PRL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRL
Entrez Gene ID	5617
Full Name	prolactin
Synonyms	GHA1
General protein information	Preferred Names prolactin Names prolactin decidual prolactin growth hormone A1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.3
Summary	This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
Disorder MIM:	176760

mRNA and Protein(s)

mRNA	Protein	Name
NM_000948.5	NP_000939.1	prolactin precursor
NM_000948.6	NP_000939.1	prolactin precursor
XM_011514754.2	XP_011513056.1	prolactin isoform X1
NM_001163558.3	NP_001157030.1	prolactin precursor
XM_011514753.2	XP_011513055.1	prolactin isoform X1
NM_001163558.2	NP_001157030.1	prolactin precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Prl	NP_036761.1
Gallus gallus (chicken)	PRL	NP_990797.2
Canis lupus familiaris (dog)	PRL	NP_001008276.2
Xenopus tropicalis (tropical clawed frog)	prl.1	NP_001093699.1
Homo sapiens (human)	PRL	NP_001157030.1
Pan troglodytes (chimpanzee)	PRL	XP_518264.1
	PRL	NP_001040593.1
Bos taurus (cattle)	PRL	NP_776378.2
Mus musculus (house mouse)	Prl	NP_035294.2

Gene Ontology
Bibliography

Related articles in PubMed

Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.
Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N
Proceedings of the National Academy of Sciences of the United States of America114(49)13042-13047(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The production of PRL by Mvarphis was increased by unknown components of rheumatoid arthritis and rheumatoid arthritis synovial fluid, where it could contribute to disease progression.
Title: Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages.

Depression and anxiety in subfertile males are associated with higher secretion of PRL.
Title: Impact of emotional disorders on semen quality in men treated for infertility.

Prolactin rs1341239 T allele decreases the risk of brick tea fluorosis in the Inner Mongolia in China population.
Title: Prolactin rs1341239 T allele may have protective role against the brick tea type skeletal fluorosis.

findings show that cysteine in the PRL catalytic site is endogenously phosphorylated as part of the catalytic cycle and that phosphocysteine levels change in response to Mg(2+) levels.
Title: Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.

changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-alpha, IL-6, IL-12, IL-10) in peripheral blood monocytes of celiac disease patients, were investiagted.
Title: Increased Expression of TLR4 and TLR7 but Not Prolactin mRNA by Peripheral Blood Monocytes in Active Celiac Disease.

The following PRL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26664	NM_000948.6 Latest version!	Homo sapiens prolactin (PRL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26664	NM_001163558.3 Latest version!	Homo sapiens prolactin (PRL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu59959	XM_011514753.2 Latest version!	Homo sapiens prolactin (PRL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu59959	XM_011514754.2 Latest version!	Homo sapiens prolactin (PRL), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu26664	NM_000948.5	Homo sapiens prolactin (PRL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26664	NM_001163558.2	Homo sapiens prolactin (PRL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRL ( NM_000948.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000939.1 Homo sapiens prolactin (PRL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26664
Clone ID Related Accession (Same CDS sequence)	NM_000948.5 , NM_000948.6 , NM_001163558.3 , NM_001163558.2
Accession Version	NM_000948.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	prolactin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015850.1 and CD106243.1. On Aug 25, 2011 this sequence version replaced NM_000948.4. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015850.1, ERR279860.1893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000939.1
CDS	520..1203
Translation	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	NM_000948.5
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000948.5

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRL ( NM_000948.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000939.1 Homo sapiens prolactin (PRL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26664
Clone ID Related Accession (Same CDS sequence)	NM_000948.5 , NM_000948.6 , NM_001163558.3 , NM_001163558.2
Accession Version	NM_000948.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	prolactin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015850.1 and CD106243.1. On Nov 23, 2018 this sequence version replaced NM_000948.5. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279860.1893.1, BC015850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306482.2/ ENSP00000302150.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000939.1
CDS	55..738
Translation	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	NM_000948.6
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000948.6

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRL ( NM_001163558.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157030.1 Homo sapiens prolactin (PRL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26664
Clone ID Related Accession (Same CDS sequence)	NM_000948.5 , NM_000948.6 , NM_001163558.3 , NM_001163558.2
Accession Version	NM_001163558.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	prolactin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from GQ305133.1 and CD106243.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_001163558.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ305133.1, X54393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157030.1
CDS	174..857
Translation	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	NM_001163558.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163558.3

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRL ( NM_001163558.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157030.1 Homo sapiens prolactin (PRL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26664
Clone ID Related Accession (Same CDS sequence)	NM_000948.5 , NM_000948.6 , NM_001163558.3 , NM_001163558.2
Accession Version	NM_001163558.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	prolactin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from GQ305133.1 and CD106243.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2011 this sequence version replaced NM_001163558.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ305133.1, X54393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157030.1
CDS	192..875
Translation	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	NM_001163558.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163558.2

