Organism	Homo sapiens(human)
Definition	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249245.3

ORF Insert Sequence:

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGG CTGGTTCTTC GTCGGATCCT GCGTCGAGCT 
GTGCGTTTCT CCATGGAGAT CTTAAAGGCA CCACCTGGCT TCCTAGGCAG CCTGGTACCT 
GTAGTGGTGG AGACACTGGG AGATGCTTAT CCAGAACTGC AAAGGAACTC AGCCCAGATC 
GCCAACCTGG TGTCAGAGGA CGAGGCAGCC TTCCTGGCCT CCCTGGAGCG GGGTAGGCGG 
ATCATTGATC GGACTCTGAG GACCCTGGGG CCTTCAGATA TGTTCCCTGC TGAAGTGGCC 
TGGTCCTTGT CACTGTGTGG AGACCTGGGA CTCCCCTTGG ACATGGTAGA GCTGATGCTG 
GAGGAGAAAG GGGTCCAGCT AGACTCCGCT GGACTGGAGC GGTTGGCCCA AGAGGAGGCC 
CAGCACCGGG CACGGCAGGC TGAGCCAGTT CAGAAGCAGG GATTGTGGCT TGATGTCCAT 
GCGCTTGGGG AGCTGCAGCG CCAAGGAGTG CCCCCAACTG ACGACAGCCC CAAGTACAAC 
TACTCCCTGC GACCCAGCGG AAGTTATGAG TTCGGCACCT GTGAGGCCCA GGTGTTGCAA 
CTGTATACAG AGGACGGGAC AGCAGTGGCC TCCGTGGGGA AAGGCCAGCG CTGTGGCCTC 
CTCTTGGACA GGACCAACTT CTACGCAGAA CAGGGGGGCC AGGCTTCAGA CCGTGGCTAC 
CTGGTGCGGG CAGGGCAAGA GGACGTGCTG TTCCCAGTAG CCCGGGCCCA GGTCTGTGGA 
GGTTTCATCC TGCATGAGGC AGTAGCCCCT GAGTGCCTGC GGTTAGGGGA CCAGGTGCAG 
CTGCATGTGG ATGAGGCCTG GCGTCTAGGC TGCATGGCGA AGCATACGGC CACCCACCTG 
CTGAACTGGG CACTGAGGCA GACCCTGGGC CCTGGCACAG AGCAGCAGGG CTCCCATCTC 
AATCCTGAGC AGCTGCGCTT GGATGTGACC ACCCAGACCC CATTGACCCC AGAGCAGCTC 
CGGGCAGTGG AGAACACTGT GCAGGAGGCC GTGGGGCAGG ATGAGGCTGT GTACATGGAG 
GAGGTGCCCC TGGCGCTCAC TGCCCAGGTC CCTGGCCTGC GCTCTCTGGA TGAGGTTTAC 
CCAGACCCTG TGCGGGTGGT ATCAGTGGGG GTGCCCGTGG CCCATGCATT GGACCCAGCC 
TCCCAAGCCG CACTGCAGAC CTCTGTGGAG CTATGCTGTG GGACGCACCT GTTACGTACT 
GGGGCTGTAG GGGACCTGGT TATCATCGGG GACCGCCAGC TTTCCAAGGG CACTACCCGC 
CTGCTGGCCG TCACTGGGGA GCAGGCCCAG CAGGCCCGAG AGCTAGGCCA GAGCCTGGCC 
CAGGAAGTGA AAGCGGCCAC TGAGCGGCTG AGTCTGGGGA GCCGGGATGT GGCGGAGGCA 
CTGAGGCTGT CCAAGGACAT AGGACGACTC ATTGAAGCTG TGGAAACTGC TGTGATGCCC 
CAGTGGCAGC GGCGGGAGCT GCTGGCCACA GTGAAGATGC TGCAGCGGCG TGCCAACACT 
GCCATCCGTA AGCTGCAAAT GGGACAGGCT GCAAAGAAAA CTCAGGAGCT GCTGGAGCGG 
CACTCGAAGG GGCCTCTGAT TGTGGACACA GTCTCTGCTG AGTCTCTCTC AGTGCTGGTG 
AAGGTGGTAC GGCAGCTGTG TGAGCAGGCC CCCAGCACGT CTGTGCTCCT ACTCAGCCCC 
CAGCCCATGG GGAAGGTGCT GTGTGCCTGT CAGGTGGCCC AGGGTGCCAT GCCCACCTTC 
ACAGCAGAGG CCTGGGCACT GGCAGTGTGC AGCCACATGG GGGGCAAGGC GTGGGGCTCA 
CGAGTGGTGG CCCAAGGCAC CGGAAGCACT ACTGACCTGG AAGCTGCCCT CAGTATAGCC 
CAAACCTATG CCCTCAGCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AARS2 ( XM_011514764.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513066.1 Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X1, mRNA.

