DPYSL5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DPYSL5
Entrez Gene ID	56896
Full Name	dihydropyrimidinase like 5
Synonyms	CRAM,CRMP-5,CRMP5,Ulip6
General protein information	Preferred Names dihydropyrimidinase like 5 Names dihydropyrimidinase-related protein 5 CRMP3-associated molecule DRP-5 ULIP-6 UNC33-like phosphoprotein 6 collapsin response mediator protein-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].
Disorder MIM:	608383

mRNA and Protein(s)

mRNA	Protein	Name
NM_001253724.1	NP_001240653.1	dihydropyrimidinase-related protein 5
NM_020134.4	NP_064519.2	dihydropyrimidinase-related protein 5
XM_024453007.1	XP_024308775.1	dihydropyrimidinase-related protein 5 isoform X1
NM_001253723.1	NP_001240652.1	dihydropyrimidinase-related protein 5
NM_020134.3	NP_064519.2	dihydropyrimidinase-related protein 5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC100910964	XP_003750165.1
Kluyveromyces lactis	KLLA0C19107g	XP_453052.1
Xenopus tropicalis (tropical clawed frog)	dpysl5	XP_002942399.2
	DPYSL5	XP_001088113.2
Bos taurus (cattle)	DPYSL5	NP_001103434.1
Danio rerio (zebrafish)	dpysl5a	NP_001018159.1
Homo sapiens (human)	DPYSL5	NP_001240652.1
Mus musculus (house mouse)	Dpysl5	NP_075534.1
Rattus norvegicus (Norway rat)	Dpysl5	NP_075412.1
Pan troglodytes (chimpanzee)	DPYSL5	XP_003308964.1
Canis lupus familiaris (dog)	DPYSL5	XP_005630294.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.
Wang L, Liu W, Tang H, Xie X, Zou C, Wang Y, Gao Z, Yin J
Cancer medicine6(5)982-993(2017 May)

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Moutal A, Honnorat J, Massoma P, D?sormeaux P, Bertrand C, Malleval C, Watrin C, Chounlamountri N, Mayeur ME, Besan?on R, Naudet N, Magadoux L, Khanna R, Ducray F, Meyronet D, Thomasset N
Cancer research75(17)3519-28(2015 Sep)

High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.
Hou T, Liang D, Yang D, He J, Huang Y, Zhang Y
International journal of clinical and experimental pathology7(3)1060-8(2014)

Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.
Brot S, Auger C, Bentata R, Rogemond V, M?nigoz S, Chounlamountri N, Girard-Egrot A, Honnorat J, Moradi-Am?li M
The Journal of biological chemistry289(4)2261-76(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings suggest that CRMP5 serves as a major mediator of Notch signaling and Akt activation by controlling the degradation of the Notch receptor, with implications for defining a biomarker signature in glioblastoma
Title: CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

present study suggested that CRAM could be a clinical prognostic marker for patients with cervical cancer
Title: High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.

study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function.
Title: Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.

identified residues that are crucial for determining the preference for hetero-oligomer or homo-oligomer formation. In spite of being the CRMP family member most closely related to dihydropyrimidinase, CRMP-5 does not have amidohydrolase activity.
Title: Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5.

New CRMP5 isoform present in the nucleus is associated with Glioma.
Title: Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.

The following DPYSL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DPYSL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14149	NM_001253723.1 Latest version!	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu14149	NM_001253724.1 Latest version!	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu14149	NM_020134.4 Latest version!	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu14149	XM_024453007.1 Latest version!	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu14149	NM_020134.3	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DPYSL5 ( NM_001253724.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001240653.1 Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14149
Clone ID Related Accession (Same CDS sequence)	NM_001253724.1 , NM_020134.4 , XM_024453007.1 , NM_001253723.1 , NM_020134.3
Accession Version	NM_001253724.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	dihydropyrimidinase-related protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA410946.1, AL713706.1, AC013472.8 and AW139156.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.803.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMN03465404 [ECO:0000348] ##Evidence-Data-END##

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240653.1
CDS	79..1773
Translation	MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Target ORF information:

RefSeq Version	NM_001253724.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253724.1

ORF Insert Sequence:

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DPYSL5 ( NM_020134.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064519.2 Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14149
Clone ID Related Accession (Same CDS sequence)	NM_001253724.1 , NM_020134.4 , XM_024453007.1 , NM_001253723.1 , NM_020134.3
Accession Version	NM_020134.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	dihydropyrimidinase-related protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF264015.1, AC013472.8 and AW139156.1. On Nov 23, 2018 this sequence version replaced NM_020134.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.269431.1, SRR1803612.190135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000288699.11/ ENSP00000288699.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064519.2
CDS	128..1822
Translation	MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Target ORF information:

RefSeq Version	NM_020134.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020134.4

ORF Insert Sequence:

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DPYSL5 ( NM_001253723.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001240652.1 Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14149
Clone ID Related Accession (Same CDS sequence)	NM_001253724.1 , NM_020134.4 , XM_024453007.1 , NM_001253723.1 , NM_020134.3
Accession Version	NM_001253723.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	dihydropyrimidinase-related protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC002874.2, AC013472.8 and AW139156.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002874.2, SRR1660803.111974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END##

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240652.1
CDS	76..1770
Translation	MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Target ORF information:

RefSeq Version	NM_001253723.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253723.1

ORF Insert Sequence:

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DPYSL5 ( NM_020134.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_064519.2 Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.

