CD248 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD248
Entrez Gene ID	57124
Full Name	CD248 molecule
Synonyms	CD164L1,TEM1
General protein information	Preferred Names CD248 molecule Names endosialin 2610111G01Rik CD164 sialomucin-like 1 CD248 antigen, endosialin CD248 molecule, endosialin tumor endothelial marker 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Disorder MIM:	606064

mRNA and Protein(s)

mRNA	Protein	Name
NM_020404.2	NP_065137.1	endosialin precursor
NM_020404.3	NP_065137.1	endosialin precursor

Pathways from BioSystems

Homologies

	CD248	XP_001110499.1
Homo sapiens (human)	CD248	NP_065137.1
Canis lupus familiaris (dog)	CD248	XP_540833.1
Rattus norvegicus (Norway rat)	LOC100911882	XP_003749087.1
Bos taurus (cattle)	CD248	XP_003588093.1
Mus musculus (house mouse)	Cd248	NP_473383.1
Pan troglodytes (chimpanzee)	CD248	XP_003313194.1
Rattus norvegicus (Norway rat)	Cd248	NP_001099795.1
Rattus norvegicus (Norway rat)	LOC100911932	XP_003749088.1

Gene Ontology
Bibliography

Related articles in PubMed

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Khan KA, Naylor AJ, Khan A, Noy PJ, Mambretti M, Lodhia P, Athwal J, Korzystka A, Buckley CD, Willcox BE, Mohammed F, Bicknell R
Oncogene36(44)6097-6108(2017 Nov)

Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells.
Hasanov Z, Ruckdeschel T, K?nig C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG
Arteriosclerosis, thrombosis, and vascular biology37(3)495-505(2017 Mar)

Persistent stromal fibroblast activation is present in chronic tendinopathy.
Dakin SG, Buckley CD, Al-Mossawi MH, Hedley R, Martinez FO, Wheway K, Watkins B, Carr AJ
Arthritis research & therapy19(1)16(2017 Jan)

Endosialin-Expressing Pericytes Promote Metastatic Dissemination.
Viski C, K?nig C, Kijewska M, Mogler C, Isacke CM, Augustin HG
Cancer research76(18)5313-25(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation
Title: Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.

Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis.
Title: Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells.

Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells.
Title: Persistent stromal fibroblast activation is present in chronic tendinopathy.

the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer
Title: Endosialin-Expressing Pericytes Promote Metastatic Dissemination.

Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas.
Title: Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells.

The following CD248 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD248 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29485	NM_020404.3 Latest version!	Homo sapiens CD248 molecule (CD248), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$379.50-$531.30 $759.00
View Old Accession Versions >>
OHu29485	NM_020404.2	Homo sapiens CD248 molecule (CD248), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$379.50-$531.30 $759.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD248 ( NM_020404.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065137.1 Homo sapiens CD248 molecule (CD248), mRNA.

Price & Availability↑

CloneID	OHu29485
Clone ID Related Accession (Same CDS sequence)	NM_020404.2 , NM_020404.3
Accession Version	NM_020404.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	endosialin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ295846.1, BC051340.1 and BQ005949.1. On Mar 12, 2004 this sequence version replaced NM_020404.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AJ295846.1, AF279142.1 [ECO:0000345] ##Evidence-Data-END##

