JPH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	JPH2
Entrez Gene ID	57158
Full Name	junctophilin 2
Synonyms	CMH17,JP-2,JP2
General protein information	Preferred Names junctophilin 2 Names junctophilin-2 junctophilin type 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008].
Disorder MIM:	605267
Disorder Html:	Cardiomyopathy, hypertrophic, 17, 613873 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_175913.3	NP_787109.2	junctophilin-2 isoform 2
NM_020433.4	NP_065166.2	junctophilin-2 isoform 1
XM_006723833.4	XP_006723896.1	junctophilin-2 isoform X1
XM_006723833.3	XP_006723896.1	junctophilin-2 isoform X1
NM_175913.4	NP_787109.2	junctophilin-2 isoform 2
XM_006723832.2	XP_006723895.1	junctophilin-2 isoform X1
NM_020433.5	NP_065166.2	junctophilin-2 isoform 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	jph2	XP_002933232.1
Bos taurus (cattle)	JPH2	XP_002692371.3
Rattus norvegicus (Norway rat)	Jph2	NP_001033063.1
Gallus gallus (chicken)	JPH2	XP_001234186.3
	JPH2	XP_001083346.1
Mus musculus (house mouse)	Jph2	NP_001192005.1
Homo sapiens (human)	JPH2	NP_065166.2
Pan troglodytes (chimpanzee)	JPH2	XP_525332.2
Danio rerio (zebrafish)	jph2	NP_001082833.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional interaction of Junctophilin 2 with small- conductance Ca
Fan HK, Luo TX, Zhao WD, Mu YH, Yang Y, Guo WJ, Tu HY, Zhang Q
Acta physiologica (Oxford, England)(2017 Oct)

Mutation in JPH2 cause dilated cardiomyopathy.
Sabater-Molina M, Navarro M, Garc?a-Molina S?ez E, Garrido I, Pascual-Figal D, Gonz?lez Carrillo J, Gimeno Blanes JR
Clinical genetics90(5)468-469(2016 Nov)

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.
Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS
The Journal of biological chemistry290(29)17946-55(2015 Jul)

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein JI, Jarskog LF, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF
Nature communications54757(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.
Title: Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.

Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.
Title: Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

The S101R mutation may have an effect upon the stability of the JP2 dyad organization with the potential to alter JP2-protein interactions regulating calcium cycling.
Title: Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response.

This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period
Title: Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.

Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.
Title: Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.

The following JPH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JPH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07425	NM_175913.4 Latest version!	Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu53055	XM_006723833.4 Latest version!	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu19281	NM_020433.5 Latest version!	Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu19281	XM_006723832.2 Latest version!	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu53055	XM_006723833.3	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu07425	NM_175913.3	Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu19281	NM_020433.4	Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

JPH2 ( NM_175913.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_787109.2 Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07425
Clone ID Related Accession (Same CDS sequence)	NM_175913.3 , NM_175913.4
Accession Version	NM_175913.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035447.6 and AL132999.1. On Mar 23, 2005 this sequence version replaced NM_175913.2. Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL132999.1, AL449546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GATGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787109.2
CDS	874..1263
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGMC

Target ORF information:

RefSeq Version	NM_175913.3
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175913.3

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GATGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( NM_175913.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_787109.2 Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07425
Clone ID Related Accession (Same CDS sequence)	NM_175913.3 , NM_175913.4
Accession Version	NM_175913.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035447.6 and AL132999.1. On Jun 2, 2019 this sequence version replaced NM_175913.3. Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL132999.1, SRR7346977.1018242.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GATGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787109.2
CDS	484..873
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGMC

Target ORF information:

RefSeq Version	NM_175913.4
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175913.4

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GATGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( XM_006723833.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723896.1 Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu53055
Clone ID Related Accession (Same CDS sequence)	XM_006723833.4 , XM_006723833.3
Accession Version	XM_006723833.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006723833.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGT CAAATGCTAC AAAGGAAACA GCAGTCTTCC AAACTGGAGA 
GGACAACGCA TTAGTGGATG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723896.1
CDS	1242..1685
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGVKCYKGNSSLPNWRGQRISGW

Target ORF information:

RefSeq Version	XM_006723833.4
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723833.4

