TWSG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TWSG1
Entrez Gene ID	57045
Full Name	twisted gastrulation BMP signaling modulator 1
Synonyms	TSG
General protein information	Preferred Names twisted gastrulation BMP signaling modulator 1 Names twisted gastrulation protein homolog 1 twisted gastrulation homolog 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.22
Disorder MIM:	605049

mRNA and Protein(s)

mRNA	Protein	Name
NM_020648.5	NP_065699.1	twisted gastrulation protein homolog 1 precursor
NM_020648.6	NP_065699.1	twisted gastrulation protein homolog 1 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TWSG1	NP_989529.1
Xenopus tropicalis (tropical clawed frog)	twsg1	NP_001006748.1
Bos taurus (cattle)	TWSG1	NP_001069557.1
Homo sapiens (human)	TWSG1	NP_065699.1
Danio rerio (zebrafish)	twsg1a	NP_571872.1
Drosophila melanogaster (fruit fly)	tsg	NP_511135.1
Pan troglodytes (chimpanzee)	TWSG1	XP_001138675.1
Canis lupus familiaris (dog)	TWSG1	XP_547668.2
Mus musculus (house mouse)	Twsg1	NP_075540.1
	TWSG1	XP_002800917.1
Rattus norvegicus (Norway rat)	Twsg1	NP_001102281.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway.
Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C
Matrix biology : journal of the International Society for Matrix Biology5549-62(2016 Sep)

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.
Troilo H, Barrett AL, Wohl AP, Jowitt TA, Collins RF, Bayley CP, Zuk AV, Sengle G, Baldock C
Biochemical Society transactions43(5)795-800(2015 Oct)

Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation.
Heinke J, Juschkat M, Charlet A, Mnich L, Helbing T, Bode C, Patterson C, Moser M
Journal of cell science126(Pt 14)3082-94(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.
Title: The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.

these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.
Title: Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation.

mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies
Title: Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly.

interferes with BMP-mediated hepcidin expression and may act with GDF15 to dysregulate iron homeostasis in thalassemia syndromes.
Title: Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.

Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation.
Title: Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.

The following TWSG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TWSG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32148	NM_020648.6 Latest version!	Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu32148	NM_020648.5	Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TWSG1 ( NM_020648.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_065699.1 Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.

Price & Availability↑

CloneID	OHu32148
Clone ID Related Accession (Same CDS sequence)	NM_020648.5 , NM_020648.6
Accession Version	NM_020648.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	twisted gastrulation protein homolog 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA735800.1, BC020490.1, AF294628.1, BU632669.1 and AI742025.1. On Jul 28, 2009 this sequence version replaced NM_020648.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020490.1, SRR1660807.133812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTAC ACTATGTTGC TGTGCTTACT CTAGCCATCC TGATGTTCCT GACATGGCTT 
CCAGAATCAC TGAGCTGTAA CAAAGCACTC TGTGCTAGTG ATGTGAGCAA ATGCCTCATT 
CAGGAGCTCT GCCAGTGCCG GCCGGGAGAA GGCAATTGCT CCTGCTGTAA GGAGTGCATG 
CTGTGTCTTG GGGCCCTTTG GGACGAGTGC TGTGACTGTG TTGGTATGTG TAATCCTCGA 
AATTATAGTG ACACACCTCC AACTTCAAAG AGCACAGTGG AGGAGCTGCA TGAACCGATC 
CCTTCTCTCT TCCGGGCACT CACAGAAGGA GATACTCAGT TGAATTGGAA CATCGTTTCT 
TTCCCTGTTG CAGAAGAACT TTCACATCAT GAGAATCTGG TTTCATTTTT AGAAACTGTG 
AACCAGCCAC ACCACCAGAA TGTGTCTGTC CCCAGCAATA ATGTTCACGC GCCTTATTCC 
AGTGACAAAG AACACATGTG TACTGTGGTT TATTTTGATG ACTGCATGTC CATACATCAG 
TGTAAAATAT CCTGTGAGTC CATGGGAGCA TCCAAATATC GCTGGTTTCA TAATGCCTGC 
TGCGAGTGCA TTGGTCCAGA ATGTATTGAC TATGGTAGTA AAACTGTCAA ATGTATGAAC 
TGCATGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065699.1
CDS	192..863
Translation	MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF

Target ORF information:

RefSeq Version	NM_020648.5
Organism	Homo sapiens(human)
Definition	Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020648.5

ORF Insert Sequence:

ATGAAGTTAC ACTATGTTGC TGTGCTTACT CTAGCCATCC TGATGTTCCT GACATGGCTT 
CCAGAATCAC TGAGCTGTAA CAAAGCACTC TGTGCTAGTG ATGTGAGCAA ATGCCTCATT 
CAGGAGCTCT GCCAGTGCCG GCCGGGAGAA GGCAATTGCT CCTGCTGTAA GGAGTGCATG 
CTGTGTCTTG GGGCCCTTTG GGACGAGTGC TGTGACTGTG TTGGTATGTG TAATCCTCGA 
AATTATAGTG ACACACCTCC AACTTCAAAG AGCACAGTGG AGGAGCTGCA TGAACCGATC 
CCTTCTCTCT TCCGGGCACT CACAGAAGGA GATACTCAGT TGAATTGGAA CATCGTTTCT 
TTCCCTGTTG CAGAAGAACT TTCACATCAT GAGAATCTGG TTTCATTTTT AGAAACTGTG 
AACCAGCCAC ACCACCAGAA TGTGTCTGTC CCCAGCAATA ATGTTCACGC GCCTTATTCC 
AGTGACAAAG AACACATGTG TACTGTGGTT TATTTTGATG ACTGCATGTC CATACATCAG 
TGTAAAATAT CCTGTGAGTC CATGGGAGCA TCCAAATATC GCTGGTTTCA TAATGCCTGC 
TGCGAGTGCA TTGGTCCAGA ATGTATTGAC TATGGTAGTA AAACTGTCAA ATGTATGAAC 
TGCATGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TWSG1 ( NM_020648.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_065699.1 Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.

