PSMA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMA2
Entrez Gene ID	5683
Full Name	proteasome subunit alpha 2
Synonyms	HC3,MU,PMSA2,PSC2
General protein information	Preferred Names proteasome subunit alpha 2 Names proteasome subunit alpha type-2 macropain subunit C3 multicatalytic endopeptidase complex subunit C3 proteasome (prosome, macropain) subunit, alpha type, 2 proteasome component C3 proteasome subunit HC3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008].
Disorder MIM:	176842

mRNA and Protein(s)

mRNA	Protein	Name
NM_002787.5	NP_002778.1	proteasome subunit alpha type-2
NM_002787.4	NP_002778.1	proteasome subunit alpha type-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSMA2	XP_528026.2
	PSMA2	XP_001097325.1
Saccharomyces cerevisiae (baker's yeast)	PRE8	NP_013618.1
Homo sapiens (human)	PSMA2	NP_002778.1
Canis lupus familiaris (dog)	PSMA2	XP_533078.3
Bos taurus (cattle)	PSMA2	NP_001029834.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001995	XP_550819.1
Neurospora crassa	NCU06764	XP_963536.1
Arabidopsis thaliana (thale cress)	PAB1	NP_001031057.1
Xenopus tropicalis (tropical clawed frog)	psma2	NP_001016382.1
Mus musculus (house mouse)	Psma2	NP_032970.2
Danio rerio (zebrafish)	psma2	NP_001019612.1
Kluyveromyces lactis	KLLA0D10373g	XP_453523.1
Schizosaccharomyces pombe (fission yeast)	pre8	NP_588320.1
Rattus norvegicus (Norway rat)	Psma2	NP_058975.1
Magnaporthe oryzae (rice blast fungus)	MGG_07165	XP_003715363.1
Arabidopsis thaliana (thale cress)	AT1G79210	NP_178042.1
Oryza sativa (rice)	Os02g0634900	NP_001047516.1
Oryza sativa (rice)	Os03g0387100	NP_001050259.1
Gallus gallus (chicken)	PSMA2	NP_001012878.2
Danio rerio (zebrafish)	si:rp71-45k5.4	NP_001122146.1
Drosophila melanogaster (fruit fly)	Pros25	NP_524328.1
Caenorhabditis elegans (roundworm)	pas-2	NP_505750.1
Eremothecium gossypii	AGOS_ADL354W	NP_983741.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal structure of the human 20S proteasome in complex with carfilzomib.
Harshbarger W, Miller C, Diedrich C, Sacchettini J
Structure (London, England : 1993)23(2)418-24(2015 Feb)

Toward an understanding of the protein interaction network of the human liver.
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X
Molecular systems biology7536(2011 Oct)

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Science signaling4(189)rs8(2011 Sep)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression level of psma6 in AML-M5 patients with complete remission was higher than that in AML-M5 patients without remission.
Title: [Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia].

The following PSMA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15225	NM_002787.5 Latest version!	Homo sapiens proteasome 20S subunit alpha 2 (PSMA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15225	NM_002787.4	Homo sapiens proteasome subunit alpha 2 (PSMA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMA2 ( NM_002787.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002778.1 Homo sapiens proteasome 20S subunit alpha 2 (PSMA2), mRNA.

