PSME2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSME2
Entrez Gene ID	5721
Full Name	proteasome activator subunit 2
Synonyms	PA28B,PA28beta,REGbeta
General protein information	Preferred Names proteasome activator subunit 2 Names proteasome activator complex subunit 2 11S regulator complex beta subunit 11S regulator complex subunit beta MCP activator, 31-kD subunit REG-beta activator of multicatalytic protease subunit 2 cell migration-inducing protein 22 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) proteasome activator 28 subunit beta proteasome activator 28-beta proteasome activator hPA28 subunit beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q12
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008].
Disorder MIM:	602161

mRNA and Protein(s)

mRNA	Protein	Name
NM_002818.2	NP_002809.2	proteasome activator complex subunit 2
NM_002818.3	NP_002809.2	proteasome activator complex subunit 2
XM_006720213.1	XP_006720276.1	proteasome activator complex subunit 2 isoform X1
XM_006720213.2	XP_006720276.1	proteasome activator complex subunit 2 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSME2	XP_001167654.1
	PSME2	XP_001112445.1
Bos taurus (cattle)	PSME2	NP_001014889.1
Canis lupus familiaris (dog)	PSME2	XP_537382.2
Rattus norvegicus (Norway rat)	Psme2	NP_058953.1
Xenopus tropicalis (tropical clawed frog)	psme2	NP_001011494.1
Homo sapiens (human)	PSME2	NP_002809.2
Mus musculus (house mouse)	Psme2	NP_035320.1
Rattus norvegicus (Norway rat)	LOC100362709	XP_002728490.2
Danio rerio (zebrafish)	psme2	NP_571449.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of PA28? as a potential novel biomarker in human esophageal squamous cell carcinoma.
Chen JY, Xu L, Fang WM, Han JY, Wang K, Zhu KS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(10)1010428317719780(2017 Oct)

Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.
Desvergne A, Ugarte N, Radjei S, Gareil M, Petropoulos I, Friguet B
Free radical biology & medicine94195-207(2016 05)

N-?-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28?.
Min L, Xu H, Wang J, Qu L, Jiang B, Zeng Y, Meng L, Jin H, Shou C
FEBS letters587(11)1630-7(2013 Jun)

PA28? regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.
Zheng DL, Huang QL, Zhou F, Huang QJ, Lin JY, Lin X
Journal of cellular biochemistry113(5)1537-46(2012 May)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The functional assays demonstrate that PA28beta inhibited cell growth, proliferation and malignancy of TE-1 cells. Among the differentially expressed proteins, PA28b is a potential tumor inhibitor
Title: Identification of PA28? as a potential novel biomarker in human esophageal squamous cell carcinoma.

Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab
Title: Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.

Naa10p suppresses 28S proteasome activity through interaction with PA28beta.
Title: N-?-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28?.

knockdown of PA28beta could enhance tumor invasion and metastasis, at least in part, through up-regulation of CLIC1 in gastric adenocarcinoma
Title: PA28? regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.

Impaired expression of proteasome subunits is involved in the loss of HLA class I expression in human colon cancer cells.
Title: Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.

The following PSME2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSME2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03129	NM_002818.3 Latest version!	Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu47816	XM_006720213.2 Latest version!	Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu03129	NM_002818.2	Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu47816	XM_006720213.1	Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSME2 ( NM_002818.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002809.2 Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.

