PSMA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMA3
Entrez Gene ID	5684
Full Name	proteasome subunit alpha 3
Synonyms	HC8,PSC3
General protein information	Preferred Names proteasome subunit alpha 3 Names proteasome subunit alpha type-3 macropain subunit C8 multicatalytic endopeptidase complex subunit C8 proteasome (prosome, macropain) subunit, alpha type, 3 proteasome component C8 proteasome subunit C8 testicular secretory protein Li 43
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q23.1
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	176843

mRNA and Protein(s)

mRNA	Protein	Name
NM_002788.3	NP_002779.1	proteasome subunit alpha type-3 isoform 1
NM_002788.4	NP_002779.1	proteasome subunit alpha type-3 isoform 1
NM_152132.2	NP_687033.1	proteasome subunit alpha type-3 isoform 2

Pathways from BioSystems

Homologies

	PSMA3	XP_001091541.1
Neurospora crassa	NCU02493	XP_965087.1
Arabidopsis thaliana (thale cress)	PAG1	NP_180270.1
Pan troglodytes (chimpanzee)	PSMA3	XP_001164848.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001973	XP_003435981.1
Kluyveromyces lactis	KLLA0A03487g	XP_451153.2
Schizosaccharomyces pombe (fission yeast)	pre10	NP_588040.1
Bos taurus (cattle)	PSMA3	NP_001029407.1
Drosophila melanogaster (fruit fly)	Prosalpha7	NP_724834.1
Caenorhabditis elegans (roundworm)	pas-7	NP_496177.2
Magnaporthe oryzae (rice blast fungus)	MGG_07727	XP_003712933.1
Canis lupus familiaris (dog)	PSMA3	XP_537460.2
Mus musculus (house mouse)	Psma3	NP_035314.3
Rattus norvegicus (Norway rat)	Psma3	NP_058976.1
Gallus gallus (chicken)	PSMA3	NP_001006491.1
Saccharomyces cerevisiae (baker's yeast)	PRE10	NP_015007.1
Oryza sativa (rice)	Os01g0811100	NP_001044588.1
Homo sapiens (human)	PSMA3	NP_002779.1
Danio rerio (zebrafish)	psma3	NP_001025358.1
Eremothecium gossypii	AGOS_ADR401C	NP_984496.1
Xenopus tropicalis (tropical clawed frog)	psma3	NP_001011257.1

Gene Ontology
Bibliography

Related articles in PubMed

Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker.
Verathamjamras C, Weeraphan C, Chokchaichamnankit D, Watcharatanyatip K, Subhasitanont P, Diskul-Na-Ayudthaya P, Mingkwan K, Luevisadpaibul V, Chutipongtanate S, Champattanachai V, Svasti J, Srisomsap C
International journal of oncology51(1)269-280(2017 Jul)

Mutations in proteasome-related genes are associated with thyroid hemiagenesis.
Budny B, Szczepanek-Parulska E, Zemojtel T, Szaflarski W, Rydzanicz M, Wesoly J, Handschuh L, Wolinski K, Piatek K, Niedziela M, Ziemnicka K, Figlerowicz M, Zabel M, Ruchala M
Endocrine56(2)279-285(2017 May)

Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.
Sjakste T, Paramonova N, Osina K, Dokane K, Sokolovska J, Sjakste N
Molecular genetics and genomics : MGG291(2)891-903(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1, PSMA3, and PSMD3.
Title: Mutations in proteasome-related genes are associated with thyroid hemiagenesis.

Our results provide evidence on new T1DM-susceptible loci in the PSMA3, PSMA6 and PSMC6 proteasome genes and give a new insight into the T1DM pathogenesis
Title: Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.

Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel.
Title: Protein Interaction between Ameloblastin and Proteasome Subunit ? Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel.

Evidence of a sex-specific association of PSMA3 genetic variants with subtypes of juvenile idiopathic arthritis.
Title: Juvenile idiopathic arthritis subtype- and sex-specific associations with genetic variants in the PSMA6/PSMC6/PSMA3 gene cluster.