ATGCTGCTGC GCCTGTTGCT GGCCTGGGCG GCCGCAGGGC CCACACTGGG CCAGGACCCC 
TGGGCTGCTG AGCCCCGTGC CGCCTGCGGC CCCAGCAGCT GCTACGCTCT CTTCCCACGG 
CGCCGCACCT TCCTGGAGGC CTGGCGGGCC TGCCGCGAGC TGGGGGGCGA CCTGGCCACT 
CCTCGGACCC CCGAGGAGGC CCAGCGTGTG GACAGCCTGG TGGGTGCGGG CCCAGCCAGC 
CGGCTGCTGT GGATCGGGCT GCAGCGGCAG GCCCGGCAAT GCCAGCTGCA GCGCCCACTG 
CGCGGCTTCA CGTGGACCAC AGGGGACCAG GACACGGCTT TCACCAACTG GGCCCAGCCA 
GCCTCTGGAG GCCCCTGCCC GGCCCAGCGC TGTGTGGCCC TGGAGGCAAG TGGCGAGCAC 
CGCTGGCTGG AGGGCTCGTG CACGCTGGCT GTCGACGGCT ACCTGTGCCA GTTTGGCTTC 
GAGGGCGCCT GCCCGGCGCT GCAAGATGAG GCGGGCCAGG CCGGCCCAGC CGTGTATACC 
ACGCCCTTCC ACCTGGTCTC CACAGAGTTT GAGTGGCTGC CCTTCGGCTC TGTGGCCGCT 
GTGCAGTGCC AGGCTGGCAG GGGAGCCTCT CTGCTCTGCG TGAAGCAGCC TGAGGGAGGT 
GTGGGCTGGT CACGGGCTGG GCCCCTGTGC CTGGGGACTG GCTGCAGCCC TGACAACGGG 
GGCTGCGAAC ACGAATGTGT GGAGGAGGTG GATGGTCACG TGTCCTGCCG CTGCACTGAG 
GGCTTCCGGC TGGCAGCAGA CGGGCGCAGT TGCGAGGACC CCTGTGCCCA GGCTCCGTGC 
GAGCAGCAGT GTGAGCCCGG TGGGCCACAA GGCTACAGCT GCCACTGTCG CCTGGGTTTC 
CGGCCAGCGG AGGATGATCC GCACCGCTGT GTGGACACAG ATGAGTGCCA GATTGCCGGT 
GTGTGCCAGC AGATGTGTGT CAACTACGTT GGTGGCTTCG AGTGTTATTG TAGCGAGGGA 
CATGAGCTGG AGGCTGATGG CATCAGCTGC AGCCCTGCAG GGGCCATGGG TGCCCAGGCT 
TCCCAGGACC TCGGAGATGA GTTGCTGGAT GACGGGGAGG ATGAGGAAGA TGAAGACGAG 
GCCTGGAAGG CCTTCAACGG TGGCTGGACG GAGATGCCTG GGATCCTGTG GATGGAGCCT 
ACGCAGCCGC CTGACTTTGC CCTGGCCTAT AGACCGAGCT TCCCAGAGGA CAGAGAGCCA 
CAGATACCCT ACCCGGAGCC CACCTGGCCA CCCCCGCTCA GTGCCCCCAG GGTCCCCTAC 
CACTCCTCAG TGCTCTCCGT CACCCGGCCT GTGGTGGTCT CTGCCACGCA TCCCACACTG 
CCTTCTGCCC ACCAGCCTCC TGTGATCCCT GCCACACACC CAGCTTTGTC CCGTGACCAC 
CAGATCCCCG TGATCGCAGC CAACTATCCA GATCTGCCTT CTGCCTACCA ACCCGGTATT 
CTCTCTGTCT CTCATTCAGC ACAGCCTCCT GCCCACCAGC CCCCTATGAT CTCAACCAAA 
TATCCGGAGC TCTTCCCTGC CCACCAGTCC CCCATGTTTC CAGACACCCG GGTCGCTGGC 
ACCCAGACCA CCACTCATTT GCCTGGAATC CCACCTAACC ATGCCCCTCT GGTCACCACC 
CTCGGTGCCC AGCTACCCCC TCAAGCCCCA GATGCCCTTG TCCTCAGAAC CCAGGCCACC 
CAGCTTCCCA TTATCCCAAC TGCCCAGCCC TCTCTGACCA CCACCTCCAG GTCCCCTGTG 
TCTCCTGCCC ATCAAATCTC TGTGCCTGCT GCCACCCAGC CCGCAGCCCT CCCCACCCTC 
CTGCCCTCTC AGAGCCCCAC TAACCAGACC TCACCCATCA GCCCTACACA TCCCCATTCC 
AAAGCCCCCC AAATCCCAAG GGAAGATGGC CCCAGTCCCA AGTTGGCCCT GTGGCTGCCC 
TCACCAGCTC CCACAGCAGC CCCAACAGCC CTGGGGGAGG CTGGTCTTGC CGAGCACAGC 
CAGAGGGATG ACCGGTGGCT GCTGGTGGCA CTCCTGGTGC CAACGTGTGT CTTTTTGGTG 
GTCCTGCTTG CACTGGGCAT CGTGTACTGC ACCCGCTGTG GCCCCCATGC ACCCAACAAG 
CGCATCACTG ACTGCTATCG CTGGGTCATC CATGCTGGGA GCAAGAGCCC AACAGAACCC 
ATGCCCCCCA GGGGCAGCCT CACAGGGGTG CAGACCTGCA GAACCAGCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065137.1
CDS	18..2291
Translation	MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

