AVEN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AVEN
Entrez Gene ID	57099
Full Name	apoptosis and caspase activation inhibitor
Synonyms	PDCD12
General protein information	Preferred Names apoptosis and caspase activation inhibitor Names cell death regulator Aven apoptosis, caspase activation inhibitor programmed cell death 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q14
Disorder MIM:	605265

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521818.2	XP_011520120.1	cell death regulator Aven isoform X1
XM_011521820.1	XP_011520122.1	cell death regulator Aven isoform X3
NM_020371.2	NP_065104.1	cell death regulator Aven
XM_024449999.1	XP_024305767.1	cell death regulator Aven isoform X2
NM_020371.3	NP_065104.1	cell death regulator Aven
XM_011521819.2	XP_011520121.1	cell death regulator Aven isoform X2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	AVEN	NP_001005791.1
Homo sapiens (human)	AVEN	NP_065104.1
Bos taurus (cattle)	AVEN	XP_002690827.3
Mus musculus (house mouse)	Aven	NP_083120.2
Rattus norvegicus (Norway rat)	Aven	NP_001101227.1
Pan troglodytes (chimpanzee)	AVEN	XP_510277.3
	AVEN	XP_001085261.1
Canis lupus familiaris (dog)	AVEN	XP_005638728.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells.
Chakrabarti M, Klionsky DJ, Ray SK
PloS one11(7)e0158537(2016)

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.
Thandapani P, Song J, Gandin V, Cai Y, Rouleau SG, Garant JM, Boisvert FM, Yu Z, Perreault JP, Topisirovic I, Richard S
eLife4(2015 Aug)

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.
Baranski Z, Booij TH, Cleton-Jansen AM, Price LS, van de Water B, Bov?e JV, Hogendoorn PC, Danen EH
The Journal of pathology236(3)348-59(2015 Jul)

Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents.
Han KY, Hwang JW, Bae GU, Kim SN, Kim YK
Molecular medicine reports11(5)3866-71(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells
Title: miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells.

The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.
Title: Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.

The findings implicate Aven in ATR-Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy.
Title: Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.

the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents.
Title: Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents.

Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
Title: Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.

The following AVEN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AVEN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu70281	XM_011521818.2 Latest version!	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70282	XM_024449999.1 Latest version!	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70282	XM_011521819.2 Latest version!	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70283	XM_011521820.1 Latest version!	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu03305	NM_020371.3 Latest version!	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu03305	NM_020371.2	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AVEN ( XM_011521818.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520120.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu70281
Clone ID Related Accession (Same CDS sequence)	XM_011521818.2
Accession Version	XM_011521818.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cell death regulator Aven isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521818.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATGGA CCCACATCCT TAGCTCAATG GAGAGCTCTA GCACCCTGTA TCCAAGTGAT 
CACTTCATAA AGGTTGAAGA TGACAGCGAT GCAGAGACCT ATGGAGAAGA GAATGATGAA 
CAGGGAAATT ATTCTAAAAG AAAGATTGTC TCTAACTGGG ATCGATATCA AGATATTGAA 
AAAGAGGTCA ATAATGAAAG TGGAGAGTCA CAGAGGGGAA CAGATTTCAG TGTCCTCCTT 
AGCTCTGCAG GGGACTCATT CTCACAGTTC CGGTTTGCTG AGGAGAAAGA ATGGGATAGT 
GAAGCTTCTT GTCCAAAACA GAATTCAGCA TTTTATGTGG ATAGTGAGTT ATTGGTTCGA 
GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA CTCAACGTTG CTGCCGAACT GGTCCAGGGT 
ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA CCAAAGAGAA CTGATGATGG CAAGGGATTA 
GGGATGCAGT TAAAGGGGCC CTTGGGGCCT GGAGGAAGGG GGCCCATCTT TGAGCTGAAA 
TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG GGCAAAGACA ACCCAAGCCC GGGTCCTTCA 
AGGGATTCTC AGAAACCCAC TTCCCCACTG CAGTCAGCAG GAGACCATTT GGAAGAAGAA 
CTAGATCTGT TGCTTAATTT AGATGCACCT ATAAAAGAGG GAGATAACAT CTTACCAGAT 
CAGACGTCTC AGGACCTGAA ATCCAAGGAA GATGGGGAGG TGGTCCAAGA GGAAGAAGTT 
TGTGCAAAAC CATCTGTGAC TGAAGAAAAA AACATGGAAC CTGAGCAACC AAGTACCTCC 
AAAAATGTTA CCGAGGAAGA GCTGGAAGAC TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520120.1
CDS	435..1328
Translation	MKWTHILSSMESSSTLYPSDHFIKVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	XM_011521818.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521818.2

