PSMC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMC2
Entrez Gene ID	5701
Full Name	proteasome 26S subunit, ATPase 2
Synonyms	MSS1,Nbla10058,S7
General protein information	Preferred Names proteasome 26S subunit, ATPase 2 Names 26S proteasome regulatory subunit 7 26S protease regulatory subunit 7 26S proteasome AAA-ATPase subunit RPT1 mammalian suppressor of sgv-1 of yeast protease 26S subunit 7 proteasome (prosome, macropain) 26S subunit, ATPase, 2 putative protein product of Nbla10058 testis secretory sperm-binding protein Li 197a
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011].
Disorder MIM:	154365

mRNA and Protein(s)

mRNA	Protein	Name
XM_005250505.1	XP_005250562.1	26S protease regulatory subunit 7 isoform X1
NM_001204453.1	NP_001191382.1	26S proteasome regulatory subunit 7 isoform 2
NM_002803.3	NP_002794.1	26S proteasome regulatory subunit 7 isoform 1
NM_002803.4	NP_002794.1	26S proteasome regulatory subunit 7 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Psmc2	NP_035318.1
Danio rerio (zebrafish)	psmc2	NP_957260.1
Caenorhabditis elegans (roundworm)	rpt-1	NP_506005.1
Bos taurus (cattle)	PSMC2	NP_001015639.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011174	XP_309476.2
Saccharomyces cerevisiae (baker's yeast)	RPT1	NP_012777.1
Kluyveromyces lactis	KLLA0E13773g	XP_454571.1
Oryza sativa (rice)	Os06g0192600	NP_001057037.1
Xenopus tropicalis (tropical clawed frog)	psmc2	NP_989155.1
Pan troglodytes (chimpanzee)	PSMC2	XP_003951151.1
Schizosaccharomyces pombe (fission yeast)	rpt1	NP_596805.1
Arabidopsis thaliana (thale cress)	RPT1A	NP_175778.1
Homo sapiens (human)	PSMC2	NP_002794.1
Magnaporthe oryzae (rice blast fungus)	MGG_01581	XP_003714559.1
Canis lupus familiaris (dog)	PSMC2	XP_533103.3
Rattus norvegicus (Norway rat)	Psmc2	NP_150239.1
Gallus gallus (chicken)	PSMC2	NP_001006225.1
Drosophila melanogaster (fruit fly)	Rpt1	NP_477473.1
Eremothecium gossypii	AGOS_ACR050C	NP_983453.1
Neurospora crassa	NCU02840	XP_964130.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration.
Song M, Wang Y, Zhang Z, Wang S
Oncotarget8(1)933-953(2017 Jan)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
Cachat A, Alais S, Chevalier SA, Journo C, Fusil F, Dutartre H, Boniface A, Ko NL, Gessain A, Cosset FL, Susp?ne R, Vartanian JP, Mahieux R
Retrovirology1193(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

structural determinants for the binding of ubiquitin-like domains to 26s proteasome
Title: Structural determinants for the binding of ubiquitin-like domains to the proteasome.

The following PSMC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11230	NM_002803.3 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu25025	NM_001204453.1 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25025	XM_005250505.1 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu107265	NM_002803.4 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMC2 ( NM_002803.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002794.1 Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11230
Clone ID Related Accession (Same CDS sequence)	NM_002803.3
Accession Version	NM_002803.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	26S proteasome regulatory subunit 7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE269755.1, BC002589.2, AC093701.4 and BU675889.1. On Mar 2, 2011 this sequence version replaced NM_002803.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.216461.1, SRR1660803.60583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGCGTGGATA GAAATAAATA TCAAATTCAC ATTCCATTGC CTCCTAAGAT TGACCCAACA 
GTTACCATGA TGCAGGTGGA AGAGAAACCT GATGTCACAT ACAGTGATGT TGGTGGCTGT 
AAGGAACAGA TTGAGAAACT GCGAGAAGTA GTTGAAACCC CATTACTTCA TCCAGAGAGG 
TTTGTGAACC TTGGCATTGA GCCTCCCAAG GGCGTGCTGC TCTTTGGTCC ACCCGGTACA 
GGCAAGACAC TCTGTGCGCG GGCAGTTGCT AATCGGACTG ATGCGTGCTT CATTCGAGTT 
ATTGGATCTG AGCTTGTACA GAAATACGTC GGTGAGGGGG CTCGAATGGT TCGTGAACTC 
TTTGAAATGG CCAGAACAAA AAAAGCCTGC CTTATCTTCT TTGATGAAAT TGATGCTATT 
GGAGGGGCTC GTTTTGATGA TGGTGCTGGA GGTGACAATG AAGTGCAGAG AACAATGTTG 
GAACTGATCA ATCAGCTTGA TGGTTTTGAT CCTCGAGGCA ATATTAAAGT GCTGATGGCC 
ACTAACAGAC CTGATACTTT GGATCCAGCA CTGATGAGGC CAGGGAGATT GGATAGAAAA 
ATTGAATTTA GCTTGCCCGA TCTAGAGGGT CGGACCCACA TATTTAAGAT TCACGCTCGT 
TCAATGAGTG TTGAAAGAGA TATCAGATTT GAACTGTTAG CACGACTGTG TCCAAATAGC 
ACTGGTGCTG AGATTAGAAG CGTCTGCACA GAGGCTGGTA TGTTTGCCAT CAGAGCACGG 
CGAAAAATTG CTACCGAGAA GGATTTCTTG GAAGCTGTAA ATAAGGTCAT TAAGTCTTAT 
GCCAAATTCA GTGCTACTCC TCGTTACATG ACATACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002794.1
CDS	189..1490
Translation	MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN

Target ORF information:

RefSeq Version	NM_002803.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002803.3

ORF Insert Sequence:

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGCGTGGATA GAAATAAATA TCAAATTCAC ATTCCATTGC CTCCTAAGAT TGACCCAACA 
GTTACCATGA TGCAGGTGGA AGAGAAACCT GATGTCACAT ACAGTGATGT TGGTGGCTGT 
AAGGAACAGA TTGAGAAACT GCGAGAAGTA GTTGAAACCC CATTACTTCA TCCAGAGAGG 
TTTGTGAACC TTGGCATTGA GCCTCCCAAG GGCGTGCTGC TCTTTGGTCC ACCCGGTACA 
GGCAAGACAC TCTGTGCGCG GGCAGTTGCT AATCGGACTG ATGCGTGCTT CATTCGAGTT 
ATTGGATCTG AGCTTGTACA GAAATACGTC GGTGAGGGGG CTCGAATGGT TCGTGAACTC 
TTTGAAATGG CCAGAACAAA AAAAGCCTGC CTTATCTTCT TTGATGAAAT TGATGCTATT 
GGAGGGGCTC GTTTTGATGA TGGTGCTGGA GGTGACAATG AAGTGCAGAG AACAATGTTG 
GAACTGATCA ATCAGCTTGA TGGTTTTGAT CCTCGAGGCA ATATTAAAGT GCTGATGGCC 
ACTAACAGAC CTGATACTTT GGATCCAGCA CTGATGAGGC CAGGGAGATT GGATAGAAAA 
ATTGAATTTA GCTTGCCCGA TCTAGAGGGT CGGACCCACA TATTTAAGAT TCACGCTCGT 
TCAATGAGTG TTGAAAGAGA TATCAGATTT GAACTGTTAG CACGACTGTG TCCAAATAGC 
ACTGGTGCTG AGATTAGAAG CGTCTGCACA GAGGCTGGTA TGTTTGCCAT CAGAGCACGG 
CGAAAAATTG CTACCGAGAA GGATTTCTTG GAAGCTGTAA ATAAGGTCAT TAAGTCTTAT 
GCCAAATTCA GTGCTACTCC TCGTTACATG ACATACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC2 ( NM_001204453.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191382.1 Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25025
Clone ID Related Accession (Same CDS sequence)	XM_005250505.1 , NM_001204453.1
Accession Version	NM_001204453.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	26S proteasome regulatory subunit 7 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE269755.1, BC002589.2 and AK298529.1. Transcript Variant: This variant (2) includes an alternate segment at its 3' terminal exon which contains a premature stop codon, compared to variant 1. This variant encodes an isoform (2) with a shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298529.1, BI912976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191382.1
CDS	189..614
Translation	MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVG

Target ORF information:

RefSeq Version	NM_001204453.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204453.1

ORF Insert Sequence:

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC2 ( XM_005250505.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005250562.1 Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25025
Clone ID Related Accession (Same CDS sequence)	XM_005250505.1 , NM_001204453.1
Accession Version	XM_005250505.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	26S protease regulatory subunit 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005250562.1
CDS	310..735
Translation	MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVG

Target ORF information:

RefSeq Version	XM_005250505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005250505.1

ORF Insert Sequence:

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC2 ( NM_002803.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002794.1 Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107265
Clone ID Related Accession (Same CDS sequence)	NM_002803.4
Accession Version	NM_002803.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	26S proteasome regulatory subunit 7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004668.1 and AC093701.4. On Nov 23, 2018 this sequence version replaced NM_002803.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.271779.1, SRR1660805.216461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000292644.5/ ENSP00000292644.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGCGTGGATA GAAATAAATA TCAAATTCAC ATTCCATTGC CTCCTAAGAT TGACCCAACA 
GTTACCATGA TGCAGGTGGA AGAGAAACCT GATGTCACAT ACAGTGATGT TGGTGGCTGT 
AAGGAACAGA TTGAGAAACT GCGAGAAGTA GTTGAAACCC CATTACTTCA TCCAGAGAGG 
TTTGTGAACC TTGGCATTGA GCCTCCCAAG GGCGTGCTGC TCTTTGGTCC ACCCGGTACA 
GGCAAGACAC TCTGTGCGCG GGCAGTTGCT AATCGGACTG ATGCGTGCTT CATTCGAGTT 
ATTGGATCTG AGCTTGTACA GAAATACGTC GGTGAGGGGG CTCGAATGGT TCGTGAACTC 
TTTGAAATGG CCAGAACAAA AAAAGCCTGC CTTATCTTCT TTGATGAAAT TGATGCTATT 
GGAGGGGCTC GTTTTGATGA TGGTGCTGGA GGTGACAATG AAGTGCAGAG AACAATGTTG 
GAACTGATCA ATCAGCTTGA TGGTTTTGAT CCTAGAGGCA ATATTAAAGT GCTGATGGCC 
ACTAACAGAC CTGATACTTT GGATCCAGCA CTGATGAGGC CAGGGAGATT GGATAGAAAA 
ATTGAATTTA GCTTGCCCGA TCTAGAGGGT CGGACCCACA TATTTAAGAT TCACGCTCGT 
TCAATGAGTG TTGAAAGAGA TATCAGATTT GAACTGTTAG CACGACTGTG TCCAAATAGC 
ACTGGTGCTG AGATTAGAAG CGTCTGCACA GAGGCTGGTA TGTTTGCCAT CAGAGCACGG 
CGAAAAATTG CTACCGAGAA GGATTTCTTG GAAGCTGTAA ATAAGGTCAT TAAGTCTTAT 
GCCAAATTCA GTGCTACTCC TCGTTACATG ACATACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002794.1
CDS	70..1371
Translation	MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN

Target ORF information:

RefSeq Version	NM_002803.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002803.4

ORF Insert Sequence:

ATGCCGGATT ACCTCGGTGC CGATCAGCGG AAGACCAAAG AGGATGAGAA GGACGACAAG 
CCCATCCGAG CTCTGGATGA GGGGGATATT GCCTTGTTGA AAACTTATGG TCAGAGCACT 
TACTCTAGGC AGATCAAGCA AGTTGAAGAT GACATTCAGC AACTTCTCAA GAAAATTAAT 
GAGCTCACTG GTATTAAAGA ATCTGACACT GGCCTGGCCC CACCAGCACT CTGGGATTTG 
GCTGCAGATA AGCAGACACT CCAGAGTGAA CAGCCTTTAC AGGTTGCCAG GTGTACAAAG 
ATAATCAATG CTGATTCGGA GGACCCAAAA TACATTATCA ACGTAAAGCA GTTTGCCAAG 
TTTGTGGTGG ACCTTAGTGA TCAGGTGGCA CCTACTGACA TTGAAGAAGG GATGAGAGTG 
GGCGTGGATA GAAATAAATA TCAAATTCAC ATTCCATTGC CTCCTAAGAT TGACCCAACA 
GTTACCATGA TGCAGGTGGA AGAGAAACCT GATGTCACAT ACAGTGATGT TGGTGGCTGT 
AAGGAACAGA TTGAGAAACT GCGAGAAGTA GTTGAAACCC CATTACTTCA TCCAGAGAGG 
TTTGTGAACC TTGGCATTGA GCCTCCCAAG GGCGTGCTGC TCTTTGGTCC ACCCGGTACA 
GGCAAGACAC TCTGTGCGCG GGCAGTTGCT AATCGGACTG ATGCGTGCTT CATTCGAGTT 
ATTGGATCTG AGCTTGTACA GAAATACGTC GGTGAGGGGG CTCGAATGGT TCGTGAACTC 
TTTGAAATGG CCAGAACAAA AAAAGCCTGC CTTATCTTCT TTGATGAAAT TGATGCTATT 
GGAGGGGCTC GTTTTGATGA TGGTGCTGGA GGTGACAATG AAGTGCAGAG AACAATGTTG 
GAACTGATCA ATCAGCTTGA TGGTTTTGAT CCTAGAGGCA ATATTAAAGT GCTGATGGCC 
ACTAACAGAC CTGATACTTT GGATCCAGCA CTGATGAGGC CAGGGAGATT GGATAGAAAA 
ATTGAATTTA GCTTGCCCGA TCTAGAGGGT CGGACCCACA TATTTAAGAT TCACGCTCGT 
TCAATGAGTG TTGAAAGAGA TATCAGATTT GAACTGTTAG CACGACTGTG TCCAAATAGC 
ACTGGTGCTG AGATTAGAAG CGTCTGCACA GAGGCTGGTA TGTTTGCCAT CAGAGCACGG 
CGAAAAATTG CTACCGAGAA GGATTTCTTG GAAGCTGTAA ATAAGGTCAT TAAGTCTTAT 
GCCAAATTCA GTGCTACTCC TCGTTACATG ACATACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration.
Oncotarget8(1)933-953(2017 Jan)
Song M,Wang Y,Zhang Z,Wang S

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
Retrovirology1193(2014 Nov)
Cachat A,Alais S,Chevalier SA,Journo C,Fusil F,Dutartre H,Boniface A,Ko NL,Gessain A,Cosset FL,Susp?ne R,Vartanian JP,Mahieux R

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PSMC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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