Price & Availability↑

CloneID	OHu03129
Clone ID Related Accession (Same CDS sequence)	NM_002818.2 , NM_002818.3
Accession Version	NM_002818.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	proteasome activator complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D45248.1. On May 7, 2003 this sequence version replaced NM_002818.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.105740.1, SRR1163658.117534.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGC CGTGTGGGGT GCGCCTGAGC GGGGAAGCCC GCAAACAGGT GGAGGTCTTC 
AGACAGAATC TTTTCCAGGA GGCTGAGGAA TTCCTCTACA GATTCTTGCC ACAGAAAATC 
ATATACCTGA ATCAGCTCTT GCAAGAGGAC TCCCTCAATG TGGCTGACTT GACTTCCCTC 
CGGGCCCCAC TGGACATCCC CATCCCAGAC CCTCCACCCA AGGATGATGA GATGGAAACA 
GATAAGCAGG AGAAGAAAGA AGTCCATAAG TGTGGATTTC TCCCTGGGAA TGAGAAAGTC 
CTGTCCCTGC TTGCCCTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA ATGCATTCTG 
GTGATTACAT GGATCCAACA CCTGATCCCC AAGATTGAAG ATGGAAATGA TTTTGGGGTA 
GCAATCCAGG AGAAGGTGCT GGAGAGGGTG AATGCCGTCA AGACCAAAGT GGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGTGGGGATG CTGTGGCCAA GGCCTCCAAG 
GAGACTCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAGGC AGCCTATGGG 
GAGCTCAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TGGAGAAAAT TGTCAACCCA AAGGGTGAAG AAAAGCCATC TATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002809.2
CDS	66..785
Translation	MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	NM_002818.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002818.2

ORF Insert Sequence:

ATGGCCAAGC CGTGTGGGGT GCGCCTGAGC GGGGAAGCCC GCAAACAGGT GGAGGTCTTC 
AGACAGAATC TTTTCCAGGA GGCTGAGGAA TTCCTCTACA GATTCTTGCC ACAGAAAATC 
ATATACCTGA ATCAGCTCTT GCAAGAGGAC TCCCTCAATG TGGCTGACTT GACTTCCCTC 
CGGGCCCCAC TGGACATCCC CATCCCAGAC CCTCCACCCA AGGATGATGA GATGGAAACA 
GATAAGCAGG AGAAGAAAGA AGTCCATAAG TGTGGATTTC TCCCTGGGAA TGAGAAAGTC 
CTGTCCCTGC TTGCCCTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA ATGCATTCTG 
GTGATTACAT GGATCCAACA CCTGATCCCC AAGATTGAAG ATGGAAATGA TTTTGGGGTA 
GCAATCCAGG AGAAGGTGCT GGAGAGGGTG AATGCCGTCA AGACCAAAGT GGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGTGGGGATG CTGTGGCCAA GGCCTCCAAG 
GAGACTCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAGGC AGCCTATGGG 
GAGCTCAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TGGAGAAAAT TGTCAACCCA AAGGGTGAAG AAAAGCCATC TATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSME2 ( NM_002818.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002809.2 Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.

Price & Availability↑

CloneID	OHu03129
Clone ID Related Accession (Same CDS sequence)	NM_002818.2 , NM_002818.3
Accession Version	NM_002818.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	proteasome activator complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136295.3. On Nov 26, 2018 this sequence version replaced NM_002818.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026580.1, SRR1163655.105740.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216802.10/ ENSP00000216802.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAGC CGTGTGGGGT GCGCCTGAGC GGGGAAGCCC GCAAACAGGT GGAGGTCTTC 
AGACAGAATC TTTTCCAGGA GGCTGAGGAA TTCCTCTACA GATTCTTGCC ACAGAAAATC 
ATATACCTGA ATCAGCTCTT GCAAGAGGAC TCCCTCAATG TGGCTGACTT GACTTCCCTC 
CGGGCCCCAC TGGACATCCC CATCCCAGAC CCTCCACCCA AGGATGATGA GATGGAAACA 
GATAAGCAGG AGAAGAAAGA AGTCCATAAG TGTGGATTTC TCCCTGGGAA TGAGAAAGTC 
CTGTCCCTGC TTGCCCTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA ATGCATTCTG 
GTGATTACAT GGATCCAACA CCTGATCCCC AAGATTGAAG ATGGAAATGA TTTTGGGGTA 
GCAATCCAGG AGAAGGTGCT GGAGAGGGTG AATGCCGTCA AGACCAAAGT GGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGTGGGGATG CTGTGGCCAA GGCCTCCAAG 
GAGACTCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAGGC AGCCTATGGG 
GAGCTCAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TGGAGAAAAT TGTCAACCCA AAGGGTGAAG AAAAGCCATC TATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002809.2
CDS	30..749
Translation	MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	NM_002818.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002818.3

