PSMA7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMA7
Entrez Gene ID	5688
Full Name	proteasome subunit alpha 7
Synonyms	C6,HEL-S-276,HSPC,RC6-1,XAPC7
General protein information	Preferred Names proteasome subunit alpha 7 Names proteasome subunit alpha type-7 epididymis secretory protein Li 276 proteasome (prosome, macropain) subunit, alpha type, 7 proteasome subunit RC6-1 proteasome subunit XAPC7 proteasome subunit alpha 4 testicular tissue protein Li 151
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.33
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012].
Disorder MIM:	606607

mRNA and Protein(s)

mRNA	Protein	Name
NM_002792.3	NP_002783.1	proteasome subunit alpha type-7
NM_002792.4	NP_002783.1	proteasome subunit alpha type-7

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSMA7	XP_514761.3
Bos taurus (cattle)	PSMA7	NP_001029405.1
Caenorhabditis elegans (roundworm)	pas-4	NP_492360.1
Mus musculus (house mouse)	Psma7	NP_036099.1
Homo sapiens (human)	PSMA7	NP_002783.1
Xenopus tropicalis (tropical clawed frog)	psma7	NP_989071.1
Canis lupus familiaris (dog)	PSMA7	XP_005635423.1
Rattus norvegicus (Norway rat)	Psma7	NP_001008218.1
Gallus gallus (chicken)	PSMA7	NP_989944.1

Gene Ontology
Bibliography

Related articles in PubMed

Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.
Zheng X, Chen F, Zhang Q, Liu Y, You P, Sun S, Lin J, Chen N
Protein & cell8(9)686-695(2017 Sep)

Disassembly of the self-assembled, double-ring structure of proteasome ?7 homo-tetradecamer by ?6.
Ishii K, Noda M, Yagi H, Thammaporn R, Seetaha S, Satoh T, Kato K, Uchiyama S
Scientific reports518167(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with Inflammatory bowel disease. It can be a very promising biomarker
Title: Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.

Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes.
Title: Proteasome system dysregulation and treatment resistance mechanisms in major depressive disorder.

Data indicate that proteasome subunit alpha 6 (PSMA6) direct contacts with proteasome subunit alpha 7 (PSMA7) tetradecamer.
Title: Disassembly of the self-assembled, double-ring structure of proteasome ?7 homo-tetradecamer by ?6.

c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit
Title: c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit.

PSMA7 functions partially through downregulation NOD1.
Title: PSMA7 directly interacts with NOD1 and regulates its function.

The following PSMA7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMA7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10095	NM_002792.4 Latest version!	Homo sapiens proteasome 20S subunit alpha 7 (PSMA7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu10095	NM_002792.3	Homo sapiens proteasome subunit alpha 7 (PSMA7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMA7 ( NM_002792.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002783.1 Homo sapiens proteasome 20S subunit alpha 7 (PSMA7), mRNA.

