TBX20 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBX20
Entrez Gene ID	57057
Full Name	T-box 20
Synonyms	ASD4
General protein information	Preferred Names T-box 20 Names T-box transcription factor TBX20 T-box protein 20
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.2
Summary	This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder MIM:	606061
Disorder Html:	Atrial septal defect 4, 611363 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001166220.1	NP_001159692.1	T-box transcription factor TBX20 isoform 2
XM_017012456.1	XP_016867945.1	T-box transcription factor TBX20 isoform X1
NM_001077653.2	NP_001071121.1	T-box transcription factor TBX20 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TBX20	NP_001071121.1
Pan troglodytes (chimpanzee)	TBX20	XP_522453.3
Gallus gallus (chicken)	TBX20	NP_989475.1
Canis lupus familiaris (dog)	TBX20	XP_539513.4
Bos taurus (cattle)	TBX20	NP_001179166.1
Mus musculus (house mouse)	Tbx20	NP_919239.1
Xenopus tropicalis (tropical clawed frog)	tbx20	NP_001030292.1
	TBX20	XP_001105053.2
Danio rerio (zebrafish)	tbx20	NP_571581.1

Gene Ontology
Bibliography

Related articles in PubMed

Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.
Kennedy L, Kaltenbrun E, Greco TM, Temple B, Herring LE, Cristea IM, Conlon FL
PLoS genetics13(9)e1007011(2017 Sep)

Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway.
Luo Z, Shen Y, Chen W, Ma X, Liu L, Huang X, Yang Z, Sun H
Genetic testing and molecular biomarkers21(7)440-444(2017 Jul)

TBX20 loss-of-function mutation responsible for familial tetralogy of Fallot or sporadic persistent truncus arteriosus.
Huang RT, Wang J, Xue S, Qiu XB, Shi HY, Li RG, Qu XK, Yang XX, Liu H, Li N, Li YJ, Xu YJ, Yang YQ
International journal of medical sciences14(4)323-332(2017)

Tbx20 controls the expression of the KCNH2 gene and of hERG channels.
Caballero R, Utrilla RG, Amor?s I, Matamoros M, P?rez-Hern?ndez M, Tinaquero D, Alfayate S, Nieto-Mar?n P, Guerrero-Serna G, Liu QH, Ramos-Mondrag?n R, Ponce-Balbuena D, Herron T, Campbell KF, Filgueiras-Rama D, Peinado R, L?pez-Send?n JL, Jalife J, Delp?n E, Tamargo J
Proceedings of the National Academy of Sciences of the United States of America114(3)E416-E425(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)
Title: Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.

results showed that the TBX20 gene is not the major gene affecting nonsyndromic congenital heart disease development
Title: Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway.

The current study associated TBX20 haploinefficiency with isolated Dilated cardiomyopathy (DCM), and expanded upon the mutational spectrum of TBX20 associated with DCM and congenital heart disease (CHD), which provides novel insight into the molecular mechanism of DCM and CHD, suggesting potential implications for early personalized treatment of these diseases.
Title: A novel TBX20 loss?of?function mutation contributes to adult?onset dilated cardiomyopathy or congenital atrial septal defect.

Silencing of TBX20 in rat myocardial and human embryonic kidney cells significantly inhibited cell proliferation, induced cell apoptosis and led to G2/M cell cycle arrest.
Title: Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase.

chromatin analysis reveals that endocardial TBX20 has roles in septation
Title: Probing chromatin landscape reveals roles of endocardial TBX20 in septation.

