RADIL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RADIL
Entrez Gene ID	55698
Full Name	Rap associating with DIL domain
Synonyms	RASIP2
General protein information	Preferred Names Rap associating with DIL domain Names ras-associating and dilute domain-containing protein Rap GTPase interactor Ras association and DIL domains
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.1
Disorder MIM:	611491

mRNA and Protein(s)

mRNA	Protein	Name
NM_018059.4	NP_060529.4	ras-associating and dilute domain-containing protein
NM_018059.5	NP_060529.4	ras-associating and dilute domain-containing protein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Radil	NP_001032295.1
Bos taurus (cattle)	RADIL	NP_001157406.1
Danio rerio (zebrafish)	radil	NP_001096039.1
Homo sapiens (human)	RADIL	NP_060529.4
Gallus gallus (chicken)	RADIL	XP_004945203.1
	RADIL	XP_001088292.1
Pan troglodytes (chimpanzee)	RADIL	XP_003318330.1
Canis lupus familiaris (dog)	RADIL	XP_005621196.1
Mus musculus (house mouse)	Radil	NP_848817.2

Gene Ontology
Bibliography

Related articles in PubMed

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity.
de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg MH
eLife5e11394(2016 Jan)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

Radil controls neutrophil adhesion and motility through ?2-integrin activation.
Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA
Molecular biology of the cell23(24)4751-65(2012 Dec)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.
Ahmed SM, Daulat AM, Meunier A, Angers S
The Journal of biological chemistry285(9)6538-51(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was shown that KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules. Radil is also important for breast cancer cell proliferation and metastasis.
Title: KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.

Studies indicate that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation. +++ ERROR +++ studies establish that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation.
Title: Radil controls neutrophil adhesion and motility through ?2-integrin activation.

Gbetagamma subunits enter in a protein complex with activated Rap1a and its effector Radil; this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
Title: G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.

The following RADIL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RADIL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02942	NM_018059.5 Latest version!	Homo sapiens Rap associating with DIL domain (RADIL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
View Old Accession Versions >>
OHu02942	NM_018059.4	Homo sapiens Rap associating with DIL domain (RADIL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RADIL ( NM_018059.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060529.4 Homo sapiens Rap associating with DIL domain (RADIL), mRNA.