ORF Insert Sequence:

ATGAAATGGA CCCACATCCT TAGCTCAATG GAGAGCTCTA GCACCCTGTA TCCAAGTGAT 
CACTTCATAA AGGTTGAAGA TGACAGCGAT GCAGAGACCT ATGGAGAAGA GAATGATGAA 
CAGGGAAATT ATTCTAAAAG AAAGATTGTC TCTAACTGGG ATCGATATCA AGATATTGAA 
AAAGAGGTCA ATAATGAAAG TGGAGAGTCA CAGAGGGGAA CAGATTTCAG TGTCCTCCTT 
AGCTCTGCAG GGGACTCATT CTCACAGTTC CGGTTTGCTG AGGAGAAAGA ATGGGATAGT 
GAAGCTTCTT GTCCAAAACA GAATTCAGCA TTTTATGTGG ATAGTGAGTT ATTGGTTCGA 
GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA CTCAACGTTG CTGCCGAACT GGTCCAGGGT 
ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA CCAAAGAGAA CTGATGATGG CAAGGGATTA 
GGGATGCAGT TAAAGGGGCC CTTGGGGCCT GGAGGAAGGG GGCCCATCTT TGAGCTGAAA 
TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG GGCAAAGACA ACCCAAGCCC GGGTCCTTCA 
AGGGATTCTC AGAAACCCAC TTCCCCACTG CAGTCAGCAG GAGACCATTT GGAAGAAGAA 
CTAGATCTGT TGCTTAATTT AGATGCACCT ATAAAAGAGG GAGATAACAT CTTACCAGAT 
CAGACGTCTC AGGACCTGAA ATCCAAGGAA GATGGGGAGG TGGTCCAAGA GGAAGAAGTT 
TGTGCAAAAC CATCTGTGAC TGAAGAAAAA AACATGGAAC CTGAGCAACC AAGTACCTCC 
AAAAATGTTA CCGAGGAAGA GCTGGAAGAC TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AVEN ( XM_024449999.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305767.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu70282
Clone ID Related Accession (Same CDS sequence)	XM_024449999.1 , XM_011521819.2
Accession Version	XM_024449999.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cell death regulator Aven isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGCTCT TCAGTGGTAG GCTGAAGCTC TCCCATACTC AGGTTGAAGA TGACAGCGAT 
GCAGAGACCT ATGGAGAAGA GAATGATGAA CAGGGAAATT ATTCTAAAAG AAAGATTGTC 
TCTAACTGGG ATCGATATCA AGATATTGAA AAAGAGGTCA ATAATGAAAG TGGAGAGTCA 
CAGAGGGGAA CAGATTTCAG TGTCCTCCTT AGCTCTGCAG GGGACTCATT CTCACAGTTC 
CGGTTTGCTG AGGAGAAAGA ATGGGATAGT GAAGCTTCTT GTCCAAAACA GAATTCAGCA 
TTTTATGTGG ATAGTGAGTT ATTGGTTCGA GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA 
CTCAACGTTG CTGCCGAACT GGTCCAGGGT ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA 
CCAAAGAGAA CTGATGATGG CAAGGGATTA GGGATGCAGT TAAAGGGGCC CTTGGGGCCT 
GGAGGAAGGG GGCCCATCTT TGAGCTGAAA TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG 
GGCAAAGACA ACCCAAGCCC GGGTCCTTCA AGGGATTCTC AGAAACCCAC TTCCCCACTG 
CAGTCAGCAG GAGACCATTT GGAAGAAGAA CTAGATCTGT TGCTTAATTT AGATGCACCT 
ATAAAAGAGG GAGATAACAT CTTACCAGAT CAGACGTCTC AGGACCTGAA ATCCAAGGAA 
GATGGGGAGG TGGTCCAAGA GGAAGAAGTT TGTGCAAAAC CATCTGTGAC TGAAGAAAAA 
AACATGGAAC CTGAGCAACC AAGTACCTCC AAAAATGTTA CCGAGGAAGA GCTGGAAGAC 
TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305767.1
CDS	186..1049
Translation	MMLFSGRLKLSHTQVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	XM_024449999.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449999.1

