PRTFDC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRTFDC1
Entrez Gene ID	56952
Full Name	phosphoribosyl transferase domain containing 1
Synonyms	HHGP
General protein information	Preferred Names phosphoribosyl transferase domain containing 1 Names phosphoribosyltransferase domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p12.1
Disorder MIM:	610751

mRNA and Protein(s)

mRNA	Protein	Name
NM_020200.6	NP_064585.1	phosphoribosyltransferase domain-containing protein 1 isoform 1
NM_020200.7	NP_064585.1	phosphoribosyltransferase domain-containing protein 1 isoform 1
NM_001282786.1	NP_001269715.1	phosphoribosyltransferase domain-containing protein 1 isoform 2
NM_001282786.2	NP_001269715.1	phosphoribosyltransferase domain-containing protein 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRTFDC1	XP_507700.1
Rattus norvegicus (Norway rat)	Prtfdc1	NP_001099597.1
Gallus gallus (chicken)	PRTFDC1	NP_001186514.1
Danio rerio (zebrafish)	LOC100334391	XP_002666638.2
Canis lupus familiaris (dog)	PRTFDC1	XP_005617043.1
Homo sapiens (human)	PRTFDC1	NP_064585.1
	LOC712819	XP_001101923.2
Bos taurus (cattle)	PRTFDC1	XP_003586817.2
Danio rerio (zebrafish)	prtfdc1	NP_955812.2
Xenopus tropicalis (tropical clawed frog)	prtfdc1	NP_001096362.1

Gene Ontology
Bibliography

Related articles in PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
Nievergelt CM, Maihofer AX, Mustapic M, Yurgil KA, Schork NJ, Miller MW, Logue MW, Geyer MA, Risbrough VB, O'Connor DT, Baker DG
Psychoneuroendocrinology51459-71(2015 Jan)

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA, Boerwinkle E
Genetic epidemiology37(8)840-5(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found evidence for PRTFDC1 as a potential novel PTSD gene, a finding that awaits further replication.
Title: Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.

These results demonstrate that PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse.
Title: PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse.

The PRTFDC1 structure has been determined at 1.7 A resolution with bound GMP. The overall structure and GMP binding mode are very similar to that observed for HPRT.
Title: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis.
Title: PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.

The following PRTFDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRTFDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12467	NM_020200.7 Latest version!	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10896	NM_001282786.2 Latest version!	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu12467	NM_020200.6	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10896	NM_001282786.1	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRTFDC1 ( NM_020200.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_064585.1 Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12467
Clone ID Related Accession (Same CDS sequence)	NM_020200.6 , NM_020200.7
Accession Version	NM_020200.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-28
Organism	Homo sapiens(human)
Product	phosphoribosyltransferase domain-containing protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX471710.1, AL512598.11, AK309614.1, AK021950.1 and BQ003226.1. On Sep 19, 2013 this sequence version replaced NM_020200.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK021950.1, SRR1660809.182180.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTATGCTGG ATTTGAGATT CCAAACTTAT TTGTGGTGGG ATATGCCTTA 
GATTACAATG AATACTTCAG AGATCTGAAT CACATATGCG TCATCAATGA GCACGGTAAA 
GAAAAATATC GAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064585.1
CDS	70..747
Translation	MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV

Target ORF information:

RefSeq Version	NM_020200.6
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020200.6

ORF Insert Sequence:

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTATGCTGG ATTTGAGATT CCAAACTTAT TTGTGGTGGG ATATGCCTTA 
GATTACAATG AATACTTCAG AGATCTGAAT CACATATGCG TCATCAATGA GCACGGTAAA 
GAAAAATATC GAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRTFDC1 ( NM_020200.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_064585.1 Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12467
Clone ID Related Accession (Same CDS sequence)	NM_020200.6 , NM_020200.7
Accession Version	NM_020200.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	phosphoribosyltransferase domain-containing protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK309614.1, AK021950.1 and BQ003226.1. On Nov 22, 2018 this sequence version replaced NM_020200.6. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR5189667.217859.1, AK021950.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320152.11/ ENSP00000318602.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTATGCTGG ATTTGAGATT CCAAACTTAT TTGTGGTGGG ATATGCCTTA 
GATTACAATG AATACTTCAG AGATCTGAAT CACATATGCG TCATCAATGA GCACGGTAAA 
GAAAAATATC GAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064585.1
CDS	32..709
Translation	MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV

Target ORF information:

RefSeq Version	NM_020200.7
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020200.7

ORF Insert Sequence:

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTATGCTGG ATTTGAGATT CCAAACTTAT TTGTGGTGGG ATATGCCTTA 
GATTACAATG AATACTTCAG AGATCTGAAT CACATATGCG TCATCAATGA GCACGGTAAA 
GAAAAATATC GAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRTFDC1 ( NM_001282786.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269715.1 Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10896
Clone ID Related Accession (Same CDS sequence)	NM_001282786.1 , NM_001282786.2
Accession Version	NM_001282786.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	phosphoribosyltransferase domain-containing protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX471710.1, AL512598.11, AK309614.1, AK294130.1, AK021950.1 and BQ003226.1. On Sep 19, 2013 this sequence version replaced XM_005252539.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.124017.1, SRR1660805.180214.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTCACATAT GCGTCATCAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269715.1
CDS	70..642
Translation	MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDSHMRHQ

Target ORF information:

RefSeq Version	NM_001282786.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282786.1

ORF Insert Sequence:

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTCACATAT GCGTCATCAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRTFDC1 ( NM_001282786.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269715.1 Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10896
Clone ID Related Accession (Same CDS sequence)	NM_001282786.1 , NM_001282786.2
Accession Version	NM_001282786.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	phosphoribosyltransferase domain-containing protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK309614.1, AK294130.1, AK021950.1 and BQ003226.1. On Jun 1, 2019 this sequence version replaced NM_001282786.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.124017.1, SRR1660805.180214.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTCACATAT GCGTCATCAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269715.1
CDS	32..604
Translation	MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDSHMRHQ

Target ORF information:

RefSeq Version	NM_001282786.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282786.2

ORF Insert Sequence:

ATGGCCGGGA GCAGCGAGGA GGCGCCAGAC TACGGGCGAG GCGTCGTGAT TATGGATGAT 
TGGCCAGGGT ATGACTTGAA TTTATTCACG TACCCACAGC ACTATTATGG AGACTTGGAG 
TATGTCCTCA TCCCTCATGG TATCATTGTG GACAGAATTG AGCGGCTGGC CAAGGATATT 
ATGAAAGACA TAGGATATAG TGACATCATG GTCCTGTGTG TGCTTAAAGG AGGTTACAAA 
TTCTGTGCTG ATCTCGTAGA ACACCTTAAG AACATCAGCC GAAATTCAGA TCGATTTGTC 
TCAATGAAGG TTGATTTCAT CAGACTAAAA AGTTACAGGA ATGACCAGTC CATGGGTGAG 
ATGCAGATAA TCGGAGGCGA TGATCTTTCA ACGCTGGCTG GAAAGAATGT TCTCATTGTT 
GAGGATGTTG TCGGAACTGG GAGGACCATG AAAGCACTAC TCAGCAATAT AGAGAAATAC 
AAGCCCAACA TGATTAAGGT AGCCAGTTTG TTGGTGAAGA GAACATCCAG AAGTGACGGC 
TTTAGACCTG ACTCACATAT GCGTCATCAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
Psychoneuroendocrinology51459-71(2015 Jan)
Nievergelt CM,Maihofer AX,Mustapic M,Yurgil KA,Schork NJ,Miller MW,Logue MW,Geyer MA,Risbrough VB,O'Connor DT,Baker DG

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Genetic epidemiology37(8)840-5(2013 Dec)
Yu B,Zheng Y,Alexander D,Manolio TA,Alonso A,Nettleton JA,Boerwinkle E

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PRTFDC1 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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