KCNK13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK13
Entrez Gene ID	56659
Full Name	potassium two pore domain channel subfamily K member 13
Synonyms	K2p13.1,THIK-1,THIK1
General protein information	Preferred Names potassium two pore domain channel subfamily K member 13 Names potassium channel subfamily K member 13 K2P13.1 potassium channel potassium channel, subfamily K, member 13 potassium channel, two pore domain subfamily K, member 13 tandem pore domain halothane-inhibited potassium channel 1 tandem pore domain potassium channel THIK-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.11
Summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013].
Disorder MIM:	607367

mRNA and Protein(s)

mRNA	Protein	Name
NM_022054.3	NP_071337.2	potassium channel subfamily K member 13
NM_022054.4	NP_071337.2	potassium channel subfamily K member 13

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNK13	XP_547951.2
Mus musculus (house mouse)	Kcnk13	NP_001157898.1
	KCNK13	XP_001089892.1
Rattus norvegicus (Norway rat)	Kcnk13	NP_071629.1
Gallus gallus (chicken)	KCNK13	XP_001235376.1
Danio rerio (zebrafish)	kcnk13b	NP_001020654.1
Xenopus tropicalis (tropical clawed frog)	kcnk13	XP_002933246.1
Danio rerio (zebrafish)	kcnk13a	NP_001103587.1
Homo sapiens (human)	KCNK13	NP_071337.2
Pan troglodytes (chimpanzee)	KCNK13	XP_001141129.1

Gene Ontology
Bibliography

Related articles in PubMed

Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
Sakamaki K, Ishii TM, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita R, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung SK, Matsuoka S, Koyamada K, Sawasaki T, Nagai T, Ueno N
Biochimica et biophysica acta1863(11)2766-2783(2016 11)

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.
Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D
The Journal of biological chemistry289(41)28202-12(2014 Oct)

Genetics of coronary artery calcification among African Americans, a meta-analysis.
Wojczynski MK, Li M, Bielak LF, Kerr KF, Reiner AP, Wong ND, Yanek LR, Qu L, White CC, Lange LA, Ferguson JF, He J, Young T, Mosley TH, Smith JA, Kral BG, Guo X, Wong Q, Ganesh SK, Heckbert SR, Griswold ME, O'Leary DH, Budoff M, Carr JJ, Taylor HA Jr, Bluemke DA, Demissie S, Hwang SJ, Paltoo DN, Polak JF, Psaty BM, Becker DM, Province MA, Post WS, O'Donnell CJ, Wilson JG, Harris TB, Kavousi M, Cupples LA, Rotter JI, Fornage M, Becker LC, Peyser PA, Borecki IB, Reilly MP
BMC medical genetics1475(2013 Jul)

Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
Morrison AC, Felix JF, Cupples LA, Glazer NL, Loehr LR, Dehghan A, Demissie S, Bis JC, Rosamond WD, Aulchenko YS, Wang YA, Haritunians T, Folsom AR, Rivadeneira F, Benjamin EJ, Lumley T, Couper D, Stricker BH, O'Donnell CJ, Rice KM, Chang PP, Hofman A, Levy D, Rotter JI, Fox ER, Uitterlinden AG, Wang TJ, Psaty BM, Willerson JT, van Duijn CM, Boerwinkle E, Witteman JC, Vasan RS, Smith NL
Circulation. Cardiovascular genetics3(3)248-55(2010 Jun)

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
Gierten J, Ficker E, Bloehs R, Schl?mer K, Kath?fer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D
British journal of pharmacology154(8)1680-90(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage.
Title: Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.

In cell and tissues co-expressing THIK1 and THIK2, heterodimeric channels may contribute to cell excitability.
Title: Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.

expression in cell hypoxia
Title: Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells.

The following KCNK13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00626	NM_022054.4 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu00626	NM_022054.3	Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK13 ( NM_022054.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071337.2 Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.

