PAK6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAK6
Entrez Gene ID	56924
Full Name	p21 (RAC1) activated kinase 6
Synonyms	PAK5
General protein information	Preferred Names p21 (RAC1) activated kinase 6 Names serine/threonine-protein kinase PAK 6 p21 protein (Cdc42/Rac)-activated kinase 6 p21(CDKN1A)-activated kinase 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q15.1
Summary	This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Disorder MIM:	608110

mRNA and Protein(s)

mRNA	Protein	Name
NM_001276718.1	NP_001263647.1	serine/threonine-protein kinase PAK 6 isoform 2
NM_020168.5	NP_064553.1	serine/threonine-protein kinase PAK 6 isoform 1
NM_001276717.1	NP_001263646.1	serine/threonine-protein kinase PAK 6 isoform 1
NM_001276718.2	NP_001263647.1	serine/threonine-protein kinase PAK 6 isoform 2

Pathways from BioSystems

Homologies

	PAK6	XP_001094298.1
Bos taurus (cattle)	PAK6	NP_001179127.1
Homo sapiens (human)	PAK6	NP_001263646.1
Canis lupus familiaris (dog)	PAK6	XP_003640077.1
Xenopus tropicalis (tropical clawed frog)	pak6	XP_002932872.2
Mus musculus (house mouse)	Pak6	NP_001028426.2
Gallus gallus (chicken)	PAK6	XP_426393.3
Danio rerio (zebrafish)	pak6b	NP_001155959.1
Danio rerio (zebrafish)	LOC100536197	XP_003200338.1
Pan troglodytes (chimpanzee)	PAK6	XP_510302.2
Rattus norvegicus (Norway rat)	Pak6	NP_001099968.1

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy.
Jiang Y, Liu W, Li T, Hu Y, Chen S, Xi S, Wen Y, Huang L, Zhao L, Xiao C, Huang X, Han Z, Liu H, Qi X, Yang Y, Yu J, Cai S, Li G
EBioMedicine2278-88(2017 Aug)

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
Durkin CH, Leite F, Cordeiro JV, Handa Y, Arakawa Y, Valderrama F, Way M
Developmental cell41(3)315-329.e7(2017 05)

Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells.
Raja R, Sahasrabuddhe NA, Radhakrishnan A, Syed N, Solanki HS, Puttamallesh VN, Balaji SA, Nanjappa V, Datta KK, Babu N, Renuse S, Patil AH, Izumchenko E, Prasad TS, Chang X, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A
Oncotarget7(38)61229-61245(2016 Sep)

PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.
Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA
Journal of cell science129(2)380-93(2016 Jan)

The emerging importance of group II PAKs.
Wells CM, Jones GE
The Biochemical journal425(3)465-73(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RhoD recruits Pak6 to the plasma membrane to antagonize RhoC signaling during cell contraction and blebbing
Title: RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.

PAK6 localization to cell-cell adhesions is Cdc42-dependent
Title: PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.

p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease
Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

negative correlation between PAK6 and EZH2 expression was observed in hepatoma tissues from HCC patients. These data identified the tumor suppressive role and potential underlying mechanism of PAK6 in hepatocarcinogenesis
Title: Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma.

PAK6 is directly targeted by miR-328. miR-328 inhibits cell growth and promotes cell apoptosis in prostate cancer cells.
Title: MicroRNA?328 directly targets p21?activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity.

The following PAK6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAK6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00400	NM_020168.5 Latest version!	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00400	NM_001276717.1 Latest version!	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu08483	NM_001276718.2 Latest version!	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu08483	NM_001276718.1	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAK6 ( NM_020168.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_064553.1 Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00400
Clone ID Related Accession (Same CDS sequence)	NM_020168.5 , NM_001276717.1
Accession Version	NM_020168.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY128655.1, DA229537.1, AJ236915.1, AK131522.1 and AK026592.1. On Mar 1, 2013 this sequence version replaced NM_020168.4. Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.17104.1, SRR1803617.148240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064553.1
CDS	500..2545
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_020168.5
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020168.5

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAK6 ( NM_001276717.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263646.1 Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu00400
Clone ID Related Accession (Same CDS sequence)	NM_020168.5 , NM_001276717.1
Accession Version	NM_001276717.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191028.1 and BC035596.1. Transcript Variant: This variant (4) differs in the 5' UTR and the 3' UTR, compared to variant 1. Variants 1 and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035596.1, SRR1803615.52363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263646.1
CDS	118..2163
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001276717.1
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276717.1

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAK6 ( NM_001276718.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263647.1 Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.

