IL26 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL26
Entrez Gene ID	55801
Full Name	interleukin 26
Synonyms	AK155,IL-26
General protein information	Preferred Names interleukin 26 Names interleukin-26
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Summary	This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008].
Disorder MIM:	605679

mRNA and Protein(s)

mRNA	Protein	Name
NM_018402.2	NP_060872.1	interleukin-26 precursor
XM_011538568.1	XP_011536870.1	interleukin-26 isoform X1
NM_018402.1	NP_060872.1	interleukin-26 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL26	NP_060872.1
Pan troglodytes (chimpanzee)	IL26	XP_001152032.1
Canis lupus familiaris (dog)	IL26	XP_851168.1
Bos taurus (cattle)	IL26	NP_001192353.1
	IL26	XP_001117154.1

Gene Ontology
Bibliography

Related articles in PubMed

IL26 modulates cytokine response and anti-TNF consumption in Crohn's disease patients with bacterial DNA.
Pi?ero P, Juanola O, Guti?rrez A, Zapater P, Gim?nez P, Steinert A, Sempere L, Gonz?lez-Navajas JM, Niess JH, Franc?s R
Journal of molecular medicine (Berlin, Germany)95(11)1227-1236(2017 Nov)

Interleukin-26 is overexpressed in Beh?et's disease and enhances Th17 related -cytokines.
Kaabachi W, Bouali E, Berra?es A, Dhifallh IB, Hamdi B, Hamzaoui K, Hamzaoui A
Immunology letters190177-184(2017 Oct)

Expression of Interleukin-26 is upregulated in inflammatory bowel disease.
Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A
World journal of gastroenterology23(30)5519-5529(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that IL-26 is a unique cationic protein more similar to a soluble pattern recognition receptor than to conventional cytokines
Title: IL-26 Confers Proinflammatory Properties to Extracellular DNA.

this study shows that single nucleotide polymorphism near IL-26 gene is associated with familial vitiligo and existence of halo nevi in Estonian patients
Title: Association analysis of class II cytokine and receptor genes in vitiligo patients.

Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
Title: The cytokine interleukin-26 as a biomarker in pediatric asthma.

IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review]
Title: Interleukin-26: An Emerging Player in Host Defense and Inflammation.

The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility.
Title: Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility.

The following IL26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14953	NM_018402.2 Latest version!	Homo sapiens interleukin 26 (IL26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14953	XM_011538568.1 Latest version!	Homo sapiens interleukin 26 (IL26), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14953	NM_018402.1	Homo sapiens interleukin 26 (IL26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL26 ( NM_018402.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060872.1 Homo sapiens interleukin 26 (IL26), mRNA.

Price & Availability↑

CloneID	OHu14953
Clone ID Related Accession (Same CDS sequence)	NM_018402.2 , XM_011538568.1 , NM_018402.1
Accession Version	NM_018402.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Homo sapiens(human)
Product	interleukin-26 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007458.14 and AJ251549.1. On Nov 22, 2018 this sequence version replaced NM_018402.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ251549.1, CF271979.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229134.5/ ENSP00000229134.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060872.1
CDS	55..570
Translation	MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ

Target ORF information:

RefSeq Version	NM_018402.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 26 (IL26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018402.2

ORF Insert Sequence:

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL26 ( NM_018402.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_060872.1 Homo sapiens interleukin 26 (IL26), mRNA.

Price & Availability↑

CloneID	OHu14953
Clone ID Related Accession (Same CDS sequence)	NM_018402.2 , XM_011538568.1 , NM_018402.1
Accession Version	NM_018402.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	interleukin-26 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ251549.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ251549.1, CF271979.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END##

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060872.1
CDS	36..551
Translation	MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ

Target ORF information:

RefSeq Version	NM_018402.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 26 (IL26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018402.1

ORF Insert Sequence:

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL26 ( XM_011538568.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536870.1 Homo sapiens interleukin 26 (IL26), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu14953
Clone ID Related Accession (Same CDS sequence)	NM_018402.2 , XM_011538568.1 , NM_018402.1
Accession Version	XM_011538568.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	interleukin-26 isoform X1
Comment

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536870.1
Translation	MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ

Target ORF information:

RefSeq Version	XM_011538568.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens interleukin 26 (IL26), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538568.1

ORF Insert Sequence:

ATGCTGGTGA ATTTCATTTT GAGGTGTGGG TTGCTGTTAG TCACTCTGTC TCTTGCCATT 
GCCAAGCACA AGCAATCTTC CTTCACCAAA AGTTGTTACC CAAGGGGAAC ATTGTCCCAA 
GCTGTTGACG CTCTCTATAT CAAAGCAGCA TGGCTCAAAG CAACGATTCC AGAAGACCGC 
ATAAAAAATA TACGATTATT AAAAAAGAAA ACAAAAAAGC AGTTTATGAA AAACTGTCAA 
TTTCAAGAAC AGCTTCTGTC CTTCTTCATG GAAGACGTTT TTGGTCAACT GCAATTGCAA 
GGCTGCAAGA AAATACGCTT TGTGGAGGAC TTTCATAGCC TTAGGCAGAA ATTGAGCCAC 
TGTATTTCCT GTGCTTCATC AGCTAGAGAG ATGAAATCCA TTACCAGGAT GAAAAGAATA 
TTTTATAGGA TTGGAAACAA AGGAATCTAC AAAGCCATCA GTGAACTGGA TATTCTTCTT 
TCCTGGATTA AAAAATTATT GGAAAGCAGT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL26 modulates cytokine response and anti-TNF consumption in Crohn's disease patients with bacterial DNA.
Journal of molecular medicine (Berlin, Germany)95(11)1227-1236(2017 Nov)
Pi?ero P,Juanola O,Guti?rrez A,Zapater P,Gim?nez P,Steinert A,Sempere L,Gonz?lez-Navajas JM,Niess JH,Franc?s R

Interleukin-26 is overexpressed in Beh?et's disease and enhances Th17 related -cytokines.
Immunology letters190177-184(2017 Oct)
Kaabachi W,Bouali E,Berra?es A,Dhifallh IB,Hamdi B,Hamzaoui K,Hamzaoui A

Expression of Interleukin-26 is upregulated in inflammatory bowel disease.
World journal of gastroenterology23(30)5519-5529(2017 Aug)
Fujii M,Nishida A,Imaeda H,Ohno M,Nishino K,Sakai S,Inatomi O,Bamba S,Kawahara M,Shimizu T,Andoh A

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IL26 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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