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CloneID	OHu70539
Clone ID Related Accession (Same CDS sequence)	XM_011514764.2
Accession Version	XM_011514764.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2868bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alanine--tRNA ligase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514764.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCATCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGAGATCT GGGGCCCCAA CCACATCTTG 
TCGCGCCAGG GCTGGAAGAG AGTTTGGCAC AGGGCATGGA CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513066.1
CDS	36..2903
Translation	MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPPYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQEIWGPNHILSRQGWKRVWHRAWTV

Target ORF information:

RefSeq Version	XM_011514764.2
Organism	Homo sapiens(human)
Definition	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514764.2

ORF Insert Sequence:

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCATCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGAGATCT GGGGCCCCAA CCACATCTTG 
TCGCGCCAGG GCTGGAAGAG AGTTTGGCAC AGGGCATGGA CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AARS2 ( NM_020745.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065796.2 Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.

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CloneID	OHu107874
Clone ID Related Accession (Same CDS sequence)	NM_020745.4
Accession Version	NM_020745.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2958bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Homo sapiens(human)
Product	alanine--tRNA ligase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL353588.25. On Nov 23, 2018 this sequence version replaced NM_020745.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.55287.1, SRR1803613.100991.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000244571.5/ ENSP00000244571.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCATCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGGTGCCA TGCCCACCTT CACAGCAGAG 
GCCTGGGCAC TGGCAGTGTG CAGCCACATG GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG 
GCCCAAGGCA CCGGAAGCAC TACTGACCTG GAAGCTGCCC TCAGTATAGC CCAAACCTAT 
GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065796.2
CDS	25..2982
Translation	MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPPYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL

Target ORF information:

RefSeq Version	NM_020745.4
Organism	Homo sapiens(human)
Definition	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020745.4

ORF Insert Sequence:

ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC 
GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG 
GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC 
TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC 
CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA 
CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT 
GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG 
GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT 
GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG 
GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG 
CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC 
TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT 
TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC 
CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA 
CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC 
AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG 
TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCATCTTC 
CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC 
TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG 
GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG 
GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT 
CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG 
TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA 
GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG 
GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG 
GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG 
CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA 
GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC 
AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG 
GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC 
CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG 
GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG 
GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG 
CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG 
GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC 
CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT 
GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC 
GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA 
GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC 
GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG 
AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG 
TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG 
CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT 
AAGCTGCAAA TGGGACAGGC TGCAAAGAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG 
GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA 
CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG 
GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGGTGCCA TGCCCACCTT CACAGCAGAG 
GCCTGGGCAC TGGCAGTGTG CAGCCACATG GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG 
GCCCAAGGCA CCGGAAGCAC TACTGACCTG GAAGCTGCCC TCAGTATAGC CCAAACCTAT 
GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AARS2 ( XM_017011112.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866601.1 Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X3, mRNA.