Price & Availability↑

CloneID	OHu00626
Clone ID Related Accession (Same CDS sequence)	NM_022054.3 , NM_022054.4
Accession Version	NM_022054.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC012779.2, EU978942.1 and AW117567.1. On Jul 16, 2013 this sequence version replaced NM_022054.2. ##Evidence-Data-START## Transcript exon combination :: BC012779.2, SRR1660807.150449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGCC GGGGTTTCAG CTGGGGCCCG GGCCACCTGA ACGAGGACAA CGCGCGCTTT 
CTGCTGCTGG CCGCGCTCAT CGTGCTCTAC CTGCTGGGCG GCGCCGCCGT CTTCTCCGCG 
CTGGAGCTGG CGCACGAGCG CCAGGCCAAG CAGCGCTGGG AGGAGCGCCT GGCCAACTTC 
AGCCGCGGCC ACAACCTGAG CCGCGACGAG CTGCGCGGCT TCCTCCGCCA CTACGAGGAG 
GCCACTCGGG CCGGCATCCG CGTGGACAAC GTCCGCCCGC GCTGGGACTT CACCGGCGCC 
TTCTACTTCG TGGGCACCGT CGTTTCCACC ATAGGGTTTG GGATGACAAC TCCGGCGACA 
GTAGGAGGAA AAATCTTTCT GATCTTTTAC GGCCTTGTTG GGTGTTCCAG CACCATCTTG 
TTCTTCAACC TCTTCCTGGA GCGCCTGATC ACCATCATCG CCTACATCAT GAAGTCGTGC 
CACCAGCGGC AGCTCCGGAG ACGAGGGGCC CTGCCCCAGG AGAGCCTGAA GGATGCGGGG 
CAGTGTGAGG TGGACAGCCT GGCCGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTATGCACAG CCTCCATCCT CATCTCTTGC TGCGCCTCAG CCATGTACAC CCCCATTGAA 
GGCTGGAGCT ACTTTGACTC ACTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTT 
GGGGACCTGG TCAGCAGCCA GAACGCCCAC TATGAGAGCC AAGGCCTCTA TCGCTTTGCC 
AACTTCGTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCTTGTTCAA TGTCATCTCT 
ATCCTCATCA AACAGTCCTT GAACTGGATC CTGAGGAAAA TGGACAGCGG GTGCTGCCCG 
CAATGCCAGA GAGGACTCTT GCGATCACGC AGGAACGTGG TGATGCCAGG CAGCGTCCGG 
AACCGCTGCA ACATCTCCAT AGAGACAGAC GGGGTGGCAG AGAGTGACAC GGACGGGCGC 
CGGCTCTCAG GGGAGATGAT CTCCATGAAG GACTTGCTGG CAGCCAACAA GGCCTCGTTG 
GCCATCCTGC AGAAGCAACT GTCTGAGATG GCCAACGGCT GCCCCCACCA GACCAGCACA 
CTGGCCCGGG ACAATGAATT CTCAGGGGGG GTGGGAGCCT TTGCAATCAT GAACAACAGG 
TTGGCAGAGA CCAGTGGGGA CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071337.2
CDS	442..1668
Translation	MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAESDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVGAFAIMNNRLAETSGDR

Target ORF information:

RefSeq Version	NM_022054.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022054.3

ORF Insert Sequence:

ATGGCTGGCC GGGGTTTCAG CTGGGGCCCG GGCCACCTGA ACGAGGACAA CGCGCGCTTT 
CTGCTGCTGG CCGCGCTCAT CGTGCTCTAC CTGCTGGGCG GCGCCGCCGT CTTCTCCGCG 
CTGGAGCTGG CGCACGAGCG CCAGGCCAAG CAGCGCTGGG AGGAGCGCCT GGCCAACTTC 
AGCCGCGGCC ACAACCTGAG CCGCGACGAG CTGCGCGGCT TCCTCCGCCA CTACGAGGAG 
GCCACTCGGG CCGGCATCCG CGTGGACAAC GTCCGCCCGC GCTGGGACTT CACCGGCGCC 
TTCTACTTCG TGGGCACCGT CGTTTCCACC ATAGGGTTTG GGATGACAAC TCCGGCGACA 
GTAGGAGGAA AAATCTTTCT GATCTTTTAC GGCCTTGTTG GGTGTTCCAG CACCATCTTG 
TTCTTCAACC TCTTCCTGGA GCGCCTGATC ACCATCATCG CCTACATCAT GAAGTCGTGC 
CACCAGCGGC AGCTCCGGAG ACGAGGGGCC CTGCCCCAGG AGAGCCTGAA GGATGCGGGG 
CAGTGTGAGG TGGACAGCCT GGCCGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTATGCACAG CCTCCATCCT CATCTCTTGC TGCGCCTCAG CCATGTACAC CCCCATTGAA 
GGCTGGAGCT ACTTTGACTC ACTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTT 
GGGGACCTGG TCAGCAGCCA GAACGCCCAC TATGAGAGCC AAGGCCTCTA TCGCTTTGCC 
AACTTCGTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCTTGTTCAA TGTCATCTCT 
ATCCTCATCA AACAGTCCTT GAACTGGATC CTGAGGAAAA TGGACAGCGG GTGCTGCCCG 
CAATGCCAGA GAGGACTCTT GCGATCACGC AGGAACGTGG TGATGCCAGG CAGCGTCCGG 
AACCGCTGCA ACATCTCCAT AGAGACAGAC GGGGTGGCAG AGAGTGACAC GGACGGGCGC 
CGGCTCTCAG GGGAGATGAT CTCCATGAAG GACTTGCTGG CAGCCAACAA GGCCTCGTTG 
GCCATCCTGC AGAAGCAACT GTCTGAGATG GCCAACGGCT GCCCCCACCA GACCAGCACA 
CTGGCCCGGG ACAATGAATT CTCAGGGGGG GTGGGAGCCT TTGCAATCAT GAACAACAGG 
TTGGCAGAGA CCAGTGGGGA CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK13 ( NM_022054.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071337.2 Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.