A combination of two-dimensional gel electrophoresis (2D-GE) and tandem mass-spectrometry revealed a large number of PSMA3-bound proteins that are involved in various aspects of mRNA metabolism, including splicing.
Title: Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism.

The following PSMA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09405	NM_152132.2 Latest version!	Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09416	NM_002788.4 Latest version!	Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09416	NM_002788.3	Homo sapiens proteasome subunit alpha 3 (PSMA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMA3 ( NM_152132.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_687033.1 Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09405
Clone ID Related Accession (Same CDS sequence)	NM_152132.2
Accession Version	NM_152132.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF128376.1 and BC005265.1. On Apr 27, 2011 this sequence version replaced NM_152132.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005265.1, BT006711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTGTGAA TGACGGTGCG 
CAACTCTACA TGATTGACCC ATCAGGTGTT TCATACGGTT ATTGGGGCTG TGCCATCGGC 
AAAGCCAGGC AAGCTGCAAA GACGGAAATA GAGAAGCTTC AGATGAAAGA AATGACCTGC 
CGTGATATCG TTAAAGAAGT TGCAAAAATA ATTTACATAG TACATGACGA AGTTAAGGAT 
AAAGCTTTTG AACTAGAACT CAGCTGGGTT GGTGAATTAA CTAATGGAAG ACATGAAATT 
GTTCCAAAAG ATATAAGAGA AGAAGCAGAG AAATATGCTA AGGAATCTCT GAAGGAAGAA 
GATGAATCAG ATGATGATAA TATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_687033.1
CDS	117..863
Translation	MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM

Target ORF information:

RefSeq Version	NM_152132.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152132.2

ORF Insert Sequence:

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTGTGAA TGACGGTGCG 
CAACTCTACA TGATTGACCC ATCAGGTGTT TCATACGGTT ATTGGGGCTG TGCCATCGGC 
AAAGCCAGGC AAGCTGCAAA GACGGAAATA GAGAAGCTTC AGATGAAAGA AATGACCTGC 
CGTGATATCG TTAAAGAAGT TGCAAAAATA ATTTACATAG TACATGACGA AGTTAAGGAT 
AAAGCTTTTG AACTAGAACT CAGCTGGGTT GGTGAATTAA CTAATGGAAG ACATGAAATT 
GTTCCAAAAG ATATAAGAGA AGAAGCAGAG AAATATGCTA AGGAATCTCT GAAGGAAGAA 
GATGAATCAG ATGATGATAA TATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA3 ( NM_002788.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002779.1 Homo sapiens proteasome subunit alpha 3 (PSMA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09416
Clone ID Related Accession (Same CDS sequence)	NM_002788.3 , NM_002788.4
Accession Version	NM_002788.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-28
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF128376.1, D00762.1 and BC038990.1. On Apr 27, 2011 this sequence version replaced NM_002788.2. Transcript Variant: This variant (1) encodes the longer isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.434482.1, SRR1163658.270054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTAGGGTCT 
TACAGTGTGA ATGACGGTGC GCAACTCTAC ATGATTGACC CATCAGGTGT TTCATACGGT 
TATTGGGGCT GTGCCATCGG CAAAGCCAGG CAAGCTGCAA AGACGGAAAT AGAGAAGCTT 
CAGATGAAAG AAATGACCTG CCGTGATATC GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGACG AAGTTAAGGA TAAAGCTTTT GAACTAGAAC TCAGCTGGGT TGGTGAATTA 
ACTAATGGAA GACATGAAAT TGTTCCAAAA GATATAAGAG AAGAAGCAGA GAAATATGCT 
AAGGAATCTC TGAAGGAAGA AGATGAATCA GATGATGATA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002779.1
CDS	117..884
Translation	MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM

Target ORF information:

RefSeq Version	NM_002788.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit alpha 3 (PSMA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002788.3

ORF Insert Sequence:

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTAGGGTCT 
TACAGTGTGA ATGACGGTGC GCAACTCTAC ATGATTGACC CATCAGGTGT TTCATACGGT 
TATTGGGGCT GTGCCATCGG CAAAGCCAGG CAAGCTGCAA AGACGGAAAT AGAGAAGCTT 
CAGATGAAAG AAATGACCTG CCGTGATATC GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGACG AAGTTAAGGA TAAAGCTTTT GAACTAGAAC TCAGCTGGGT TGGTGAATTA 
ACTAATGGAA GACATGAAAT TGTTCCAAAA GATATAAGAG AAGAAGCAGA GAAATATGCT 
AAGGAATCTC TGAAGGAAGA AGATGAATCA GATGATGATA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA3 ( NM_002788.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002779.1 Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09416
Clone ID Related Accession (Same CDS sequence)	NM_002788.3 , NM_002788.4
Accession Version	NM_002788.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF128376.1, D00762.1 and BC038990.1. On Nov 22, 2018 this sequence version replaced NM_002788.3. Transcript Variant: This variant (1) encodes the longer isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.451352.1, SRR1163658.270054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216455.9/ ENSP00000216455.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTAGGGTCT 
TACAGTGTGA ATGACGGTGC GCAACTCTAC ATGATTGACC CATCAGGTGT TTCATACGGT 
TATTGGGGCT GTGCCATCGG CAAAGCCAGG CAAGCTGCAA AGACGGAAAT AGAGAAGCTT 
CAGATGAAAG AAATGACCTG CCGTGATATC GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGACG AAGTTAAGGA TAAAGCTTTT GAACTAGAAC TCAGCTGGGT TGGTGAATTA 
ACTAATGGAA GACATGAAAT TGTTCCAAAA GATATAAGAG AAGAAGCAGA GAAATATGCT 
AAGGAATCTC TGAAGGAAGA AGATGAATCA GATGATGATA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002779.1
CDS	79..846
Translation	MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM

Target ORF information:

RefSeq Version	NM_002788.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002788.4

ORF Insert Sequence:

ATGAGCTCAA TCGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGACGGAAGA 
GTTTTTCAAG TTGAATATGC TATGAAGGCT GTGGAAAATA GTAGTACAGC TATTGGAATC 
AGATGCAAAG ATGGTGTTGT CTTTGGGGTA GAAAAATTAG TCCTTTCTAA ACTTTATGAA 
GAAGGTTCCA ACAAAAGACT TTTTAATGTT GATCGGCATG TTGGAATGGC AGTAGCAGGT 
TTGTTGGCAG ATGCTCGTTC TTTAGCAGAC ATAGCAAGAG AAGAAGCTTC CAACTTCAGA 
TCTAACTTTG GCTACAACAT TCCACTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTG 
CATGCATATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTAGGGTCT 
TACAGTGTGA ATGACGGTGC GCAACTCTAC ATGATTGACC CATCAGGTGT TTCATACGGT 
TATTGGGGCT GTGCCATCGG CAAAGCCAGG CAAGCTGCAA AGACGGAAAT AGAGAAGCTT 
CAGATGAAAG AAATGACCTG CCGTGATATC GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGACG AAGTTAAGGA TAAAGCTTTT GAACTAGAAC TCAGCTGGGT TGGTGAATTA 
ACTAATGGAA GACATGAAAT TGTTCCAAAA GATATAAGAG AAGAAGCAGA GAAATATGCT 
AAGGAATCTC TGAAGGAAGA AGATGAATCA GATGATGATA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker.
International journal of oncology51(1)269-280(2017 Jul)
Verathamjamras C,Weeraphan C,Chokchaichamnankit D,Watcharatanyatip K,Subhasitanont P,Diskul-Na-Ayudthaya P,Mingkwan K,Luevisadpaibul V,Chutipongtanate S,Champattanachai V,Svasti J,Srisomsap C

Mutations in proteasome-related genes are associated with thyroid hemiagenesis.
Endocrine56(2)279-285(2017 May)
Budny B,Szczepanek-Parulska E,Zemojtel T,Szaflarski W,Rydzanicz M,Wesoly J,Handschuh L,Wolinski K,Piatek K,Niedziela M,Ziemnicka K,Figlerowicz M,Zabel M,Ruchala M

Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.
Molecular genetics and genomics : MGG291(2)891-903(2016 Apr)
Sjakste T,Paramonova N,Osina K,Dokane K,Sokolovska J,Sjakste N

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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PSMA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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