S100A14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100A14
Entrez Gene ID	57402
Full Name	S100 calcium binding protein A14
Synonyms	BCMP84,S100A15
General protein information	Preferred Names S100 calcium binding protein A14 Names protein S100-A14 S114 breast cancer membrane protein 84
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011].
Disorder MIM:	607986

mRNA and Protein(s)

mRNA	Protein	Name
XM_005245362.1	XP_005245419.1	protein S100-A14 isoform X1
XM_017001875.1	XP_016857364.1	protein S100-A14 isoform X1
NM_020672.2	NP_065723.1	protein S100-A14
NM_020672.3	NP_065723.1	protein S100-A14

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	S100A14	XP_005622875.1
Mus musculus (house mouse)	S100a14	NP_079669.2
Homo sapiens (human)	S100A14	NP_065723.1
Pan troglodytes (chimpanzee)	S100A14	XP_003949611.1
Bos taurus (cattle)	S100A14	NP_001073102.1

Gene Ontology
Bibliography

Related articles in PubMed

Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer.
Zhu M, Wang H, Cui J, Li W, An G, Pan Y, Zhang Q, Xing R, Lu Y
Cell death & disease8(7)e2938(2017 Jul)

Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.
Chen YC, Lin MC, Hsiao CC, Zheng YX, Chen KD, Sung MT, Chen CJ, Wang TY, Lin YY, Chang HC, Chen YM, Chang JC
Oncotarget8(28)45710-45724(2017 Jul)

Clinicopathological Significance of S100A14 Expression in Lung Adenocarcinoma.
Katono K, Sato Y, Kobayashi M, Saito K, Nagashio R, Ryuge S, Igawa S, Nakashima H, Shiomi K, Satoh Y, Ichinoe M, Murakumo Y, Saegusa M, Masuda N
Oncology research and treatment40(10)594-602(2017)

KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer.
Zhao H, Guo E, Hu T, Sun Q, Wu J, Lin X, Luo D, Sun C, Wang C, Zhou B, Li N, Xia M, Lu H, Meng L, Xu X, Hu J, Ma D, Chen G, Zhu T
Oncotarget7(28)43924-43938(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified a two-gene signature including KCNN4 and S100A14 which was related to recurrence in optimally debulked serous ovarian carcinoma patients
Title: KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer.

S100A14 is expressed in epithelial-like, but not in mesenchymal-like, triple-negative breast cancer cells in vitro.
Title: S100A14 is a novel independent prognostic biomarker in the triple-negative breast cancer subtype.

Data show that the genetic variant 425G>A on the 5'-UTR of calcium-binding protein S100A14 was associated with reduced S100A14 expression in gastric cancer (GC) cells.
Title: Downregulation of 425G>a variant of calcium-binding protein S100A14 associated with poor differentiation and prognosis in gastric cancer.

Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion
Title: Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.

The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts
Title: The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts.

The following S100A14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100A14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15825	NM_020672.3 Latest version!	Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15825	XM_017001875.1 Latest version!	Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15825	XM_005245362.1 Latest version!	Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15825	NM_020672.2	Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100A14 ( NM_020672.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065723.1 Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.

Price & Availability↑

CloneID	OHu15825
Clone ID Related Accession (Same CDS sequence)	XM_005245362.1 , XM_017001875.1 , NM_020672.2 , NM_020672.3
Accession Version	NM_020672.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein S100-A14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG677973.1, AY007220.1 and BX470102.12. On Dec 6, 2011 this sequence version replaced NM_020672.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279871.3038.1, ERR279834.11404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065723.1
CDS	117..431
Translation	MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH

Target ORF information:

RefSeq Version	NM_020672.2
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020672.2

ORF Insert Sequence:

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A14 ( NM_020672.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065723.1 Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.

Price & Availability↑

CloneID	OHu15825
Clone ID Related Accession (Same CDS sequence)	XM_005245362.1 , XM_017001875.1 , NM_020672.2 , NM_020672.3
Accession Version	NM_020672.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	protein S100-A14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG677973.1, AY007220.1 and BX470102.12. On Nov 22, 2018 this sequence version replaced NM_020672.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.138654.1, ERR279834.11404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000344616.4/ ENSP00000340463.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065723.1
CDS	110..424
Translation	MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH

Target ORF information:

RefSeq Version	NM_020672.3
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020672.3

ORF Insert Sequence:

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A14 ( XM_005245362.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245419.1 Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu15825
Clone ID Related Accession (Same CDS sequence)	XM_005245362.1 , XM_017001875.1 , NM_020672.2 , NM_020672.3
Accession Version	XM_005245362.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein S100-A14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005245419.1
CDS	113..427
Translation	MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH

Target ORF information:

RefSeq Version	XM_005245362.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245362.1

ORF Insert Sequence:

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A14 ( XM_017001875.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857364.1 Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu15825
Clone ID Related Accession (Same CDS sequence)	XM_005245362.1 , XM_017001875.1 , NM_020672.2 , NM_020672.3
Accession Version	XM_017001875.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein S100-A14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857364.1
CDS	205..519
Translation	MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH

Target ORF information:

RefSeq Version	XM_017001875.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A14 (S100A14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001875.1

ORF Insert Sequence:

ATGGGACAGT GTCGGTCAGC CAACGCAGAG GATGCTCAGG AATTCAGTGA TGTGGAGAGG 
GCCATTGAGA CCCTCATCAA GAACTTTCAC CAGTACTCCG TGGAGGGTGG GAAGGAGACG 
CTGACCCCTT CTGAGCTACG GGACCTGGTC ACCCAGCAGC TGCCCCATCT CATGCCGAGC 
AACTGTGGCC TGGAAGAGAA AATTGCCAAC CTGGGCAGCT GCAATGACTC TAAACTGGAG 
TTCAGGAGTT TCTGGGAGCT GATTGGAGAA GCGGCCAAGA GTGTGAAGCT GGAGAGGCCT 
GTCCGGGGGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer.
Cell death & disease8(7)e2938(2017 Jul)
Zhu M,Wang H,Cui J,Li W,An G,Pan Y,Zhang Q,Xing R,Lu Y

Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.
Oncotarget8(28)45710-45724(2017 Jul)
Chen YC,Lin MC,Hsiao CC,Zheng YX,Chen KD,Sung MT,Chen CJ,Wang TY,Lin YY,Chang HC,Chen YM,Chang JC

Clinicopathological Significance of S100A14 Expression in Lung Adenocarcinoma.
Oncology research and treatment40(10)594-602(2017)
Katono K,Sato Y,Kobayashi M,Saito K,Nagashio R,Ryuge S,Igawa S,Nakashima H,Shiomi K,Satoh Y,Ichinoe M,Murakumo Y,Saegusa M,Masuda N

KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer.
Oncotarget7(28)43924-43938(2016 Jul)
Zhao H,Guo E,Hu T,Sun Q,Wu J,Lin X,Luo D,Sun C,Wang C,Zhou B,Li N,Xia M,Lu H,Meng L,Xu X,Hu J,Ma D,Chen G,Zhu T

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S100A14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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