Price & Availability↑

CloneID	OHu32148
Clone ID Related Accession (Same CDS sequence)	NM_020648.5 , NM_020648.6
Accession Version	NM_020648.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	twisted gastrulation protein homolog 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP001033.6. On Nov 23, 2018 this sequence version replaced NM_020648.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020490.1, SRR1660807.133812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262120.10/ ENSP00000262120.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTTAC ACTATGTTGC TGTGCTTACT CTAGCCATCC TGATGTTCCT GACATGGCTT 
CCAGAATCAC TGAGCTGTAA CAAAGCACTC TGTGCTAGTG ATGTGAGCAA ATGCCTCATT 
CAGGAGCTCT GCCAGTGCCG GCCGGGAGAA GGCAATTGCT CCTGCTGTAA GGAGTGCATG 
CTGTGTCTTG GGGCCCTTTG GGACGAGTGC TGTGACTGTG TTGGTATGTG TAATCCTCGA 
AATTATAGTG ACACACCTCC AACTTCAAAG AGCACAGTGG AGGAGCTGCA TGAACCGATC 
CCTTCTCTCT TCCGGGCACT CACAGAAGGA GATACTCAGT TGAATTGGAA CATCGTTTCT 
TTCCCTGTTG CAGAAGAACT TTCACATCAT GAGAATCTGG TTTCATTTTT AGAAACTGTG 
AACCAGCCAC ACCACCAGAA TGTGTCTGTC CCCAGCAATA ATGTTCACGC GCCTTATTCC 
AGTGACAAAG AACACATGTG TACTGTGGTT TATTTTGATG ACTGCATGTC CATACATCAG 
TGTAAAATAT CCTGTGAGTC CATGGGAGCA TCCAAATATC GCTGGTTTCA TAATGCCTGC 
TGCGAGTGCA TTGGTCCAGA ATGTATTGAC TATGGTAGTA AAACTGTCAA ATGTATGAAC 
TGCATGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065699.1
CDS	186..857
Translation	MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF

Target ORF information:

RefSeq Version	NM_020648.6
Organism	Homo sapiens(human)
Definition	Homo sapiens twisted gastrulation BMP signaling modulator 1 (TWSG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020648.6

ORF Insert Sequence:

ATGAAGTTAC ACTATGTTGC TGTGCTTACT CTAGCCATCC TGATGTTCCT GACATGGCTT 
CCAGAATCAC TGAGCTGTAA CAAAGCACTC TGTGCTAGTG ATGTGAGCAA ATGCCTCATT 
CAGGAGCTCT GCCAGTGCCG GCCGGGAGAA GGCAATTGCT CCTGCTGTAA GGAGTGCATG 
CTGTGTCTTG GGGCCCTTTG GGACGAGTGC TGTGACTGTG TTGGTATGTG TAATCCTCGA 
AATTATAGTG ACACACCTCC AACTTCAAAG AGCACAGTGG AGGAGCTGCA TGAACCGATC 
CCTTCTCTCT TCCGGGCACT CACAGAAGGA GATACTCAGT TGAATTGGAA CATCGTTTCT 
TTCCCTGTTG CAGAAGAACT TTCACATCAT GAGAATCTGG TTTCATTTTT AGAAACTGTG 
AACCAGCCAC ACCACCAGAA TGTGTCTGTC CCCAGCAATA ATGTTCACGC GCCTTATTCC 
AGTGACAAAG AACACATGTG TACTGTGGTT TATTTTGATG ACTGCATGTC CATACATCAG 
TGTAAAATAT CCTGTGAGTC CATGGGAGCA TCCAAATATC GCTGGTTTCA TAATGCCTGC 
TGCGAGTGCA TTGGTCCAGA ATGTATTGAC TATGGTAGTA AAACTGTCAA ATGTATGAAC 
TGCATGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway.
Matrix biology : journal of the International Society for Matrix Biology5549-62(2016 Sep)
Troilo H,Barrett AL,Zuk AV,Lockhart-Cairns MP,Wohl AP,Bayley CP,Dajani R,Tunnicliffe RB,Green L,Jowitt TA,Sengle G,Baldock C

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.
Biochemical Society transactions43(5)795-800(2015 Oct)
Troilo H,Barrett AL,Wohl AP,Jowitt TA,Collins RF,Bayley CP,Zuk AV,Sengle G,Baldock C

Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation.
Journal of cell science126(Pt 14)3082-94(2013 Jul)
Heinke J,Juschkat M,Charlet A,Mnich L,Helbing T,Bode C,Patterson C,Moser M

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TWSG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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