Price & Availability↑

CloneID	OHu02942
Clone ID Related Accession (Same CDS sequence)	NM_018059.4 , NM_018059.5
Accession Version	NM_018059.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	ras-associating and dilute domain-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG722917.1, DA241653.1, BC117317.1, AC092610.1, BC004919.2 and EF560723.1. On Jun 6, 2007 this sequence version replaced NM_018059.3. ##Evidence-Data-START## CDS exon combination :: EF560723.1, BC143526.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTTATG GGACGCACTT CATCATGTCC CCGCCCACCA AGAGCAAACT GAAGCGGCAG 
AGCCAGCTGT TGTCCAGCAT GCTGTCCCGG ACGCTGAGCT ACAAGTACCG GGACCTGGAC 
TCCACCTTCT CCAGCCTGGG CGCCAGCGAT GACCCCGCCG AGCTCTCCAC CCAGCTGTCG 
GCCCCTGGTG TCCTGAAGGT GTTTGGGGAC AGTGTCTGCA CAGGAACCCA CTACAAGAGC 
GTCCTGGCCA CCGGCACCTC CAGCGCCCGT GAGCTGGTGA AGGAGGCGCT GGAGCGGTAC 
GCCCTGGACC CCAGGCAGGC CGGCCAGTAC GTGCTGTGTG ACGTGGTGGG CCAAGCCGGC 
GATGCTGGGC AGCGGTGGCA GGCCCGGTGC TTTCGGGTGT TTGGGGACAG TGAGAAGCCC 
CTCTTGATCC AGGAATTATG GAAACCCCGA GAAGGTTTAT CCCGGAGGTT TGAGCTGAGG 
AAGAGGTCGG ACGTGGAGGA GCTGGCAGCC AAGGAGGTGG ACACCATCAC GGCAGGGATA 
AACGCCCAGG CCCGGAGGCT GCAGCGGAGT CGCGCGAAGG GAACCCCGAC CCCGGCCCTG 
GGGGATGCCC GGAGCTCTCC TCCACCCCGG TTGCGCCGCA CAGTCAGTGA GACCAGCCTG 
AGCCCAGTGA ACGCCCTGCC CGCTGCCGCC CAGGGCCCCG AGGAGCCCGG CCCCGACGCC 
ATGCGGTACT CGCTGTACCA GTCCCCGCAT CTGCTCCTTC TGCAGGGCTA CAGCCAGCAG 
CACGACAGCC TGGTGTATGT GCTCAACCGG GACCGGCACA CGGTGGGCCA GCGGACCCCC 
TCCAGCAAGC CCAGCATCAG CCTCTCAGCC CCCGACATCC TGCCTCTACA CTGCACCATC 
CGCCGGCAAC CGCTCCCGGA CAGCGGCCAG GCCGCGGGGA GGCTGGTCCT GGAGCCCATC 
CCCGGGGCGC ACATCTCCGT CAACTTCTCC GAGGTGGGGC ACAGGACCGT GGTGCTGCAC 
CACGGGGACC TGCTCTCCCT GGGGCTCTAC TACCTGCTGC TATTCAAGGA CCCCGCGCAG 
GCCCAGCCCC TGCCCGCCCG GGCCTTGGCG CGCCTCCGGG CTGTGCCGCA GAGCTGCCGG 
CTGTGCGGGG CCGCGCTCGG GGCCCGGGGA GCCGCCTCCC CTACTCAGGC CGCCCTGCCC 
CGGCGCCAGC AGCTGCTCCT GGAGTTTGAG CCCCACCTGG AGGACACGCT GCTGCAGAGG 
ATCATGACGT TGATCGAGCC GGGGGGCGAC GACCACAAGC TGACCCCCGC CTTCCTCCTG 
TGCCTCTGCA TCCAGCACTC GGCCACCCAC TTCCAGCCGG GCACATTCGG GCAGCTCCTG 
CTCAAGATAG CCAGGCTGAT CCGCGAGACT GTCTGGGAGA AAACCAAAGA ACTAGCAGAG 
AAGCAGGCGC AACTCCAGGA GCCCATCTCG CTGGCCAGCT GCGCCATGGC TGATCTGGTT 