ORF Insert Sequence:

ATGATGCTCT TCAGTGGTAG GCTGAAGCTC TCCCATACTC AGGTTGAAGA TGACAGCGAT 
GCAGAGACCT ATGGAGAAGA GAATGATGAA CAGGGAAATT ATTCTAAAAG AAAGATTGTC 
TCTAACTGGG ATCGATATCA AGATATTGAA AAAGAGGTCA ATAATGAAAG TGGAGAGTCA 
CAGAGGGGAA CAGATTTCAG TGTCCTCCTT AGCTCTGCAG GGGACTCATT CTCACAGTTC 
CGGTTTGCTG AGGAGAAAGA ATGGGATAGT GAAGCTTCTT GTCCAAAACA GAATTCAGCA 
TTTTATGTGG ATAGTGAGTT ATTGGTTCGA GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA 
CTCAACGTTG CTGCCGAACT GGTCCAGGGT ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA 
CCAAAGAGAA CTGATGATGG CAAGGGATTA GGGATGCAGT TAAAGGGGCC CTTGGGGCCT 
GGAGGAAGGG GGCCCATCTT TGAGCTGAAA TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG 
GGCAAAGACA ACCCAAGCCC GGGTCCTTCA AGGGATTCTC AGAAACCCAC TTCCCCACTG 
CAGTCAGCAG GAGACCATTT GGAAGAAGAA CTAGATCTGT TGCTTAATTT AGATGCACCT 
ATAAAAGAGG GAGATAACAT CTTACCAGAT CAGACGTCTC AGGACCTGAA ATCCAAGGAA 
GATGGGGAGG TGGTCCAAGA GGAAGAAGTT TGTGCAAAAC CATCTGTGAC TGAAGAAAAA 
AACATGGAAC CTGAGCAACC AAGTACCTCC AAAAATGTTA CCGAGGAAGA GCTGGAAGAC 
TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AVEN ( XM_011521819.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520121.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu70282
Clone ID Related Accession (Same CDS sequence)	XM_024449999.1 , XM_011521819.2
Accession Version	XM_011521819.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cell death regulator Aven isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521819.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGCTCT TCAGTGGTAG GCTGAAGCTC TCCCATACTC AGGTTGAAGA TGACAGCGAT 
GCAGAGACCT ATGGAGAAGA GAATGATGAA CAGGGAAATT ATTCTAAAAG AAAGATTGTC 
TCTAACTGGG ATCGATATCA AGATATTGAA AAAGAGGTCA ATAATGAAAG TGGAGAGTCA 
CAGAGGGGAA CAGATTTCAG TGTCCTCCTT AGCTCTGCAG GGGACTCATT CTCACAGTTC 
CGGTTTGCTG AGGAGAAAGA ATGGGATAGT GAAGCTTCTT GTCCAAAACA GAATTCAGCA 
TTTTATGTGG ATAGTGAGTT ATTGGTTCGA GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA 
CTCAACGTTG CTGCCGAACT GGTCCAGGGT ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA 
CCAAAGAGAA CTGATGATGG CAAGGGATTA GGGATGCAGT TAAAGGGGCC CTTGGGGCCT 
GGAGGAAGGG GGCCCATCTT TGAGCTGAAA TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG 
GGCAAAGACA ACCCAAGCCC GGGTCCTTCA AGGGATTCTC AGAAACCCAC TTCCCCACTG 
CAGTCAGCAG GAGACCATTT GGAAGAAGAA CTAGATCTGT TGCTTAATTT AGATGCACCT 
ATAAAAGAGG GAGATAACAT CTTACCAGAT CAGACGTCTC AGGACCTGAA ATCCAAGGAA 
GATGGGGAGG TGGTCCAAGA GGAAGAAGTT TGTGCAAAAC CATCTGTGAC TGAAGAAAAA 
AACATGGAAC CTGAGCAACC AAGTACCTCC AAAAATGTTA CCGAGGAAGA GCTGGAAGAC 
TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520121.1
CDS	508..1371
Translation	MMLFSGRLKLSHTQVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	XM_011521819.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521819.2

