CYP26B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP26B1
Entrez Gene ID	56603
Full Name	cytochrome P450 family 26 subfamily B member 1
Synonyms	CYP26A2,P450RAI-2,P450RAI2,RHFCA
General protein information	Preferred Names cytochrome P450 family 26 subfamily B member 1 Names cytochrome P450 26B1 cytochrome P450 family 26 subfamily A member 1 cytochrome P450 retinoic acid-inactivating 2 cytochrome P450 retinoid metabolizing protein cytochrome P450, family 26, subfamily B, polypeptide 1 cytochrome P450, subfamily XXVIB, polypeptide 1 retinoic acid-metabolizing cytochrome
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.2
Summary	This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
Disorder MIM:	605207
Disorder Html:	Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies, 614416 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011532988.1	XP_011531290.1	cytochrome P450 26B1 isoform X2
NM_019885.3	NP_063938.1	cytochrome P450 26B1 isoform 1
XM_005264433.4	XP_005264490.1	cytochrome P450 26B1 isoform X1
NM_001277742.1	NP_001264671.1	cytochrome P450 26B1 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cyp26b1	NP_780684.1
Homo sapiens (human)	CYP26B1	NP_063938.1
Pan troglodytes (chimpanzee)	LOC738157	XP_001149367.1
Arabidopsis thaliana (thale cress)	CYP707A1	NP_567581.1
Canis lupus familiaris (dog)	CYP26B1	XP_540236.2
Rattus norvegicus (Norway rat)	Cyp26b1	NP_851601.1
	LOC704750	XP_001103025.2
Bos taurus (cattle)	CYP26B1	NP_001179722.1
Danio rerio (zebrafish)	cyp26b1	NP_997831.1
Arabidopsis thaliana (thale cress)	CYP707A2	NP_180473.1
Arabidopsis thaliana (thale cress)	CYP707A3	NP_851136.1
Xenopus tropicalis (tropical clawed frog)	cyp26b1	NP_001072655.1

Gene Ontology
Bibliography

Related articles in PubMed

Biallelic mutations in CYP26B1: A differential diagnosis for Pfeiffer and Antley-Bixler syndromes.
Morton JE, Frentz S, Morgan T, Sutherland-Smith AJ, Robertson SP
American journal of medical genetics. Part A170(10)2706-10(2016 Oct)

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
Nelson CH, Peng CC, Lutz JD, Yeung CK, Zelter A, Isoherranen N
FEBS letters590(16)2527-35(2016 08)

Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells.
Elmabsout AA, Kumawat A, Saenz-M?ndez P, Krivospitskaya O, S?venstrand H, Olofsson PS, Eriksson LA, Strid A, Valen G, T?rm? H, Sirsj? A
PloS one7(5)e36839(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we provide the third family affected by the disorder and the first affected individual to survive beyond infancy. This woman homozygous for c.1303G>A; p.(Gly435Ser) in CYP26B1, which was associated with multisutural synostosis, radiohumeral synostosis, normal bone mineral density, and apparent intellectual disability, a phenotype with significant similarities to Antley-Bixler and Pfeiffer syndromes.
Title: Biallelic mutations in CYP26B1: A differential diagnosis for Pfeiffer and Antley-Bixler syndromes.

Holo-CRABPs had higher affinity for CYP26B1 than free atRA, but both apo-CRABPs(CRABP-I and CRABP-II ) inhibited the formation of 4-OH-RA by CYP26B1.
Title: Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.

Study investigated the distribution of Cyp26a1 and Cyp26b1 transcripts in the rat and human brain, identifying several novel regions of expression, including the cerebral cortex for both enzymes and striatum for Cyp26b1.
Title: Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.

There was increased expression of mRNA CYP26B1 in oral cancer tissue compared to adjacent noncancerous tissues.
Title: Association study between novel CYP26 polymorphisms and the risk of betel quid-related malignant oral disorders.

SNPs in three genes CYP26B1 rs2241057, CISD1 rs2251039, rs2590370, and TBX1 rs4819522 were involved in six potential pathways to influence serum prostate-specific antigen levels.
Title: Pathway analysis of genome-wide association study on serum prostate-specific antigen levels.

