TCIM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCIM
Entrez Gene ID	56892
Full Name	transcriptional and immune response regulator
Synonyms	C8orf4,TC-1,TC1
General protein information	Preferred Names transcriptional and immune response regulator Names transcriptional and immune response regulator human thyroid cancer 1 protein C8orf4 thyroid cancer protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.21
Summary	This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011].
Disorder MIM:	607702

mRNA and Protein(s)

mRNA	Protein	Name
NM_020130.5	NP_064515.2	transcriptional and immune response regulator
NM_020130.4	NP_064515.1	transcriptional and immune response regulator

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C8H8orf4	XP_519724.2
Rattus norvegicus (Norway rat)	LOC100910163	XP_003751670.1
Canis lupus familiaris (dog)	C16H8orf4	XP_003432158.2
Mus musculus (house mouse)	1810011O10Rik	NP_081207.1
Gallus gallus (chicken)	C8ORF4	XP_001232955.1
Homo sapiens (human)	C8orf4	NP_064515.1
Rattus norvegicus (Norway rat)	LOC684871	NP_001108515.1
Danio rerio (zebrafish)	zgc:110340	NP_001013490.1
	C8H8orf4	XP_001093849.1
Xenopus tropicalis (tropical clawed frog)	c8orf4	XP_002932624.2
Bos taurus (cattle)	C27H8orf4	NP_001030567.1

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
Evans IC, Barnes JL, Garner IM, Pearce DR, Maher TM, Shiwen X, Renzoni EA, Wells AU, Denton CP, Laurent GJ, Abraham DJ, McAnulty RJ
Clinical science (London, England : 1979)130(8)575-86(2016 Apr)

The high expression of TC1 (C8orf4) was correlated with the expression of ?-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
Zhang P, Cao HY, Bai LL, Li WN, Wang Y, Chen SY, Zhang L, Yang LH, Xu HT, Wang EH
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(9)7061-7(2015 Sep)

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.
Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, Fan Z
Nature communications67122(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4.
Title: Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.

the high expression of TC1 was common in oral tongue squamous cell carcinomas and correlated with the expression of b-catenin and cyclin D1 and the progression of oral tongue squamous cell carcinomas
Title: The high expression of TC1 (C8orf4) was correlated with the expression of ?-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.

C8orf4 negatively regulates the self-renewal of liver CSCs via suppression of NOTCH2 signalling
Title: C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.

TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.
Title: TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.

TC-1 expression is associated with aggressive biologic behavior in lung cancer and might coordinate with the Wnt/beta-catenin pathway as a positive upstream regulator that induces these behaviors.
Title: TC-1 (c8orf4) enhances aggressive biologic behavior in lung cancer through the Wnt/?-catenin pathway.

The following TCIM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCIM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu55848	NM_020130.4 Latest version!	Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu108596	NM_020130.5 Latest version!	Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCIM ( NM_020130.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064515.1 Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.

Price & Availability↑

CloneID	OHu55848
Clone ID Related Accession (Same CDS sequence)	NM_020130.4
Accession Version	NM_020130.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-01
Organism	Homo sapiens(human)
Product	transcriptional and immune response regulator
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC021672.1, BX434108.2, AI861861.1 and AI935347.1. On Nov 9, 2011 this sequence version replaced NM_020130.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.

ATGAAAGCAA AGCGAAGCCA CCAAGCCATC ATCATGTCCA CGTCGCTACG AGTCAGCCCA 
TCCATCCATG GCTACCACTT CGACACAGCC TCTCGTAAGA AAGCCGTGGG CAACATCTTT 
GAAAACACAG ACCAAGAATC ACTAGAAAGG CTCTTCAGAA ACTCTGGAGA CAAGAAAGCA 
GAGGAGAGAG CCAAGATCAT TTTTGCCATA GATCAAGATG TGGAGGAGAA AACGCGTGCC 
CTGATGGCCT TGAAGAAGAG GACAAAAGAC AAGCTTTTCC AGTTTCTGAA ACTGCGGAAA 
TATTCCATCA AAGTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064515.1
CDS	66..386
Translation	MKAKRSHQAIIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH

Target ORF information:

RefSeq Version	NM_020130.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020130.4

ORF Insert Sequence:

ATGAAAGCAA AGCGAAGCCA CCAAGCCATC ATCATGTCCA CGTCGCTACG AGTCAGCCCA 
TCCATCCATG GCTACCACTT CGACACAGCC TCTCGTAAGA AAGCCGTGGG CAACATCTTT 
GAAAACACAG ACCAAGAATC ACTAGAAAGG CTCTTCAGAA ACTCTGGAGA CAAGAAAGCA 
GAGGAGAGAG CCAAGATCAT TTTTGCCATA GATCAAGATG TGGAGGAGAA AACGCGTGCC 
CTGATGGCCT TGAAGAAGAG GACAAAAGAC AAGCTTTTCC AGTTTCTGAA ACTGCGGAAA 
TATTCCATCA AAGTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCIM ( NM_020130.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_064515.2 Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.

Price & Availability↑

CloneID	OHu108596
Clone ID Related Accession (Same CDS sequence)	NM_020130.5
Accession Version	NM_020130.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	transcriptional and immune response regulator
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022733.8. On May 17, 2019 this sequence version replaced NM_020130.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DRR138516.100253.1, SRR1660807.62929.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000315792.5/ ENSP00000319914.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGCAA AGCGAAGCCA CCAAGCCGTC ATCATGTCCA CGTCGCTACG AGTCAGCCCA 
TCCATCCATG GCTACCACTT CGACACAGCC TCTCGTAAGA AAGCCGTGGG CAACATCTTT 
GAAAACACAG ACCAAGAATC ACTAGAAAGG CTCTTCAGAA ACTCTGGAGA CAAGAAAGCA 
GAGGAGAGAG CCAAGATCAT TTTTGCCATA GATCAAGATG TGGAGGAGAA AACGCGTGCC 
CTGATGGCCT TGAAGAAGAG GACAAAAGAC AAGCTTTTCC AGTTTCTGAA ACTGCGGAAA 
TATTCCATCA AAGTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064515.2
CDS	52..372
Translation	MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH

Target ORF information:

RefSeq Version	NM_020130.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transcriptional and immune response regulator (TCIM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020130.5

ORF Insert Sequence:

ATGAAAGCAA AGCGAAGCCA CCAAGCCGTC ATCATGTCCA CGTCGCTACG AGTCAGCCCA 
TCCATCCATG GCTACCACTT CGACACAGCC TCTCGTAAGA AAGCCGTGGG CAACATCTTT 
GAAAACACAG ACCAAGAATC ACTAGAAAGG CTCTTCAGAA ACTCTGGAGA CAAGAAAGCA 
GAGGAGAGAG CCAAGATCAT TTTTGCCATA GATCAAGATG TGGAGGAGAA AACGCGTGCC 
CTGATGGCCT TGAAGAAGAG GACAAAAGAC AAGCTTTTCC AGTTTCTGAA ACTGCGGAAA 
TATTCCATCA AAGTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
Clinical science (London, England : 1979)130(8)575-86(2016 Apr)
Evans IC,Barnes JL,Garner IM,Pearce DR,Maher TM,Shiwen X,Renzoni EA,Wells AU,Denton CP,Laurent GJ,Abraham DJ,McAnulty RJ

The high expression of TC1 (C8orf4) was correlated with the expression of ?-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(9)7061-7(2015 Sep)
Zhang P,Cao HY,Bai LL,Li WN,Wang Y,Chen SY,Zhang L,Yang LH,Xu HT,Wang EH

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.
Nature communications67122(2015 May)
Zhu P,Wang Y,Du Y,He L,Huang G,Zhang G,Yan X,Fan Z

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TCIM cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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