Target ORF information:

RefSeq Version	NM_020404.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD248 molecule (CD248), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020404.2

ORF Insert Sequence:

ATGCTGCTGC GCCTGTTGCT GGCCTGGGCG GCCGCAGGGC CCACACTGGG CCAGGACCCC 
TGGGCTGCTG AGCCCCGTGC CGCCTGCGGC CCCAGCAGCT GCTACGCTCT CTTCCCACGG 
CGCCGCACCT TCCTGGAGGC CTGGCGGGCC TGCCGCGAGC TGGGGGGCGA CCTGGCCACT 
CCTCGGACCC CCGAGGAGGC CCAGCGTGTG GACAGCCTGG TGGGTGCGGG CCCAGCCAGC 
CGGCTGCTGT GGATCGGGCT GCAGCGGCAG GCCCGGCAAT GCCAGCTGCA GCGCCCACTG 
CGCGGCTTCA CGTGGACCAC AGGGGACCAG GACACGGCTT TCACCAACTG GGCCCAGCCA 
GCCTCTGGAG GCCCCTGCCC GGCCCAGCGC TGTGTGGCCC TGGAGGCAAG TGGCGAGCAC 
CGCTGGCTGG AGGGCTCGTG CACGCTGGCT GTCGACGGCT ACCTGTGCCA GTTTGGCTTC 
GAGGGCGCCT GCCCGGCGCT GCAAGATGAG GCGGGCCAGG CCGGCCCAGC CGTGTATACC 
ACGCCCTTCC ACCTGGTCTC CACAGAGTTT GAGTGGCTGC CCTTCGGCTC TGTGGCCGCT 
GTGCAGTGCC AGGCTGGCAG GGGAGCCTCT CTGCTCTGCG TGAAGCAGCC TGAGGGAGGT 
GTGGGCTGGT CACGGGCTGG GCCCCTGTGC CTGGGGACTG GCTGCAGCCC TGACAACGGG 
GGCTGCGAAC ACGAATGTGT GGAGGAGGTG GATGGTCACG TGTCCTGCCG CTGCACTGAG 
GGCTTCCGGC TGGCAGCAGA CGGGCGCAGT TGCGAGGACC CCTGTGCCCA GGCTCCGTGC 
GAGCAGCAGT GTGAGCCCGG TGGGCCACAA GGCTACAGCT GCCACTGTCG CCTGGGTTTC 
CGGCCAGCGG AGGATGATCC GCACCGCTGT GTGGACACAG ATGAGTGCCA GATTGCCGGT 
GTGTGCCAGC AGATGTGTGT CAACTACGTT GGTGGCTTCG AGTGTTATTG TAGCGAGGGA 
CATGAGCTGG AGGCTGATGG CATCAGCTGC AGCCCTGCAG GGGCCATGGG TGCCCAGGCT 
TCCCAGGACC TCGGAGATGA GTTGCTGGAT GACGGGGAGG ATGAGGAAGA TGAAGACGAG 
GCCTGGAAGG CCTTCAACGG TGGCTGGACG GAGATGCCTG GGATCCTGTG GATGGAGCCT 
ACGCAGCCGC CTGACTTTGC CCTGGCCTAT AGACCGAGCT TCCCAGAGGA CAGAGAGCCA 
CAGATACCCT ACCCGGAGCC CACCTGGCCA CCCCCGCTCA GTGCCCCCAG GGTCCCCTAC 
CACTCCTCAG TGCTCTCCGT CACCCGGCCT GTGGTGGTCT CTGCCACGCA TCCCACACTG 
CCTTCTGCCC ACCAGCCTCC TGTGATCCCT GCCACACACC CAGCTTTGTC CCGTGACCAC 
CAGATCCCCG TGATCGCAGC CAACTATCCA GATCTGCCTT CTGCCTACCA ACCCGGTATT 
CTCTCTGTCT CTCATTCAGC ACAGCCTCCT GCCCACCAGC CCCCTATGAT CTCAACCAAA 
TATCCGGAGC TCTTCCCTGC CCACCAGTCC CCCATGTTTC CAGACACCCG GGTCGCTGGC 
ACCCAGACCA CCACTCATTT GCCTGGAATC CCACCTAACC ATGCCCCTCT GGTCACCACC 
CTCGGTGCCC AGCTACCCCC TCAAGCCCCA GATGCCCTTG TCCTCAGAAC CCAGGCCACC 
CAGCTTCCCA TTATCCCAAC TGCCCAGCCC TCTCTGACCA CCACCTCCAG GTCCCCTGTG 
TCTCCTGCCC ATCAAATCTC TGTGCCTGCT GCCACCCAGC CCGCAGCCCT CCCCACCCTC 
CTGCCCTCTC AGAGCCCCAC TAACCAGACC TCACCCATCA GCCCTACACA TCCCCATTCC 
AAAGCCCCCC AAATCCCAAG GGAAGATGGC CCCAGTCCCA AGTTGGCCCT GTGGCTGCCC 
TCACCAGCTC CCACAGCAGC CCCAACAGCC CTGGGGGAGG CTGGTCTTGC CGAGCACAGC 
CAGAGGGATG ACCGGTGGCT GCTGGTGGCA CTCCTGGTGC CAACGTGTGT CTTTTTGGTG 
GTCCTGCTTG CACTGGGCAT CGTGTACTGC ACCCGCTGTG GCCCCCATGC ACCCAACAAG 
CGCATCACTG ACTGCTATCG CTGGGTCATC CATGCTGGGA GCAAGAGCCC AACAGAACCC 
ATGCCCCCCA GGGGCAGCCT CACAGGGGTG CAGACCTGCA GAACCAGCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD248 ( NM_020404.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065137.1 Homo sapiens CD248 molecule (CD248), mRNA.

