PROS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PROS1
Entrez Gene ID	5627
Full Name	protein S
Synonyms	PROS,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6
General protein information	Preferred Names protein S Names vitamin K-dependent protein S protein S (alpha) protein Sa vitamin K-dependent plasma protein S
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q11.1
Summary	This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015].
Disorder MIM:	176880
Disorder Html:	Thrombophilia due to protein S deficiency, autosomal dominant, 612336 (3); Thrombophilia due to protein S deficiency, autosomal recessive, 614514 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000313.3	NP_000304.2	vitamin K-dependent protein S isoform 2 preproprotein
NM_000313.4	NP_000304.2	vitamin K-dependent protein S isoform 2 preproprotein
NM_001314077.1	NP_001301006.1	vitamin K-dependent protein S isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PROS1	XP_005639500.1
Danio rerio (zebrafish)	pros1	NP_001070791.1
Pan troglodytes (chimpanzee)	PROS1	XP_516603.3
Gallus gallus (chicken)	PROS1	XP_416641.2
Xenopus tropicalis (tropical clawed frog)	pros1	NP_001119539.1
	PROS1	NP_001038191.1
Mus musculus (house mouse)	Pros1	NP_035303.1
Rattus norvegicus (Norway rat)	Pros1	NP_112348.2
Homo sapiens (human)	PROS1	NP_000304.2
Bos taurus (cattle)	PROS1	NP_776863.1

Gene Ontology
Bibliography

Related articles in PubMed

Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.
Lundwall A, Dackowski W, Cohen E, Shaffer M, Mahr A, Dahlb?ck B, Stenflo J, Wydro R
Proceedings of the National Academy of Sciences of the United States of America83(18)6716-20(1986 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Due to the versatility exemplified, this probe holds great promise for exploring the role of protein S-nitrosylation in the pathophysiological process of a variety of vascular diseases
Title: A fluorogenic probe for imaging protein S-nitrosylation in live cells.

There was no association between PS-Tokushima and recurrent pregnancy loss and a PS deficiency or low PS activity was shown not to serve as a reliable clinical predictor of subsequent miscarriage.
Title: Genotyping analysis of protein S-Tokushima (K196E) and the involvement of protein S antigen and activity in patients with recurrent pregnancy loss.

In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).
Title: Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13).

The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001).
Title: Whole Exome Sequencing Reveals Severe Thrombophilia in Acute Unprovoked Idiopathic Fatal Pulmonary Embolism.

we identify PROS1 as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression
Title: Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL.

The following PROS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21617	NM_000313.4 Latest version!	Homo sapiens protein S (PROS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu38054	NM_001314077.1 Latest version!	Homo sapiens protein S (PROS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu21617	NM_000313.3	Homo sapiens protein S (PROS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PROS1 ( NM_000313.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000304.2 Homo sapiens protein S (PROS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21617
Clone ID Related Accession (Same CDS sequence)	NM_000313.3 , NM_000313.4
Accession Version	NM_000313.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	vitamin K-dependent protein S isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB275740.1, BC015801.1, AC144562.5 and AI139337.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced NM_000313.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.22483.1, SRR1803614.138384.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT 
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA 
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT 
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA 
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG 
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT 
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA 
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA 
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA 
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC 
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT 
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT 
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG 
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT 
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC 
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC 
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA 
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT 
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT 
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG 
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA 
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT 
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG 
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA 
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT 
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG 
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT 
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC 
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT 
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT 
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG 
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT 
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000304.2
CDS	342..2372
Translation	MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS

Target ORF information:

RefSeq Version	NM_000313.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein S (PROS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000313.3

ORF Insert Sequence:

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT 
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA 
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT 
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA 
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG 
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT 
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA 
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA 
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA 
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC 
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT 
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT 
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG 
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT 
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC 
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC 
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA 
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT 
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT 
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG 
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA 
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT 
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG 
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA 
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT 
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG 
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT 
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC 
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT 
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT 
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG 
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT 
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROS1 ( NM_000313.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000304.2 Homo sapiens protein S (PROS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21617
Clone ID Related Accession (Same CDS sequence)	NM_000313.3 , NM_000313.4
Accession Version	NM_000313.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	vitamin K-dependent protein S isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015801.1, AC144562.5 and AI139337.1. On Aug 31, 2019 this sequence version replaced NM_000313.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292994.1, Y00692.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT 
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA 
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT 
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA 
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG 
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT 
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA 
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA 
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA 
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC 
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT 
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT 
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG 
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT 
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC 
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC 
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA 
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT 
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT 
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG 
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA 
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT 
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG 
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA 
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT 
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG 
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT 
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC 
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT 
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT 
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG 
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT 
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000304.2
CDS	148..2178
Translation	MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS

Target ORF information:

RefSeq Version	NM_000313.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein S (PROS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000313.4

ORF Insert Sequence:

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT 
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA 
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT 
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA 
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG 
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT 
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA 
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA 
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA 
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC 
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT 
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT 
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG 
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT 
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC 
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC 
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA 
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT 
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT 
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG 
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA 
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT 
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG 
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA 
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT 
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG 
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT 
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC 
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT 
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT 
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG 
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT 
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROS1 ( NM_001314077.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001301006.1 Homo sapiens protein S (PROS1), transcript variant 1, mRNA.