CCAGACTTGC AGCCCATTCT TTTCTGGATG TCTAACTCCA TCGAGCTCCT GTACTTTATC 
CAGCAGAAAT GCCCACTCTA CATGCAGAGC ATGGAGGAGC AGCTGGACAT CACAGGCTCG 
AAGGAATCGC TGTTCTCCTG CACGCTGACG GCCAGCGAGG AGGCCATGGC GGTGCTGGAG 
GAGGTGGTGC TGTACGCCTT CCAGCAGTGC GTCTACTATG TCTCCAAGTC CCTGTACATC 
TGCCTCCCGG CACTCCTGGA GTGCCCGCCA TTCCAGACGG AGCGCCGTGA GAGCTGGTCC 
TCGGCCCCCG AACTGCCCGA GGAGCTGCGC CGCGTGGTGT CTGTGTACCA GGCAGCCCTG 
GACCTCCTGC GGCAGCTGCA GGTGCACCCC GAGGTGGCCT CGCAGATGCT CGCCTACCTC 
TTCTTCTTCT CCGGGACACT GCTTCTCAAC CAGCTCCTCG ACAGGGGCCC CTCCCTGAGC 
TGCTTCCACT GGCCCAGAGG TGTCCAGGCC TGCGCCCGCC TGCAGCAGCT CCTGGAGTGG 
ATGCGGAGCG CCGGCTTCGG GGCGGCTGGA GAGCACTTCT TCCAGAAGCT CTCCTGCACC 
CTCAACCTGC TGGCCACACC CAGGGCCCAG CTCATCCAGA TGAGCTGGAC AGCCCTGCGG 
GCTGCGTTCC CCGCACTGAG CCCAGCACAG CTGCACCGGC TGCTGACTCA CTACCAGCTG 
GCCTCGGCCA TGGGCCCCAT GAGCACCTGG GAGCCAGGGG CCCAGGACAG CCCCGAGGCC 
TTCAGGTCAG AGGATGTTCT GGAGTCCTAC GAAAACCCCC CACCCATCGT CCTGCCCAGC 
GACGGCTTCC AGGTGGACTT GGAAGCCAAC TGCCTGGACG ACAGCATCTA CCAGCACCTG 
CTCTACGTCC GCCACTTTCT GTGGGGTCTG CGGAGCAGAG CCAGCCCCGG CAGCCCTGGC 
AGGCCTGGCA GTGGGGCCTC CCAGCCAGTG TGCCCCGAGG GTATGCACCA CGTGGTCCTT 
GACGGGCACC TGGAGGCCCC GAGCTGCCCC CTGGCTCCCA GGGACCCTGG CCCAGCAGCC 
CGGGAAGTGG CCCCGGAGCG TACTCTTCCC TTGAGGGGGG CTCCCTGGGC ACAGGCCCCC 
CCTGGAAGGC AACCCAGCCG TGGGGGCTCC CAGGCTGGCC CCCCGCACAC GGACTCGTCC 
TGCTTGCTCA CGCCTCCCAG CACTCCACTT GGCCCTGAGC CTGGGGACCC CGACTGGCCA 
GAGTCCGGCG GCCCCTGTGG AAAAGCGCTC CCAGAGAGGC AGAGGAACGG ACTCAGCGGC 
CTCCGGGGTG CAGCTCCGGA AGGAGACTCT GCAGCCCTTG CGGAGGAGTC CCCTCCAGCC 
CCGTCCAGCC GCAGCTCCAG CACCGAGGAC TTCTGCTACG TCTTCACGGT GGAGCTGGAA 
CGAGGCCCCT CCGGGCTGGG GATGGGCCTG ATCGACGGGA TGCACACGCA CCTGGGCGCC 
CCCGGGCTCT ACATCCAGAC CCTGCTCCCG GGCAGCCCCG CAGCGGCCGA CGGGCGCCTG 
TCGCTGGGGG ACCGTATCCT GGAGGTGAAT GGCAGCAGCC TCCTGGGCCT TGGCTACCTG 
AGAGCTGTGG ACCTGATCCG TCATGGCGGG AAGAAGATGC GGTTCCTGGT CGCGAAGTCC 
GACGTGGAAA CAGCCAAGAA GATCCATTTC CGCACGCCCC CTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060529.4
CDS	174..3401
Translation	MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGINAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDAMRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL

Target ORF information:

RefSeq Version	NM_018059.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rap associating with DIL domain (RADIL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018059.4

ORF Insert Sequence:

ATGTTTTATG GGACGCACTT CATCATGTCC CCGCCCACCA AGAGCAAACT GAAGCGGCAG 
AGCCAGCTGT TGTCCAGCAT GCTGTCCCGG ACGCTGAGCT ACAAGTACCG GGACCTGGAC 
TCCACCTTCT CCAGCCTGGG CGCCAGCGAT GACCCCGCCG AGCTCTCCAC CCAGCTGTCG 
GCCCCTGGTG TCCTGAAGGT GTTTGGGGAC AGTGTCTGCA CAGGAACCCA CTACAAGAGC 
GTCCTGGCCA CCGGCACCTC CAGCGCCCGT GAGCTGGTGA AGGAGGCGCT GGAGCGGTAC 
GCCCTGGACC CCAGGCAGGC CGGCCAGTAC GTGCTGTGTG ACGTGGTGGG CCAAGCCGGC 
GATGCTGGGC AGCGGTGGCA GGCCCGGTGC TTTCGGGTGT TTGGGGACAG TGAGAAGCCC 
CTCTTGATCC AGGAATTATG GAAACCCCGA GAAGGTTTAT CCCGGAGGTT TGAGCTGAGG 
AAGAGGTCGG ACGTGGAGGA GCTGGCAGCC AAGGAGGTGG ACACCATCAC GGCAGGGATA 
AACGCCCAGG CCCGGAGGCT GCAGCGGAGT CGCGCGAAGG GAACCCCGAC CCCGGCCCTG 
GGGGATGCCC GGAGCTCTCC TCCACCCCGG TTGCGCCGCA CAGTCAGTGA GACCAGCCTG 
AGCCCAGTGA ACGCCCTGCC CGCTGCCGCC CAGGGCCCCG AGGAGCCCGG CCCCGACGCC 
ATGCGGTACT CGCTGTACCA GTCCCCGCAT CTGCTCCTTC TGCAGGGCTA CAGCCAGCAG 
CACGACAGCC TGGTGTATGT GCTCAACCGG GACCGGCACA CGGTGGGCCA GCGGACCCCC 
TCCAGCAAGC CCAGCATCAG CCTCTCAGCC CCCGACATCC TGCCTCTACA CTGCACCATC 
CGCCGGCAAC CGCTCCCGGA CAGCGGCCAG GCCGCGGGGA GGCTGGTCCT GGAGCCCATC 
CCCGGGGCGC ACATCTCCGT CAACTTCTCC GAGGTGGGGC ACAGGACCGT GGTGCTGCAC 
CACGGGGACC TGCTCTCCCT GGGGCTCTAC TACCTGCTGC TATTCAAGGA CCCCGCGCAG 
GCCCAGCCCC TGCCCGCCCG GGCCTTGGCG CGCCTCCGGG CTGTGCCGCA GAGCTGCCGG 
CTGTGCGGGG CCGCGCTCGG GGCCCGGGGA GCCGCCTCCC CTACTCAGGC CGCCCTGCCC 
CGGCGCCAGC AGCTGCTCCT GGAGTTTGAG CCCCACCTGG AGGACACGCT GCTGCAGAGG 
ATCATGACGT TGATCGAGCC GGGGGGCGAC GACCACAAGC TGACCCCCGC CTTCCTCCTG 
TGCCTCTGCA TCCAGCACTC GGCCACCCAC TTCCAGCCGG GCACATTCGG GCAGCTCCTG 
CTCAAGATAG CCAGGCTGAT CCGCGAGACT GTCTGGGAGA AAACCAAAGA ACTAGCAGAG 
AAGCAGGCGC AACTCCAGGA GCCCATCTCG CTGGCCAGCT GCGCCATGGC TGATCTGGTT 
CCAGACTTGC AGCCCATTCT TTTCTGGATG TCTAACTCCA TCGAGCTCCT GTACTTTATC 
CAGCAGAAAT GCCCACTCTA CATGCAGAGC ATGGAGGAGC AGCTGGACAT CACAGGCTCG 