ORF Insert Sequence:

ATGATGCTCT TCAGTGGTAG GCTGAAGCTC TCCCATACTC AGGTTGAAGA TGACAGCGAT 
GCAGAGACCT ATGGAGAAGA GAATGATGAA CAGGGAAATT ATTCTAAAAG AAAGATTGTC 
TCTAACTGGG ATCGATATCA AGATATTGAA AAAGAGGTCA ATAATGAAAG TGGAGAGTCA 
CAGAGGGGAA CAGATTTCAG TGTCCTCCTT AGCTCTGCAG GGGACTCATT CTCACAGTTC 
CGGTTTGCTG AGGAGAAAGA ATGGGATAGT GAAGCTTCTT GTCCAAAACA GAATTCAGCA 
TTTTATGTGG ATAGTGAGTT ATTGGTTCGA GCCCTTCAAG AGCTGCCTCT CTGCCTCCGA 
CTCAACGTTG CTGCCGAACT GGTCCAGGGT ACAGTTCCTT TAGAGGTTCC TCAGGTGAAA 
CCAAAGAGAA CTGATGATGG CAAGGGATTA GGGATGCAGT TAAAGGGGCC CTTGGGGCCT 
GGAGGAAGGG GGCCCATCTT TGAGCTGAAA TCTGTGGCTG CTGGCTGCCC TGTGTTGCTG 
GGCAAAGACA ACCCAAGCCC GGGTCCTTCA AGGGATTCTC AGAAACCCAC TTCCCCACTG 
CAGTCAGCAG GAGACCATTT GGAAGAAGAA CTAGATCTGT TGCTTAATTT AGATGCACCT 
ATAAAAGAGG GAGATAACAT CTTACCAGAT CAGACGTCTC AGGACCTGAA ATCCAAGGAA 
GATGGGGAGG TGGTCCAAGA GGAAGAAGTT TGTGCAAAAC CATCTGTGAC TGAAGAAAAA 
AACATGGAAC CTGAGCAACC AAGTACCTCC AAAAATGTTA CCGAGGAAGA GCTGGAAGAC 
TGGTTGGACA GCATGATTTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AVEN ( XM_011521820.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520122.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X7, mRNA.