The following CYP26B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP26B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20816	NM_019885.3 Latest version!	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$214.50-$300.30 $429.00
OHu70058	XM_011532988.1 Latest version!	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu04231	NM_001277742.1 Latest version!	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu35491	XM_005264433.4 Latest version!	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP26B1 ( NM_019885.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_063938.1 Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20816
Clone ID Related Accession (Same CDS sequence)	NM_019885.3
Accession Version	NM_019885.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	cytochrome P450 26B1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308258.1, BC109205.2, AF252297.1 and AA484668.1. This sequence is a reference standard in the RefSeqGene project. On Apr 19, 2013 this sequence version replaced NM_019885.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF252297.1, SRR1803613.132826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTCTTTG AGGGCTTGGA TCTGGTGTCG GCGCTGGCCA CCCTCGCCGC GTGCCTGGTG 
TCCGTGACGC TGCTGCTGGC CGTGTCGCAG CAGCTGTGGC AGCTGCGCTG GGCCGCCACT 
CGCGACAAGA GCTGCAAGCT GCCCATCCCC AAGGGATCCA TGGGCTTCCC GCTCATCGGA 
GAGACCGGCC ACTGGCTGCT GCAGGGTTCT GGCTTCCAGT CGTCGCGGAG GGAGAAGTAT 
GGCAACGTGT TCAAGACGCA TTTGTTGGGG CGGCCGCTGA TACGCGTGAC CGGCGCGGAG 
AACGTGCGCA AGATCCTCAT GGGCGAGCAC CACCTCGTGA GCACCGAGTG GCCTCGCAGC 
ACCCGCATGT TGCTGGGCCC CAACACGGTG TCCAATTCCA TTGGCGACAT CCACCGCAAC 
AAGCGCAAGG TCTTCTCCAA GATCTTCAGC CACGAGGCCC TGGAGAGTTA CCTGCCCAAG 
ATCCAGCTGG TGATCCAGGA CACACTGCGC GCCTGGAGCA GCCACCCCGA GGCCATCAAC 
GTGTACCAGG AGGCGCAGAA GCTGACCTTC CGCATGGCCA TCCGGGTGCT GCTGGGCTTC 
AGCATCCCTG AGGAGGACCT TGGGCACCTC TTTGAGGTCT ACCAGCAGTT TGTGGACAAT 
GTCTTCTCCC TGCCTGTCGA CCTGCCCTTC AGTGGCTACC GGCGGGGCAT TCAGGCTCGG 
CAGATCCTGC AGAAGGGGCT GGAGAAGGCC ATCCGGGAGA AGCTGCAGTG CACACAGGGC 
AAGGACTACT TGGACGCCCT GGACCTCCTC ATTGAGAGCA GCAAGGAGCA CGGGAAGGAG 
ATGACCATGC AGGAGCTGAA GGACGGGACC CTGGAGCTGA TCTTTGCGGC CTATGCCACC 
ACGGCCAGCG CCAGCACCTC ACTCATCATG CAGCTGCTGA AGCACCCCAC TGTGCTGGAG 
AAGCTGCGGG ATGAGCTGCG GGCTCATGGC ATCCTGCACA GTGGCGGCTG CCCCTGCGAG 
GGCACACTGC GCCTGGACAC GCTCAGTGGG CTGCGCTACC TGGACTGCGT CATCAAGGAG 
GTCATGCGCC TGTTCACGCC CATTTCCGGC GGCTACCGCA CTGTGCTGCA GACCTTCGAG 
CTTGATGGTT TCCAGATCCC CAAAGGCTGG AGTGTCATGT ATAGCATCCG GGACACCCAT 
GACACAGCGC CCGTGTTCAA AGACGTGAAC GTGTTCGACC CCGATCGCTT CAGCCAGGCG 
CGGAGCGAGG ACAAGGATGG CCGCTTCCAT TACCTCCCGT TCGGTGGCGG TGTCCGGACC 
TGCCTGGGCA AGCACCTGGC CAAGCTGTTC CTGAAGGTGC TGGCGGTGGA GCTGGCTAGC 
ACCAGCCGCT TTGAGCTGGC CACACGGACC TTCCCCCGCA TCACCTTGGT CCCCGTCCTG 
CACCCCGTGG ATGGCCTCAG CGTCAAGTTC TTTGGCCTGG ACTCCAACCA GAACGAGATC 
CTGCCGGAGA CGGAGGCCAT GCTGAGCGCC ACAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063938.1
CDS	29..1567
Translation	MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Target ORF information:

RefSeq Version	NM_019885.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019885.3

ORF Insert Sequence:

ATGCTCTTTG AGGGCTTGGA TCTGGTGTCG GCGCTGGCCA CCCTCGCCGC GTGCCTGGTG 
TCCGTGACGC TGCTGCTGGC CGTGTCGCAG CAGCTGTGGC AGCTGCGCTG GGCCGCCACT 
CGCGACAAGA GCTGCAAGCT GCCCATCCCC AAGGGATCCA TGGGCTTCCC GCTCATCGGA 
GAGACCGGCC ACTGGCTGCT GCAGGGTTCT GGCTTCCAGT CGTCGCGGAG GGAGAAGTAT 
GGCAACGTGT TCAAGACGCA TTTGTTGGGG CGGCCGCTGA TACGCGTGAC CGGCGCGGAG 
AACGTGCGCA AGATCCTCAT GGGCGAGCAC CACCTCGTGA GCACCGAGTG GCCTCGCAGC 
ACCCGCATGT TGCTGGGCCC CAACACGGTG TCCAATTCCA TTGGCGACAT CCACCGCAAC 
AAGCGCAAGG TCTTCTCCAA GATCTTCAGC CACGAGGCCC TGGAGAGTTA CCTGCCCAAG 
ATCCAGCTGG TGATCCAGGA CACACTGCGC GCCTGGAGCA GCCACCCCGA GGCCATCAAC 
GTGTACCAGG AGGCGCAGAA GCTGACCTTC CGCATGGCCA TCCGGGTGCT GCTGGGCTTC 
AGCATCCCTG AGGAGGACCT TGGGCACCTC TTTGAGGTCT ACCAGCAGTT TGTGGACAAT 
GTCTTCTCCC TGCCTGTCGA CCTGCCCTTC AGTGGCTACC GGCGGGGCAT TCAGGCTCGG 
CAGATCCTGC AGAAGGGGCT GGAGAAGGCC ATCCGGGAGA AGCTGCAGTG CACACAGGGC 
AAGGACTACT TGGACGCCCT GGACCTCCTC ATTGAGAGCA GCAAGGAGCA CGGGAAGGAG 
ATGACCATGC AGGAGCTGAA GGACGGGACC CTGGAGCTGA TCTTTGCGGC CTATGCCACC 
ACGGCCAGCG CCAGCACCTC ACTCATCATG CAGCTGCTGA AGCACCCCAC TGTGCTGGAG 
AAGCTGCGGG ATGAGCTGCG GGCTCATGGC ATCCTGCACA GTGGCGGCTG CCCCTGCGAG 
GGCACACTGC GCCTGGACAC GCTCAGTGGG CTGCGCTACC TGGACTGCGT CATCAAGGAG 
GTCATGCGCC TGTTCACGCC CATTTCCGGC GGCTACCGCA CTGTGCTGCA GACCTTCGAG 
CTTGATGGTT TCCAGATCCC CAAAGGCTGG AGTGTCATGT ATAGCATCCG GGACACCCAT 
GACACAGCGC CCGTGTTCAA AGACGTGAAC GTGTTCGACC CCGATCGCTT CAGCCAGGCG 
CGGAGCGAGG ACAAGGATGG CCGCTTCCAT TACCTCCCGT TCGGTGGCGG TGTCCGGACC 
TGCCTGGGCA AGCACCTGGC CAAGCTGTTC CTGAAGGTGC TGGCGGTGGA GCTGGCTAGC 
ACCAGCCGCT TTGAGCTGGC CACACGGACC TTCCCCCGCA TCACCTTGGT CCCCGTCCTG 