AAGGAATCGC TGTTCTCCTG CACGCTGACG GCCAGCGAGG AGGCCATGGC GGTGCTGGAG 
GAGGTGGTGC TGTACGCCTT CCAGCAGTGC GTCTACTATG TCTCCAAGTC CCTGTACATC 
TGCCTCCCGG CACTCCTGGA GTGCCCGCCA TTCCAGACGG AGCGCCGTGA GAGCTGGTCC 
TCGGCCCCCG AACTGCCCGA GGAGCTGCGC CGCGTGGTGT CTGTGTACCA GGCAGCCCTG 
GACCTCCTGC GGCAGCTGCA GGTGCACCCC GAGGTGGCCT CGCAGATGCT CGCCTACCTC 
TTCTTCTTCT CCGGGACACT GCTTCTCAAC CAGCTCCTCG ACAGGGGCCC CTCCCTGAGC 
TGCTTCCACT GGCCCAGAGG TGTCCAGGCC TGCGCCCGCC TGCAGCAGCT CCTGGAGTGG 
ATGCGGAGCG CCGGCTTCGG GGCGGCTGGA GAGCACTTCT TCCAGAAGCT CTCCTGCACC 
CTCAACCTGC TGGCCACACC CAGGGCCCAG CTCATCCAGA TGAGCTGGAC AGCCCTGCGG 
GCTGCGTTCC CCGCACTGAG CCCAGCACAG CTGCACCGGC TGCTGACTCA CTACCAGCTG 
GCCTCGGCCA TGGGCCCCAT GAGCACCTGG GAGCCAGGGG CCCAGGACAG CCCCGAGGCC 
TTCAGGTCAG AGGATGTTCT GGAGTCCTAC GAAAACCCCC CACCCATCGT CCTGCCCAGC 
GACGGCTTCC AGGTGGACTT GGAAGCCAAC TGCCTGGACG ACAGCATCTA CCAGCACCTG 
CTCTACGTCC GCCACTTTCT GTGGGGTCTG CGGAGCAGAG CCAGCCCCGG CAGCCCTGGC 
AGGCCTGGCA GTGGGGCCTC CCAGCCAGTG TGCCCCGAGG GTATGCACCA CGTGGTCCTT 
GACGGGCACC TGGAGGCCCC GAGCTGCCCC CTGGCTCCCA GGGACCCTGG CCCAGCAGCC 
CGGGAAGTGG CCCCGGAGCG TACTCTTCCC TTGAGGGGGG CTCCCTGGGC ACAGGCCCCC 
CCTGGAAGGC AACCCAGCCG TGGGGGCTCC CAGGCTGGCC CCCCGCACAC GGACTCGTCC 
TGCTTGCTCA CGCCTCCCAG CACTCCACTT GGCCCTGAGC CTGGGGACCC CGACTGGCCA 
GAGTCCGGCG GCCCCTGTGG AAAAGCGCTC CCAGAGAGGC AGAGGAACGG ACTCAGCGGC 
CTCCGGGGTG CAGCTCCGGA AGGAGACTCT GCAGCCCTTG CGGAGGAGTC CCCTCCAGCC 
CCGTCCAGCC GCAGCTCCAG CACCGAGGAC TTCTGCTACG TCTTCACGGT GGAGCTGGAA 
CGAGGCCCCT CCGGGCTGGG GATGGGCCTG ATCGACGGGA TGCACACGCA CCTGGGCGCC 
CCCGGGCTCT ACATCCAGAC CCTGCTCCCG GGCAGCCCCG CAGCGGCCGA CGGGCGCCTG 
TCGCTGGGGG ACCGTATCCT GGAGGTGAAT GGCAGCAGCC TCCTGGGCCT TGGCTACCTG 
AGAGCTGTGG ACCTGATCCG TCATGGCGGG AAGAAGATGC GGTTCCTGGT CGCGAAGTCC 
GACGTGGAAA CAGCCAAGAA GATCCATTTC CGCACGCCCC CTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RADIL ( NM_018059.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060529.4 Homo sapiens Rap associating with DIL domain (RADIL), mRNA.