Price & Availability↑

CloneID	OHu70283
Clone ID Related Accession (Same CDS sequence)	XM_011521820.1
Accession Version	XM_011521820.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cell death regulator Aven isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAGGGG TTGAAGATGA CAGCGATGCA GAGACCTATG GAGAAGAGAA TGATGAACAG 
GGAAATTATT CTAAAAGAAA GATTGTCTCT AACTGGGATC GATATCAAGA TATTGAAAAA 
GAGGTCAATA ATGAAAGTGG AGAGTCACAG AGGGGAACAG ATTTCAGTGT CCTCCTTAGC 
TCTGCAGGGG ACTCATTCTC ACAGTTCCGG TTTGCTGAGG AGAAAGAATG GGATAGTGAA 
GCTTCTTGTC CAAAACAGAA TTCAGCATTT TATGTGGATA GTGAGTTATT GGTTCGAGCC 
CTTCAAGAGC TGCCTCTCTG CCTCCGACTC AACGTTGCTG CCGAACTGGT CCAGGGTACA 
GTTCCTTTAG AGGTTCCTCA GGTGAAACCA AAGAGAACTG ATGATGGCAA GGGATTAGGG 
ATGCAGTTAA AGGGGCCCTT GGGGCCTGGA GGAAGGGGGC CCATCTTTGA GCTGAAATCT 
GTGGCTGCTG GCTGCCCTGT GTTGCTGGGC AAAGACAACC CAAGCCCGGG TCCTTCAAGG 
GATTCTCAGA AACCCACTTC CCCACTGCAG TCAGCAGGAG ACCATTTGGA AGAAGAACTA 
GATCTGTTGC TTAATTTAGA TGCACCTATA AAAGAGGGAG ATAACATCTT ACCAGATCAG 
ACGTCTCAGG ACCTGAAATC CAAGGAAGAT GGGGAGGTGG TCCAAGAGGA AGAAGTTTGT 
GCAAAACCAT CTGTGACTGA AGAAAAAAAC ATGGAACCTG AGCAACCAAG TACCTCCAAA 
AATGTTACCG AGGAAGAGCT GGAAGACTGG TTGGACAGCA TGATTTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520122.1
CDS	16..846
Translation	MRGVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	XM_011521820.1
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), transcript variant X7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521820.1

ORF Insert Sequence:

ATGAGAGGGG TTGAAGATGA CAGCGATGCA GAGACCTATG GAGAAGAGAA TGATGAACAG 
GGAAATTATT CTAAAAGAAA GATTGTCTCT AACTGGGATC GATATCAAGA TATTGAAAAA 
GAGGTCAATA ATGAAAGTGG AGAGTCACAG AGGGGAACAG ATTTCAGTGT CCTCCTTAGC 
TCTGCAGGGG ACTCATTCTC ACAGTTCCGG TTTGCTGAGG AGAAAGAATG GGATAGTGAA 
GCTTCTTGTC CAAAACAGAA TTCAGCATTT TATGTGGATA GTGAGTTATT GGTTCGAGCC 
CTTCAAGAGC TGCCTCTCTG CCTCCGACTC AACGTTGCTG CCGAACTGGT CCAGGGTACA 
GTTCCTTTAG AGGTTCCTCA GGTGAAACCA AAGAGAACTG ATGATGGCAA GGGATTAGGG 
ATGCAGTTAA AGGGGCCCTT GGGGCCTGGA GGAAGGGGGC CCATCTTTGA GCTGAAATCT 
GTGGCTGCTG GCTGCCCTGT GTTGCTGGGC AAAGACAACC CAAGCCCGGG TCCTTCAAGG 
GATTCTCAGA AACCCACTTC CCCACTGCAG TCAGCAGGAG ACCATTTGGA AGAAGAACTA 
GATCTGTTGC TTAATTTAGA TGCACCTATA AAAGAGGGAG ATAACATCTT ACCAGATCAG 
ACGTCTCAGG ACCTGAAATC CAAGGAAGAT GGGGAGGTGG TCCAAGAGGA AGAAGTTTGT 
GCAAAACCAT CTGTGACTGA AGAAAAAAAC ATGGAACCTG AGCAACCAAG TACCTCCAAA 
AATGTTACCG AGGAAGAGCT GGAAGACTGG TTGGACAGCA TGATTTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AVEN ( NM_020371.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065104.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.