Price & Availability↑

CloneID	OHu29485
Clone ID Related Accession (Same CDS sequence)	NM_020404.2 , NM_020404.3
Accession Version	NM_020404.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	endosialin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ295846.1 and BC051340.1. On Nov 23, 2018 this sequence version replaced NM_020404.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AJ295846.1, BC051340.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311330.4/ ENSP00000308117.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTGC GCCTGTTGCT GGCCTGGGCG GCCGCAGGGC CCACACTGGG CCAGGACCCC 
TGGGCTGCTG AGCCCCGTGC CGCCTGCGGC CCCAGCAGCT GCTACGCTCT CTTCCCACGG 
CGCCGCACCT TCCTGGAGGC CTGGCGGGCC TGCCGCGAGC TGGGGGGCGA CCTGGCCACT 
CCTCGGACCC CCGAGGAGGC CCAGCGTGTG GACAGCCTGG TGGGTGCGGG CCCAGCCAGC 
CGGCTGCTGT GGATCGGGCT GCAGCGGCAG GCCCGGCAAT GCCAGCTGCA GCGCCCACTG 
CGCGGCTTCA CGTGGACCAC AGGGGACCAG GACACGGCTT TCACCAACTG GGCCCAGCCA 
GCCTCTGGAG GCCCCTGCCC GGCCCAGCGC TGTGTGGCCC TGGAGGCAAG TGGCGAGCAC 
CGCTGGCTGG AGGGCTCGTG CACGCTGGCT GTCGACGGCT ACCTGTGCCA GTTTGGCTTC 
GAGGGCGCCT GCCCGGCGCT GCAAGATGAG GCGGGCCAGG CCGGCCCAGC CGTGTATACC 
ACGCCCTTCC ACCTGGTCTC CACAGAGTTT GAGTGGCTGC CCTTCGGCTC TGTGGCCGCT 
GTGCAGTGCC AGGCTGGCAG GGGAGCCTCT CTGCTCTGCG TGAAGCAGCC TGAGGGAGGT 
GTGGGCTGGT CACGGGCTGG GCCCCTGTGC CTGGGGACTG GCTGCAGCCC TGACAACGGG 
GGCTGCGAAC ACGAATGTGT GGAGGAGGTG GATGGTCACG TGTCCTGCCG CTGCACTGAG 
GGCTTCCGGC TGGCAGCAGA CGGGCGCAGT TGCGAGGACC CCTGTGCCCA GGCTCCGTGC 
GAGCAGCAGT GTGAGCCCGG TGGGCCACAA GGCTACAGCT GCCACTGTCG CCTGGGTTTC 
CGGCCAGCGG AGGATGATCC GCACCGCTGT GTGGACACAG ATGAGTGCCA GATTGCCGGT 
