PRSS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRSS2
Entrez Gene ID	5645
Full Name	serine protease 2
Synonyms	TRY2,TRY8,TRYP2
General protein information	Preferred Names serine protease 2 Names trypsin-2 anionic trypsinogen protease serine 2 preproprotein protease, serine 2 protease, serine, 2 (trypsin 2) trypsin II trypsinogen 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015].
Disorder MIM:	601564
Disorder Html:	{Pancreatitis, chronic, protection against}, 167800 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002770.4	NP_002761.1	trypsin-2 isoform 2 preproprotein
NM_001303414.1	NP_001290343.1	trypsin-2 isoform 1 preproprotein
NM_002770.3	NP_002761.1	trypsin-2 isoform 2 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100686744	XP_003432104.1
Pan troglodytes (chimpanzee)	LOC100615529	XP_003318892.1
	PRSS2	NP_001040585.1
Danio rerio (zebrafish)	zgc:66382	NP_955899.2
Homo sapiens (human)	PRSS2	NP_002761.1
Mus musculus (house mouse)	Prss2	NP_033456.1
Rattus norvegicus (Norway rat)	Prss1	NP_036767.1
Gallus gallus (chicken)	PRSS2	NP_990715.1
Xenopus tropicalis (tropical clawed frog)	try10	NP_001011209.1
Bos taurus (cattle)	PRSS2	NP_777115.1
Danio rerio (zebrafish)	si:ch73-103b2.3	XP_003200238.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009966	XP_319102.4

Gene Ontology
Bibliography

Related articles in PubMed

Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.
Polonikov AV, Samgina TA, Nazarenko PM, Bushueva OY, Ivanov VP
Pancreas46(2)230-236(2017 Feb)

Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
Avanthi SU, Ravi Kanth VV, Agarwal J, Lakhtakia S, Gangineni K, Rao GV, Reddy DN, Talukdar R
Journal of gastroenterology and hepatology30(12)1796-801(2015 Dec)

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, F?rec C, Drenth JP, Witt H, Rosendahl J,
Gut64(9)1426-33(2015 Sep)

Correlations between serum trypsinogen-2 and pancreatic cancer.
Cao J, Xia C, Cui T, Guo H, Li H, Ren Y, Wang S
Hepato-gastroenterology62(138)435-40(2015 Mar-Apr)

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.
Rowen L, Koop BF, Hood L
Science (New York, N.Y.)272(5269)1755-62(1996 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis
Title: Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.

PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis.
Title: Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.

Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis.
Title: Correlations between serum trypsinogen-2 and pancreatic cancer.

Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen.
Title: Trypsin-mediated enzymatic degradation of type II collagen in the human vitreous.

Two associations with alcoholic pancreatitis at genome-wide significance were identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study.
Title: Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

The following PRSS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu41664	NM_001303414.1 Latest version!	Homo sapiens serine protease 2 (PRSS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu59967	NM_002770.4 Latest version!	Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu59967	NM_002770.3	Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRSS2 ( NM_001303414.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290343.1 Homo sapiens serine protease 2 (PRSS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu41664
Clone ID Related Accession (Same CDS sequence)	NM_001303414.1
Accession Version	NM_001303414.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	trypsin-2 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005814.2, DQ846873.1, AC245427.3, BC030260.1, CA867206.1 and BQ786948.1. On or before Jan 7, 2015 this sequence version replaced XM_006716052.1, XM_005276996.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ846873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151405, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC GGCAATTAAC TCAAAATTAT CAGGAAGAGG GTGTGAATAT 
CACCGCATCC AGGTGAGACT GGGAGAGCAC AACATCGAAG TCCTGGAGGG GAATGAACAG 
TTCATCAATG CGGCCAAGAT CATCCGCCAC CCCAAATACA ACAGCCGGAC TCTGGACAAT 
GACATCCTGC TGATCAAGCT CTCCTCACCT GCCGTCATCA ATTCCCGCGT GTCCGCCATC 
TCTCTGCCCA CTGCCCCTCC AGCTGCTGGC ACCGAGTCCC TCATCTCCGG CTGGGGCAAC 
ACTCTGAGTT CTGGTGCCGA CTACCCAGAC GAGCTGCAGT GCCTGGATGC TCCTGTGCTG 
AGCCAGGCTG AGTGTGAAGC CTCCTACCCT GGAAAGATTA CCAACAACAT GTTCTGTGTG 
GGCTTCCTCG AGGGAGGCAA GGATTCCTGC CAGGGTGATT CTGGTGGCCC TGTGGTCTCC 
AATGGAGAGC TCCAAGGAAT TGTCTCCTGG GGCTATGGCT GTGCCCAGAA GAACAGGCCT 
GGAGTCTACA CCAAGGTCTA CAACTATGTG GACTGGATTA AGGACACCAT AGCTGCCAAC 
AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290343.1
CDS	41..826
Translation	MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS

Target ORF information:

RefSeq Version	NM_001303414.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 2 (PRSS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303414.1

ORF Insert Sequence:

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC GGCAATTAAC TCAAAATTAT CAGGAAGAGG GTGTGAATAT 
CACCGCATCC AGGTGAGACT GGGAGAGCAC AACATCGAAG TCCTGGAGGG GAATGAACAG 
TTCATCAATG CGGCCAAGAT CATCCGCCAC CCCAAATACA ACAGCCGGAC TCTGGACAAT 
GACATCCTGC TGATCAAGCT CTCCTCACCT GCCGTCATCA ATTCCCGCGT GTCCGCCATC 
TCTCTGCCCA CTGCCCCTCC AGCTGCTGGC ACCGAGTCCC TCATCTCCGG CTGGGGCAAC 
ACTCTGAGTT CTGGTGCCGA CTACCCAGAC GAGCTGCAGT GCCTGGATGC TCCTGTGCTG 
AGCCAGGCTG AGTGTGAAGC CTCCTACCCT GGAAAGATTA CCAACAACAT GTTCTGTGTG 
GGCTTCCTCG AGGGAGGCAA GGATTCCTGC CAGGGTGATT CTGGTGGCCC TGTGGTCTCC 
AATGGAGAGC TCCAAGGAAT TGTCTCCTGG GGCTATGGCT GTGCCCAGAA GAACAGGCCT 
GGAGTCTACA CCAAGGTCTA CAACTATGTG GACTGGATTA AGGACACCAT AGCTGCCAAC 
AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS2 ( NM_002770.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002761.1 Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu59967
Clone ID Related Accession (Same CDS sequence)	NM_002770.4 , NM_002770.3
Accession Version	NM_002770.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	trypsin-2 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005814.2, BC030260.1, AC245427.3 and CA867206.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_002770.3. Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA772699.1, CA776091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAACAGTT CATCAATGCG GCCAAGATCA TCCGCCACCC CAAATACAAC 
AGCCGGACTC TGGACAATGA CATCCTGCTG ATCAAGCTCT CCTCACCTGC CGTCATCAAT 
TCCCGCGTGT CCGCCATCTC TCTGCCCACT GCCCCTCCAG CTGCTGGCAC CGAGTCCCTC 
ATCTCCGGCT GGGGCAACAC TCTGAGTTCT GGTGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTGAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AACAACATGT TCTGTGTGGG CTTCCTCGAG GGAGGCAAGG ATTCCTGCCA GGGTGATTCT 
GGTGGCCCTG TGGTCTCCAA TGGAGAGCTC CAAGGAATTG TCTCCTGGGG CTATGGCTGT 
GCCCAGAAGA ACAGGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGGA CTGGATTAAG 
GACACCATAG CTGCCAACAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002761.1
CDS	14..757
Translation	MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS

Target ORF information:

RefSeq Version	NM_002770.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002770.4

ORF Insert Sequence:

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAACAGTT CATCAATGCG GCCAAGATCA TCCGCCACCC CAAATACAAC 
AGCCGGACTC TGGACAATGA CATCCTGCTG ATCAAGCTCT CCTCACCTGC CGTCATCAAT 
TCCCGCGTGT CCGCCATCTC TCTGCCCACT GCCCCTCCAG CTGCTGGCAC CGAGTCCCTC 
ATCTCCGGCT GGGGCAACAC TCTGAGTTCT GGTGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTGAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AACAACATGT TCTGTGTGGG CTTCCTCGAG GGAGGCAAGG ATTCCTGCCA GGGTGATTCT 
GGTGGCCCTG TGGTCTCCAA TGGAGAGCTC CAAGGAATTG TCTCCTGGGG CTATGGCTGT 
GCCCAGAAGA ACAGGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGGA CTGGATTAAG 
GACACCATAG CTGCCAACAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS2 ( NM_002770.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002761.1 Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu59967
Clone ID Related Accession (Same CDS sequence)	NM_002770.4 , NM_002770.3
Accession Version	NM_002770.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	trypsin-2 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005814.2, BC030260.1, AC245427.3, CA867206.1 and BQ786948.1. This sequence is a reference standard in the RefSeqGene project. On Jan 7, 2015 this sequence version replaced NM_002770.2. Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA777773.1, BC107784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAACAGTT CATCAATGCG GCCAAGATCA TCCGCCACCC CAAATACAAC 
AGCCGGACTC TGGACAATGA CATCCTGCTG ATCAAGCTCT CCTCACCTGC CGTCATCAAT 
TCCCGCGTGT CCGCCATCTC TCTGCCCACT GCCCCTCCAG CTGCTGGCAC CGAGTCCCTC 
ATCTCCGGCT GGGGCAACAC TCTGAGTTCT GGTGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTGAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AACAACATGT TCTGTGTGGG CTTCCTCGAG GGAGGCAAGG ATTCCTGCCA GGGTGATTCT 
GGTGGCCCTG TGGTCTCCAA TGGAGAGCTC CAAGGAATTG TCTCCTGGGG CTATGGCTGT 
GCCCAGAAGA ACAGGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGGA CTGGATTAAG 
GACACCATAG CTGCCAACAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002761.1
CDS	41..784
Translation	MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS

Target ORF information:

RefSeq Version	NM_002770.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002770.3

ORF Insert Sequence:

ATGAATCTAC TTCTGATCCT TACCTTTGTT GCAGCTGCTG TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACATCTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
TTGAATTCTG GCTACCACTT CTGCGGTGGC TCCCTCATCA GCGAACAGTG GGTGGTGTCA 
GCAGGTCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAACAGTT CATCAATGCG GCCAAGATCA TCCGCCACCC CAAATACAAC 
AGCCGGACTC TGGACAATGA CATCCTGCTG ATCAAGCTCT CCTCACCTGC CGTCATCAAT 
TCCCGCGTGT CCGCCATCTC TCTGCCCACT GCCCCTCCAG CTGCTGGCAC CGAGTCCCTC 
ATCTCCGGCT GGGGCAACAC TCTGAGTTCT GGTGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTGAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AACAACATGT TCTGTGTGGG CTTCCTCGAG GGAGGCAAGG ATTCCTGCCA GGGTGATTCT 
GGTGGCCCTG TGGTCTCCAA TGGAGAGCTC CAAGGAATTG TCTCCTGGGG CTATGGCTGT 
GCCCAGAAGA ACAGGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGGA CTGGATTAAG 
GACACCATAG CTGCCAACAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.
Pancreas46(2)230-236(2017 Feb)
Polonikov AV,Samgina TA,Nazarenko PM,Bushueva OY,Ivanov VP

Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
Journal of gastroenterology and hepatology30(12)1796-801(2015 Dec)
Avanthi SU,Ravi Kanth VV,Agarwal J,Lakhtakia S,Gangineni K,Rao GV,Reddy DN,Talukdar R

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Gut64(9)1426-33(2015 Sep)
Derikx MH,Kovacs P,Scholz M,Masson E,Chen JM,Ruffert C,Lichtner P,Te Morsche RH,Cavestro GM,F?rec C,Drenth JP,Witt H,Rosendahl J,

Correlations between serum trypsinogen-2 and pancreatic cancer.
Hepato-gastroenterology62(138)435-40(2015 Mar-Apr)
Cao J,Xia C,Cui T,Guo H,Li H,Ren Y,Wang S

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.
Science (New York, N.Y.)272(5269)1755-62(1996 Jun)
Rowen L,Koop BF,Hood L

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PRSS2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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