Price & Availability↑

CloneID	OHu00626
Clone ID Related Accession (Same CDS sequence)	NM_022054.3 , NM_022054.4
Accession Version	NM_022054.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC012779.2, EU978942.1 and AW117567.1. On Nov 23, 2018 this sequence version replaced NM_022054.3. ##Evidence-Data-START## Transcript exon combination :: BC012779.2, SRR1660807.150449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282146.5/ ENSP00000282146.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGGCC GGGGTTTCAG CTGGGGCCCG GGCCACCTGA ACGAGGACAA CGCGCGCTTT 
CTGCTGCTGG CCGCGCTCAT CGTGCTCTAC CTGCTGGGCG GCGCCGCCGT CTTCTCCGCG 
CTGGAGCTGG CGCACGAGCG CCAGGCCAAG CAGCGCTGGG AGGAGCGCCT GGCCAACTTC 
AGCCGCGGCC ACAACCTGAG CCGCGACGAG CTGCGCGGCT TCCTCCGCCA CTACGAGGAG 
GCCACTCGGG CCGGCATCCG CGTGGACAAC GTCCGCCCGC GCTGGGACTT CACCGGCGCC 
TTCTACTTCG TGGGCACCGT CGTTTCCACC ATAGGGTTTG GGATGACAAC TCCGGCGACA 
GTAGGAGGAA AAATCTTTCT GATCTTTTAC GGCCTTGTTG GGTGTTCCAG CACCATCTTG 
TTCTTCAACC TCTTCCTGGA GCGCCTGATC ACCATCATCG CCTACATCAT GAAGTCGTGC 
CACCAGCGGC AGCTCCGGAG ACGAGGGGCC CTGCCCCAGG AGAGCCTGAA GGATGCGGGG 
CAGTGTGAGG TGGACAGCCT GGCCGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTATGCACAG CCTCCATCCT CATCTCTTGC TGCGCCTCAG CCATGTACAC CCCCATTGAA 
GGCTGGAGCT ACTTTGACTC ACTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTT 
GGGGACCTGG TCAGCAGCCA GAACGCCCAC TATGAGAGCC AAGGCCTCTA TCGCTTTGCC 
AACTTCGTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCTTGTTCAA TGTCATCTCT 
ATCCTCATCA AACAGTCCTT GAACTGGATC CTGAGGAAAA TGGACAGCGG GTGCTGCCCG 
CAATGCCAGA GAGGACTCTT GCGATCACGC AGGAACGTGG TGATGCCAGG CAGCGTCCGG 
AACCGCTGCA ACATCTCCAT AGAGACAGAC GGGGTGGCAG AGAGTGACAC GGACGGGCGC 
CGGCTCTCAG GGGAGATGAT CTCCATGAAG GACTTGCTGG CAGCCAACAA GGCCTCGTTG 
GCCATCCTGC AGAAGCAACT GTCTGAGATG GCCAACGGCT GCCCCCACCA GACCAGCACA 
CTGGCCCGGG ACAATGAATT CTCAGGGGGG GTGGGAGCCT TTGCAATCAT GAACAACAGG 
TTGGCAGAGA CCAGTGGGGA CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071337.2
CDS	213..1439
Translation	MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAESDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVGAFAIMNNRLAETSGDR

Target ORF information:

RefSeq Version	NM_022054.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 13 (KCNK13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022054.4

ORF Insert Sequence:

ATGGCTGGCC GGGGTTTCAG CTGGGGCCCG GGCCACCTGA ACGAGGACAA CGCGCGCTTT 
CTGCTGCTGG CCGCGCTCAT CGTGCTCTAC CTGCTGGGCG GCGCCGCCGT CTTCTCCGCG 
CTGGAGCTGG CGCACGAGCG CCAGGCCAAG CAGCGCTGGG AGGAGCGCCT GGCCAACTTC 
AGCCGCGGCC ACAACCTGAG CCGCGACGAG CTGCGCGGCT TCCTCCGCCA CTACGAGGAG 
GCCACTCGGG CCGGCATCCG CGTGGACAAC GTCCGCCCGC GCTGGGACTT CACCGGCGCC 
TTCTACTTCG TGGGCACCGT CGTTTCCACC ATAGGGTTTG GGATGACAAC TCCGGCGACA 
GTAGGAGGAA AAATCTTTCT GATCTTTTAC GGCCTTGTTG GGTGTTCCAG CACCATCTTG 
TTCTTCAACC TCTTCCTGGA GCGCCTGATC ACCATCATCG CCTACATCAT GAAGTCGTGC 
CACCAGCGGC AGCTCCGGAG ACGAGGGGCC CTGCCCCAGG AGAGCCTGAA GGATGCGGGG 
CAGTGTGAGG TGGACAGCCT GGCCGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTATGCACAG CCTCCATCCT CATCTCTTGC TGCGCCTCAG CCATGTACAC CCCCATTGAA 
GGCTGGAGCT ACTTTGACTC ACTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTT 
GGGGACCTGG TCAGCAGCCA GAACGCCCAC TATGAGAGCC AAGGCCTCTA TCGCTTTGCC 
AACTTCGTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCTTGTTCAA TGTCATCTCT 
ATCCTCATCA AACAGTCCTT GAACTGGATC CTGAGGAAAA TGGACAGCGG GTGCTGCCCG 
CAATGCCAGA GAGGACTCTT GCGATCACGC AGGAACGTGG TGATGCCAGG CAGCGTCCGG 
AACCGCTGCA ACATCTCCAT AGAGACAGAC GGGGTGGCAG AGAGTGACAC GGACGGGCGC 
CGGCTCTCAG GGGAGATGAT CTCCATGAAG GACTTGCTGG CAGCCAACAA GGCCTCGTTG 
GCCATCCTGC AGAAGCAACT GTCTGAGATG GCCAACGGCT GCCCCCACCA GACCAGCACA 
CTGGCCCGGG ACAATGAATT CTCAGGGGGG GTGGGAGCCT TTGCAATCAT GAACAACAGG 
TTGGCAGAGA CCAGTGGGGA CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
Biochimica et biophysica acta1863(11)2766-2783(2016 11)
Sakamaki K,Ishii TM,Sakata T,Takemoto K,Takagi C,Takeuchi A,Morishita R,Takahashi H,Nozawa A,Shinoda H,Chiba K,Sugimoto H,Saito A,Tamate S,Satou Y,Jung SK,Matsuoka S,Koyamada K,Sawasaki T,Nagai T,Ueno N

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.
The Journal of biological chemistry289(41)28202-12(2014 Oct)
Blin S,Chatelain FC,Feliciangeli S,Kang D,Lesage F,Bichet D

Genetics of coronary artery calcification among African Americans, a meta-analysis.
BMC medical genetics1475(2013 Jul)
Wojczynski MK,Li M,Bielak LF,Kerr KF,Reiner AP,Wong ND,Yanek LR,Qu L,White CC,Lange LA,Ferguson JF,He J,Young T,Mosley TH,Smith JA,Kral BG,Guo X,Wong Q,Ganesh SK,Heckbert SR,Griswold ME,O'Leary DH,Budoff M,Carr JJ,Taylor HA Jr,Bluemke DA,Demissie S,Hwang SJ,Paltoo DN,Polak JF,Psaty BM,Becker DM,Province MA,Post WS,O'Donnell CJ,Wilson JG,Harris TB,Kavousi M,Cupples LA,Rotter JI,Fornage M,Becker LC,Peyser PA,Borecki IB,Reilly MP

Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
Circulation. Cardiovascular genetics3(3)248-55(2010 Jun)
Morrison AC,Felix JF,Cupples LA,Glazer NL,Loehr LR,Dehghan A,Demissie S,Bis JC,Rosamond WD,Aulchenko YS,Wang YA,Haritunians T,Folsom AR,Rivadeneira F,Benjamin EJ,Lumley T,Couper D,Stricker BH,O'Donnell CJ,Rice KM,Chang PP,Hofman A,Levy D,Rotter JI,Fox ER,Uitterlinden AG,Wang TJ,Psaty BM,Willerson JT,van Duijn CM,Boerwinkle E,Witteman JC,Vasan RS,Smith NL

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
British journal of pharmacology154(8)1680-90(2008 Aug)
Gierten J,Ficker E,Bloehs R,Schl?mer K,Kath?fer S,Scholz E,Zitron E,Kiesecker C,Bauer A,Becker R,Katus HA,Karle CA,Thomas D

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KCNK13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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