B2M cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B2M
Entrez Gene ID	567
Full Name	beta-2-microglobulin
Synonyms	IMD43
General protein information	Preferred Names beta-2-microglobulin Names beta-2-microglobulin beta chain of MHC class I molecules beta-2-microglobin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.1
Summary	This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].
Disorder MIM:	109700
Disorder Html:	Immunodeficiency 43, 241600 (3); ?Amyloidosis, familial visceral, 105200 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004048.3	NP_004039.1	beta-2-microglobulin precursor
NM_004048.2	NP_004039.1	beta-2-microglobulin precursor
XM_005254549.3	XP_005254606.1	beta-2-microglobulin isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	B2M	XP_003640095.1
Rattus norvegicus (Norway rat)	B2m	NP_036644.1
Bos taurus (cattle)	B2M	NP_776318.1
Mus musculus (house mouse)	B2m	NP_033865.2
Danio rerio (zebrafish)	b2ml	NP_998291.1
	B2M	NP_001040602.1
Danio rerio (zebrafish)	b2m	NP_001153240.1
Homo sapiens (human)	B2M	NP_004039.1
Bos taurus (cattle)	LOC783680	XP_002691165.1
Gallus gallus (chicken)	B2M	XP_004943685.1
Pan troglodytes (chimpanzee)	B2M	NP_001009066.1

Gene Ontology
Bibliography

Related articles in PubMed

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed ?
Merkle PS, Irving M, Hongjian S, Ferber M, J?rgensen TJD, Scholten K, Luescher I, Coukos G, Zoete V, Cuendet MA, Michielin O, Rand KD
Biochemistry56(30)3945-3961(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M.
Title: The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed ?

High B2M levels were associated with an increased risk of ischemic stroke in this study of middle-aged women
Title: Prospective association between ?

results suggest that doxycycline and rifamycin are general inhibitors of Cu(II)-induced beta2m amyloid formation.
Title: Small molecule-mediated inhibition of ?-2-microglobulin-based amyloid fibril formation.

Heparin-induced amyloid fibrillation of beta2 -microglobulin explained by solubility and a supersaturation-dependent conformational phase diagram
Title: Heparin-induced amyloid fibrillation of ?

Serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of diseased coronary vessels.
Title: High levels of serum ?2-microglobulin predict severity of coronary artery disease.

The following B2M gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B2M cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18032	NM_004048.3 Latest version!	Homo sapiens beta-2-microglobulin (B2M), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu48451	XM_005254549.3 Latest version!	Homo sapiens beta-2-microglobulin (B2M), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu18032	NM_004048.2	Homo sapiens beta-2-microglobulin (B2M), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B2M ( NM_004048.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004039.1 Homo sapiens beta-2-microglobulin (B2M), mRNA.

Price & Availability↑

CloneID	OHu18032
Clone ID Related Accession (Same CDS sequence)	NM_004048.3 , NM_004048.2
Accession Version	NM_004048.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	beta-2-microglobulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315776.1, BC032589.1, AC122108.2 and BE645555.1. This sequence is a reference standard in the RefSeqGene project. On May 16, 2018 this sequence version replaced NM_004048.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.89046.1, SRR1803614.167326.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23144825 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGATCG AGACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004039.1
CDS	31..390
Translation	MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Target ORF information:

RefSeq Version	NM_004048.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-2-microglobulin (B2M), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004048.3

ORF Insert Sequence:

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGATCG AGACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B2M ( NM_004048.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004039.1 Homo sapiens beta-2-microglobulin (B2M), mRNA.

Price & Availability↑

CloneID	OHu18032
Clone ID Related Accession (Same CDS sequence)	NM_004048.3 , NM_004048.2
Accession Version	NM_004048.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	beta-2-microglobulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU658737.1, BC032589.1 and AI686916.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2003 this sequence version replaced NM_004048.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.71593.1, SRR1660805.10518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23144825 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGATCG AGACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004039.1
CDS	61..420
Translation	MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Target ORF information:

RefSeq Version	NM_004048.2
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-2-microglobulin (B2M), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004048.2

ORF Insert Sequence:

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGATCG AGACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B2M ( XM_005254549.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005254606.1 Homo sapiens beta-2-microglobulin (B2M), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu48451
Clone ID Related Accession (Same CDS sequence)	XM_005254549.3
Accession Version	XM_005254549.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	beta-2-microglobulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005254549.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGGTAA GTCTTACATT 
CTTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005254606.1
CDS	56..424
Translation	MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWGKSYILL

Target ORF information:

RefSeq Version	XM_005254549.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-2-microglobulin (B2M), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254549.3

ORF Insert Sequence:

ATGTCTCGCT CCGTGGCCTT AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT 
ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC CAGCAGAGAA TGGAAAGTCA 
AATTTCCTGA ATTGCTATGT GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG 
AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT TGTCTTTCAG CAAGGACTGG 
TCTTTCTATC TCTTGTACTA CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC 
CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA AGTGGGGTAA GTCTTACATT 
CTTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed ?
Biochemistry56(30)3945-3961(2017 08)
Merkle PS,Irving M,Hongjian S,Ferber M,J?rgensen TJD,Scholten K,Luescher I,Coukos G,Zoete V,Cuendet MA,Michielin O,Rand KD

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B2M cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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