SLURP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLURP1
Entrez Gene ID	57152
Full Name	secreted LY6/PLAUR domain containing 1
Synonyms	ANUP,ARS,ArsB,LY6LS,MDM
General protein information	Preferred Names secreted LY6/PLAUR domain containing 1 Names secreted Ly-6/uPAR-related protein 1 ARS(component B)-81/S SLURP-1 anti-neoplastic urinary protein lymphocyte antigen 6-like secreted secreted Ly6/uPAR related protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008].
Disorder MIM:	606119
Disorder Html:	Meleda disease, 248300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020427.2	NP_065160.1	secreted Ly-6/uPAR-related protein 1 precursor
NM_020427.3	NP_065160.1	secreted Ly-6/uPAR-related protein 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLURP1	XP_002692640.1
Canis lupus familiaris (dog)	SLURP1	XP_539190.2
Pan troglodytes (chimpanzee)	SLURP1	XP_001149955.1
Mus musculus (house mouse)	Slurp1	NP_065265.1
Rattus norvegicus (Norway rat)	Slurp1	NP_001124016.1
Homo sapiens (human)	SLURP1	NP_065160.1
	SLURP1	XP_001092510.1

Gene Ontology
Bibliography

Related articles in PubMed

SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.
Bergqvist C, Kadara H, Hamie L, Nemer G, Safi R, Karouni M, Marrouche N, Abbas O, Hasbani DJ, Kibbi AG, Nassar D, Shimomura Y, Kurban M
International journal of dermatology57(2)162-170(2018 Feb)

A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family.
Shah K, Nasir A, Irfanullah, Shahzad S, Khan S, Ahmad W
Clinical and experimental dermatology41(6)675-679(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified a mutation in SLURP1 in five members of a consanguineous family in Pakistan, who had Mal de Meleda.
Title: A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family.

This supports the hypothesis that the antiproliferative activity of SLURP-1 is related to 'metabotropic' signaling pathway through alpha7-nAChR, that activates intracellular signaling cascades without opening the receptor channel.
Title: Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of ?7 Nicotinic Acetylcholine Receptor.

Results of this study suggest understand Mal de Meleda, it will be important to identify proteins that interact with mutatated SLURP1. In any such studies, it will be important to assess binding of mutant SLURP1 proteins that cause Mal de Meleda.
Title: Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de?Meleda.

novel splice site mutation c.58+5G>T in mal de Meleda in India
Title: A novel mutation in SLURP1 in patients with mal de Meleda from the Indian subcontinent.

SLURP1 participates in pathophysiology of psoriasis by regulating keratinocyte proliferation and differentiation, and by suppressing the growth of S. aureus
Title: IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus.

The following SLURP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLURP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18418	NM_020427.3 Latest version!	Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18418	NM_020427.2	Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLURP1 ( NM_020427.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065160.1 Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.

Price & Availability↑

CloneID	OHu18418
Clone ID Related Accession (Same CDS sequence)	NM_020427.2 , NM_020427.3
Accession Version	NM_020427.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR-related protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X99977.1. This sequence is a reference standard in the RefSeqGene project. On Dec 12, 2001 this sequence version replaced NM_020427.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI092857.1, BQ027886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCTCTC GCTGGGCTGT GCAGCTGCTG CTCGTGGCAG CCTGGAGCAT GGGCTGTGGT 
GAGGCCCTCA AGTGCTACAC CTGCAAGGAG CCCATGACCA GTGCTTCCTG CAGGACCATT 
ACCCGCTGCA AGCCAGAGGA CACAGCCTGC ATGACCACGC TGGTGACGGT GGAGGCAGAG 
TACCCCTTCA ACCAGAGCCC CGTGGTGACC CGCTCCTGCT CCAGCTCCTG TGTGGCCACC 
GACCCCGACA GCATCGGGGC CGCCCACCTG ATCTTCTGCT GCTTCCGAGA CCTCTGCAAC 
TCGGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065160.1
CDS	27..338
Translation	MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL

Target ORF information:

RefSeq Version	NM_020427.2
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020427.2

ORF Insert Sequence:

ATGGCCTCTC GCTGGGCTGT GCAGCTGCTG CTCGTGGCAG CCTGGAGCAT GGGCTGTGGT 
GAGGCCCTCA AGTGCTACAC CTGCAAGGAG CCCATGACCA GTGCTTCCTG CAGGACCATT 
ACCCGCTGCA AGCCAGAGGA CACAGCCTGC ATGACCACGC TGGTGACGGT GGAGGCAGAG 
TACCCCTTCA ACCAGAGCCC CGTGGTGACC CGCTCCTGCT CCAGCTCCTG TGTGGCCACC 
GACCCCGACA GCATCGGGGC CGCCCACCTG ATCTTCTGCT GCTTCCGAGA CCTCTGCAAC 
TCGGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLURP1 ( NM_020427.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065160.1 Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.

Price & Availability↑

CloneID	OHu18418
Clone ID Related Accession (Same CDS sequence)	NM_020427.2 , NM_020427.3
Accession Version	NM_020427.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	secreted Ly-6/uPAR-related protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC083841.9. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_020427.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105135.1, BQ027886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246515.2/ ENSP00000246515.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTCTC GCTGGGCTGT GCAGCTGCTG CTCGTGGCAG CCTGGAGCAT GGGCTGTGGT 
GAGGCCCTCA AGTGCTACAC CTGCAAGGAG CCCATGACCA GTGCTTCCTG CAGGACCATT 
ACCCGCTGCA AGCCAGAGGA CACAGCCTGC ATGACCACGC TGGTGACGGT GGAGGCAGAG 
TACCCCTTCA ACCAGAGCCC CGTGGTGACC CGCTCCTGCT CCAGCTCCTG TGTGGCCACC 
GACCCCGACA GCATCGGGGC CGCCCACCTG ATCTTCTGCT GCTTCCGAGA CCTCTGCAAC 
TCGGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065160.1
CDS	22..333
Translation	MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL

Target ORF information:

RefSeq Version	NM_020427.3
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020427.3

ORF Insert Sequence:

ATGGCCTCTC GCTGGGCTGT GCAGCTGCTG CTCGTGGCAG CCTGGAGCAT GGGCTGTGGT 
GAGGCCCTCA AGTGCTACAC CTGCAAGGAG CCCATGACCA GTGCTTCCTG CAGGACCATT 
ACCCGCTGCA AGCCAGAGGA CACAGCCTGC ATGACCACGC TGGTGACGGT GGAGGCAGAG 
TACCCCTTCA ACCAGAGCCC CGTGGTGACC CGCTCCTGCT CCAGCTCCTG TGTGGCCACC 
GACCCCGACA GCATCGGGGC CGCCCACCTG ATCTTCTGCT GCTTCCGAGA CCTCTGCAAC 
TCGGAACTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.
International journal of dermatology57(2)162-170(2018 Feb)
Bergqvist C,Kadara H,Hamie L,Nemer G,Safi R,Karouni M,Marrouche N,Abbas O,Hasbani DJ,Kibbi AG,Nassar D,Shimomura Y,Kurban M

A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family.
Clinical and experimental dermatology41(6)675-679(2016 Aug)
Shah K,Nasir A,Irfanullah,Shahzad S,Khan S,Ahmad W

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SLURP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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