Price & Availability↑

CloneID	OHu10095
Clone ID Related Accession (Same CDS sequence)	NM_002792.3 , NM_002792.4
Accession Version	NM_002792.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG575009.1, AF054185.1 and BU632089.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002792.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.498155.1, SRR1163657.409375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370873.9/ ENSP00000359910.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTACG ACCGCGCCAT CACCGTCTTC TCGCCCGACG GCCACCTCTT CCAAGTGGAG 
TACGCGCAGG AGGCCGTCAA GAAGGGCTCG ACCGCGGTTG GTGTTCGAGG AAGAGACATT 
GTTGTTCTTG GTGTGGAGAA GAAGTCAGTG GCCAAACTGC AGGATGAAAG AACAGTGCGG 
AAGATCTGTG CTTTGGATGA CAACGTCTGC ATGGCCTTTG CAGGCCTCAC CGCCGATGCA 
AGGATAGTCA TCAACAGGGC CCGGGTGGAG TGCCAGAGCC ACCGGCTGAC TGTGGAGGAC 
CCGGTCACTG TGGAGTACAT CACCCGCTAC ATCGCCAGTC TGAAGCAGCG TTATACGCAG 
AGCAATGGGC GCAGGCCGTT TGGCATCTCT GCCCTCATCG TGGGTTTCGA CTTTGATGGC 
ACTCCTAGGC TCTATCAGAC TGACCCCTCG GGCACATACC ATGCCTGGAA GGCCAATGCC 
ATAGGTCGGG GTGCCAAGTC AGTGCGCGAG TTCCTGGAGA AGAACTATAC TGACGAAGCC 
ATTGAAACAG ATGATCTGAC CATTAAGCTG GTGATCAAGG CACTCCTGGA AGTGGTTCAG 
TCAGGTGGCA AAAACATTGA ACTTGCTGTC ATGAGGCGAG ATCAATCCCT CAAGATTTTA 
AATCCTGAAG AAATTGAGAA GTATGTTGCT GAAATTGAAA AAGAAAAAGA AGAAAACGAA 
AAGAAGAAAC AAAAGAAAGC ATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002783.1
CDS	92..838
Translation	MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Target ORF information:

RefSeq Version	NM_002792.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 7 (PSMA7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002792.4

ORF Insert Sequence:

ATGAGCTACG ACCGCGCCAT CACCGTCTTC TCGCCCGACG GCCACCTCTT CCAAGTGGAG 
TACGCGCAGG AGGCCGTCAA GAAGGGCTCG ACCGCGGTTG GTGTTCGAGG AAGAGACATT 
GTTGTTCTTG GTGTGGAGAA GAAGTCAGTG GCCAAACTGC AGGATGAAAG AACAGTGCGG 
AAGATCTGTG CTTTGGATGA CAACGTCTGC ATGGCCTTTG CAGGCCTCAC CGCCGATGCA 
AGGATAGTCA TCAACAGGGC CCGGGTGGAG TGCCAGAGCC ACCGGCTGAC TGTGGAGGAC 
CCGGTCACTG TGGAGTACAT CACCCGCTAC ATCGCCAGTC TGAAGCAGCG TTATACGCAG 
AGCAATGGGC GCAGGCCGTT TGGCATCTCT GCCCTCATCG TGGGTTTCGA CTTTGATGGC 
ACTCCTAGGC TCTATCAGAC TGACCCCTCG GGCACATACC ATGCCTGGAA GGCCAATGCC 
ATAGGTCGGG GTGCCAAGTC AGTGCGCGAG TTCCTGGAGA AGAACTATAC TGACGAAGCC 
ATTGAAACAG ATGATCTGAC CATTAAGCTG GTGATCAAGG CACTCCTGGA AGTGGTTCAG 
TCAGGTGGCA AAAACATTGA ACTTGCTGTC ATGAGGCGAG ATCAATCCCT CAAGATTTTA 
AATCCTGAAG AAATTGAGAA GTATGTTGCT GAAATTGAAA AAGAAAAAGA AGAAAACGAA 
AAGAAGAAAC AAAAGAAAGC ATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA7 ( NM_002792.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002783.1 Homo sapiens proteasome subunit alpha 7 (PSMA7), mRNA.