GTGTGCCAGC AGATGTGTGT CAACTACGTT GGTGGCTTCG AGTGTTATTG TAGCGAGGGA 
CATGAGCTGG AGGCTGATGG CATCAGCTGC AGCCCTGCAG GGGCCATGGG TGCCCAGGCT 
TCCCAGGACC TCGGAGATGA GTTGCTGGAT GACGGGGAGG ATGAGGAAGA TGAAGACGAG 
GCCTGGAAGG CCTTCAACGG TGGCTGGACG GAGATGCCTG GGATCCTGTG GATGGAGCCT 
ACGCAGCCGC CTGACTTTGC CCTGGCCTAT AGACCGAGCT TCCCAGAGGA CAGAGAGCCA 
CAGATACCCT ACCCGGAGCC CACCTGGCCA CCCCCGCTCA GTGCCCCCAG GGTCCCCTAC 
CACTCCTCAG TGCTCTCCGT CACCCGGCCT GTGGTGGTCT CTGCCACGCA TCCCACACTG 
CCTTCTGCCC ACCAGCCTCC TGTGATCCCT GCCACACACC CAGCTTTGTC CCGTGACCAC 
CAGATCCCCG TGATCGCAGC CAACTATCCA GATCTGCCTT CTGCCTACCA ACCCGGTATT 
CTCTCTGTCT CTCATTCAGC ACAGCCTCCT GCCCACCAGC CCCCTATGAT CTCAACCAAA 
TATCCGGAGC TCTTCCCTGC CCACCAGTCC CCCATGTTTC CAGACACCCG GGTCGCTGGC 
ACCCAGACCA CCACTCATTT GCCTGGAATC CCACCTAACC ATGCCCCTCT GGTCACCACC 
CTCGGTGCCC AGCTACCCCC TCAAGCCCCA GATGCCCTTG TCCTCAGAAC CCAGGCCACC 
CAGCTTCCCA TTATCCCAAC TGCCCAGCCC TCTCTGACCA CCACCTCCAG GTCCCCTGTG 
TCTCCTGCCC ATCAAATCTC TGTGCCTGCT GCCACCCAGC CCGCAGCCCT CCCCACCCTC 
CTGCCCTCTC AGAGCCCCAC TAACCAGACC TCACCCATCA GCCCTACACA TCCCCATTCC 
AAAGCCCCCC AAATCCCAAG GGAAGATGGC CCCAGTCCCA AGTTGGCCCT GTGGCTGCCC 
TCACCAGCTC CCACAGCAGC CCCAACAGCC CTGGGGGAGG CTGGTCTTGC CGAGCACAGC 
CAGAGGGATG ACCGGTGGCT GCTGGTGGCA CTCCTGGTGC CAACGTGTGT CTTTTTGGTG 
GTCCTGCTTG CACTGGGCAT CGTGTACTGC ACCCGCTGTG GCCCCCATGC ACCCAACAAG 
CGCATCACTG ACTGCTATCG CTGGGTCATC CATGCTGGGA GCAAGAGCCC AACAGAACCC 
ATGCCCCCCA GGGGCAGCCT CACAGGGGTG CAGACCTGCA GAACCAGCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065137.1
CDS	18..2291
Translation	MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

