ACOT13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACOT13
Entrez Gene ID	55856
Full Name	acyl-CoA thioesterase 13
Synonyms	HT012,PNAS-27,THEM2
General protein information	Preferred Names acyl-CoA thioesterase 13 Names acyl-coenzyme A thioesterase 13 hypothalamus protein HT012 thioesterase superfamily member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.3
Summary	This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009].
Disorder MIM:	615652

mRNA and Protein(s)

mRNA	Protein	Name
NM_018473.3	NP_060943.1	acyl-coenzyme A thioesterase 13 isoform 1
NM_001160094.1	NP_001153566.1	acyl-coenzyme A thioesterase 13 isoform 2
NM_018473.4	NP_060943.1	acyl-coenzyme A thioesterase 13 isoform 1

Pathways from BioSystems

Homologies

	ACOT13	NP_001165421.1
Oryza sativa (rice)	Os04g0436100	NP_001052851.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007238	XP_308560.2
Caenorhabditis elegans (roundworm)	F42H10.6	NP_498872.1
Xenopus tropicalis (tropical clawed frog)	acot13	NP_001005098.1
Homo sapiens (human)	ACOT13	NP_060943.1
Canis lupus familiaris (dog)	ACOT13	XP_853542.1
Pan troglodytes (chimpanzee)	ACOT13	XP_001171713.1
Bos taurus (cattle)	ACOT13	NP_001095315.1
Mus musculus (house mouse)	Acot13	NP_080066.1
Rattus norvegicus (Norway rat)	Acot13	NP_001099581.1
Danio rerio (zebrafish)	acot13	NP_001074272.1
Drosophila melanogaster (fruit fly)	CG16986	NP_647732.1
Arabidopsis thaliana (thale cress)	AT1G04290	NP_563705.1

Gene Ontology
Bibliography

Related articles in PubMed

Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
Eicher JD, Montgomery AM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ Jr, Dale AM, Jernigan TL, Gruen JR,
Brain imaging and behavior10(1)272-82(2016 Mar)

Molecular mechanism of a hotdog-fold acyl-CoA thioesterase.
Cantu DC, Ard?vol A, Rovira C, Reilly PJ
Chemistry (Weinheim an der Bergstrasse, Germany)20(29)9045-51(2014 Jul)

Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.
Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE
The Journal of biological chemistry288(46)33376-86(2013 Nov)

Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia.
Venkatesh SK, Siddaiah A, Padakannaya P, Ramachandra NB
Gene529(2)215-9(2013 Oct)

Genetic variants of FOXP2 and KIAA0319/TTRAP/THEM2 locus are associated with altered brain activation in distinct language-related regions.
Pinel P, Fauchereau F, Moreno A, Barbot A, Lathrop M, Zelenika D, Le Bihan D, Poline JB, Bourgeron T, Dehaene S
The Journal of neuroscience : the official journal of the Society for Neuroscience32(3)817-25(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Markers in DYX2 genes KIAA0319 and FAM65B were associated with cortical thickness in the left developing orbitofrontal region and global fractional anisotropy, respectively. KIAA0319 and ACOT13 were suggestively associated with overall fractional anisotropy and left pars opercularis cortical thickness, respectively.
Title: Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.

This study models the reaction of the hTHEM2 enzyme by first-principles methods to elucidate atomic and electronic details of the mechanism, its transition-state (TS) conformation, and the free-energy landscape of the process.
Title: Molecular mechanism of a hotdog-fold acyl-CoA thioesterase.

study failed to show any association of THEM2 SNPs with developmental dyslexia in an Indian population.
Title: Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia.