Price & Availability↑

CloneID	OHu02942
Clone ID Related Accession (Same CDS sequence)	NM_018059.4 , NM_018059.5
Accession Version	NM_018059.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	ras-associating and dilute domain-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092610.1, BG722917.1, DA241653.1, BC117317.1, BC004919.2 and EF560723.1. On May 17, 2019 this sequence version replaced NM_018059.4. ##Evidence-Data-START## CDS exon combination :: EF560723.1, BC143526.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000399583.4/ ENSP00000382492.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTATG GGACGCACTT CATCATGTCC CCGCCCACCA AGAGCAAACT GAAGCGGCAG 
AGCCAGCTGT TGTCCAGCAT GCTGTCCCGG ACGCTGAGCT ACAAGTACCG GGACCTGGAC 
TCCACCTTCT CCAGCCTGGG CGCCAGCGAT GACCCCGCCG AGCTCTCCAC CCAGCTGTCG 
GCCCCTGGTG TCCTGAAGGT GTTTGGGGAC AGTGTCTGCA CAGGAACCCA CTACAAGAGC 
GTCCTGGCCA CCGGCACCTC CAGCGCCCGT GAGCTGGTGA AGGAGGCGCT GGAGCGGTAC 
GCCCTGGACC CCAGGCAGGC CGGCCAGTAC GTGCTGTGTG ACGTGGTGGG CCAAGCCGGC 
GATGCTGGGC AGCGGTGGCA GGCCCGGTGC TTTCGGGTGT TTGGGGACAG TGAGAAGCCC 
CTCTTGATCC AGGAATTATG GAAACCCCGA GAAGGTTTAT CCCGGAGGTT TGAGCTGAGG 
AAGAGGTCGG ACGTGGAGGA GCTGGCAGCC AAGGAGGTGG ACACCATCAC GGCAGGGATA 
AACGCCCAGG CCCGGAGGCT GCAGCGGAGT CGCGCGAAGG GAACCCCGAC CCCGGCCCTG 
GGGGATGCCC GGAGCTCTCC TCCACCCCGG TTGCGCCGCA CAGTCAGTGA GACCAGCCTG 
AGCCCAGTGA ACGCCCTGCC CGCTGCCGCC CAGGGCCCCG AGGAGCCCGG CCCCGACGCC 
ATGCGGTACT CGCTGTACCA GTCCCCGCAT CTGCTCCTTC TGCAGGGCTA CAGCCAGCAG 
CACGACAGCC TGGTGTATGT GCTCAACCGG GACCGGCACA CGGTGGGCCA GCGGACCCCC 
TCCAGCAAGC CCAGCATCAG CCTCTCAGCC CCCGACATCC TGCCTCTACA CTGCACCATC 
CGCCGGCAAC CGCTCCCGGA CAGCGGCCAG GCCGCGGGGA GGCTGGTCCT GGAGCCCATC 
CCCGGGGCGC ACATCTCCGT CAACTTCTCC GAGGTGGGGC ACAGGACCGT GGTGCTGCAC 
CACGGGGACC TGCTCTCCCT GGGGCTCTAC TACCTGCTGC TATTCAAGGA CCCCGCGCAG 
GCCCAGCCCC TGCCCGCCCG GGCCTTGGCG CGCCTCCGGG CTGTGCCGCA GAGCTGCCGG 
CTGTGCGGGG CCGCGCTCGG GGCCCGGGGA GCCGCCTCCC CTACTCAGGC CGCCCTGCCC 
CGGCGCCAGC AGCTGCTCCT GGAGTTTGAG CCCCACCTGG AGGACACGCT GCTGCAGAGG 
ATCATGACGT TGATCGAGCC GGGGGGCGAC GACCACAAGC TGACCCCCGC CTTCCTCCTG 
TGCCTCTGCA TCCAGCACTC GGCCACCCAC TTCCAGCCGG GCACATTCGG GCAGCTCCTG 
CTCAAGATAG CCAGGCTGAT CCGCGAGACT GTCTGGGAGA AAACCAAAGA ACTAGCAGAG 