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGGG TCCCTCCTGC TGCTGCTGGT GTCAAACCTG 
CTCCTGTGCC AGAGCGTGGC CCCCTTGCCC ATCTGTCCCG GCGGGGCTGC CCGATGCCAG 
GTGACCCTTC GAGACCTGTT TGACCGCGCC GTCGTCCTGT CCCACTACAT CCATAACCTC 
TCCTCAGAAA TGTTCAGCGA ATTCGATAAA CGGTATACCC ATGGCCGGGG GTTCATTACC 
AAGGCCATCA ACAGCTGCCA CACTTCTTCC CTTGCCACCC CCGAAGACAA GGAGCAAGCC 
CAACAGATGA ATCAAAAAGA CTTTCTGAGC CTGATAGTCA GCATATTGCG ATCCTGGAAT 
GAGCCTCTGT ATCATCTGGT CACGGAAGTA CGTGGTATGC AAGAAGCCCC GGAGGCTATC 
CTATCCAAAG CTGTAGAGAT TGAGGAGCAA ACCAAACGGC TTCTAGAGGG CATGGAGCTG 
ATAGTCAGCC AGGTTCATCC TGAAACCAAA GAAAATGAGA TCTACCCTGT CTGGTCGGGA 
CTTCCATCCC TGCAGATGGC TGATGAAGAG TCTCGCCTTT CTGCTTATTA TAACCTGCTC 
CACTGCCTAC GCAGGGATTC ACATAAAATC GACAATTATC TCAAGCTCCT GAAGTGCCGA 
ATCATCCACA ACAACAACTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRL ( XM_011514754.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513056.1 Homo sapiens prolactin (PRL), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu59959
Clone ID Related Accession (Same CDS sequence)	XM_011514754.2 , XM_011514753.2
Accession Version	XM_011514754.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prolactin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514754.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACATCA AAGGATCGCC ATGGAAAGCA GGGTCCCTCC TGCTGCTGCT GGTGTCAAAC 
CTGCTCCTGT GCCAGAGCGT GGCCCCCTTG CCCATCTGTC CCGGCGGGGC TGCCCGATGC 
CAGGTGACCC TTCGAGACCT GTTTGACCGC GCCGTCGTCC TGTCCCACTA CATCCATAAC 
CTCTCCTCAG AAATGTTCAG CGAATTCGAT AAACGGTATA CCCATGGCCG GGGGTTCATT 
ACCAAGGCCA TCAACAGCTG CCACACTTCT TCCCTTGCCA CCCCCGAAGA CAAGGAGCAA 
GCCCAACAGA TGAATCAAAA AGACTTTCTG AGCCTGATAG TCAGCATATT GCGATCCTGG 
AATGAGCCTC TGTATCATCT GGTCACGGAA GTACGTGGTA TGCAAGAAGC CCCGGAGGCT 
ATCCTATCCA AAGCTGTAGA GATTGAGGAG CAAACCAAAC GGCTTCTAGA GGGCATGGAG 
CTGATAGTCA GCCAGGTTCA TCCTGAAACC AAAGAAAATG AGATCTACCC TGTCTGGTCG 
GGACTTCCAT CCCTGCAGAT GGCTGATGAA GAGTCTCGCC TTTCTGCTTA TTATAACCTG 
CTCCACTGCC TACGCAGGGA TTCACATAAA ATCGACAATT ATCTCAAGCT CCTGAAGTGC 
CGAATCATCC ACAACAACAA CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513056.1
CDS	249..935
Translation	MNIKGSPWKAGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	XM_011514754.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514754.2

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGCA GGGTCCCTCC TGCTGCTGCT GGTGTCAAAC 
CTGCTCCTGT GCCAGAGCGT GGCCCCCTTG CCCATCTGTC CCGGCGGGGC TGCCCGATGC 
CAGGTGACCC TTCGAGACCT GTTTGACCGC GCCGTCGTCC TGTCCCACTA CATCCATAAC 
CTCTCCTCAG AAATGTTCAG CGAATTCGAT AAACGGTATA CCCATGGCCG GGGGTTCATT 
ACCAAGGCCA TCAACAGCTG CCACACTTCT TCCCTTGCCA CCCCCGAAGA CAAGGAGCAA 
GCCCAACAGA TGAATCAAAA AGACTTTCTG AGCCTGATAG TCAGCATATT GCGATCCTGG 
AATGAGCCTC TGTATCATCT GGTCACGGAA GTACGTGGTA TGCAAGAAGC CCCGGAGGCT 
ATCCTATCCA AAGCTGTAGA GATTGAGGAG CAAACCAAAC GGCTTCTAGA GGGCATGGAG 
CTGATAGTCA GCCAGGTTCA TCCTGAAACC AAAGAAAATG AGATCTACCC TGTCTGGTCG 
GGACTTCCAT CCCTGCAGAT GGCTGATGAA GAGTCTCGCC TTTCTGCTTA TTATAACCTG 
CTCCACTGCC TACGCAGGGA TTCACATAAA ATCGACAATT ATCTCAAGCT CCTGAAGTGC 
CGAATCATCC ACAACAACAA CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRL ( XM_011514753.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513055.1 Homo sapiens prolactin (PRL), transcript variant X1, mRNA.