Target ORF information:

RefSeq Version	NM_020404.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD248 molecule (CD248), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020404.3

ORF Insert Sequence:

ATGCTGCTGC GCCTGTTGCT GGCCTGGGCG GCCGCAGGGC CCACACTGGG CCAGGACCCC 
TGGGCTGCTG AGCCCCGTGC CGCCTGCGGC CCCAGCAGCT GCTACGCTCT CTTCCCACGG 
CGCCGCACCT TCCTGGAGGC CTGGCGGGCC TGCCGCGAGC TGGGGGGCGA CCTGGCCACT 
CCTCGGACCC CCGAGGAGGC CCAGCGTGTG GACAGCCTGG TGGGTGCGGG CCCAGCCAGC 
CGGCTGCTGT GGATCGGGCT GCAGCGGCAG GCCCGGCAAT GCCAGCTGCA GCGCCCACTG 
CGCGGCTTCA CGTGGACCAC AGGGGACCAG GACACGGCTT TCACCAACTG GGCCCAGCCA 
GCCTCTGGAG GCCCCTGCCC GGCCCAGCGC TGTGTGGCCC TGGAGGCAAG TGGCGAGCAC 
CGCTGGCTGG AGGGCTCGTG CACGCTGGCT GTCGACGGCT ACCTGTGCCA GTTTGGCTTC 
GAGGGCGCCT GCCCGGCGCT GCAAGATGAG GCGGGCCAGG CCGGCCCAGC CGTGTATACC 
ACGCCCTTCC ACCTGGTCTC CACAGAGTTT GAGTGGCTGC CCTTCGGCTC TGTGGCCGCT 
GTGCAGTGCC AGGCTGGCAG GGGAGCCTCT CTGCTCTGCG TGAAGCAGCC TGAGGGAGGT 
GTGGGCTGGT CACGGGCTGG GCCCCTGTGC CTGGGGACTG GCTGCAGCCC TGACAACGGG 
GGCTGCGAAC ACGAATGTGT GGAGGAGGTG GATGGTCACG TGTCCTGCCG CTGCACTGAG 
GGCTTCCGGC TGGCAGCAGA CGGGCGCAGT TGCGAGGACC CCTGTGCCCA GGCTCCGTGC 
GAGCAGCAGT GTGAGCCCGG TGGGCCACAA GGCTACAGCT GCCACTGTCG CCTGGGTTTC 
CGGCCAGCGG AGGATGATCC GCACCGCTGT GTGGACACAG ATGAGTGCCA GATTGCCGGT 
GTGTGCCAGC AGATGTGTGT CAACTACGTT GGTGGCTTCG AGTGTTATTG TAGCGAGGGA 
CATGAGCTGG AGGCTGATGG CATCAGCTGC AGCCCTGCAG GGGCCATGGG TGCCCAGGCT 
TCCCAGGACC TCGGAGATGA GTTGCTGGAT GACGGGGAGG ATGAGGAAGA TGAAGACGAG 
GCCTGGAAGG CCTTCAACGG TGGCTGGACG GAGATGCCTG GGATCCTGTG GATGGAGCCT 
ACGCAGCCGC CTGACTTTGC CCTGGCCTAT AGACCGAGCT TCCCAGAGGA CAGAGAGCCA 
CAGATACCCT ACCCGGAGCC CACCTGGCCA CCCCCGCTCA GTGCCCCCAG GGTCCCCTAC 
CACTCCTCAG TGCTCTCCGT CACCCGGCCT GTGGTGGTCT CTGCCACGCA TCCCACACTG 
CCTTCTGCCC ACCAGCCTCC TGTGATCCCT GCCACACACC CAGCTTTGTC CCGTGACCAC 
CAGATCCCCG TGATCGCAGC CAACTATCCA GATCTGCCTT CTGCCTACCA ACCCGGTATT 