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CloneID	OHu14149
Clone ID Related Accession (Same CDS sequence)	NM_001253724.1 , NM_020134.4 , XM_024453007.1 , NM_001253723.1 , NM_020134.3
Accession Version	NM_020134.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	dihydropyrimidinase-related protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF264015.1, AC013472.8 and AW139156.1. On May 10, 2008 this sequence version replaced NM_020134.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.190135.1, SRR1660807.156937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064519.2
CDS	159..1853
Translation	MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Target ORF information:

RefSeq Version	NM_020134.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020134.3

ORF Insert Sequence:

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DPYSL5 ( XM_024453007.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308775.1 Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant X1, mRNA.

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CloneID	OHu14149
Clone ID Related Accession (Same CDS sequence)	NM_001253724.1 , NM_020134.4 , XM_024453007.1 , NM_001253723.1 , NM_020134.3
Accession Version	XM_024453007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dihydropyrimidinase-related protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308775.1
CDS	23..1717
Translation	MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Target ORF information:

RefSeq Version	XM_024453007.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024453007.1

ORF Insert Sequence:

ATGCTTGCCA ACTCAGCCAG CGTGAGGATC CTCATCAAGG GAGGCAAGGT GGTGAACGAT 
GACTGCACCC ACGAGGCTGA CGTCTACATC GAGAATGGCA TCATCCAGCA GGTGGGCCGC 
GAGCTCATGA TCCCTGGCGG GGCCAAGGTG ATTGATGCCA CAGGAAAACT GGTGATCCCT 
GGTGGCATCG ACACCAGCAC CCACTTCCAC CAGACCTTCA TGAATGCCAC GTGCGTGGAC 
GACTTCTACC ATGGGACCAA GGCAGCACTC GTCGGAGGCA CCACCATGAT CATCGGCCAC 
GTCCTGCCCG ACAAGGAGAC CTCCCTTGTG GACGCTTATG AGAAGTGCCG AGGTCTGGCC 
GACCCCAAGG TCTGCTGTGA TTACGCCCTC CACGTGGGGA TCACCTGGTG GGCACCCAAG 
GTGAAAGCAG AAATGGAGAC ACTGGTGAGG GAGAAGGGTG TCAACTCGTT CCAGATGTTC 
ATGACCTACA AGGACCTGTA CATGCTTCGA GACAGTGAGC TGTACCAAGT GTTGCACGCT 
TGCAAGGACA TTGGGGCAAT CGCCCGCGTC CATGCTGAAA ATGGGGAGCT TGTGGCCGAG 
GGTGCTAAGG AGGCACTGGA TTTGGGGATC ACAGGCCCAG AAGGAATCGA GATCAGCCGT 
CCAGAGGAGC TGGAAGCTGA AGCCACTCAT CGTGTTATCA CCATTGCAAA CAGGACTCAC 
TGTCCAATCT ACCTGGTCAA CGTGTCCAGT ATCTCGGCTG GTGACGTTAT CGCAGCTGCT 
AAGATGCAAG GGAAGGTTGT GCTGGCGGAG ACCACCACTG CACATGCCAC GCTGACAGGC 
TTACACTACT ACCACCAGGA CTGGTCCCAC GCGGCTGCCT ATGTCACGGT GCCTCCCCTG 
AGACTGGACA CCAACACCTC AACCTACCTC ATGAGCCTGC TGGCCAATGA CACTCTGAAC 
ATCGTGGCAT CAGATCACCG GCCTTTCACC ACAAAGCAGA AAGCTATGGG CAAGGAAGAC 
TTCACCAAGA TCCCACATGG AGTGAGTGGC GTGCAGGACC GCATGAGCGT CATCTGGGAG 
AGAGGAGTGG TTGGAGGAAA GATGGATGAG AACCGTTTTG TGGCCGTTAC CAGTTCCAAC 
GCAGCTAAGC TTCTGAACCT GTATCCCCGC AAGGGCCGCA TTATTCCCGG AGCCGATGCT 
GATGTGGTGG TGTGGGACCC AGAAGCCACA AAGACCATCT CAGCCAGCAC GCAGGTCCAG 
GGAGGAGACT TCAACCTGTA TGAGAACATG CGCTGCCACG GCGTGCCACT GGTCACCATC 
AGCCGGGGGC GCGTCGTGTA TGAGAACGGC GTCTTCATGT GCGCCGAGGG CACCGGCAAG 
TTCTGTCCCC TGAGGTCCTT CCCAGACACT GTCTACAAGA AGCTGGTCCA GAGAGAGAAG 
ACTTTAAAGG TTAGAGGAGT GGACCGCACT CCCTACCTGG GGGATGTCGC TGTTGTCGTG 
CACCCTGGGA AAAAAGAGAT GGGAACCCCA CTCGCAGACA CTCCTACCCG GCCCGTCACC 
CGGCATGGGG GCATGAGGGA CCTTCACGAA TCCAGCTTCA GCCTCTCTGG CTCTCAGATC 
GATGACCATG TTCCAAAGCG AGCTTCAGCT CGGATCCTCG CTCCTCCCGG AGGCAGGTCG 
AGTGGCATTT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.
Cancer medicine6(5)982-993(2017 May)
Wang L,Liu W,Tang H,Xie X,Zou C,Wang Y,Gao Z,Yin J

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Cancer research75(17)3519-28(2015 Sep)
Moutal A,Honnorat J,Massoma P,D?sormeaux P,Bertrand C,Malleval C,Watrin C,Chounlamountri N,Mayeur ME,Besan?on R,Naudet N,Magadoux L,Khanna R,Ducray F,Meyronet D,Thomasset N

High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.
International journal of clinical and experimental pathology7(3)1060-8(2014)
Hou T,Liang D,Yang D,He J,Huang Y,Zhang Y

Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.
The Journal of biological chemistry289(4)2261-76(2014 Jan)
Brot S,Auger C,Bentata R,Rogemond V,M?nigoz S,Chounlamountri N,Girard-Egrot A,Honnorat J,Moradi-Am?li M

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DPYSL5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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