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CloneID	OHu38054
Clone ID Related Accession (Same CDS sequence)	NM_001314077.1
Accession Version	NM_001314077.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2127bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	vitamin K-dependent protein S isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA408604.1, AC117474.7, BG702968.1, DB076220.1, BC015801.1, AC144562.5 and AI139337.1. This sequence is a reference standard in the RefSeqGene project. On Oct 5, 2015 this sequence version replaced XM_005247626.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.119921.1, SRR1803614.15631.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTG TTTATATTTT AGAAATGATT TTATATACAA CCGTGCATGC 
ATTTCTGTAT TGGTCGGCTT ATCTGGATGC AATTTTTTCT ATTCTATATG CTTTTTGTCA 
AAGCAACAGG CTTCACAAGT CCTGGTTAGG AAGCGTCGTG CAAATTCTTT ACTTGAAGAA 
ACCAAACAGG GTAATCTTGA AAGAGAATGC ATCGAAGAAC TGTGCAATAA AGAAGAAGCC 
AGGGAGGTCT TTGAAAATGA CCCGGAAACG GATTATTTTT ATCCAAAATA CTTAGTTTGT 
CTTCGCTCTT TTCAAACTGG GTTATTCACT GCTGCACGTC AGTCAACTAA TGCTTATCCT 
GACCTAAGAA GCTGTGTCAA TGCCATTCCA GACCAGTGTA GTCCTCTGCC ATGCAATGAA 
GATGGATATA TGAGCTGCAA AGATGGAAAA GCTTCTTTTA CTTGCACTTG TAAACCAGGT 
TGGCAAGGAG AAAAGTGTGA ATTTGACATA AATGAATGCA AAGATCCCTC AAATATAAAT 
GGAGGTTGCA GTCAAATTTG TGATAATACA CCTGGAAGTT ACCACTGTTC CTGTAAAAAT 
GGTTTTGTTA TGCTTTCAAA TAAGAAAGAT TGTAAAGATG TGGATGAATG CTCTTTGAAG 
CCAAGCATTT GTGGCACAGC TGTGTGCAAG AACATCCCAG GAGATTTTGA ATGTGAATGC 
CCCGAAGGCT ACAGATATAA TCTCAAATCA AAGTCTTGTG AAGATATAGA TGAATGCTCT 
GAGAACATGT GTGCTCAGCT TTGTGTCAAT TACCCTGGAG GTTACACTTG CTATTGTGAT 
GGGAAGAAAG GATTCAAACT TGCCCAAGAT CAGAAGAGTT GTGAGGTTGT TTCAGTGTGC 
CTTCCCTTGA ACCTTGACAC AAAGTATGAA TTACTTTACT TGGCGGAGCA GTTTGCAGGG 
GTTGTTTTAT ATTTAAAATT TCGTTTGCCA GAAATCAGCA GATTTTCAGC AGAATTTGAT 
TTCCGGACAT ATGATTCAGA AGGCGTGATA CTGTACGCAG AATCTATCGA TCACTCAGCG 
TGGCTCCTGA TTGCACTTCG TGGTGGAAAG ATTGAAGTTC AGCTTAAGAA TGAACATACA 
TCCAAAATCA CAACTGGAGG TGATGTTATT AATAATGGTC TATGGAATAT GGTGTCTGTG 
GAAGAATTAG AACATAGTAT TAGCATTAAA ATAGCTAAAG AAGCTGTGAT GGATATAAAT 
AAACCTGGAC CCCTTTTTAA GCCGGAAAAT GGATTGCTGG AAACCAAAGT ATACTTTGCA 
GGATTCCCTC GGAAAGTGGA AAGTGAACTC ATTAAACCGA TTAACCCTCG TCTAGATGGA 
TGTATACGAA GCTGGAATTT GATGAAGCAA GGAGCTTCTG GAATAAAGGA AATTATTCAA 
GAAAAACAAA ATAAGCATTG CCTGGTTACT GTGGAGAAGG GCTCCTACTA TCCTGGTTCT 
GGAATTGCTC AATTTCACAT AGATTATAAT AATGTATCCA GTGCTGAGGG TTGGCATGTA 
AATGTGACCT TGAATATTCG TCCATCCACG GGCACTGGTG TTATGCTTGC CTTGGTTTCT 
GGTAACAACA CAGTGCCCTT TGCTGTGTCC TTGGTGGACT CCACCTCTGA AAAATCACAG 
GATATTCTGT TATCTGTTGA AAATACTGTA ATATATCGGA TACAGGCCCT AAGTCTATGT 
TCCGATCAAC AATCTCATCT GGAATTTAGA GTCAACAGAA ACAATCTGGA GTTGTCGACA 
CCACTTAAAA TAGAAACCAT CTCCCATGAA GACCTTCAAA GACAACTTGC CGTCTTGGAC 
AAAGCAATGA AAGCAAAAGT GGCCACATAC CTGGGTGGCC TTCCAGATGT TCCATTCAGT 
GCCACACCAG TGAATGCCTT TTATAATGGC TGCATGGAAG TGAATATTAA TGGTGTACAG 
TTGGATCTGG ATGAAGCCAT TTCTAAACAT AATGATATTA GAGCTCACTC ATGTCCATCA 
GTTTGGAAAA AGACAAAGAA TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001301006.1
CDS	333..2459
Translation	MRVLGGRCGALLACLLLVLPVSEANFCLYFRNDFIYNRACISVLVGLSGCNFFYSICFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS

Target ORF information:

RefSeq Version	NM_001314077.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein S (PROS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001314077.1

ORF Insert Sequence:

ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTG TTTATATTTT AGAAATGATT TTATATACAA CCGTGCATGC 
ATTTCTGTAT TGGTCGGCTT ATCTGGATGC AATTTTTTCT ATTCTATATG CTTTTTGTCA 
AAGCAACAGG CTTCACAAGT CCTGGTTAGG AAGCGTCGTG CAAATTCTTT ACTTGAAGAA 
ACCAAACAGG GTAATCTTGA AAGAGAATGC ATCGAAGAAC TGTGCAATAA AGAAGAAGCC 
AGGGAGGTCT TTGAAAATGA CCCGGAAACG GATTATTTTT ATCCAAAATA CTTAGTTTGT 
CTTCGCTCTT TTCAAACTGG GTTATTCACT GCTGCACGTC AGTCAACTAA TGCTTATCCT 
GACCTAAGAA GCTGTGTCAA TGCCATTCCA GACCAGTGTA GTCCTCTGCC ATGCAATGAA 
GATGGATATA TGAGCTGCAA AGATGGAAAA GCTTCTTTTA CTTGCACTTG TAAACCAGGT 
TGGCAAGGAG AAAAGTGTGA ATTTGACATA AATGAATGCA AAGATCCCTC AAATATAAAT 
GGAGGTTGCA GTCAAATTTG TGATAATACA CCTGGAAGTT ACCACTGTTC CTGTAAAAAT 
GGTTTTGTTA TGCTTTCAAA TAAGAAAGAT TGTAAAGATG TGGATGAATG CTCTTTGAAG 
CCAAGCATTT GTGGCACAGC TGTGTGCAAG AACATCCCAG GAGATTTTGA ATGTGAATGC 
CCCGAAGGCT ACAGATATAA TCTCAAATCA AAGTCTTGTG AAGATATAGA TGAATGCTCT 
GAGAACATGT GTGCTCAGCT TTGTGTCAAT TACCCTGGAG GTTACACTTG CTATTGTGAT 
GGGAAGAAAG GATTCAAACT TGCCCAAGAT CAGAAGAGTT GTGAGGTTGT TTCAGTGTGC 
CTTCCCTTGA ACCTTGACAC AAAGTATGAA TTACTTTACT TGGCGGAGCA GTTTGCAGGG 
GTTGTTTTAT ATTTAAAATT TCGTTTGCCA GAAATCAGCA GATTTTCAGC AGAATTTGAT 
TTCCGGACAT ATGATTCAGA AGGCGTGATA CTGTACGCAG AATCTATCGA TCACTCAGCG 
TGGCTCCTGA TTGCACTTCG TGGTGGAAAG ATTGAAGTTC AGCTTAAGAA TGAACATACA 
TCCAAAATCA CAACTGGAGG TGATGTTATT AATAATGGTC TATGGAATAT GGTGTCTGTG 
GAAGAATTAG AACATAGTAT TAGCATTAAA ATAGCTAAAG AAGCTGTGAT GGATATAAAT 
AAACCTGGAC CCCTTTTTAA GCCGGAAAAT GGATTGCTGG AAACCAAAGT ATACTTTGCA 
GGATTCCCTC GGAAAGTGGA AAGTGAACTC ATTAAACCGA TTAACCCTCG TCTAGATGGA 
TGTATACGAA GCTGGAATTT GATGAAGCAA GGAGCTTCTG GAATAAAGGA AATTATTCAA 
GAAAAACAAA ATAAGCATTG CCTGGTTACT GTGGAGAAGG GCTCCTACTA TCCTGGTTCT 
GGAATTGCTC AATTTCACAT AGATTATAAT AATGTATCCA GTGCTGAGGG TTGGCATGTA 
AATGTGACCT TGAATATTCG TCCATCCACG GGCACTGGTG TTATGCTTGC CTTGGTTTCT 
GGTAACAACA CAGTGCCCTT TGCTGTGTCC TTGGTGGACT CCACCTCTGA AAAATCACAG 
GATATTCTGT TATCTGTTGA AAATACTGTA ATATATCGGA TACAGGCCCT AAGTCTATGT 
TCCGATCAAC AATCTCATCT GGAATTTAGA GTCAACAGAA ACAATCTGGA GTTGTCGACA 
CCACTTAAAA TAGAAACCAT CTCCCATGAA GACCTTCAAA GACAACTTGC CGTCTTGGAC 
AAAGCAATGA AAGCAAAAGT GGCCACATAC CTGGGTGGCC TTCCAGATGT TCCATTCAGT 
GCCACACCAG TGAATGCCTT TTATAATGGC TGCATGGAAG TGAATATTAA TGGTGTACAG 
TTGGATCTGG ATGAAGCCAT TTCTAAACAT AATGATATTA GAGCTCACTC ATGTCCATCA 
GTTTGGAAAA AGACAAAGAA TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.
Proceedings of the National Academy of Sciences of the United States of America83(18)6716-20(1986 Sep)
Lundwall A,Dackowski W,Cohen E,Shaffer M,Mahr A,Dahlb?ck B,Stenflo J,Wydro R

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PROS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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