Price & Availability↑

CloneID	OHu10095
Clone ID Related Accession (Same CDS sequence)	NM_002792.3 , NM_002792.4
Accession Version	NM_002792.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY039591.1, BG575009.1, AF054185.1, BU632089.1 and BU687782.1. This sequence is a reference standard in the RefSeqGene project. On Jul 12, 2012 this sequence version replaced NM_002792.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.282150.1, SRR1163658.174452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTACG ACCGCGCCAT CACCGTCTTC TCGCCCGACG GCCACCTCTT CCAAGTGGAG 
TACGCGCAGG AGGCCGTCAA GAAGGGCTCG ACCGCGGTTG GTGTTCGAGG AAGAGACATT 
GTTGTTCTTG GTGTGGAGAA GAAGTCAGTG GCCAAACTGC AGGATGAAAG AACAGTGCGG 
AAGATCTGTG CTTTGGATGA CAACGTCTGC ATGGCCTTTG CAGGCCTCAC CGCCGATGCA 
AGGATAGTCA TCAACAGGGC CCGGGTGGAG TGCCAGAGCC ACCGGCTGAC TGTGGAGGAC 
CCGGTCACTG TGGAGTACAT CACCCGCTAC ATCGCCAGTC TGAAGCAGCG TTATACGCAG 
AGCAATGGGC GCAGGCCGTT TGGCATCTCT GCCCTCATCG TGGGTTTCGA CTTTGATGGC 
ACTCCTAGGC TCTATCAGAC TGACCCCTCG GGCACATACC ATGCCTGGAA GGCCAATGCC 
ATAGGTCGGG GTGCCAAGTC AGTGCGCGAG TTCCTGGAGA AGAACTATAC TGACGAAGCC 
ATTGAAACAG ATGATCTGAC CATTAAGCTG GTGATCAAGG CACTCCTGGA AGTGGTTCAG 
TCAGGTGGCA AAAACATTGA ACTTGCTGTC ATGAGGCGAG ATCAATCCCT CAAGATTTTA 
AATCCTGAAG AAATTGAGAA GTATGTTGCT GAAATTGAAA AAGAAAAAGA AGAAAACGAA 
AAGAAGAAAC AAAAGAAAGC ATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002783.1
CDS	156..902
Translation	MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Target ORF information:

RefSeq Version	NM_002792.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit alpha 7 (PSMA7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002792.3

ORF Insert Sequence:

ATGAGCTACG ACCGCGCCAT CACCGTCTTC TCGCCCGACG GCCACCTCTT CCAAGTGGAG 
TACGCGCAGG AGGCCGTCAA GAAGGGCTCG ACCGCGGTTG GTGTTCGAGG AAGAGACATT 
GTTGTTCTTG GTGTGGAGAA GAAGTCAGTG GCCAAACTGC AGGATGAAAG AACAGTGCGG 
AAGATCTGTG CTTTGGATGA CAACGTCTGC ATGGCCTTTG CAGGCCTCAC CGCCGATGCA 
AGGATAGTCA TCAACAGGGC CCGGGTGGAG TGCCAGAGCC ACCGGCTGAC TGTGGAGGAC 
CCGGTCACTG TGGAGTACAT CACCCGCTAC ATCGCCAGTC TGAAGCAGCG TTATACGCAG 
AGCAATGGGC GCAGGCCGTT TGGCATCTCT GCCCTCATCG TGGGTTTCGA CTTTGATGGC 
ACTCCTAGGC TCTATCAGAC TGACCCCTCG GGCACATACC ATGCCTGGAA GGCCAATGCC 
ATAGGTCGGG GTGCCAAGTC AGTGCGCGAG TTCCTGGAGA AGAACTATAC TGACGAAGCC 
ATTGAAACAG ATGATCTGAC CATTAAGCTG GTGATCAAGG CACTCCTGGA AGTGGTTCAG 
TCAGGTGGCA AAAACATTGA ACTTGCTGTC ATGAGGCGAG ATCAATCCCT CAAGATTTTA 
AATCCTGAAG AAATTGAGAA GTATGTTGCT GAAATTGAAA AAGAAAAAGA AGAAAACGAA 
AAGAAGAAAC AAAAGAAAGC ATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.
Protein & cell8(9)686-695(2017 Sep)
Zheng X,Chen F,Zhang Q,Liu Y,You P,Sun S,Lin J,Chen N

Disassembly of the self-assembled, double-ring structure of proteasome ?7 homo-tetradecamer by ?6.
Scientific reports518167(2015 Dec)
Ishii K,Noda M,Yagi H,Thammaporn R,Seetaha S,Satoh T,Kato K,Uchiyama S

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PSMA7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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