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CloneID	OHu03305
Clone ID Related Accession (Same CDS sequence)	NM_020371.2 , NM_020371.3
Accession Version	NM_020371.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cell death regulator Aven
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU855198.1, BC010488.1 and BC063533.1. On Dec 17, 2004 this sequence version replaced NM_020371.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF283508.1, BC010488.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGCAGGCGG AGCGAGGAGC TCGGGGAGGC CGTGGGCGGC GGCCAGGCCG CGGCCGGCCT 
GGCGGAGATC GCCACAGCGA GCGGCCCGGA GCCGCAGCGG CGGTAGCCAG AGGCGGCGGC 
GGAGGCGGCG GCGGGGACGG AGGCGGACGC CGGGGCCGTG GCCGTGGCCG GGGCTTCCGC 
GGCGCTCGCG GAGGCCGAGG AGGAGGAGGC GCCCCGCGAG GCAGCCGCCG GGAGCCGGGA 
GGCTGGGGCG CAGGGGCCAG CGCGCCGGTT GAAGATGACA GCGATGCAGA GACCTATGGA 
GAAGAGAATG ATGAACAGGG AAATTATTCT AAAAGAAAGA TTGTCTCTAA CTGGGATCGA 
TATCAAGATA TTGAAAAAGA GGTCAATAAT GAAAGTGGAG AGTCACAGAG GGGAACAGAT 
TTCAGTGTCC TCCTTAGCTC TGCAGGGGAC TCATTCTCAC AGTTCCGGTT TGCTGAGGAG 
AAAGAATGGG ATAGTGAAGC TTCTTGTCCA AAACAGAATT CAGCATTTTA TGTGGATAGT 
GAGTTATTGG TTCGAGCCCT TCAAGAGCTG CCTCTCTGCC TCCGACTCAA CGTTGCTGCC 
GAACTGGTCC AGGGTACAGT TCCTTTAGAG GTTCCTCAGG TGAAACCAAA GAGAACTGAT 
GATGGCAAGG GATTAGGGAT GCAGTTAAAG GGGCCCTTGG GGCCTGGAGG AAGGGGGCCC 
ATCTTTGAGC TGAAATCTGT GGCTGCTGGC TGCCCTGTGT TGCTGGGCAA AGACAACCCA 
AGCCCGGGTC CTTCAAGGGA TTCTCAGAAA CCCACTTCCC CACTGCAGTC AGCAGGAGAC 
CATTTGGAAG AAGAACTAGA TCTGTTGCTT AATTTAGATG CACCTATAAA AGAGGGAGAT 
AACATCTTAC CAGATCAGAC GTCTCAGGAC CTGAAATCCA AGGAAGATGG GGAGGTGGTC 
CAAGAGGAAG AAGTTTGTGC AAAACCATCT GTGACTGAAG AAAAAAACAT GGAACCTGAG 
CAACCAAGTA CCTCCAAAAA TGTTACCGAG GAAGAGCTGG AAGACTGGTT GGACAGCATG 
ATTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065104.1
CDS	57..1145
Translation	MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	NM_020371.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020371.2

ORF Insert Sequence:

ATGCAGGCGG AGCGAGGAGC TCGGGGAGGC CGTGGGCGGC GGCCAGGCCG CGGCCGGCCT 
GGCGGAGATC GCCACAGCGA GCGGCCCGGA GCCGCAGCGG CGGTAGCCAG AGGCGGCGGC 
GGAGGCGGCG GCGGGGACGG AGGCGGACGC CGGGGCCGTG GCCGTGGCCG GGGCTTCCGC 
GGCGCTCGCG GAGGCCGAGG AGGAGGAGGC GCCCCGCGAG GCAGCCGCCG GGAGCCGGGA 
GGCTGGGGCG CAGGGGCCAG CGCGCCGGTT GAAGATGACA GCGATGCAGA GACCTATGGA 
GAAGAGAATG ATGAACAGGG AAATTATTCT AAAAGAAAGA TTGTCTCTAA CTGGGATCGA 
TATCAAGATA TTGAAAAAGA GGTCAATAAT GAAAGTGGAG AGTCACAGAG GGGAACAGAT 
TTCAGTGTCC TCCTTAGCTC TGCAGGGGAC TCATTCTCAC AGTTCCGGTT TGCTGAGGAG 
AAAGAATGGG ATAGTGAAGC TTCTTGTCCA AAACAGAATT CAGCATTTTA TGTGGATAGT 
GAGTTATTGG TTCGAGCCCT TCAAGAGCTG CCTCTCTGCC TCCGACTCAA CGTTGCTGCC 
GAACTGGTCC AGGGTACAGT TCCTTTAGAG GTTCCTCAGG TGAAACCAAA GAGAACTGAT 
GATGGCAAGG GATTAGGGAT GCAGTTAAAG GGGCCCTTGG GGCCTGGAGG AAGGGGGCCC 
ATCTTTGAGC TGAAATCTGT GGCTGCTGGC TGCCCTGTGT TGCTGGGCAA AGACAACCCA 
AGCCCGGGTC CTTCAAGGGA TTCTCAGAAA CCCACTTCCC CACTGCAGTC AGCAGGAGAC 
CATTTGGAAG AAGAACTAGA TCTGTTGCTT AATTTAGATG CACCTATAAA AGAGGGAGAT 
AACATCTTAC CAGATCAGAC GTCTCAGGAC CTGAAATCCA AGGAAGATGG GGAGGTGGTC 
CAAGAGGAAG AAGTTTGTGC AAAACCATCT GTGACTGAAG AAAAAAACAT GGAACCTGAG 
CAACCAAGTA CCTCCAAAAA TGTTACCGAG GAAGAGCTGG AAGACTGGTT GGACAGCATG 
ATTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AVEN ( NM_020371.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065104.1 Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.

