AZU1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AZU1
Entrez Gene ID	566
Full Name	azurocidin 1
Synonyms	AZAMP,AZU,CAP37,HBP,HUMAZUR,NAZC,hHBP
General protein information	Preferred Names azurocidin 1 Names azurocidin cationic antimicrobial protein 37 cationic antimicrobial protein CAP37 heparin-binding protein neutrophil azurocidin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015].
Disorder MIM:	162815

mRNA and Protein(s)

mRNA	Protein	Name
NM_001700.5	NP_001691.1	azurocidin preproprotein
NM_001700.3	NP_001691.1	azurocidin preproprotein
NM_001700.4	NP_001691.1	azurocidin preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	AZU1	NP_001691.1
Pan troglodytes (chimpanzee)	AZU1	XP_524023.1
Bos taurus (cattle)	AZU1	XP_005209379.1

Gene Ontology
Bibliography

Related articles in PubMed

HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-?B pathways in vascular endothelial cells.
Chang M, Guo F, Zhou Z, Huang X, Yi L, Dou Y, Huan J
Cellular signalling4385-94(2018 Mar)

The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease.
Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Anne Pereira H
Histochemistry and cell biology144(4)293-308(2015 Oct)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties.
Kasus-Jacobi A, Noor-Mohammadi S, Griffith GL, Hinsley H, Mathias L, Pereira HA
Journal of leukocyte biology97(2)341-50(2015 Feb)

Basic residues in azurocidin/HBP contribute to both heparin binding and antimicrobial activity.
McCabe D, Cukierman T, Gabay JE
The Journal of biological chemistry277(30)27477-88(2002 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neuronal CAP37 may modulate the neuroinflammatory response in Alzheimer disease.
Title: The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease.

identified a multifunctional bioactive peptide, based on CAP37, that induces cell migration, possesses antibacterial and LPS-binding activity, and is effective at healing infected and noninfected corneal wounds in vivo.
Title: A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties.

Low levels of azurocidin in maternal serum in the first trimester were associated with subsequent preterm prelabor rupture of membranes.
Title: Azurocidin levels in maternal serum in the first trimester can predict preterm prelabor rupture of membranes.

Plasma levels of heparin-binding protein were significantly higher in patients with acute respiratory distress syndrome.
Title: Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome.

AZU1 exhibited high affinity binding to PTX3 in a calcium ion-dependent manner
Title: The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.

The following AZU1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AZU1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03670	NM_001700.5 Latest version!	Homo sapiens azurocidin 1 (AZU1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu03670	NM_001700.3	Homo sapiens azurocidin 1 (AZU1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu03670	NM_001700.4	Homo sapiens azurocidin 1 (AZU1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AZU1 ( NM_001700.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001691.1 Homo sapiens azurocidin 1 (AZU1), mRNA.

Price & Availability↑

CloneID	OHu03670
Clone ID Related Accession (Same CDS sequence)	NM_001700.5 , NM_001700.3 , NM_001700.4
Accession Version	NM_001700.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	azurocidin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093931.1 and BU617927.1. On Nov 22, 2018 this sequence version replaced NM_001700.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58794.1, ERR279847.7758.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233997.4/ ENSP00000233997.1 Protein has antimicrobial activity :: PMID: 11994286 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001691.1
CDS	11..766
Translation	MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA

Target ORF information:

RefSeq Version	NM_001700.5
Organism	Homo sapiens(human)
Definition	Homo sapiens azurocidin 1 (AZU1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001700.5

ORF Insert Sequence:

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AZU1 ( NM_001700.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001691.1 Homo sapiens azurocidin 1 (AZU1), mRNA.

Price & Availability↑

CloneID	OHu03670
Clone ID Related Accession (Same CDS sequence)	NM_001700.5 , NM_001700.3 , NM_001700.4
Accession Version	NM_001700.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	azurocidin preproprotein
Comment

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001691.1
Translation	MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA

Target ORF information:

RefSeq Version	NM_001700.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens azurocidin 1 (AZU1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001700.3

ORF Insert Sequence:

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AZU1 ( NM_001700.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001691.1 Homo sapiens azurocidin 1 (AZU1), mRNA.

Price & Availability↑

CloneID	OHu03670
Clone ID Related Accession (Same CDS sequence)	NM_001700.5 , NM_001700.3 , NM_001700.4
Accession Version	NM_001700.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	azurocidin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093931.1 and BU617927.1. On Nov 17, 2015 this sequence version replaced NM_001700.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093931.1, X58794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11994286 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001691.1
CDS	22..777
Translation	MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA

Target ORF information:

RefSeq Version	NM_001700.4
Organism	Homo sapiens(human)
Definition	Homo sapiens azurocidin 1 (AZU1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001700.4

ORF Insert Sequence:

ATGACCCGGC TGACAGTCCT GGCCCTGCTG GCTGGTCTGC TGGCGTCCTC GAGGGCCGGC 
TCCAGCCCCC TTTTGGACAT CGTTGGCGGC CGGAAGGCGA GGCCCCGCCA GTTCCCGTTC 
CTGGCCTCCA TTCAGAATCA AGGCAGGCAC TTCTGCGGGG GTGCCCTGAT CCATGCCCGC 
TTCGTGATGA CCGCGGCCAG CTGCTTCCAA AGCCAGAACC CCGGGGTTAG CACCGTGGTG 
CTGGGTGCCT ATGACCTGAG GCGGCGGGAG AGGCAGTCCC GCCAGACGTT TTCCATCAGC 
AGCATGAGCG AGAATGGCTA CGACCCCCAG CAGAACCTGA ACGACCTGAT GCTGCTTCAG 
CTGGACCGTG AGGCCAACCT CACCAGCAGC GTGACGATAC TGCCACTGCC TCTGCAGAAC 
GCCACGGTGG AAGCCGGCAC CAGATGCCAG GTGGCCGGCT GGGGGAGCCA GCGCAGTGGG 
GGGCGTCTCT CCCGTTTTCC CAGGTTTGTC AACGTGACTG TGACCCCCGA GGACCAGTGT 
CGCCCCAACA ACGTGTGCAC CGGTGTGCTC ACCCGCCGCG GTGGCATCTG CAATGGGGAC 
GGGGGCACCC CCCTCGTCTG CGAGGGCCTG GCCCACGGCG TGGCCTCCTT TTCCCTGGGG 
CCCTGTGGCC GAGGCCCTGA CTTCTTCACC CGAGTGGCGC TCTTCCGAGA CTGGATCGAT 
GGTGTTCTCA ACAACCCGGG ACCGGGGCCA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-?B pathways in vascular endothelial cells.
Cellular signalling4385-94(2018 Mar)
Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease.
Histochemistry and cell biology144(4)293-308(2015 Oct)
Brock AJ,Kasus-Jacobi A,Lerner M,Logan S,Adesina AM,Anne Pereira H

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties.
Journal of leukocyte biology97(2)341-50(2015 Feb)
Kasus-Jacobi A,Noor-Mohammadi S,Griffith GL,Hinsley H,Mathias L,Pereira HA

Basic residues in azurocidin/HBP contribute to both heparin binding and antimicrobial activity.
The Journal of biological chemistry277(30)27477-88(2002 Jul)
McCabe D,Cukierman T,Gabay JE

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AZU1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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