The results of this study confirmed that both FOXP2 and KIAA0319/TTRAP/THEM2 genes play an important role in human language development, but probably through different cerebral pathways.
Title: Genetic variants of FOXP2 and KIAA0319/TTRAP/THEM2 locus are associated with altered brain activation in distinct language-related regions.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following ACOT13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACOT13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08798	NM_018473.4 Latest version!	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08816	NM_001160094.1 Latest version!	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu08798	NM_018473.3	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACOT13 ( NM_018473.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060943.1 Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08798
Clone ID Related Accession (Same CDS sequence)	NM_018473.3 , NM_018473.4
Accession Version	NM_018473.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase 13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB214267.1, BC000894.1, AL031775.1 and CB852340.1. On May 12, 2009 this sequence version replaced NM_018473.2. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB214267.1, SRR1803614.16882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAGCA TGACTCAGTC TCTGCGGGAG GTGATAAAGG CCATGACCAA GGCTCGCAAT 
TTTGAGAGAG TTTTGGGAAA GATTACTCTT GTCTCTGCTG CTCCTGGGAA AGTGATTTGT 
GAAATGAAAG TAGAAGAAGA GCATACCAAT GCAATAGGCA CTCTCCACGG CGGTTTGACA 
GCCACGTTAG TAGATAACAT ATCAACAATG GCTCTGCTAT GCACGGAAAG GGGAGCACCC 
GGAGTCAGTG TCGATATGAA CATAACGTAC ATGTCACCTG CAAAATTAGG AGAAGATATA 
GTGATTACAG CACATGTTCT GAAGCAAGGA AAAACACTTG CATTTACCTC TGTGGATCTG 
ACCAACAAGG CCACAGGAAA ATTAATAGCA CAAGGAAGAC ACACAAAACA CCTGGGAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060943.1
CDS	230..652
Translation	MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN

Target ORF information:

RefSeq Version	NM_018473.3
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018473.3

ORF Insert Sequence:

ATGACCAGCA TGACTCAGTC TCTGCGGGAG GTGATAAAGG CCATGACCAA GGCTCGCAAT 
TTTGAGAGAG TTTTGGGAAA GATTACTCTT GTCTCTGCTG CTCCTGGGAA AGTGATTTGT 
GAAATGAAAG TAGAAGAAGA GCATACCAAT GCAATAGGCA CTCTCCACGG CGGTTTGACA 
GCCACGTTAG TAGATAACAT ATCAACAATG GCTCTGCTAT GCACGGAAAG GGGAGCACCC 
GGAGTCAGTG TCGATATGAA CATAACGTAC ATGTCACCTG CAAAATTAGG AGAAGATATA 
GTGATTACAG CACATGTTCT GAAGCAAGGA AAAACACTTG CATTTACCTC TGTGGATCTG 
ACCAACAAGG CCACAGGAAA ATTAATAGCA CAAGGAAGAC ACACAAAACA CCTGGGAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACOT13 ( NM_018473.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060943.1 Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08798
Clone ID Related Accession (Same CDS sequence)	NM_018473.3 , NM_018473.4
Accession Version	NM_018473.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase 13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB214267.1, BC000894.1, AL031775.1 and CB852340.1. On Nov 23, 2018 this sequence version replaced NM_018473.3. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA893550.1, SRR1803614.16882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230048.5/ ENSP00000230048.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAGCA TGACTCAGTC TCTGCGGGAG GTGATAAAGG CCATGACCAA GGCTCGCAAT 
TTTGAGAGAG TTTTGGGAAA GATTACTCTT GTCTCTGCTG CTCCTGGGAA AGTGATTTGT 
GAAATGAAAG TAGAAGAAGA GCATACCAAT GCAATAGGCA CTCTCCACGG CGGTTTGACA 
GCCACGTTAG TAGATAACAT ATCAACAATG GCTCTGCTAT GCACGGAAAG GGGAGCACCC 
GGAGTCAGTG TCGATATGAA CATAACGTAC ATGTCACCTG CAAAATTAGG AGAAGATATA 
GTGATTACAG CACATGTTCT GAAGCAAGGA AAAACACTTG CATTTACCTC TGTGGATCTG 
ACCAACAAGG CCACAGGAAA ATTAATAGCA CAAGGAAGAC ACACAAAACA CCTGGGAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060943.1
CDS	188..610
Translation	MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN

Target ORF information:

RefSeq Version	NM_018473.4
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018473.4

ORF Insert Sequence:

ATGACCAGCA TGACTCAGTC TCTGCGGGAG GTGATAAAGG CCATGACCAA GGCTCGCAAT 
TTTGAGAGAG TTTTGGGAAA GATTACTCTT GTCTCTGCTG CTCCTGGGAA AGTGATTTGT 
GAAATGAAAG TAGAAGAAGA GCATACCAAT GCAATAGGCA CTCTCCACGG CGGTTTGACA 
GCCACGTTAG TAGATAACAT ATCAACAATG GCTCTGCTAT GCACGGAAAG GGGAGCACCC 
GGAGTCAGTG TCGATATGAA CATAACGTAC ATGTCACCTG CAAAATTAGG AGAAGATATA 
GTGATTACAG CACATGTTCT GAAGCAAGGA AAAACACTTG CATTTACCTC TGTGGATCTG 
ACCAACAAGG CCACAGGAAA ATTAATAGCA CAAGGAAGAC ACACAAAACA CCTGGGAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACOT13 ( NM_001160094.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001153566.1 Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08816
Clone ID Related Accession (Same CDS sequence)	NM_001160094.1
Accession Version	NM_001160094.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase 13 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB214267.1, AK309738.1, AL031775.1 and CB852340.1. Transcript Variant: This variant (2) includes an alternate exon and uses a distinct start codon, compared to variant (1). The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.38993.1, SRR1803611.38718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTAGAA AGATTACTCT TGTCTCTGCT GCTCCTGGGA AAGTGATTTG TGAAATGAAA 
GTAGAAGAAG AGCATACCAA TGCAATAGGC ACTCTCCACG GCGGTTTGAC AGCCACGTTA 
GTAGATAACA TATCAACAAT GGCTCTGCTA TGCACGGAAA GGGGAGCACC CGGAGTCAGT 
GTCGATATGA ACATAACGTA CATGTCACCT GCAAAATTAG GAGAAGATAT AGTGATTACA 
GCACATGTTC TGAAGCAAGG AAAAACACTT GCATTTACCT CTGTGGATCT GACCAACAAG 
GCCACAGGAA AATTAATAGC ACAAGGAAGA CACACAAAAC ACCTGGGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153566.1
CDS	588..941
Translation	MVRKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN

Target ORF information:

RefSeq Version	NM_001160094.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001160094.1

ORF Insert Sequence:

ATGGTTAGAA AGATTACTCT TGTCTCTGCT GCTCCTGGGA AAGTGATTTG TGAAATGAAA 
GTAGAAGAAG AGCATACCAA TGCAATAGGC ACTCTCCACG GCGGTTTGAC AGCCACGTTA 
GTAGATAACA TATCAACAAT GGCTCTGCTA TGCACGGAAA GGGGAGCACC CGGAGTCAGT 
GTCGATATGA ACATAACGTA CATGTCACCT GCAAAATTAG GAGAAGATAT AGTGATTACA 
GCACATGTTC TGAAGCAAGG AAAAACACTT GCATTTACCT CTGTGGATCT GACCAACAAG 
GCCACAGGAA AATTAATAGC ACAAGGAAGA CACACAAAAC ACCTGGGAAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
Brain imaging and behavior10(1)272-82(2016 Mar)
Eicher JD,Montgomery AM,Akshoomoff N,Amaral DG,Bloss CS,Libiger O,Schork NJ,Darst BF,Casey BJ,Chang L,Ernst T,Frazier J,Kaufmann WE,Keating B,Kenet T,Kennedy D,Mostofsky S,Murray SS,Sowell ER,Bartsch H,Kuperman JM,Brown TT,Hagler DJ Jr,Dale AM,Jernigan TL,Gruen JR,

Molecular mechanism of a hotdog-fold acyl-CoA thioesterase.
Chemistry (Weinheim an der Bergstrasse, Germany)20(29)9045-51(2014 Jul)
Cantu DC,Ard?vol A,Rovira C,Reilly PJ

Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.
The Journal of biological chemistry288(46)33376-86(2013 Nov)
Kang HW,Ozdemir C,Kawano Y,LeClair KB,Vernochet C,Kahn CR,Hagen SJ,Cohen DE

Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia.
Gene529(2)215-9(2013 Oct)
Venkatesh SK,Siddaiah A,Padakannaya P,Ramachandra NB

Genetic variants of FOXP2 and KIAA0319/TTRAP/THEM2 locus are associated with altered brain activation in distinct language-related regions.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(3)817-25(2012 Jan)
Pinel P,Fauchereau F,Moreno A,Barbot A,Lathrop M,Zelenika D,Le Bihan D,Poline JB,Bourgeron T,Dehaene S

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ACOT13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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