Price & Availability↑

CloneID	OHu03305
Clone ID Related Accession (Same CDS sequence)	NM_020371.2 , NM_020371.3
Accession Version	NM_020371.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cell death regulator Aven
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069045.11, BU855198.1, BC010488.1 and BC063533.1. On Nov 23, 2018 this sequence version replaced NM_020371.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF283508.1, SRR1163655.595169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467150, SAMN03267750 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306730.8/ ENSP00000306822.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCGG AGCGAGGAGC TCGGGGAGGC CGTGGGCGGC GGCCAGGCCG CGGCCGGCCT 
GGCGGAGATC GCCACAGCGA GCGGCCCGGA GCCGCAGCGG CGGTAGCCAG AGGCGGCGGC 
GGAGGCGGCG GCGGGGACGG AGGCGGACGC CGGGGCCGTG GCCGTGGCCG GGGCTTCCGC 
GGCGCTCGCG GAGGCCGAGG AGGAGGAGGC GCCCCGCGAG GCAGCCGCCG GGAGCCGGGA 
GGCTGGGGCG CAGGGGCCAG CGCGCCGGTT GAAGATGACA GCGATGCAGA GACCTATGGA 
GAAGAGAATG ATGAACAGGG AAATTATTCT AAAAGAAAGA TTGTCTCTAA CTGGGATCGA 
TATCAAGATA TTGAAAAAGA GGTCAATAAT GAAAGTGGAG AGTCACAGAG GGGAACAGAT 
TTCAGTGTCC TCCTTAGCTC TGCAGGGGAC TCATTCTCAC AGTTCCGGTT TGCTGAGGAG 
AAAGAATGGG ATAGTGAAGC TTCTTGTCCA AAACAGAATT CAGCATTTTA TGTGGATAGT 
GAGTTATTGG TTCGAGCCCT TCAAGAGCTG CCTCTCTGCC TCCGACTCAA CGTTGCTGCC 
GAACTGGTCC AGGGTACAGT TCCTTTAGAG GTTCCTCAGG TGAAACCAAA GAGAACTGAT 
GATGGCAAGG GATTAGGGAT GCAGTTAAAG GGGCCCTTGG GGCCTGGAGG AAGGGGGCCC 
ATCTTTGAGC TGAAATCTGT GGCTGCTGGC TGCCCTGTGT TGCTGGGCAA AGACAACCCA 
AGCCCGGGTC CTTCAAGGGA TTCTCAGAAA CCCACTTCCC CACTGCAGTC AGCAGGAGAC 
CATTTGGAAG AAGAACTAGA TCTGTTGCTT AATTTAGATG CACCTATAAA AGAGGGAGAT 
AACATCTTAC CAGATCAGAC GTCTCAGGAC CTGAAATCCA AGGAAGATGG GGAGGTGGTC 
CAAGAGGAAG AAGTTTGTGC AAAACCATCT GTGACTGAAG AAAAAAACAT GGAACCTGAG 
CAACCAAGTA CCTCCAAAAA TGTTACCGAG GAAGAGCTGG AAGACTGGTT GGACAGCATG 
ATTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065104.1
CDS	159..1247
Translation	MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