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGT CAAATGCTAC AAAGGAAACA GCAGTCTTCC AAACTGGAGA 
GGACAACGCA TTAGTGGATG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( XM_006723833.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723896.1 Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu53055
Clone ID Related Accession (Same CDS sequence)	XM_006723833.4 , XM_006723833.3
Accession Version	XM_006723833.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723833.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGT CAAATGCTAC AAAGGAAACA GCAGTCTTCC AAACTGGAGA 
GGACAACGCA TTAGTGGATG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723896.1
CDS	866..1309
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGVKCYKGNSSLPNWRGQRISGW

Target ORF information:

RefSeq Version	XM_006723833.3
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723833.3

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGT CAAATGCTAC AAAGGAAACA GCAGTCTTCC AAACTGGAGA 
GGACAACGCA TTAGTGGATG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( NM_020433.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_065166.2 Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19281
Clone ID Related Accession (Same CDS sequence)	NM_020433.4 , XM_006723832.2 , NM_020433.5
Accession Version	NM_020433.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035447.6, BC029957.1, AL034419.22, BC043206.2 and AW014086.1. On Oct 16, 2019 this sequence version replaced NM_020433.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.3035581.1, DRR138527.84416.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065166.2
CDS	484..2574
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT

Target ORF information:

RefSeq Version	NM_020433.5
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020433.5

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( NM_020433.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065166.2 Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.

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CloneID	OHu19281
Clone ID Related Accession (Same CDS sequence)	NM_020433.4 , XM_006723832.2 , NM_020433.5
Accession Version	NM_020433.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-09
Organism	Homo sapiens(human)
Product	junctophilin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035447.6, BC029957.1, AL034419.22, BC043206.2 and AW014086.1. This sequence is a reference standard in the RefSeqGene project. On Mar 23, 2005 this sequence version replaced NM_020433.3. Transcript Variant: This variant (1) is the longer variant and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065166.2
CDS	874..2964
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT

Target ORF information:

RefSeq Version	NM_020433.4
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020433.4

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH2 ( XM_006723832.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723895.1 Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19281
Clone ID Related Accession (Same CDS sequence)	NM_020433.4 , XM_006723832.2 , NM_020433.5
Accession Version	XM_006723832.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	junctophilin-2 isoform X1
Comment

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_006723895.1

Translation

MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT

Target ORF information:

RefSeq Version	XM_006723832.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723832.2

ORF Insert Sequence:

ATGAGTGGGG GCCGCTTCGA CTTTGATGAT GGAGGGGCGT ACTGCGGGGG CTGGGAGGGG 
GGAAAGGCCC ATGGGCATGG ACTGTGCACA GGCCCCAAGG GCCAGGGCGA ATACTCTGGC 
TCCTGGAACT TTGGCTTTGA GGTGGCAGGT GTCTACACCT GGCCCAGCGG AAACACCTTT 
GAGGGATACT GGAGCCAGGG CAAACGGCAT GGGCTGGGCA TAGAGACCAA GGGGCGCTGG 
CTCTACAAGG GCGAGTGGAC ACATGGCTTC AAGGGACGCT ACGGAATCCG GCAGAGCTCA 
AGCAGCGGTG CCAAGTATGA GGGCACCTGG AACAATGGCC TGCAAGACGG CTATGGCACC 
GAGACCTATG CTGATGGAGG GACGTACCAA GGCCAGTTCA CCAACGGCAT GCGCCATGGC 
TACGGAGTAC GCCAGAGCGT GCCCTACGGG ATGGCCGTGG TGGTGCGCTC GCCGCTGCGC 
ACGTCGCTGT CGTCCCTGCG CAGCGAGCAC AGCAACGGCA CGGTGGCCCC GGACTCTCCC 
GCCTCGCCGG CCTCCGACGG CCCCGCGCTG CCCTCGCCCG CCATCCCGCG TGGCGGCTTC 
GCGCTCAGCC TCCTGGCCAA TGCCGAGGCG GCCGCGCGGG CGCCCAAGGG CGGCGGCCTC 
TTCCAGCGGG GCGCGCTGCT GGGCAAGCTG CGGCGCGCAG AGTCGCGCAC GTCCGTGGGT 
AGCCAGCGCA GCCGTGTCAG CTTCCTTAAG AGCGACCTCA GCTCGGGCGC CAGCGACGCC 
GCGTCCACCG CCAGCCTGGG AGAGGCCGCC GAGGGCGCCG ACGAGGCCGC ACCCTTCGAG 
GCCGATATCG ACGCCACCAC CACCGAGACC TACATGGGCG AGTGGAAGAA CGACAAACGC 
TCGGGCTTCG GCGTGAGCGA ACGCTCCAGT GGCCTCCGCT ACGAGGGCGA GTGGCTGGAC 
AACCTGCGCC ACGGCTATGG CTGCACCACG CTGCCCGACG GCCACCGCGA GGAGGGCAAG 
TACCGCCACA ACGTGCTGGT CAAGGACACC AAGCGCCGCA TGCTGCAGCT CAAGAGCAAC 
AAGGTCCGCC AGAAAGTGGA GCACAGTGTG GAGGGTGCCC AGCGCGCCGC TGCTATCGCG 
CGCCAGAAGG CCGAGATTGC CGCCTCCAGG ACAAGCCACG CCAAGGCCAA AGCTGAGGCA 
GCGGAACAGG CCGCCCTGGC TGCCAACCAG GAGTCCAACA TTGCTCGCAC TTTGGCCAGG 
GAGCTGGCTC CGGACTTCTA CCAGCCAGGT CCGGAATATC AGAAGCGCCG GCTGCTGCAG 
GAGATCCTGG AGAACTCGGA GAGCCTGCTG GAGCCCCCCG ACCGGGGCGC CGGCGCAGCG 
GGCCTCCCAC AGCCGCCCCG CGAGAGCCCG CAGCTGCACG AGCGTGAGAC CCCTCGGCCC 
GAGGGTGGCT CCCCGTCACC GGCCGGGACG CCCCCGCAGC CCAAGCGGCC CAGGCCCGGG 
GTGTCCAAGG ACGGCCTGCT GAGCCCAGGC GCCTGGAACG GCGAGCCCAG CGGTGAGGGC 
AGCCGGTCAG TCACTCCGTC CGAGGGCGCG GGCCGCCGCA GCCCCGCGCG TCCAGCCACC 
GAGCGCATGG CCATCGAGGC TCTGCAGGCA CCGCCTGCGC CGTCGCGGGA GCCGGAGGTG 
GCGCTTTACC AGGGCTACCA CAGCTATGCT GTGCGCACCA CGCCGCCCGA GCCCCCACCC 
TTTGAGGACC AGCCCGAGCC CGAGGTCTCC GGGTCCGAGT CCGCGCCCTC GTCCCCGGCC 
ACCGCCCCGC TGCAGGCCCC CACGCTCCGA GGCCCCGAGC CTGCACGCGA GACCCCCGCC 
AAGCTGGAGC CCAAGCCCAT CATCCCCAAA GCCGAGCCCA GGGCCAAGGC CCGCAAGACT 
GAGGCTCGAG GGCTGACCAA GGCGGGGGCC AAGAAGAAGG CGCGGAAGGA GGCCGCACTG 
GCGGCAGAGG CGGAGGTGGA GGTGGAAGAG GTCCCCAACA CCATCCTCAT CTGCATGGTG 
ATCCTGCTGA ACATCGGCCT GGCCATCCTC TTTGTTCACC TCCTGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional interaction of Junctophilin 2 with small- conductance Ca
Acta physiologica (Oxford, England)(2017 Oct)
Fan HK,Luo TX,Zhao WD,Mu YH,Yang Y,Guo WJ,Tu HY,Zhang Q

Mutation in JPH2 cause dilated cardiomyopathy.
Clinical genetics90(5)468-469(2016 Nov)
Sabater-Molina M,Navarro M,Garc?a-Molina S?ez E,Garrido I,Pascual-Figal D,Gonz?lez Carrillo J,Gimeno Blanes JR

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.
The Journal of biological chemistry290(29)17946-55(2015 Jul)
Guo A,Hall D,Zhang C,Peng T,Miller JD,Kutschke W,Grueter CE,Johnson FL,Lin RZ,Song LS

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications54757(2014 Sep)
Goldstein JI,Jarskog LF,Hilliard C,Alfirevic A,Duncan L,Fourches D,Huang H,Lek M,Neale BM,Ripke S,Shianna K,Szatkiewicz JP,Tropsha A,van den Oord EJ,Cascorbi I,Dettling M,Gazit E,Goff DC,Holden AL,Kelly DL,Malhotra AK,Nielsen J,Pirmohamed M,Rujescu D,Werge T,Levy DL,Josiassen RC,Kennedy JL,Lieberman JA,Daly MJ,Sullivan PF

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JPH2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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