ORF Insert Sequence:

ATGGCCAAGC CGTGTGGGGT GCGCCTGAGC GGGGAAGCCC GCAAACAGGT GGAGGTCTTC 
AGACAGAATC TTTTCCAGGA GGCTGAGGAA TTCCTCTACA GATTCTTGCC ACAGAAAATC 
ATATACCTGA ATCAGCTCTT GCAAGAGGAC TCCCTCAATG TGGCTGACTT GACTTCCCTC 
CGGGCCCCAC TGGACATCCC CATCCCAGAC CCTCCACCCA AGGATGATGA GATGGAAACA 
GATAAGCAGG AGAAGAAAGA AGTCCATAAG TGTGGATTTC TCCCTGGGAA TGAGAAAGTC 
CTGTCCCTGC TTGCCCTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA ATGCATTCTG 
GTGATTACAT GGATCCAACA CCTGATCCCC AAGATTGAAG ATGGAAATGA TTTTGGGGTA 
GCAATCCAGG AGAAGGTGCT GGAGAGGGTG AATGCCGTCA AGACCAAAGT GGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGTGGGGATG CTGTGGCCAA GGCCTCCAAG 
GAGACTCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAGGC AGCCTATGGG 
GAGCTCAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TGGAGAAAAT TGTCAACCCA AAGGGTGAAG AAAAGCCATC TATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSME2 ( XM_006720213.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006720276.1 Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu47816
Clone ID Related Accession (Same CDS sequence)	XM_006720213.1 , XM_006720213.2
Accession Version	XM_006720213.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	proteasome activator complex subunit 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAACAG ATAAGCAGGA GAAGAAAGAA GTCCATAAGT GTGGATTTCT CCCTGGGAAT 
GAGAAAGTCC TGTCCCTGCT TGCCCTGGTT AAGCCAGAAG TCTGGACTCT CAAAGAGAAA 
TGCATTCTGG TGATTACATG GATCCAACAC CTGATCCCCA AGATTGAAGA TGGAAATGAT 
TTTGGGGTAG CAATCCAGGA GAAGGTGCTG GAGAGGGTGA ATGCCGTCAA GACCAAAGTG 
GAAGCTTTCC AGACAACCAT TTCCAAGTAC TTCTCAGAAC GTGGGGATGC TGTGGCCAAG 
GCCTCCAAGG AGACTCATGT AATGGATTAC CGGGCCTTGG TGCATGAGCG AGATGAGGCA 
GCCTATGGGG AGCTCAGGGC CATGGTGCTG GACCTGAGGG CCTTCTATGC TGAGCTTTAT 
CATATCATCA GCAGCAACCT GGAGAAAATT GTCAACCCAA AGGGTGAAGA AAAGCCATCT 
ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006720276.1
CDS	1091..1579
Translation	METDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	XM_006720213.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006720213.1

ORF Insert Sequence:

ATGGAAACAG ATAAGCAGGA GAAGAAAGAA GTCCATAAGT GTGGATTTCT CCCTGGGAAT 
GAGAAAGTCC TGTCCCTGCT TGCCCTGGTT AAGCCAGAAG TCTGGACTCT CAAAGAGAAA 
TGCATTCTGG TGATTACATG GATCCAACAC CTGATCCCCA AGATTGAAGA TGGAAATGAT 
TTTGGGGTAG CAATCCAGGA GAAGGTGCTG GAGAGGGTGA ATGCCGTCAA GACCAAAGTG 
GAAGCTTTCC AGACAACCAT TTCCAAGTAC TTCTCAGAAC GTGGGGATGC TGTGGCCAAG 
GCCTCCAAGG AGACTCATGT AATGGATTAC CGGGCCTTGG TGCATGAGCG AGATGAGGCA 
GCCTATGGGG AGCTCAGGGC CATGGTGCTG GACCTGAGGG CCTTCTATGC TGAGCTTTAT 
CATATCATCA GCAGCAACCT GGAGAAAATT GTCAACCCAA AGGGTGAAGA AAAGCCATCT 
ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSME2 ( XM_006720213.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006720276.1 Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu47816
Clone ID Related Accession (Same CDS sequence)	XM_006720213.1 , XM_006720213.2
Accession Version	XM_006720213.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proteasome activator complex subunit 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006720213.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAACAG ATAAGCAGGA GAAGAAAGAA GTCCATAAGT GTGGATTTCT CCCTGGGAAT 
GAGAAAGTCC TGTCCCTGCT TGCCCTGGTT AAGCCAGAAG TCTGGACTCT CAAAGAGAAA 
TGCATTCTGG TGATTACATG GATCCAACAC CTGATCCCCA AGATTGAAGA TGGAAATGAT 
TTTGGGGTAG CAATCCAGGA GAAGGTGCTG GAGAGGGTGA ATGCCGTCAA GACCAAAGTG 
GAAGCTTTCC AGACAACCAT TTCCAAGTAC TTCTCAGAAC GTGGGGATGC TGTGGCCAAG 
GCCTCCAAGG AGACTCATGT AATGGATTAC CGGGCCTTGG TGCATGAGCG AGATGAGGCA 
GCCTATGGGG AGCTCAGGGC CATGGTGCTG GACCTGAGGG CCTTCTATGC TGAGCTTTAT 
CATATCATCA GCAGCAACCT GGAGAAAATT GTCAACCCAA AGGGTGAAGA AAAGCCATCT 
ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006720276.1
CDS	421..909
Translation	METDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	XM_006720213.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome activator subunit 2 (PSME2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006720213.2

ORF Insert Sequence:

ATGGAAACAG ATAAGCAGGA GAAGAAAGAA GTCCATAAGT GTGGATTTCT CCCTGGGAAT 
GAGAAAGTCC TGTCCCTGCT TGCCCTGGTT AAGCCAGAAG TCTGGACTCT CAAAGAGAAA 
TGCATTCTGG TGATTACATG GATCCAACAC CTGATCCCCA AGATTGAAGA TGGAAATGAT 
TTTGGGGTAG CAATCCAGGA GAAGGTGCTG GAGAGGGTGA ATGCCGTCAA GACCAAAGTG 
GAAGCTTTCC AGACAACCAT TTCCAAGTAC TTCTCAGAAC GTGGGGATGC TGTGGCCAAG 
GCCTCCAAGG AGACTCATGT AATGGATTAC CGGGCCTTGG TGCATGAGCG AGATGAGGCA 
GCCTATGGGG AGCTCAGGGC CATGGTGCTG GACCTGAGGG CCTTCTATGC TGAGCTTTAT 
CATATCATCA GCAGCAACCT GGAGAAAATT GTCAACCCAA AGGGTGAAGA AAAGCCATCT 
ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of PA28? as a potential novel biomarker in human esophageal squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(10)1010428317719780(2017 Oct)
Chen JY,Xu L,Fang WM,Han JY,Wang K,Zhu KS

Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.
Free radical biology & medicine94195-207(2016 05)
Desvergne A,Ugarte N,Radjei S,Gareil M,Petropoulos I,Friguet B

N-?-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28?.
FEBS letters587(11)1630-7(2013 Jun)
Min L,Xu H,Wang J,Qu L,Jiang B,Zeng Y,Meng L,Jin H,Shou C

PA28? regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.
Journal of cellular biochemistry113(5)1537-46(2012 May)
Zheng DL,Huang QL,Zhou F,Huang QJ,Lin JY,Lin X

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

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PSME2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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