Target ORF information:

RefSeq Version	NM_020371.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apoptosis and caspase activation inhibitor (AVEN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020371.3

ORF Insert Sequence:

ATGCAGGCGG AGCGAGGAGC TCGGGGAGGC CGTGGGCGGC GGCCAGGCCG CGGCCGGCCT 
GGCGGAGATC GCCACAGCGA GCGGCCCGGA GCCGCAGCGG CGGTAGCCAG AGGCGGCGGC 
GGAGGCGGCG GCGGGGACGG AGGCGGACGC CGGGGCCGTG GCCGTGGCCG GGGCTTCCGC 
GGCGCTCGCG GAGGCCGAGG AGGAGGAGGC GCCCCGCGAG GCAGCCGCCG GGAGCCGGGA 
GGCTGGGGCG CAGGGGCCAG CGCGCCGGTT GAAGATGACA GCGATGCAGA GACCTATGGA 
GAAGAGAATG ATGAACAGGG AAATTATTCT AAAAGAAAGA TTGTCTCTAA CTGGGATCGA 
TATCAAGATA TTGAAAAAGA GGTCAATAAT GAAAGTGGAG AGTCACAGAG GGGAACAGAT 
TTCAGTGTCC TCCTTAGCTC TGCAGGGGAC TCATTCTCAC AGTTCCGGTT TGCTGAGGAG 
AAAGAATGGG ATAGTGAAGC TTCTTGTCCA AAACAGAATT CAGCATTTTA TGTGGATAGT 
GAGTTATTGG TTCGAGCCCT TCAAGAGCTG CCTCTCTGCC TCCGACTCAA CGTTGCTGCC 
GAACTGGTCC AGGGTACAGT TCCTTTAGAG GTTCCTCAGG TGAAACCAAA GAGAACTGAT 
GATGGCAAGG GATTAGGGAT GCAGTTAAAG GGGCCCTTGG GGCCTGGAGG AAGGGGGCCC 
ATCTTTGAGC TGAAATCTGT GGCTGCTGGC TGCCCTGTGT TGCTGGGCAA AGACAACCCA 
AGCCCGGGTC CTTCAAGGGA TTCTCAGAAA CCCACTTCCC CACTGCAGTC AGCAGGAGAC 
CATTTGGAAG AAGAACTAGA TCTGTTGCTT AATTTAGATG CACCTATAAA AGAGGGAGAT 
AACATCTTAC CAGATCAGAC GTCTCAGGAC CTGAAATCCA AGGAAGATGG GGAGGTGGTC 
CAAGAGGAAG AAGTTTGTGC AAAACCATCT GTGACTGAAG AAAAAAACAT GGAACCTGAG 
CAACCAAGTA CCTCCAAAAA TGTTACCGAG GAAGAGCTGG AAGACTGGTT GGACAGCATG 
ATTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells.
PloS one11(7)e0158537(2016)
Chakrabarti M,Klionsky DJ,Ray SK

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.
eLife4(2015 Aug)
Thandapani P,Song J,Gandin V,Cai Y,Rouleau SG,Garant JM,Boisvert FM,Yu Z,Perreault JP,Topisirovic I,Richard S

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.
The Journal of pathology236(3)348-59(2015 Jul)
Baranski Z,Booij TH,Cleton-Jansen AM,Price LS,van de Water B,Bov?e JV,Hogendoorn PC,Danen EH

Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents.
Molecular medicine reports11(5)3866-71(2015 May)
Han KY,Hwang JW,Bae GU,Kim SN,Kim YK

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AVEN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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