RNF114 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF114
Entrez Gene ID	55905
Full Name	ring finger protein 114
Synonyms	PSORS12,ZNF313
General protein information	Preferred Names ring finger protein 114 Names E3 ubiquitin-protein ligase RNF114 RING-type E3 ubiquitin transferase RNF114 zinc finger protein 228 zinc finger protein 313
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.13
Disorder MIM:	612451

mRNA and Protein(s)

mRNA	Protein	Name
NM_018683.3	NP_061153.1	E3 ubiquitin-protein ligase RNF114
NM_018683.4	NP_061153.1	E3 ubiquitin-protein ligase RNF114

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RNF114	NP_001019702.1
Pan troglodytes (chimpanzee)	RNF114	NP_001120978.1
Danio rerio (zebrafish)	rnf114	NP_001001828.2
Canis lupus familiaris (dog)	RNF114	XP_534453.3
Mus musculus (house mouse)	Rnf114	NP_109668.2
Rattus norvegicus (Norway rat)	Rnf114	NP_001001517.1
Homo sapiens (human)	RNF114	NP_061153.1
Gallus gallus (chicken)	RNF114	NP_001001767.2
Xenopus tropicalis (tropical clawed frog)	rnf114	NP_001001857.1

Gene Ontology
Bibliography

Related articles in PubMed

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG
Proceedings of the National Academy of Sciences of the United States of America111(43)15532-7(2014 Oct)

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Armstrong DL, Zidovetzki R, Alarc?n-Riquelme ME, Tsao BP, Criswell LA, Kimberly RP, Harley JB, Sivils KL, Vyse TJ, Gaffney PM, Langefeld CD, Jacob CO
Genes and immunity15(6)347-54(2014 Sep)

The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-?B activity and T-cell activation.
Rodriguez MS, Ega?a I, Lopitz-Otsoa F, Aillet F, Lopez-Mato MP, Dorronsoro A, Dorronroso A, Lobato-Gil S, Sutherland JD, Barrio R, Trigueros C, Lang V
Cell death & disease5e1399(2014 Aug)

Identification of RNF114 as a novel positive regulatory protein for T cell activation.
Yang P, Lu Y, Li M, Zhang K, Li C, Chen H, Tao D, Zhang S, Ma Y
Immunobiology219(6)432-9(2014 Jun)

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH, Chi SG
Cell death and differentiation20(8)1055-67(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XAF1 stimulates HIPK2-mediated Ser-46 phosphorylation of p53 and XAF1 also steps up the termination of p53-mediated cell-cycle arrest by activating ZNF313.
Title: XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.

RNF114 is a new partner of A2O involved in the regulation of NF-kappaB activity that contributes to the control of signaling pathways modulating T cell-mediated immune response.
Title: The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-?B activity and T-cell activation.

RNF114 over-expression had a promotion effect on T cell activation with an average 43.97% increment and the upregulatory roles showed a dose-dependent effect with 18.44% increment.
Title: Identification of RNF114 as a novel positive regulatory protein for T cell activation.

A single nucleotide plymorphism had an association with psoriasis in this Chinese Uygur population: SNP rs495337 in the gene encoding for zinc finger protein 313 (P < 0.001; OR = 0.80)
Title: Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population.

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).

The following RNF114 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF114 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17185	NM_018683.4 Latest version!	Homo sapiens ring finger protein 114 (RNF114), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17185	NM_018683.3	Homo sapiens ring finger protein 114 (RNF114), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF114 ( NM_018683.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061153.1 Homo sapiens ring finger protein 114 (RNF114), mRNA.

