CLK4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLK4
Entrez Gene ID	57396
Full Name	CDC like kinase 4
General protein information	Preferred Names CDC like kinase 4 Names dual specificity protein kinase CLK4 protein serine threonine kinase Clk4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.3
Summary	The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	607969

mRNA and Protein(s)

mRNA	Protein	Name
XM_011534602.1	XP_011532904.1	dual specificity protein kinase CLK4 isoform X1
NM_020666.3	NP_065717.1	dual specificity protein kinase CLK4
NM_020666.2	NP_065717.1	dual specificity protein kinase CLK4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CLK4	XP_414614.3
Homo sapiens (human)	CLK4	NP_065717.1
	CLK4	XP_001097751.1
Danio rerio (zebrafish)	clk4a	XP_003199888.1
Magnaporthe oryzae (rice blast fungus)	MGG_16904	XP_003712873.1
Canis lupus familiaris (dog)	CLK4	XP_531875.2
Pan troglodytes (chimpanzee)	CLK4	XP_001148601.2
Bos taurus (cattle)	CLK4	NP_001179917.1
Mus musculus (house mouse)	Clk4	NP_031740.1
Neurospora crassa	NCU00230	XP_957701.2

Gene Ontology
Bibliography

Related articles in PubMed

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.
Petsalaki E, Zachos G
Nature communications711451(2016 Apr)

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U
Circulation research104(5)589-99(2009 Mar)

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)

Structural analysis of UBL5, a novel ubiquitin-like modifier.
McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM
Protein science : a publication of the Protein Society12(7)1562-6(2003 Jul)

Beacon interacts with cdc2/cdc28-like kinases.
Kantham L, Kerr-Bayles L, Godde N, Quick M, Webb R, Sunderland T, Bond J, Walder K, Augert G, Collier G
Biochemical and biophysical research communications304(1)125-9(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clk1, Clk2 and Clk4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.
Title: Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

The following CLK4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLK4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03397	NM_020666.3 Latest version!	Homo sapiens CDC like kinase 4 (CLK4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu03397	XM_011534602.1 Latest version!	Homo sapiens CDC-like kinase 4 (CLK4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu03397	NM_020666.2	Homo sapiens CDC like kinase 4 (CLK4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLK4 ( NM_020666.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065717.1 Homo sapiens CDC like kinase 4 (CLK4), mRNA.

Price & Availability↑

CloneID	OHu03397
Clone ID Related Accession (Same CDS sequence)	XM_011534602.1 , NM_020666.3 , NM_020666.2
Accession Version	NM_020666.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	dual specificity protein kinase CLK4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015942.1, BC063116.1 and CB127989.1. On Nov 23, 2018 this sequence version replaced NM_020666.2. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.41785.1, SRR1660803.83941.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000316308.9/ ENSP00000316948.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065717.1
CDS	106..1551
Translation	MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK

Target ORF information:

RefSeq Version	NM_020666.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC like kinase 4 (CLK4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020666.3

ORF Insert Sequence:

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLK4 ( NM_020666.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065717.1 Homo sapiens CDC like kinase 4 (CLK4), mRNA.

Price & Availability↑

CloneID	OHu03397
Clone ID Related Accession (Same CDS sequence)	XM_011534602.1 , NM_020666.3 , NM_020666.2
Accession Version	NM_020666.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-13
Organism	Homo sapiens(human)
Product	dual specificity protein kinase CLK4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015942.1, BC063116.1 and CB127989.1. On May 27, 2004 this sequence version replaced NM_020666.1. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.109690.1, SRR1660803.83941.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065717.1
CDS	109..1554
Translation	MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK

Target ORF information:

RefSeq Version	NM_020666.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC like kinase 4 (CLK4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020666.2

ORF Insert Sequence:

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLK4 ( XM_011534602.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011532904.1 Homo sapiens CDC-like kinase 4 (CLK4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu03397
Clone ID Related Accession (Same CDS sequence)	XM_011534602.1 , NM_020666.3 , NM_020666.2
Accession Version	XM_011534602.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	dual specificity protein kinase CLK4 isoform X1
Comment

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011532904.1

Translation

MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK

Target ORF information:

RefSeq Version	XM_011534602.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens CDC-like kinase 4 (CLK4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011534602.1

ORF Insert Sequence:

ATGCGGCATT CCAAAAGAAC TCACTGTCCT GATTGGGATA GCAGAGAAAG CTGGGGACAT 
GAAAGCTATC GTGGAAGTCA CAAGCGGAAG AGGAGATCTC ATAGTAGCAC ACAAGAGAAC 
AGGCATTGTA AACCACATCA CCAGTTTAAA GAATCTGATT GTCATTATTT AGAAGCAAGG 
TCCTTGAATG AGCGAGATTA TCGGGACCGG AGATACGTTG ACGAATACAG GAATGACTAC 
TGTGAAGGAT ATGTTCCTAG ACATTATCAC AGAGACATTG AAAGCGGGTA TCGAATCCAC 
TGCAGTAAAT CTTCAGTCCG CAGCAGGAGA AGCAGTCCTA AAAGGAAGCG CAATAGACAC 
TGTTCAAGTC ATCAGTCACG TTCGAAGAGC CACCGAAGGA AAAGATCCAG GAGTATAGAG 
GATGATGAGG AGGGTCACCT GATCTGTCAA AGTGGAGACG TTCTAAGAGC AAGATATGAA 
ATCGTGGACA CTTTGGGTGA AGGAGCCTTT GGCAAAGTTG TAGAGTGCAT TGATCATGGC 
ATGGATGGCA TGCATGTAGC AGTGAAAATC GTAAAAAATG TAGGCCGTTA CCGTGAAGCA 
GCTCGTTCAG AAATCCAAGT ATTAGAGCAC TTAAATAGTA CTGATCCCAA TAGTGTCTTC 
CGATGTGTCC AGATGCTAGA ATGGTTTGAT CATCATGGTC ATGTTTGTAT TGTGTTTGAA 
CTACTGGGAC TTAGTACTTA CGATTTCATT AAAGAAAACA GCTTTCTGCC ATTTCAAATT 
GACCACATCA GGCAGATGGC GTATCAGATC TGCCAGTCAA TAAATTTTTT ACATCATAAT 
AAATTAACCC ATACAGATCT GAAGCCTGAA AATATTTTGT TTGTGAAGTC TGACTATGTA 
GTCAAATATA ATTCTAAAAT GAAACGTGAT GAACGCACAC TGAAAAACAC AGATATCAAA 
GTTGTTGACT TTGGAAGTGC AACGTATGAT GATGAACATC ACAGTACTTT GGTGTCTACC 
CGGCACTACA GAGCTCCCGA GGTCATTTTG GCTTTAGGTT GGTCTCAGCC TTGTGATGTT 
TGGAGCATAG GTTGCATTCT TATTGAATAT TACCTTGGTT TCACAGTCTT TCAGACTCAT 
GATAGTAAAG AGCACCTGGC AATGATGGAA CGAATATTAG GACCCATACC ACAACACATG 
ATTCAGAAAA CAAGAAAACG CAAGTATTTT CACCATAACC AGCTAGATTG GGATGAACAC 
AGTTCTGCTG GTAGATATGT TAGGAGACGC TGCAAACCGT TGAAGGAATT TATGCTTTGT 
CATGATGAAG AACATGAGAA ACTGTTTGAC CTGGTTCGAA GAATGTTAGA ATATGATCCA 
ACTCAAAGAA TTACCTTGGA TGAAGCATTG CAGCATCCTT TCTTTGACTT ATTAAAAAAG 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.
Nature communications711451(2016 Apr)
Petsalaki E,Zachos G

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Circulation research104(5)589-99(2009 Mar)
Eisenreich A,Bogdanov VY,Zakrzewicz A,Pries A,Antoniak S,Poller W,Schultheiss HP,Rauch U

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)
Wang AG,Yoon SY,Oh JH,Jeon YJ,Kim M,Kim JM,Byun SS,Yang JO,Kim JH,Kim DG,Yeom YI,Yoo HS,Kim YS,Kim NS

Structural analysis of UBL5, a novel ubiquitin-like modifier.
Protein science : a publication of the Protein Society12(7)1562-6(2003 Jul)
McNally T,Huang Q,Janis RS,Liu Z,Olejniczak ET,Reilly RM

Beacon interacts with cdc2/cdc28-like kinases.
Biochemical and biophysical research communications304(1)125-9(2003 Apr)
Kantham L,Kerr-Bayles L,Godde N,Quick M,Webb R,Sunderland T,Bond J,Walder K,Augert G,Collier G

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CLK4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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