CACCCCGTGG ATGGCCTCAG CGTCAAGTTC TTTGGCCTGG ACTCCAACCA GAACGAGATC 
CTGCCGGAGA CGGAGGCCAT GCTGAGCGCC ACAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP26B1 ( XM_011532988.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531290.1 Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu70058
Clone ID Related Accession (Same CDS sequence)	XM_011532988.1
Accession Version	XM_011532988.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome P450 26B1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCATCC GGGTGCTGCT GGGCTTCAGC ATCCCTGAGG AGGACCTTGG GCACCTCTTT 
GAGGTCTACC AGCAGTTTGT GGACAATGTC TTCTCCCTGC CTGTCGACCT GCCCTTCAGT 
GGCTACCGGC GGGGCATTCA GGCTCGGCAG ATCCTGCAGA AGGGGCTGGA GAAGGCCATC 
CGGGAGAAGC TGCAGTGCAC ACAGGGCAAG GACTACTTGG ACGCCCTGGA CCTCCTCATT 
GAGAGCAGCA AGGAGCACGG GAAGGAGATG ACCATGCAGG AGCTGAAGGA CGGGACCCTG 
GAGCTGATCT TTGCGGCCTA TGCCACCACG GCCAGCGCCA GCACCTCACT CATCATGCAG 
CTGCTGAAGC ACCCCACTGT GCTGGAGAAG CTGCGGGATG AGCTGCGGGC TCATGGCATC 
CTGCACAGTG GCGGCTGCCC CTGCGAGGGC ACACTGCGCC TGGACACGCT CAGTGGGCTG 
CGCTACCTGG ACTGCGTCAT CAAGGAGGTC ATGCGCCTGT TCACGCCCAT TTCCGGCGGC 
TACCGCACTG TGCTGCAGAC CTTCGAGCTT GATGGTTTCC AGATCCCCAA AGGCTGGAGT 
GTCATGTATA GCATCCGGGA CACCCATGAC ACAGCGCCCG TGTTCAAAGA CGTGAACGTG 
TTCGACCCCG ATCGCTTCAG CCAGGCGCGG AGCGAGGACA AGGATGGCCG CTTCCATTAC 
CTCCCGTTCG GTGGCGGTGT CCGGACCTGC CTGGGCAAGC ACCTGGCCAA GCTGTTCCTG 
AAGGTGCTGG CGGTGGAGCT GGCTAGCACC AGCCGCTTTG AGCTGGCCAC ACGGACCTTC 
CCCCGCATCA CCTTGGTCCC CGTCCTGCAC CCCGTGGATG GCCTCAGCGT CAAGTTCTTT 
GGCCTGGACT CCAACCAGAA CGAGATCCTG CCGGAGACGG AGGCCATGCT GAGCGCCACA 
GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531290.1
CDS	163..1128
Translation	MAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Target ORF information:

RefSeq Version	XM_011532988.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532988.1

ORF Insert Sequence:

ATGGCCATCC GGGTGCTGCT GGGCTTCAGC ATCCCTGAGG AGGACCTTGG GCACCTCTTT 
GAGGTCTACC AGCAGTTTGT GGACAATGTC TTCTCCCTGC CTGTCGACCT GCCCTTCAGT 
GGCTACCGGC GGGGCATTCA GGCTCGGCAG ATCCTGCAGA AGGGGCTGGA GAAGGCCATC 
CGGGAGAAGC TGCAGTGCAC ACAGGGCAAG GACTACTTGG ACGCCCTGGA CCTCCTCATT 
GAGAGCAGCA AGGAGCACGG GAAGGAGATG ACCATGCAGG AGCTGAAGGA CGGGACCCTG 
GAGCTGATCT TTGCGGCCTA TGCCACCACG GCCAGCGCCA GCACCTCACT CATCATGCAG 
CTGCTGAAGC ACCCCACTGT GCTGGAGAAG CTGCGGGATG AGCTGCGGGC TCATGGCATC 
CTGCACAGTG GCGGCTGCCC CTGCGAGGGC ACACTGCGCC TGGACACGCT CAGTGGGCTG 
CGCTACCTGG ACTGCGTCAT CAAGGAGGTC ATGCGCCTGT TCACGCCCAT TTCCGGCGGC 
TACCGCACTG TGCTGCAGAC CTTCGAGCTT GATGGTTTCC AGATCCCCAA AGGCTGGAGT 
GTCATGTATA GCATCCGGGA CACCCATGAC ACAGCGCCCG TGTTCAAAGA CGTGAACGTG 
TTCGACCCCG ATCGCTTCAG CCAGGCGCGG AGCGAGGACA AGGATGGCCG CTTCCATTAC 
CTCCCGTTCG GTGGCGGTGT CCGGACCTGC CTGGGCAAGC ACCTGGCCAA GCTGTTCCTG 
AAGGTGCTGG CGGTGGAGCT GGCTAGCACC AGCCGCTTTG AGCTGGCCAC ACGGACCTTC 
CCCCGCATCA CCTTGGTCCC CGTCCTGCAC CCCGTGGATG GCCTCAGCGT CAAGTTCTTT 
GGCCTGGACT CCAACCAGAA CGAGATCCTG CCGGAGACGG AGGCCATGCT GAGCGCCACA 
GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP26B1 ( NM_001277742.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001264671.1 Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04231
Clone ID Related Accession (Same CDS sequence)	NM_001277742.1
Accession Version	NM_001277742.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	cytochrome P450 26B1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308258.1, AK294814.1, AF252297.1 and AA484668.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294814.1, FJ467289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCTTTG AGGGCTTGGA TCTGGTGTCG GCGCTGGCCA CCCTCGCCGC GTGCCTGGTG 
TCCGTGACGC TGCTGCTGGC CGTGTCGCAG CAGCTGTGGC AGCTGCGCTG GGCCGCCACT 
CGCGACAAGA GCTGCAAGCT GCCCATCCCC AAGGGATCCA TGGGCTTCCC GCTCATCGGA 
GAGACCGGCC ACTGGCTGCT GCAGGTCTTC TCCAAGATCT TCAGCCACGA GGCCCTGGAG 
AGTTACCTGC CCAAGATCCA GCTGGTGATC CAGGACACAC TGCGCGCCTG GAGCAGCCAC 
CCCGAGGCCA TCAACGTGTA CCAGGAGGCG CAGAAGCTGA CCTTCCGCAT GGCCATCCGG 
GTGCTGCTGG GCTTCAGCAT CCCTGAGGAG GACCTTGGGC ACCTCTTTGA GGTCTACCAG 
CAGTTTGTGG ACAATGTCTT CTCCCTGCCT GTCGACCTGC CCTTCAGTGG CTACCGGCGG 
GGCATTCAGG CTCGGCAGAT CCTGCAGAAG GGGCTGGAGA AGGCCATCCG GGAGAAGCTG 
CAGTGCACAC AGGGCAAGGA CTACTTGGAC GCCCTGGACC TCCTCATTGA GAGCAGCAAG 
GAGCACGGGA AGGAGATGAC CATGCAGGAG CTGAAGGACG GGACCCTGGA GCTGATCTTT 
GCGGCCTATG CCACCACGGC CAGCGCCAGC ACCTCACTCA TCATGCAGCT GCTGAAGCAC 
CCCACTGTGC TGGAGAAGCT GCGGGATGAG CTGCGGGCTC ATGGCATCCT GCACAGTGGC 
GGCTGCCCCT GCGAGGGCAC ACTGCGCCTG GACACGCTCA GTGGGCTGCG CTACCTGGAC 
TGCGTCATCA AGGAGGTCAT GCGCCTGTTC ACGCCCATTT CCGGCGGCTA CCGCACTGTG 
CTGCAGACCT TCGAGCTTGA TGGTTTCCAG ATCCCCAAAG GCTGGAGTGT CATGTATAGC 
ATCCGGGACA CCCATGACAC AGCGCCCGTG TTCAAAGACG TGAACGTGTT CGACCCCGAT 
CGCTTCAGCC AGGCGCGGAG CGAGGACAAG GATGGCCGCT TCCATTACCT CCCGTTCGGT 
GGCGGTGTCC GGACCTGCCT GGGCAAGCAC CTGGCCAAGC TGTTCCTGAA GGTGCTGGCG 
GTGGAGCTGG CTAGCACCAG CCGCTTTGAG CTGGCCACAC GGACCTTCCC CCGCATCACC 
TTGGTCCCCG TCCTGCACCC CGTGGATGGC CTCAGCGTCA AGTTCTTTGG CCTGGACTCC 
AACCAGAACG AGATCCTGCC GGAGACGGAG GCCATGCTGA GCGCCACAGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264671.1
CDS	29..1342
Translation	MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Target ORF information:

RefSeq Version	NM_001277742.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277742.1

ORF Insert Sequence:

ATGCTCTTTG AGGGCTTGGA TCTGGTGTCG GCGCTGGCCA CCCTCGCCGC GTGCCTGGTG 
TCCGTGACGC TGCTGCTGGC CGTGTCGCAG CAGCTGTGGC AGCTGCGCTG GGCCGCCACT 
CGCGACAAGA GCTGCAAGCT GCCCATCCCC AAGGGATCCA TGGGCTTCCC GCTCATCGGA 
GAGACCGGCC ACTGGCTGCT GCAGGTCTTC TCCAAGATCT TCAGCCACGA GGCCCTGGAG 
AGTTACCTGC CCAAGATCCA GCTGGTGATC CAGGACACAC TGCGCGCCTG GAGCAGCCAC 
CCCGAGGCCA TCAACGTGTA CCAGGAGGCG CAGAAGCTGA CCTTCCGCAT GGCCATCCGG 
GTGCTGCTGG GCTTCAGCAT CCCTGAGGAG GACCTTGGGC ACCTCTTTGA GGTCTACCAG 
CAGTTTGTGG ACAATGTCTT CTCCCTGCCT GTCGACCTGC CCTTCAGTGG CTACCGGCGG 
GGCATTCAGG CTCGGCAGAT CCTGCAGAAG GGGCTGGAGA AGGCCATCCG GGAGAAGCTG 
CAGTGCACAC AGGGCAAGGA CTACTTGGAC GCCCTGGACC TCCTCATTGA GAGCAGCAAG 
GAGCACGGGA AGGAGATGAC CATGCAGGAG CTGAAGGACG GGACCCTGGA GCTGATCTTT 
GCGGCCTATG CCACCACGGC CAGCGCCAGC ACCTCACTCA TCATGCAGCT GCTGAAGCAC 
CCCACTGTGC TGGAGAAGCT GCGGGATGAG CTGCGGGCTC ATGGCATCCT GCACAGTGGC 
GGCTGCCCCT GCGAGGGCAC ACTGCGCCTG GACACGCTCA GTGGGCTGCG CTACCTGGAC 
TGCGTCATCA AGGAGGTCAT GCGCCTGTTC ACGCCCATTT CCGGCGGCTA CCGCACTGTG 
CTGCAGACCT TCGAGCTTGA TGGTTTCCAG ATCCCCAAAG GCTGGAGTGT CATGTATAGC 
ATCCGGGACA CCCATGACAC AGCGCCCGTG TTCAAAGACG TGAACGTGTT CGACCCCGAT 
CGCTTCAGCC AGGCGCGGAG CGAGGACAAG GATGGCCGCT TCCATTACCT CCCGTTCGGT 
GGCGGTGTCC GGACCTGCCT GGGCAAGCAC CTGGCCAAGC TGTTCCTGAA GGTGCTGGCG 
GTGGAGCTGG CTAGCACCAG CCGCTTTGAG CTGGCCACAC GGACCTTCCC CCGCATCACC 
TTGGTCCCCG TCCTGCACCC CGTGGATGGC CTCAGCGTCA AGTTCTTTGG CCTGGACTCC 
AACCAGAACG AGATCCTGCC GGAGACGGAG GCCATGCTGA GCGCCACAGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP26B1 ( XM_005264433.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264490.1 Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X1, mRNA.