CTCTCTGTCT CTCATTCAGC ACAGCCTCCT GCCCACCAGC CCCCTATGAT CTCAACCAAA 
TATCCGGAGC TCTTCCCTGC CCACCAGTCC CCCATGTTTC CAGACACCCG GGTCGCTGGC 
ACCCAGACCA CCACTCATTT GCCTGGAATC CCACCTAACC ATGCCCCTCT GGTCACCACC 
CTCGGTGCCC AGCTACCCCC TCAAGCCCCA GATGCCCTTG TCCTCAGAAC CCAGGCCACC 
CAGCTTCCCA TTATCCCAAC TGCCCAGCCC TCTCTGACCA CCACCTCCAG GTCCCCTGTG 
TCTCCTGCCC ATCAAATCTC TGTGCCTGCT GCCACCCAGC CCGCAGCCCT CCCCACCCTC 
CTGCCCTCTC AGAGCCCCAC TAACCAGACC TCACCCATCA GCCCTACACA TCCCCATTCC 
AAAGCCCCCC AAATCCCAAG GGAAGATGGC CCCAGTCCCA AGTTGGCCCT GTGGCTGCCC 
TCACCAGCTC CCACAGCAGC CCCAACAGCC CTGGGGGAGG CTGGTCTTGC CGAGCACAGC 
CAGAGGGATG ACCGGTGGCT GCTGGTGGCA CTCCTGGTGC CAACGTGTGT CTTTTTGGTG 
GTCCTGCTTG CACTGGGCAT CGTGTACTGC ACCCGCTGTG GCCCCCATGC ACCCAACAAG 
CGCATCACTG ACTGCTATCG CTGGGTCATC CATGCTGGGA GCAAGAGCCC AACAGAACCC 
ATGCCCCCCA GGGGCAGCCT CACAGGGGTG CAGACCTGCA GAACCAGCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Oncogene36(44)6097-6108(2017 Nov)
Khan KA,Naylor AJ,Khan A,Noy PJ,Mambretti M,Lodhia P,Athwal J,Korzystka A,Buckley CD,Willcox BE,Mohammed F,Bicknell R

Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells.
Arteriosclerosis, thrombosis, and vascular biology37(3)495-505(2017 Mar)
Hasanov Z,Ruckdeschel T,K?nig C,Mogler C,Kapel SS,Korn C,Spegg C,Eichwald V,Wieland M,Appak S,Augustin HG

Persistent stromal fibroblast activation is present in chronic tendinopathy.
Arthritis research & therapy19(1)16(2017 Jan)
Dakin SG,Buckley CD,Al-Mossawi MH,Hedley R,Martinez FO,Wheway K,Watkins B,Carr AJ

Endosialin-Expressing Pericytes Promote Metastatic Dissemination.
Cancer research76(18)5313-25(2016 Sep)
Viski C,K?nig C,Kijewska M,Mogler C,Isacke CM,Augustin HG

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CD248 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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