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CloneID	OHu59959
Clone ID Related Accession (Same CDS sequence)	XM_011514754.2 , XM_011514753.2
Accession Version	XM_011514753.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prolactin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514753.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACATCA AAGGATCGCC ATGGAAAGCA GGGTCCCTCC TGCTGCTGCT GGTGTCAAAC 
CTGCTCCTGT GCCAGAGCGT GGCCCCCTTG CCCATCTGTC CCGGCGGGGC TGCCCGATGC 
CAGGTGACCC TTCGAGACCT GTTTGACCGC GCCGTCGTCC TGTCCCACTA CATCCATAAC 
CTCTCCTCAG AAATGTTCAG CGAATTCGAT AAACGGTATA CCCATGGCCG GGGGTTCATT 
ACCAAGGCCA TCAACAGCTG CCACACTTCT TCCCTTGCCA CCCCCGAAGA CAAGGAGCAA 
GCCCAACAGA TGAATCAAAA AGACTTTCTG AGCCTGATAG TCAGCATATT GCGATCCTGG 
AATGAGCCTC TGTATCATCT GGTCACGGAA GTACGTGGTA TGCAAGAAGC CCCGGAGGCT 
ATCCTATCCA AAGCTGTAGA GATTGAGGAG CAAACCAAAC GGCTTCTAGA GGGCATGGAG 
CTGATAGTCA GCCAGGTTCA TCCTGAAACC AAAGAAAATG AGATCTACCC TGTCTGGTCG 
GGACTTCCAT CCCTGCAGAT GGCTGATGAA GAGTCTCGCC TTTCTGCTTA TTATAACCTG 
CTCCACTGCC TACGCAGGGA TTCACATAAA ATCGACAATT ATCTCAAGCT CCTGAAGTGC 
CGAATCATCC ACAACAACAA CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513055.1
CDS	236..922
Translation	MNIKGSPWKAGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Target ORF information:

RefSeq Version	XM_011514753.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin (PRL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514753.2

ORF Insert Sequence:

ATGAACATCA AAGGATCGCC ATGGAAAGCA GGGTCCCTCC TGCTGCTGCT GGTGTCAAAC 
CTGCTCCTGT GCCAGAGCGT GGCCCCCTTG CCCATCTGTC CCGGCGGGGC TGCCCGATGC 
CAGGTGACCC TTCGAGACCT GTTTGACCGC GCCGTCGTCC TGTCCCACTA CATCCATAAC 
CTCTCCTCAG AAATGTTCAG CGAATTCGAT AAACGGTATA CCCATGGCCG GGGGTTCATT 
ACCAAGGCCA TCAACAGCTG CCACACTTCT TCCCTTGCCA CCCCCGAAGA CAAGGAGCAA 
GCCCAACAGA TGAATCAAAA AGACTTTCTG AGCCTGATAG TCAGCATATT GCGATCCTGG 
AATGAGCCTC TGTATCATCT GGTCACGGAA GTACGTGGTA TGCAAGAAGC CCCGGAGGCT 
ATCCTATCCA AAGCTGTAGA GATTGAGGAG CAAACCAAAC GGCTTCTAGA GGGCATGGAG 
CTGATAGTCA GCCAGGTTCA TCCTGAAACC AAAGAAAATG AGATCTACCC TGTCTGGTCG 
GGACTTCCAT CCCTGCAGAT GGCTGATGAA GAGTCTCGCC TTTCTGCTTA TTATAACCTG 
CTCCACTGCC TACGCAGGGA TTCACATAAA ATCGACAATT ATCTCAAGCT CCTGAAGTGC 
CGAATCATCC ACAACAACAA CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.
Proceedings of the National Academy of Sciences of the United States of America114(49)13042-13047(2017 Dec)
Sairenji TJ,Ikezawa J,Kaneko R,Masuda S,Uchida K,Takanashi Y,Masuda H,Sairenji T,Amano I,Takatsuru Y,Sayama K,Haglund K,Dikic I,Koibuchi N,Shimokawa N

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PRL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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