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CloneID	OHu96712
Clone ID Related Accession (Same CDS sequence)	XM_017011112.1
Accession Version	XM_017011112.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alanine--tRNA ligase, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG TCACTGTGTG GAGACCTGGG ACTCCCCTTG 
GACATGGTAG AGCTGATGCT GGAGGAGAAA GGGGTCCAGC TAGACTCCGC TGGACTGGAG 
CGGTTGGCCC AAGAGGAGGC CCAGCACCGG GCACGGCAGG CTGAGCCAGT TCAGAAGCAG 
GGATTGTGGC TTGATGTCCA TGCGCTTGGG GAGCTGCAGC GCCAAGGAGT GCCCCCAACT 
GACGACAGCC CCAAGTACAA CTACTCCCTG CGACCCAGCG GAAGTTATGA GTTCGGCACC 
TGTGAGGCCC AGGTGTTGCA ACTGTATACA GAGGACGGGA CAGCAGTGGC CTCCGTGGGG 
AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC AGGACCAACT TCTACGCAGA ACAGGGGGGC 
CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG GCAGGGCAAG AGGACGTGCT GTTCCCAGTA 
GCCCGGGCCC AGGTCTGTGG AGGTTTCATC CTGCATGAGG CAGTAGCCCC TGAGTGCCTG 
CGGTTAGGGG ACCAGGTGCA GCTGCATGTG GATGAGGCCT GGCGTCTAGG CTGCATGGCG 
AAGCATACGG CCACCCACCT GCTGAACTGG GCACTGAGGC AGACCCTGGG CCCTGGCACA 
GAGCAGCAGG GCTCCCATCT CAATCCTGAG CAGCTGCGCT TGGATGTGAC CACCCAGACC 
CCATTGACCC CAGAGCAGCT CCGGGCAGTG GAGAACACTG TGCAGGAGGC CGTGGGGCAG 
GATGAGGCTG TGTACATGGA GGAGGTGCCC CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG 
CGCTCTCTGG ATGAGGTTTA CCCAGACCCT GTGCGGGTGG TATCAGTGGG GGTGCCCGTG 
GCCCATGCAT TGGACCCAGC CTCCCAAGCC GCACTGCAGA CCTCTGTGGA GCTATGCTGT 
GGGACGCACC TGTTACGTAC TGGGGCTGTA GGGGACCTGG TTATCATCGG GGACCGCCAG 
CTTTCCAAGG GCACTACCCG CCTGCTGGCC GTCACTGGGG AGCAGGCCCA GCAGGCCCGA 
GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG 
AGCCGGGATG TGGCGGAGGC ACTGAGGCTG TCCAAGGACA TAGGACGACT CATTGAAGCT 
GTGGAAACTG CTGTGATGCC CCAGTGGCAG CGGCGGGAGC TGCTGGCCAC AGTGAAGATG 
CTGCAGCGGC GTGCCAACAC TGCCATCCGT AAGCTGCAAA TGGGACAGGC TGCAAAGAAA 
ACTCAGGAGC TGCTGGAGCG GCACTCGAAG GGGCCTCTGA TTGTGGACAC AGTCTCTGCT 
GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA CGGCAGCTGT GTGAGCAGGC CCCCAGCACG 
TCTGTGCTCC TACTCAGCCC CCAGCCCATG GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC 
CAGGGTGCCA TGCCCACCTT CACAGCAGAG GCCTGGGCAC TGGCAGTGTG CAGCCACATG 
GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG GCCCAAGGCA CCGGAAGCAC TACTGACCTG 
GAAGCTGCCC TCAGTATAGC CCAAACCTAT GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866601.1
CDS	876..2543
Translation	MFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL

Target ORF information:

RefSeq Version	XM_017011112.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (AARS2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011112.1

ORF Insert Sequence:

ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG TCACTGTGTG GAGACCTGGG ACTCCCCTTG 
GACATGGTAG AGCTGATGCT GGAGGAGAAA GGGGTCCAGC TAGACTCCGC TGGACTGGAG 
CGGTTGGCCC AAGAGGAGGC CCAGCACCGG GCACGGCAGG CTGAGCCAGT TCAGAAGCAG 
GGATTGTGGC TTGATGTCCA TGCGCTTGGG GAGCTGCAGC GCCAAGGAGT GCCCCCAACT 
GACGACAGCC CCAAGTACAA CTACTCCCTG CGACCCAGCG GAAGTTATGA GTTCGGCACC 
TGTGAGGCCC AGGTGTTGCA ACTGTATACA GAGGACGGGA CAGCAGTGGC CTCCGTGGGG 
AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC AGGACCAACT TCTACGCAGA ACAGGGGGGC 
CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG GCAGGGCAAG AGGACGTGCT GTTCCCAGTA 
GCCCGGGCCC AGGTCTGTGG AGGTTTCATC CTGCATGAGG CAGTAGCCCC TGAGTGCCTG 
CGGTTAGGGG ACCAGGTGCA GCTGCATGTG GATGAGGCCT GGCGTCTAGG CTGCATGGCG 
AAGCATACGG CCACCCACCT GCTGAACTGG GCACTGAGGC AGACCCTGGG CCCTGGCACA 
GAGCAGCAGG GCTCCCATCT CAATCCTGAG CAGCTGCGCT TGGATGTGAC CACCCAGACC 
CCATTGACCC CAGAGCAGCT CCGGGCAGTG GAGAACACTG TGCAGGAGGC CGTGGGGCAG 
GATGAGGCTG TGTACATGGA GGAGGTGCCC CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG 
CGCTCTCTGG ATGAGGTTTA CCCAGACCCT GTGCGGGTGG TATCAGTGGG GGTGCCCGTG 
GCCCATGCAT TGGACCCAGC CTCCCAAGCC GCACTGCAGA CCTCTGTGGA GCTATGCTGT 
GGGACGCACC TGTTACGTAC TGGGGCTGTA GGGGACCTGG TTATCATCGG GGACCGCCAG 
CTTTCCAAGG GCACTACCCG CCTGCTGGCC GTCACTGGGG AGCAGGCCCA GCAGGCCCGA 
GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG 
AGCCGGGATG TGGCGGAGGC ACTGAGGCTG TCCAAGGACA TAGGACGACT CATTGAAGCT 
GTGGAAACTG CTGTGATGCC CCAGTGGCAG CGGCGGGAGC TGCTGGCCAC AGTGAAGATG 
CTGCAGCGGC GTGCCAACAC TGCCATCCGT AAGCTGCAAA TGGGACAGGC TGCAAAGAAA 
ACTCAGGAGC TGCTGGAGCG GCACTCGAAG GGGCCTCTGA TTGTGGACAC AGTCTCTGCT 
GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA CGGCAGCTGT GTGAGCAGGC CCCCAGCACG 
TCTGTGCTCC TACTCAGCCC CCAGCCCATG GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC 
CAGGGTGCCA TGCCCACCTT CACAGCAGAG GCCTGGGCAC TGGCAGTGTG CAGCCACATG 
GGGGGCAAGG CGTGGGGCTC ACGAGTGGTG GCCCAAGGCA CCGGAAGCAC TACTGACCTG 
GAAGCTGCCC TCAGTATAGC CCAAACCTAT GCCCTCAGCC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia.
JAMA neurology73(12)1433-1439(2016 Dec)
Lynch DS,Zhang WJ,Lakshmanan R,Kinsella JA,Uzun GA,Karbay M,T?fek?ioglu Z,Hanagasi H,Burke G,Foulds N,Hammans SR,Bhattacharjee A,Wilson H,Adams M,Walker M,Nicoll JA,Chataway J,Fox N,Davagnanam I,Phadke R,Houlden H

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AARS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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