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CloneID	OHu35491
Clone ID Related Accession (Same CDS sequence)	XM_005264433.4
Accession Version	XM_005264433.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome P450 26B1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005264433.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAAATA AAACCTGCGT GCTCGTCTGT GGTTCTGGCT TCCAGTCGTC GCGGAGGGAG 
AAGTATGGCA ACGTGTTCAA GACGCATTTG TTGGGGCGGC CGCTGATACG CGTGACCGGC 
GCGGAGAACG TGCGCAAGAT CCTCATGGGC GAGCACCACC TCGTGAGCAC CGAGTGGCCT 
CGCAGCACCC GCATGTTGCT GGGCCCCAAC ACGGTGTCCA ATTCCATTGG CGACATCCAC 
CGCAACAAGC GCAAGGTCTT CTCCAAGATC TTCAGCCACG AGGCCCTGGA GAGTTACCTG 
CCCAAGATCC AGCTGGTGAT CCAGGACACA CTGCGCGCCT GGAGCAGCCA CCCCGAGGCC 
ATCAACGTGT ACCAGGAGGC GCAGAAGCTG ACCTTCCGCA TGGCCATCCG GGTGCTGCTG 
GGCTTCAGCA TCCCTGAGGA GGACCTTGGG CACCTCTTTG AGGTCTACCA GCAGTTTGTG 
GACAATGTCT TCTCCCTGCC TGTCGACCTG CCCTTCAGTG GCTACCGGCG GGGCATTCAG 
GCTCGGCAGA TCCTGCAGAA GGGGCTGGAG AAGGCCATCC GGGAGAAGCT GCAGTGCACA 
CAGGGCAAGG ACTACTTGGA CGCCCTGGAC CTCCTCATTG AGAGCAGCAA GGAGCACGGG 
AAGGAGATGA CCATGCAGGA GCTGAAGGAC GGGACCCTGG AGCTGATCTT TGCGGCCTAT 
GCCACCACGG CCAGCGCCAG CACCTCACTC ATCATGCAGC TGCTGAAGCA CCCCACTGTG 
CTGGAGAAGC TGCGGGATGA GCTGCGGGCT CATGGCATCC TGCACAGTGG CGGCTGCCCC 
TGCGAGGGCA CACTGCGCCT GGACACGCTC AGTGGGCTGC GCTACCTGGA CTGCGTCATC 
AAGGAGGTCA TGCGCCTGTT CACGCCCATT TCCGGCGGCT ACCGCACTGT GCTGCAGACC 
TTCGAGCTTG ATGGTTTCCA GATCCCCAAA GGCTGGAGTG TCATGTATAG CATCCGGGAC 
ACCCATGACA CAGCGCCCGT GTTCAAAGAC GTGAACGTGT TCGACCCCGA TCGCTTCAGC 
CAGGCGCGGA GCGAGGACAA GGATGGCCGC TTCCATTACC TCCCGTTCGG TGGCGGTGTC 
CGGACCTGCC TGGGCAAGCA CCTGGCCAAG CTGTTCCTGA AGGTGCTGGC GGTGGAGCTG 
GCTAGCACCA GCCGCTTTGA GCTGGCCACA CGGACCTTCC CCCGCATCAC CTTGGTCCCC 
GTCCTGCACC CCGTGGATGG CCTCAGCGTC AAGTTCTTTG GCCTGGACTC CAACCAGAAC 
GAGATCCTGC CGGAGACGGA GGCCATGCTG AGCGCCACAG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264490.1
CDS	167..1531
Translation	MKNKTCVLVCGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Target ORF information:

RefSeq Version	XM_005264433.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 26 subfamily B member 1 (CYP26B1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264433.4

ORF Insert Sequence:

ATGAAAAATA AAACCTGCGT GCTCGTCTGT GGTTCTGGCT TCCAGTCGTC GCGGAGGGAG 
AAGTATGGCA ACGTGTTCAA GACGCATTTG TTGGGGCGGC CGCTGATACG CGTGACCGGC 
GCGGAGAACG TGCGCAAGAT CCTCATGGGC GAGCACCACC TCGTGAGCAC CGAGTGGCCT 
CGCAGCACCC GCATGTTGCT GGGCCCCAAC ACGGTGTCCA ATTCCATTGG CGACATCCAC 
CGCAACAAGC GCAAGGTCTT CTCCAAGATC TTCAGCCACG AGGCCCTGGA GAGTTACCTG 
CCCAAGATCC AGCTGGTGAT CCAGGACACA CTGCGCGCCT GGAGCAGCCA CCCCGAGGCC 
ATCAACGTGT ACCAGGAGGC GCAGAAGCTG ACCTTCCGCA TGGCCATCCG GGTGCTGCTG 
GGCTTCAGCA TCCCTGAGGA GGACCTTGGG CACCTCTTTG AGGTCTACCA GCAGTTTGTG 
GACAATGTCT TCTCCCTGCC TGTCGACCTG CCCTTCAGTG GCTACCGGCG GGGCATTCAG 
GCTCGGCAGA TCCTGCAGAA GGGGCTGGAG AAGGCCATCC GGGAGAAGCT GCAGTGCACA 
CAGGGCAAGG ACTACTTGGA CGCCCTGGAC CTCCTCATTG AGAGCAGCAA GGAGCACGGG 
AAGGAGATGA CCATGCAGGA GCTGAAGGAC GGGACCCTGG AGCTGATCTT TGCGGCCTAT 
GCCACCACGG CCAGCGCCAG CACCTCACTC ATCATGCAGC TGCTGAAGCA CCCCACTGTG 
CTGGAGAAGC TGCGGGATGA GCTGCGGGCT CATGGCATCC TGCACAGTGG CGGCTGCCCC 
TGCGAGGGCA CACTGCGCCT GGACACGCTC AGTGGGCTGC GCTACCTGGA CTGCGTCATC 
AAGGAGGTCA TGCGCCTGTT CACGCCCATT TCCGGCGGCT ACCGCACTGT GCTGCAGACC 
TTCGAGCTTG ATGGTTTCCA GATCCCCAAA GGCTGGAGTG TCATGTATAG CATCCGGGAC 
ACCCATGACA CAGCGCCCGT GTTCAAAGAC GTGAACGTGT TCGACCCCGA TCGCTTCAGC 
CAGGCGCGGA GCGAGGACAA GGATGGCCGC TTCCATTACC TCCCGTTCGG TGGCGGTGTC 
CGGACCTGCC TGGGCAAGCA CCTGGCCAAG CTGTTCCTGA AGGTGCTGGC GGTGGAGCTG 
GCTAGCACCA GCCGCTTTGA GCTGGCCACA CGGACCTTCC CCCGCATCAC CTTGGTCCCC 
GTCCTGCACC CCGTGGATGG CCTCAGCGTC AAGTTCTTTG GCCTGGACTC CAACCAGAAC 
GAGATCCTGC CGGAGACGGA GGCCATGCTG AGCGCCACAG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biallelic mutations in CYP26B1: A differential diagnosis for Pfeiffer and Antley-Bixler syndromes.
American journal of medical genetics. Part A170(10)2706-10(2016 Oct)
Morton JE,Frentz S,Morgan T,Sutherland-Smith AJ,Robertson SP

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
FEBS letters590(16)2527-35(2016 08)
Nelson CH,Peng CC,Lutz JD,Yeung CK,Zelter A,Isoherranen N

Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells.
PloS one7(5)e36839(2012)
Elmabsout AA,Kumawat A,Saenz-M?ndez P,Krivospitskaya O,S?venstrand H,Olofsson PS,Eriksson LA,Strid A,Valen G,T?rm? H,Sirsj? A

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CYP26B1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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