Price & Availability↑

CloneID	OHu17185
Clone ID Related Accession (Same CDS sequence)	NM_018683.3 , NM_018683.4
Accession Version	NM_018683.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF114
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK091976.1, BM830132.1, BC013695.1 and AF131742.1. On Jan 13, 2004 this sequence version replaced NM_018683.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066919.1, BX640603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC AACAGCGGGA CTGCGGGGGT GCTGCGCAGC TGGCGGGGCC GGCGGCGGAG 
GCTGACCCCC TAGGACGCTT CACGTGTCCC GTGTGCTTAG AGGTGTACGA GAAGCCGGTA 
CAGGTGCCCT GCGGACACGT CTTTTGCTCT GCATGCCTGC AGGAATGTCT GAAGCCGAAG 
AAGCCTGTCT GTGGGGTGTG TCGCAGCGCT CTGGCACCTG GCGTCCGAGC CGTGGAGCTC 
GAGCGGCAGA TCGAGAGCAC AGAGACTTCT TGCCATGGCT GCCGTAAGAA TTTCTTCCTG 
TCCAAGATCC GGTCCCACGT GGCTACTTGT TCCAAATACC AGAATTACAT CATGGAAGGT 
GTGAAGGCCA CCATTAAGGA TGCATCTCTT CAGCCAAGGA ATGTTCCAAA CCGTTACACC 
TTTCCTTGTC CTTACTGTCC TGAGAAGAAC TTTGATCAGG AAGGACTTGT GGAACACTGC 
AAATTATTCC ATAGCACGGA TACCAAATCT GTGGTTTGTC CGATATGTGC CTCGATGCCC 
TGGGGAGACC CCAACTACCG CAGCGCCAAC TTCAGAGAGC ACATCCAGCG CCGGCACCGG 
TTTTCTTATG ACACTTTTGT GGATTATGAT GTTGATGAAG AGGACATGAT GAATCAGGTG 
TTGCAGCGCT CCATCATCGA CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061153.1
CDS	37..723
Translation	MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ

Target ORF information:

RefSeq Version	NM_018683.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 114 (RNF114), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018683.3

ORF Insert Sequence:

ATGGCGGCGC AACAGCGGGA CTGCGGGGGT GCTGCGCAGC TGGCGGGGCC GGCGGCGGAG 
GCTGACCCCC TAGGACGCTT CACGTGTCCC GTGTGCTTAG AGGTGTACGA GAAGCCGGTA 
CAGGTGCCCT GCGGACACGT CTTTTGCTCT GCATGCCTGC AGGAATGTCT GAAGCCGAAG 
AAGCCTGTCT GTGGGGTGTG TCGCAGCGCT CTGGCACCTG GCGTCCGAGC CGTGGAGCTC 
GAGCGGCAGA TCGAGAGCAC AGAGACTTCT TGCCATGGCT GCCGTAAGAA TTTCTTCCTG 
TCCAAGATCC GGTCCCACGT GGCTACTTGT TCCAAATACC AGAATTACAT CATGGAAGGT 
GTGAAGGCCA CCATTAAGGA TGCATCTCTT CAGCCAAGGA ATGTTCCAAA CCGTTACACC 
TTTCCTTGTC CTTACTGTCC TGAGAAGAAC TTTGATCAGG AAGGACTTGT GGAACACTGC 
AAATTATTCC ATAGCACGGA TACCAAATCT GTGGTTTGTC CGATATGTGC CTCGATGCCC 
TGGGGAGACC CCAACTACCG CAGCGCCAAC TTCAGAGAGC ACATCCAGCG CCGGCACCGG 
TTTTCTTATG ACACTTTTGT GGATTATGAT GTTGATGAAG AGGACATGAT GAATCAGGTG 
TTGCAGCGCT CCATCATCGA CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF114 ( NM_018683.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061153.1 Homo sapiens ring finger protein 114 (RNF114), mRNA.