Price & Availability↑

CloneID	OHu15225
Clone ID Related Accession (Same CDS sequence)	NM_002787.5 , NM_002787.4
Accession Version	NM_002787.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-29
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010132.5. On Nov 22, 2018 this sequence version replaced NM_002787.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1082236.1, SRR3476690.13824.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000223321.9/ ENSP00000223321.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGC GCGGGTACAG CTTTTCGCTG ACTACATTCA GCCCGTCTGG TAAACTTGTC 
CAGATTGAAT ATGCTTTGGC TGCTGTAGCT GGAGGAGCCC CGTCCGTGGG AATTAAAGCT 
GCAAATGGTG TGGTATTAGC AACTGAGAAA AAACAGAAAT CCATTCTGTA TGATGAGCGA 
AGTGTACACA AAGTAGAACC AATTACCAAG CATATAGGTT TGGTGTACAG TGGCATGGGC 
CCCGATTACA GAGTGCTTGT GCACAGAGCT CGAAAACTAG CTCAACAATA CTATCTTGTG 
TACCAAGAAC CCATTCCTAC AGCTCAGCTG GTACAGAGAG TAGCTTCTGT GATGCAAGAA 
TATACTCAGT CAGGTGGTGT TCGTCCATTT GGAGTTTCTT TACTTATTTG TGGTTGGAAT 
GAGGGACGAC CATATTTATT TCAGTCAGAT CCATCTGGAG CTTACTTTGC CTGGAAAGCT 
ACAGCAATGG GAAAGAACTA TGTGAATGGG AAGACTTTCC TTGAGAAAAG ATATAATGAA 
GATCTGGAAC TTGAAGATGC CATTCATACA GCCATCTTAA CCCTAAAGGA AAGCTTTGAA 
GGGCAAATGA CAGAGGATAA CATAGAAGTT GGAATCTGCA ATGAAGCTGG ATTTAGGAGG 
CTTACTCCAA CTGAAGTTAA GGATTACTTG GCTGCCATAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002778.1
CDS	17..721
Translation	MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Target ORF information:

RefSeq Version	NM_002787.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 2 (PSMA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002787.5

ORF Insert Sequence:

ATGGCGGAGC GCGGGTACAG CTTTTCGCTG ACTACATTCA GCCCGTCTGG TAAACTTGTC 
CAGATTGAAT ATGCTTTGGC TGCTGTAGCT GGAGGAGCCC CGTCCGTGGG AATTAAAGCT 
GCAAATGGTG TGGTATTAGC AACTGAGAAA AAACAGAAAT CCATTCTGTA TGATGAGCGA 
AGTGTACACA AAGTAGAACC AATTACCAAG CATATAGGTT TGGTGTACAG TGGCATGGGC 
CCCGATTACA GAGTGCTTGT GCACAGAGCT CGAAAACTAG CTCAACAATA CTATCTTGTG 
TACCAAGAAC CCATTCCTAC AGCTCAGCTG GTACAGAGAG TAGCTTCTGT GATGCAAGAA 
TATACTCAGT CAGGTGGTGT TCGTCCATTT GGAGTTTCTT TACTTATTTG TGGTTGGAAT 
GAGGGACGAC CATATTTATT TCAGTCAGAT CCATCTGGAG CTTACTTTGC CTGGAAAGCT 
ACAGCAATGG GAAAGAACTA TGTGAATGGG AAGACTTTCC TTGAGAAAAG ATATAATGAA 
GATCTGGAAC TTGAAGATGC CATTCATACA GCCATCTTAA CCCTAAAGGA AAGCTTTGAA 
GGGCAAATGA CAGAGGATAA CATAGAAGTT GGAATCTGCA ATGAAGCTGG ATTTAGGAGG 
CTTACTCCAA CTGAAGTTAA GGATTACTTG GCTGCCATAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA2 ( NM_002787.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002778.1 Homo sapiens proteasome subunit alpha 2 (PSMA2), mRNA.