The following TBX20 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBX20 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10999	NM_001166220.1 Latest version!	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu23047	NM_001077653.2 Latest version!	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu97405	XM_017012456.1 Latest version!	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBX20 ( NM_001166220.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159692.1 Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10999
Clone ID Related Accession (Same CDS sequence)	NM_001166220.1
Accession Version	NM_001166220.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX20 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009531.11 and BC120946.1. Transcript Variant: This variant (2) has an alternate 3' end, as compared to variant 1. The resulting isoform (2) is C-terminal truncated, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120946.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760, SAMN03568912 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTTCA CGGCGTCCCC CAAGCCCCAA CTCTCCTCTC GGGCCAACGC CTTCTCCATT 
GCCGCGCTCA TGTCGAGCGG CGGCTCTAAG GAGAAGGAGG CGACGGAGAA CACAATCAAA 
CCCCTGGAGC AATTTGTGGA GAAGTCGTCC TGTGCCCAGC CCCTGGGTGA GCTGACCAGC 
CTGGATGCTC ATGGGGAGTT TGGTGGAGGC AGTGGCAGCA GCCCGTCCTC CTCCTCTCTG 
TGCACTGAGC CACTGATCCC CACCACCCCC ATCATCCCCA GTGAGGAAAT GGCCAAAATT 
GCCTGCAGCC TGGAGACCAA GGAGCTTTGG GACAAATTCC ATGAGCTGGG CACCGAGATG 
ATCATCACCA AGTCGGGCAG GAGGATGTTT CCAACCATCC GGGTGTCCTT TTCGGGGGTG 
GATCCTGAGG CCAAGTACAT AGTCCTGATG GACATCGTCC CTGTGGACAA CAAGAGGTAC 
CGCTACGCCT ACCACCGGTC CTCCTGGCTG GTGGCTGGCA AGGCCGACCC GCCGTTGCCA 
GCCAGGCTCT ATGTGCATCC AGATTCTCCT TTTACCGGTG AGCAACTACT CAAACAGATG 
GTGTCTTTTG AAAAGGTGAA ACTCACCAAC AATGAACTGG ATCAACATGG CCATATAATT 
TTGAACTCAA TGCATAAGTA CCAGCCAAGG GTGCACATCA TTAAGAAGAA AGACCACACA 
GCCTCATTGC TCAACCTGAA GTCTGAAGAA TTTAGAACTT TCATCTTTCC AGAAACAGTT 
TTTACGGCAG TCACTGCCTA CCAGAATCAA CTGATAACGA AGCTGAAAAT AGATAGCAAT 
CCTTTTGCCA AAGGATTCCG GGATTCCTCC AGGCTCACTG ACATTGAGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159692.1
CDS	481..1374
Translation	MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLEQFVEKSSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIER

Target ORF information:

RefSeq Version	NM_001166220.1
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166220.1

ORF Insert Sequence:

ATGGAGTTCA CGGCGTCCCC CAAGCCCCAA CTCTCCTCTC GGGCCAACGC CTTCTCCATT 
GCCGCGCTCA TGTCGAGCGG CGGCTCTAAG GAGAAGGAGG CGACGGAGAA CACAATCAAA 
CCCCTGGAGC AATTTGTGGA GAAGTCGTCC TGTGCCCAGC CCCTGGGTGA GCTGACCAGC 
CTGGATGCTC ATGGGGAGTT TGGTGGAGGC AGTGGCAGCA GCCCGTCCTC CTCCTCTCTG 
TGCACTGAGC CACTGATCCC CACCACCCCC ATCATCCCCA GTGAGGAAAT GGCCAAAATT 
GCCTGCAGCC TGGAGACCAA GGAGCTTTGG GACAAATTCC ATGAGCTGGG CACCGAGATG 
ATCATCACCA AGTCGGGCAG GAGGATGTTT CCAACCATCC GGGTGTCCTT TTCGGGGGTG 
GATCCTGAGG CCAAGTACAT AGTCCTGATG GACATCGTCC CTGTGGACAA CAAGAGGTAC 
CGCTACGCCT ACCACCGGTC CTCCTGGCTG GTGGCTGGCA AGGCCGACCC GCCGTTGCCA 
GCCAGGCTCT ATGTGCATCC AGATTCTCCT TTTACCGGTG AGCAACTACT CAAACAGATG 
GTGTCTTTTG AAAAGGTGAA ACTCACCAAC AATGAACTGG ATCAACATGG CCATATAATT 
TTGAACTCAA TGCATAAGTA CCAGCCAAGG GTGCACATCA TTAAGAAGAA AGACCACACA 
GCCTCATTGC TCAACCTGAA GTCTGAAGAA TTTAGAACTT TCATCTTTCC AGAAACAGTT 
TTTACGGCAG TCACTGCCTA CCAGAATCAA CTGATAACGA AGCTGAAAAT AGATAGCAAT 
CCTTTTGCCA AAGGATTCCG GGATTCCTCC AGGCTCACTG ACATTGAGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBX20 ( NM_001077653.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001071121.1 Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23047
Clone ID Related Accession (Same CDS sequence)	NM_001077653.2
Accession Version	NM_001077653.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX20 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009531.11, DQ986374.1 and AC005826.1. This sequence is a reference standard in the RefSeqGene project. On Oct 15, 2009 this sequence version replaced NM_001077653.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ986374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760, SAMN03568912 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000408931.4/ ENSP00000386170.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGTTCA CGGCGTCCCC CAAGCCCCAA CTCTCCTCTC GGGCCAACGC CTTCTCCATT 
GCCGCGCTCA TGTCGAGCGG CGGCTCTAAG GAGAAGGAGG CGACGGAGAA CACAATCAAA 
CCCCTGGAGC AATTTGTGGA GAAGTCGTCC TGTGCCCAGC CCCTGGGTGA GCTGACCAGC 
CTGGATGCTC ATGGGGAGTT TGGTGGAGGC AGTGGCAGCA GCCCGTCCTC CTCCTCTCTG 
TGCACTGAGC CACTGATCCC CACCACCCCC ATCATCCCCA GTGAGGAAAT GGCCAAAATT 
GCCTGCAGCC TGGAGACCAA GGAGCTTTGG GACAAATTCC ATGAGCTGGG CACCGAGATG 
ATCATCACCA AGTCGGGCAG GAGGATGTTT CCAACCATCC GGGTGTCCTT TTCGGGGGTG 
GATCCTGAGG CCAAGTACAT AGTCCTGATG GACATCGTCC CTGTGGACAA CAAGAGGTAC 
CGCTACGCCT ACCACCGGTC CTCCTGGCTG GTGGCTGGCA AGGCCGACCC GCCGTTGCCA 
GCCAGGCTCT ATGTGCATCC AGATTCTCCT TTTACCGGTG AGCAACTACT CAAACAGATG 
GTGTCTTTTG AAAAGGTGAA ACTCACCAAC AATGAACTGG ATCAACATGG CCATATAATT 
TTGAACTCAA TGCATAAGTA CCAGCCAAGG GTGCACATCA TTAAGAAGAA AGACCACACA 
GCCTCATTGC TCAACCTGAA GTCTGAAGAA TTTAGAACTT TCATCTTTCC AGAAACAGTT 
TTTACGGCAG TCACTGCCTA CCAGAATCAA CTGATAACGA AGCTGAAAAT AGATAGCAAT 
CCTTTTGCCA AAGGATTCCG GGATTCCTCC AGGCTCACTG ACATTGAGAG GGAAAGTGTG 
GAGAGCCTGA TTCAAAAGCA TTCCTATGCA CGCTCACCCA TCCGTACCTA CGGAGGAGAA 
GAAGATGTCT TGGGGGATGA GAGTCAGACA ACCCCAAATC GAGGGTCAGC CTTTACAACA 
TCTGATAATT TGTCTCTCAG CTCCTGGGTA TCATCTTCTT CCAGTTTTCC TGGGTTTCAG 
CACCCACAGT CCCTGACTGC TCTTGGCACC AGCACAGCAT CCATAGCAAC ACCCATTCCT 
CACCCCATCC AGGGTTCTCT GCCACCATAT AGCCGACTGG GAATGCCTCT GACACCATCG 
GCCATTGCCA GCTCCATGCA AGGGAGTGGC CCCACATTCC CTTCATTCCA CATGCCGCGA 
TACCATCACT ATTTTCAGCA GGGGCCCTAT GCTGCCATTC AAGGACTACG CCATTCCTCT 
GCTGTGATGA CGCCATTTGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071121.1
CDS	481..1824
Translation	MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLEQFVEKSSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGDESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV

Target ORF information:

RefSeq Version	NM_001077653.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077653.2

ORF Insert Sequence:

ATGGAGTTCA CGGCGTCCCC CAAGCCCCAA CTCTCCTCTC GGGCCAACGC CTTCTCCATT 
GCCGCGCTCA TGTCGAGCGG CGGCTCTAAG GAGAAGGAGG CGACGGAGAA CACAATCAAA 
CCCCTGGAGC AATTTGTGGA GAAGTCGTCC TGTGCCCAGC CCCTGGGTGA GCTGACCAGC 
CTGGATGCTC ATGGGGAGTT TGGTGGAGGC AGTGGCAGCA GCCCGTCCTC CTCCTCTCTG 
TGCACTGAGC CACTGATCCC CACCACCCCC ATCATCCCCA GTGAGGAAAT GGCCAAAATT 
GCCTGCAGCC TGGAGACCAA GGAGCTTTGG GACAAATTCC ATGAGCTGGG CACCGAGATG 
ATCATCACCA AGTCGGGCAG GAGGATGTTT CCAACCATCC GGGTGTCCTT TTCGGGGGTG 
GATCCTGAGG CCAAGTACAT AGTCCTGATG GACATCGTCC CTGTGGACAA CAAGAGGTAC 
CGCTACGCCT ACCACCGGTC CTCCTGGCTG GTGGCTGGCA AGGCCGACCC GCCGTTGCCA 
GCCAGGCTCT ATGTGCATCC AGATTCTCCT TTTACCGGTG AGCAACTACT CAAACAGATG 
GTGTCTTTTG AAAAGGTGAA ACTCACCAAC AATGAACTGG ATCAACATGG CCATATAATT 
TTGAACTCAA TGCATAAGTA CCAGCCAAGG GTGCACATCA TTAAGAAGAA AGACCACACA 
GCCTCATTGC TCAACCTGAA GTCTGAAGAA TTTAGAACTT TCATCTTTCC AGAAACAGTT 
TTTACGGCAG TCACTGCCTA CCAGAATCAA CTGATAACGA AGCTGAAAAT AGATAGCAAT 
CCTTTTGCCA AAGGATTCCG GGATTCCTCC AGGCTCACTG ACATTGAGAG GGAAAGTGTG 
GAGAGCCTGA TTCAAAAGCA TTCCTATGCA CGCTCACCCA TCCGTACCTA CGGAGGAGAA 
GAAGATGTCT TGGGGGATGA GAGTCAGACA ACCCCAAATC GAGGGTCAGC CTTTACAACA 
TCTGATAATT TGTCTCTCAG CTCCTGGGTA TCATCTTCTT CCAGTTTTCC TGGGTTTCAG 
CACCCACAGT CCCTGACTGC TCTTGGCACC AGCACAGCAT CCATAGCAAC ACCCATTCCT 
CACCCCATCC AGGGTTCTCT GCCACCATAT AGCCGACTGG GAATGCCTCT GACACCATCG 
GCCATTGCCA GCTCCATGCA AGGGAGTGGC CCCACATTCC CTTCATTCCA CATGCCGCGA 
TACCATCACT ATTTTCAGCA GGGGCCCTAT GCTGCCATTC AAGGACTACG CCATTCCTCT 
GCTGTGATGA CGCCATTTGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBX20 ( XM_017012456.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867945.1 Homo sapiens T-box transcription factor 20 (TBX20), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu97405
Clone ID Related Accession (Same CDS sequence)	XM_017012456.1
Accession Version	XM_017012456.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX20 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTCTT TTGAAAAGGT GAAACTCACC AACAATGAAC TGGATCAACA TGGCCATATA 
ATTTTGAACT CAATGCATAA GTACCAGCCA AGGGTGCACA TCATTAAGAA GAAAGACCAC 
ACAGCCTCAT TGCTCAACCT GAAGTCTGAA GAATTTAGAA CTTTCATCTT TCCAGAAACA 
GTTTTTACGG CAGTCACTGC CTACCAGAAT CAACTGATAA CGAAGCTGAA AATAGATAGC 
AATCCTTTTG CCAAAGGATT CCGGGATTCC TCCAGGCTCA CTGACATTGA GAGGGAAAGT 
GTGGAGAGCC TGATTCAAAA GCATTCCTAT GCACGCTCAC CCATCCGTAC CTACGGAGGA 
GAAGAAGATG TCTTGGGGGA TGAGAGTCAG ACAACCCCAA ATCGAGGGTC AGCCTTTACA 
ACATCTGATA ATTTGTCTCT CAGCTCCTGG GTATCATCTT CTTCCAGTTT TCCTGGGTTT 
CAGCACCCAC AGTCCCTGAC TGCTCTTGGC ACCAGCACAG CATCCATAGC AACACCCATT 
CCTCACCCCA TCCAGGGTTC TCTGCCACCA TATAGCCGAC TGGGAATGCC TCTGACACCA 
TCGGCCATTG CCAGCTCCAT GCAAGGGAGT GGCCCCACAT TCCCTTCATT CCACATGCCG 
CGATACCATC ACTATTTTCA GCAGGGGCCC TATGCTGCCA TTCAAGGACT ACGCCATTCC 
TCTGCTGTGA TGACGCCATT TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867945.1
CDS	3043..3789
Translation	MVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGDESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV

Target ORF information:

RefSeq Version	XM_017012456.1
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 20 (TBX20), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012456.1

ORF Insert Sequence:

ATGGTGTCTT TTGAAAAGGT GAAACTCACC AACAATGAAC TGGATCAACA TGGCCATATA 
ATTTTGAACT CAATGCATAA GTACCAGCCA AGGGTGCACA TCATTAAGAA GAAAGACCAC 
ACAGCCTCAT TGCTCAACCT GAAGTCTGAA GAATTTAGAA CTTTCATCTT TCCAGAAACA 
GTTTTTACGG CAGTCACTGC CTACCAGAAT CAACTGATAA CGAAGCTGAA AATAGATAGC 
AATCCTTTTG CCAAAGGATT CCGGGATTCC TCCAGGCTCA CTGACATTGA GAGGGAAAGT 
GTGGAGAGCC TGATTCAAAA GCATTCCTAT GCACGCTCAC CCATCCGTAC CTACGGAGGA 
GAAGAAGATG TCTTGGGGGA TGAGAGTCAG ACAACCCCAA ATCGAGGGTC AGCCTTTACA 
ACATCTGATA ATTTGTCTCT CAGCTCCTGG GTATCATCTT CTTCCAGTTT TCCTGGGTTT 
CAGCACCCAC AGTCCCTGAC TGCTCTTGGC ACCAGCACAG CATCCATAGC AACACCCATT 
CCTCACCCCA TCCAGGGTTC TCTGCCACCA TATAGCCGAC TGGGAATGCC TCTGACACCA 
TCGGCCATTG CCAGCTCCAT GCAAGGGAGT GGCCCCACAT TCCCTTCATT CCACATGCCG 
CGATACCATC ACTATTTTCA GCAGGGGCCC TATGCTGCCA TTCAAGGACT ACGCCATTCC 
TCTGCTGTGA TGACGCCATT TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.
PLoS genetics13(9)e1007011(2017 Sep)
Kennedy L,Kaltenbrun E,Greco TM,Temple B,Herring LE,Cristea IM,Conlon FL

Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway.
Genetic testing and molecular biomarkers21(7)440-444(2017 Jul)
Luo Z,Shen Y,Chen W,Ma X,Liu L,Huang X,Yang Z,Sun H

TBX20 loss-of-function mutation responsible for familial tetralogy of Fallot or sporadic persistent truncus arteriosus.
International journal of medical sciences14(4)323-332(2017)
Huang RT,Wang J,Xue S,Qiu XB,Shi HY,Li RG,Qu XK,Yang XX,Liu H,Li N,Li YJ,Xu YJ,Yang YQ

Tbx20 controls the expression of the KCNH2 gene and of hERG channels.
Proceedings of the National Academy of Sciences of the United States of America114(3)E416-E425(2017 Jan)
Caballero R,Utrilla RG,Amor?s I,Matamoros M,P?rez-Hern?ndez M,Tinaquero D,Alfayate S,Nieto-Mar?n P,Guerrero-Serna G,Liu QH,Ramos-Mondrag?n R,Ponce-Balbuena D,Herron T,Campbell KF,Filgueiras-Rama D,Peinado R,L?pez-Send?n JL,Jalife J,Delp?n E,Tamargo J

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TBX20 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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