Price & Availability↑

CloneID	OHu17185
Clone ID Related Accession (Same CDS sequence)	NM_018683.3 , NM_018683.4
Accession Version	NM_018683.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF114
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK091976.1, BM830132.1, BC013695.1 and AF131742.1. On Nov 23, 2018 this sequence version replaced NM_018683.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066919.1, BX640603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244061.6/ ENSP00000244061.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC AACAGCGGGA CTGCGGGGGT GCTGCGCAGC TGGCGGGGCC GGCGGCGGAG 
GCTGACCCCC TAGGACGCTT CACGTGTCCC GTGTGCTTAG AGGTGTACGA GAAGCCGGTA 
CAGGTGCCCT GCGGACACGT CTTTTGCTCT GCATGCCTGC AGGAATGTCT GAAGCCGAAG 
AAGCCTGTCT GTGGGGTGTG TCGCAGCGCT CTGGCACCTG GCGTCCGAGC CGTGGAGCTC 
GAGCGGCAGA TCGAGAGCAC AGAGACTTCT TGCCATGGCT GCCGTAAGAA TTTCTTCCTG 
TCCAAGATCC GGTCCCACGT GGCTACTTGT TCCAAATACC AGAATTACAT CATGGAAGGT 
GTGAAGGCCA CCATTAAGGA TGCATCTCTT CAGCCAAGGA ATGTTCCAAA CCGTTACACC 
TTTCCTTGTC CTTACTGTCC TGAGAAGAAC TTTGATCAGG AAGGACTTGT GGAACACTGC 
AAATTATTCC ATAGCACGGA TACCAAATCT GTGGTTTGTC CGATATGTGC CTCGATGCCC 
TGGGGAGACC CCAACTACCG CAGCGCCAAC TTCAGAGAGC ACATCCAGCG CCGGCACCGG 
TTTTCTTATG ACACTTTTGT GGATTATGAT GTTGATGAAG AGGACATGAT GAATCAGGTG 
TTGCAGCGCT CCATCATCGA CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061153.1
CDS	17..703
Translation	MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ

Target ORF information:

RefSeq Version	NM_018683.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 114 (RNF114), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018683.4

ORF Insert Sequence:

ATGGCGGCGC AACAGCGGGA CTGCGGGGGT GCTGCGCAGC TGGCGGGGCC GGCGGCGGAG 
GCTGACCCCC TAGGACGCTT CACGTGTCCC GTGTGCTTAG AGGTGTACGA GAAGCCGGTA 
CAGGTGCCCT GCGGACACGT CTTTTGCTCT GCATGCCTGC AGGAATGTCT GAAGCCGAAG 
AAGCCTGTCT GTGGGGTGTG TCGCAGCGCT CTGGCACCTG GCGTCCGAGC CGTGGAGCTC 
GAGCGGCAGA TCGAGAGCAC AGAGACTTCT TGCCATGGCT GCCGTAAGAA TTTCTTCCTG 
TCCAAGATCC GGTCCCACGT GGCTACTTGT TCCAAATACC AGAATTACAT CATGGAAGGT 
GTGAAGGCCA CCATTAAGGA TGCATCTCTT CAGCCAAGGA ATGTTCCAAA CCGTTACACC 
TTTCCTTGTC CTTACTGTCC TGAGAAGAAC TTTGATCAGG AAGGACTTGT GGAACACTGC 
AAATTATTCC ATAGCACGGA TACCAAATCT GTGGTTTGTC CGATATGTGC CTCGATGCCC 
TGGGGAGACC CCAACTACCG CAGCGCCAAC TTCAGAGAGC ACATCCAGCG CCGGCACCGG 
TTTTCTTATG ACACTTTTGT GGATTATGAT GTTGATGAAG AGGACATGAT GAATCAGGTG 
TTGCAGCGCT CCATCATCGA CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
Proceedings of the National Academy of Sciences of the United States of America111(43)15532-7(2014 Oct)
Lee MG,Han J,Jeong SI,Her NG,Lee JH,Ha TK,Kang MJ,Ryu BK,Chi SG

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Genes and immunity15(6)347-54(2014 Sep)
Armstrong DL,Zidovetzki R,Alarc?n-Riquelme ME,Tsao BP,Criswell LA,Kimberly RP,Harley JB,Sivils KL,Vyse TJ,Gaffney PM,Langefeld CD,Jacob CO

The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-?B activity and T-cell activation.
Cell death & disease5e1399(2014 Aug)
Rodriguez MS,Ega?a I,Lopitz-Otsoa F,Aillet F,Lopez-Mato MP,Dorronsoro A,Dorronroso A,Lobato-Gil S,Sutherland JD,Barrio R,Trigueros C,Lang V

Identification of RNF114 as a novel positive regulatory protein for T cell activation.
Immunobiology219(6)432-9(2014 Jun)
Yang P,Lu Y,Li M,Zhang K,Li C,Chen H,Tao D,Zhang S,Ma Y

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
Cell death and differentiation20(8)1055-67(2013 Aug)
Han J,Kim YL,Lee KW,Her NG,Ha TK,Yoon S,Jeong SI,Lee JH,Kang MJ,Lee MG,Ryu BK,Baik JH,Chi SG

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RNF114 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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