Price & Availability↑

CloneID	OHu15225
Clone ID Related Accession (Same CDS sequence)	NM_002787.5 , NM_002787.4
Accession Version	NM_002787.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010132.5. On Aug 16, 2007 this sequence version replaced NM_002787.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047697.1, SRR1803613.154980.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGAGC GCGGGTACAG CTTTTCGCTG ACTACATTCA GCCCGTCTGG TAAACTTGTC 
CAGATTGAAT ATGCTTTGGC TGCTGTAGCT GGAGGAGCCC CGTCCGTGGG AATTAAAGCT 
GCAAATGGTG TGGTATTAGC AACTGAGAAA AAACAGAAAT CCATTCTGTA TGATGAGCGA 
AGTGTACACA AAGTAGAACC AATTACCAAG CATATAGGTT TGGTGTACAG TGGCATGGGC 
CCCGATTACA GAGTGCTTGT GCACAGAGCT CGAAAACTAG CTCAACAATA CTATCTTGTG 
TACCAAGAAC CCATTCCTAC AGCTCAGCTG GTACAGAGAG TAGCTTCTGT GATGCAAGAA 
TATACTCAGT CAGGTGGTGT TCGTCCATTT GGAGTTTCTT TACTTATTTG TGGTTGGAAT 
GAGGGACGAC CATATTTATT TCAGTCAGAT CCATCTGGAG CTTACTTTGC CTGGAAAGCT 
ACAGCAATGG GAAAGAACTA TGTGAATGGG AAGACTTTCC TTGAGAAAAG ATATAATGAA 
GATCTGGAAC TTGAAGATGC CATTCATACA GCCATCTTAA CCCTAAAGGA AAGCTTTGAA 
GGGCAAATGA CAGAGGATAA CATAGAAGTT GGAATCTGCA ATGAAGCTGG ATTTAGGAGG 
CTTACTCCAA CTGAAGTTAA GGATTACTTG GCTGCCATAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002778.1
CDS	49..753
Translation	MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Target ORF information:

RefSeq Version	NM_002787.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit alpha 2 (PSMA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002787.4

ORF Insert Sequence:

ATGGCGGAGC GCGGGTACAG CTTTTCGCTG ACTACATTCA GCCCGTCTGG TAAACTTGTC 
CAGATTGAAT ATGCTTTGGC TGCTGTAGCT GGAGGAGCCC CGTCCGTGGG AATTAAAGCT 
GCAAATGGTG TGGTATTAGC AACTGAGAAA AAACAGAAAT CCATTCTGTA TGATGAGCGA 
AGTGTACACA AAGTAGAACC AATTACCAAG CATATAGGTT TGGTGTACAG TGGCATGGGC 
CCCGATTACA GAGTGCTTGT GCACAGAGCT CGAAAACTAG CTCAACAATA CTATCTTGTG 
TACCAAGAAC CCATTCCTAC AGCTCAGCTG GTACAGAGAG TAGCTTCTGT GATGCAAGAA 
TATACTCAGT CAGGTGGTGT TCGTCCATTT GGAGTTTCTT TACTTATTTG TGGTTGGAAT 
GAGGGACGAC CATATTTATT TCAGTCAGAT CCATCTGGAG CTTACTTTGC CTGGAAAGCT 
ACAGCAATGG GAAAGAACTA TGTGAATGGG AAGACTTTCC TTGAGAAAAG ATATAATGAA 
GATCTGGAAC TTGAAGATGC CATTCATACA GCCATCTTAA CCCTAAAGGA AAGCTTTGAA 
GGGCAAATGA CAGAGGATAA CATAGAAGTT GGAATCTGCA ATGAAGCTGG ATTTAGGAGG 
CTTACTCCAA CTGAAGTTAA GGATTACTTG GCTGCCATAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal structure of the human 20S proteasome in complex with carfilzomib.
Structure (London, England : 1993)23(2)418-24(2015 Feb)
Harshbarger W,Miller C,Diedrich C,Sacchettini J

Toward an understanding of the protein interaction network of the human liver.
Molecular systems biology7536(2011 Oct)
Wang J,Huo K,Ma L,Tang L,Li D,Huang X,Yuan Y,Li C,Wang W,Guan W,Chen H,Jin C,Wei J,Zhang W,Yang Y,Liu Q,Zhou Y,Zhang C,Wu Z,Xu W,Zhang Y,Liu T,Yu D,Zhang Y,Chen L,Zhu D,Zhong X,Kang L,Gan X,Yu X,Ma Q,Yan J,Zhou L,Liu Z,Zhu Y,Zhou T,He F,Yang X

A directed protein interaction network for investigating intracellular signal transduction.
Science signaling4(189)rs8(2011 Sep)
Vinayagam A,Stelzl U,Foulle R,Plassmann S,Zenkner M,Timm J,Assmus HE,Andrade-Navarro MA,Wanker EE

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

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PSMA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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