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CloneID	OHu08483
Clone ID Related Accession (Same CDS sequence)	NM_001276718.1 , NM_001276718.2
Accession Version	NM_001276718.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK131522.1, AC020658.6, BC035596.1 and AK026592.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131522.1, SRR1660803.211743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTCTCCC CAGTGCTGCG AGACTTCCTG GAGCGGATGC TGGTGCGGGA CCCCCAAGAG 
AGAGCCACAG CCCAGGAGCT CCTAGACCAC CCCTTCCTGC TGCAGACAGG GCTACCTGAG 
TGCCTGGTGC CCCTGATCCA GCTCTACCGA AAGCAGACCT CCACCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263647.1
CDS	913..2823
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001276718.1
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276718.1

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTCTCCC CAGTGCTGCG AGACTTCCTG GAGCGGATGC TGGTGCGGGA CCCCCAAGAG 
AGAGCCACAG CCCAGGAGCT CCTAGACCAC CCCTTCCTGC TGCAGACAGG GCTACCTGAG 
TGCCTGGTGC CCCTGATCCA GCTCTACCGA AAGCAGACCT CCACCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAK6 ( NM_001276718.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263647.1 Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu08483
Clone ID Related Accession (Same CDS sequence)	NM_001276718.1 , NM_001276718.2
Accession Version	NM_001276718.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020658.6, AK131522.1, BC035596.1 and AK026592.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001276718.1. Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131522.1, SRR1660803.211743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTCTCCC CAGTGCTGCG AGACTTCCTG GAGCGGATGC TGGTGCGGGA CCCCCAAGAG 
AGAGCCACAG CCCAGGAGCT CCTAGACCAC CCCTTCCTGC TGCAGACAGG GCTACCTGAG 
TGCCTGGTGC CCCTGATCCA GCTCTACCGA AAGCAGACCT CCACCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263647.1
CDS	941..2851
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001276718.2
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276718.2

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTCTCCC CAGTGCTGCG AGACTTCCTG GAGCGGATGC TGGTGCGGGA CCCCCAAGAG 
AGAGCCACAG CCCAGGAGCT CCTAGACCAC CCCTTCCTGC TGCAGACAGG GCTACCTGAG 
TGCCTGGTGC CCCTGATCCA GCTCTACCGA AAGCAGACCT CCACCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy.
EBioMedicine2278-88(2017 Aug)
Jiang Y,Liu W,Li T,Hu Y,Chen S,Xi S,Wen Y,Huang L,Zhao L,Xiao C,Huang X,Han Z,Liu H,Qi X,Yang Y,Yu J,Cai S,Li G

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
Developmental cell41(3)315-329.e7(2017 05)
Durkin CH,Leite F,Cordeiro JV,Handa Y,Arakawa Y,Valderrama F,Way M

Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells.
Oncotarget7(38)61229-61245(2016 Sep)
Raja R,Sahasrabuddhe NA,Radhakrishnan A,Syed N,Solanki HS,Puttamallesh VN,Balaji SA,Nanjappa V,Datta KK,Babu N,Renuse S,Patil AH,Izumchenko E,Prasad TS,Chang X,Rangarajan A,Sidransky D,Pandey A,Gowda H,Chatterjee A

PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.
Journal of cell science129(2)380-93(2016 Jan)
Morse EM,Sun X,Olberding JR,Ha BH,Boggon TJ,Calderwood DA

The emerging importance of group II PAKs.
The Biochemical journal425(3)465-73(2010 Jan)
Wells CM,Jones GE

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PAK6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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