AAGCAGGCGC AACTCCAGGA GCCCATCTCG CTGGCCAGCT GCGCCATGGC TGATCTGGTT 
CCAGACTTGC AGCCCATTCT TTTCTGGATG TCTAACTCCA TCGAGCTCCT GTACTTTATC 
CAGCAGAAAT GCCCACTCTA CATGCAGAGC ATGGAGGAGC AGCTGGACAT CACAGGCTCG 
AAGGAATCGC TGTTCTCCTG CACGCTGACG GCCAGCGAGG AGGCCATGGC GGTGCTGGAG 
GAGGTGGTGC TGTACGCCTT CCAGCAGTGC GTCTACTATG TCTCCAAGTC CCTGTACATC 
TGCCTCCCGG CACTCCTGGA GTGCCCGCCA TTCCAGACGG AGCGCCGTGA GAGCTGGTCC 
TCGGCCCCCG AACTGCCCGA GGAGCTGCGC CGCGTGGTGT CTGTGTACCA GGCAGCCCTG 
GACCTCCTGC GGCAGCTGCA GGTGCACCCC GAGGTGGCCT CGCAGATGCT CGCCTACCTC 
TTCTTCTTCT CCGGGACACT GCTTCTCAAC CAGCTCCTCG ACAGGGGCCC CTCCCTGAGC 
TGCTTCCACT GGCCCAGAGG TGTCCAGGCC TGCGCCCGCC TGCAGCAGCT CCTGGAGTGG 
ATGCGGAGCG CCGGCTTCGG GGCGGCTGGA GAGCACTTCT TCCAGAAGCT CTCCTGCACC 
CTCAACCTGC TGGCCACACC CAGGGCCCAG CTCATCCAGA TGAGCTGGAC AGCCCTGCGG 
GCTGCGTTCC CCGCACTGAG CCCAGCACAG CTGCACCGGC TGCTGACTCA CTACCAGCTG 
GCCTCGGCCA TGGGCCCCAT GAGCACCTGG GAGCCAGGGG CCCAGGACAG CCCCGAGGCC 
TTCAGGTCAG AGGATGTTCT GGAGTCCTAC GAAAACCCCC CACCCATCGT CCTGCCCAGC 
GACGGCTTCC AGGTGGACTT GGAAGCCAAC TGCCTGGACG ACAGCATCTA CCAGCACCTG 
CTCTACGTCC GCCACTTTCT GTGGGGTCTG CGGAGCAGAG CCAGCCCCGG CAGCCCTGGC 
AGGCCTGGCA GTGGGGCCTC CCAGCCAGTG TGCCCCGAGG GTATGCACCA CGTGGTCCTT 
GACGGGCACC TGGAGGCCCC GAGCTGCCCC CTGGCTCCCA GGGACCCTGG CCCAGCAGCC 
CGGGAAGTGG CCCCGGAGCG TACTCTTCCC TTGAGGGGGG CTCCCTGGGC ACAGGCCCCC 
CCTGGAAGGC AACCCAGCCG TGGGGGCTCC CAGGCTGGCC CCCCGCACAC GGACTCGTCC 
TGCTTGCTCA CGCCTCCCAG CACTCCACTT GGCCCTGAGC CTGGGGACCC CGACTGGCCA 
GAGTCCGGCG GCCCCTGTGG AAAAGCGCTC CCAGAGAGGC AGAGGAACGG ACTCAGCGGC 
CTCCGGGGTG CAGCTCCGGA AGGAGACTCT GCAGCCCTTG CGGAGGAGTC CCCTCCAGCC 
CCGTCCAGCC GCAGCTCCAG CACCGAGGAC TTCTGCTACG TCTTCACGGT GGAGCTGGAA 
CGAGGCCCCT CCGGGCTGGG GATGGGCCTG ATCGACGGGA TGCACACGCA CCTGGGCGCC 
CCCGGGCTCT ACATCCAGAC CCTGCTCCCG GGCAGCCCCG CAGCGGCCGA CGGGCGCCTG 
TCGCTGGGGG ACCGTATCCT GGAGGTGAAT GGCAGCAGCC TCCTGGGCCT TGGCTACCTG 
AGAGCTGTGG ACCTGATCCG TCATGGCGGG AAGAAGATGC GGTTCCTGGT CGCGAAGTCC 
GACGTGGAAA CAGCCAAGAA GATCCATTTC CGCACGCCCC CTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060529.4
CDS	186..3413
Translation	MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGINAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDAMRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL

Target ORF information:

RefSeq Version	NM_018059.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Rap associating with DIL domain (RADIL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018059.5

ORF Insert Sequence:

ATGTTTTATG GGACGCACTT CATCATGTCC CCGCCCACCA AGAGCAAACT GAAGCGGCAG 
AGCCAGCTGT TGTCCAGCAT GCTGTCCCGG ACGCTGAGCT ACAAGTACCG GGACCTGGAC 
TCCACCTTCT CCAGCCTGGG CGCCAGCGAT GACCCCGCCG AGCTCTCCAC CCAGCTGTCG 
GCCCCTGGTG TCCTGAAGGT GTTTGGGGAC AGTGTCTGCA CAGGAACCCA CTACAAGAGC 
GTCCTGGCCA CCGGCACCTC CAGCGCCCGT GAGCTGGTGA AGGAGGCGCT GGAGCGGTAC 
GCCCTGGACC CCAGGCAGGC CGGCCAGTAC GTGCTGTGTG ACGTGGTGGG CCAAGCCGGC 
GATGCTGGGC AGCGGTGGCA GGCCCGGTGC TTTCGGGTGT TTGGGGACAG TGAGAAGCCC 
CTCTTGATCC AGGAATTATG GAAACCCCGA GAAGGTTTAT CCCGGAGGTT TGAGCTGAGG 
AAGAGGTCGG ACGTGGAGGA GCTGGCAGCC AAGGAGGTGG ACACCATCAC GGCAGGGATA 
AACGCCCAGG CCCGGAGGCT GCAGCGGAGT CGCGCGAAGG GAACCCCGAC CCCGGCCCTG 
GGGGATGCCC GGAGCTCTCC TCCACCCCGG TTGCGCCGCA CAGTCAGTGA GACCAGCCTG 
AGCCCAGTGA ACGCCCTGCC CGCTGCCGCC CAGGGCCCCG AGGAGCCCGG CCCCGACGCC 
ATGCGGTACT CGCTGTACCA GTCCCCGCAT CTGCTCCTTC TGCAGGGCTA CAGCCAGCAG 
CACGACAGCC TGGTGTATGT GCTCAACCGG GACCGGCACA CGGTGGGCCA GCGGACCCCC 
TCCAGCAAGC CCAGCATCAG CCTCTCAGCC CCCGACATCC TGCCTCTACA CTGCACCATC 
CGCCGGCAAC CGCTCCCGGA CAGCGGCCAG GCCGCGGGGA GGCTGGTCCT GGAGCCCATC 
CCCGGGGCGC ACATCTCCGT CAACTTCTCC GAGGTGGGGC ACAGGACCGT GGTGCTGCAC 
CACGGGGACC TGCTCTCCCT GGGGCTCTAC TACCTGCTGC TATTCAAGGA CCCCGCGCAG 
GCCCAGCCCC TGCCCGCCCG GGCCTTGGCG CGCCTCCGGG CTGTGCCGCA GAGCTGCCGG 
CTGTGCGGGG CCGCGCTCGG GGCCCGGGGA GCCGCCTCCC CTACTCAGGC CGCCCTGCCC 
CGGCGCCAGC AGCTGCTCCT GGAGTTTGAG CCCCACCTGG AGGACACGCT GCTGCAGAGG 
ATCATGACGT TGATCGAGCC GGGGGGCGAC GACCACAAGC TGACCCCCGC CTTCCTCCTG 
TGCCTCTGCA TCCAGCACTC GGCCACCCAC TTCCAGCCGG GCACATTCGG GCAGCTCCTG 
CTCAAGATAG CCAGGCTGAT CCGCGAGACT GTCTGGGAGA AAACCAAAGA ACTAGCAGAG 
AAGCAGGCGC AACTCCAGGA GCCCATCTCG CTGGCCAGCT GCGCCATGGC TGATCTGGTT 
CCAGACTTGC AGCCCATTCT TTTCTGGATG TCTAACTCCA TCGAGCTCCT GTACTTTATC 
CAGCAGAAAT GCCCACTCTA CATGCAGAGC ATGGAGGAGC AGCTGGACAT CACAGGCTCG 
AAGGAATCGC TGTTCTCCTG CACGCTGACG GCCAGCGAGG AGGCCATGGC GGTGCTGGAG 
GAGGTGGTGC TGTACGCCTT CCAGCAGTGC GTCTACTATG TCTCCAAGTC CCTGTACATC 
TGCCTCCCGG CACTCCTGGA GTGCCCGCCA TTCCAGACGG AGCGCCGTGA GAGCTGGTCC 
TCGGCCCCCG AACTGCCCGA GGAGCTGCGC CGCGTGGTGT CTGTGTACCA GGCAGCCCTG 
GACCTCCTGC GGCAGCTGCA GGTGCACCCC GAGGTGGCCT CGCAGATGCT CGCCTACCTC 
TTCTTCTTCT CCGGGACACT GCTTCTCAAC CAGCTCCTCG ACAGGGGCCC CTCCCTGAGC 
TGCTTCCACT GGCCCAGAGG TGTCCAGGCC TGCGCCCGCC TGCAGCAGCT CCTGGAGTGG 
ATGCGGAGCG CCGGCTTCGG GGCGGCTGGA GAGCACTTCT TCCAGAAGCT CTCCTGCACC 
CTCAACCTGC TGGCCACACC CAGGGCCCAG CTCATCCAGA TGAGCTGGAC AGCCCTGCGG 
GCTGCGTTCC CCGCACTGAG CCCAGCACAG CTGCACCGGC TGCTGACTCA CTACCAGCTG 
GCCTCGGCCA TGGGCCCCAT GAGCACCTGG GAGCCAGGGG CCCAGGACAG CCCCGAGGCC 
TTCAGGTCAG AGGATGTTCT GGAGTCCTAC GAAAACCCCC CACCCATCGT CCTGCCCAGC 
GACGGCTTCC AGGTGGACTT GGAAGCCAAC TGCCTGGACG ACAGCATCTA CCAGCACCTG 
CTCTACGTCC GCCACTTTCT GTGGGGTCTG CGGAGCAGAG CCAGCCCCGG CAGCCCTGGC 
AGGCCTGGCA GTGGGGCCTC CCAGCCAGTG TGCCCCGAGG GTATGCACCA CGTGGTCCTT 
GACGGGCACC TGGAGGCCCC GAGCTGCCCC CTGGCTCCCA GGGACCCTGG CCCAGCAGCC 
CGGGAAGTGG CCCCGGAGCG TACTCTTCCC TTGAGGGGGG CTCCCTGGGC ACAGGCCCCC 
CCTGGAAGGC AACCCAGCCG TGGGGGCTCC CAGGCTGGCC CCCCGCACAC GGACTCGTCC 
TGCTTGCTCA CGCCTCCCAG CACTCCACTT GGCCCTGAGC CTGGGGACCC CGACTGGCCA 
GAGTCCGGCG GCCCCTGTGG AAAAGCGCTC CCAGAGAGGC AGAGGAACGG ACTCAGCGGC 
CTCCGGGGTG CAGCTCCGGA AGGAGACTCT GCAGCCCTTG CGGAGGAGTC CCCTCCAGCC 
CCGTCCAGCC GCAGCTCCAG CACCGAGGAC TTCTGCTACG TCTTCACGGT GGAGCTGGAA 
CGAGGCCCCT CCGGGCTGGG GATGGGCCTG ATCGACGGGA TGCACACGCA CCTGGGCGCC 
CCCGGGCTCT ACATCCAGAC CCTGCTCCCG GGCAGCCCCG CAGCGGCCGA CGGGCGCCTG 
TCGCTGGGGG ACCGTATCCT GGAGGTGAAT GGCAGCAGCC TCCTGGGCCT TGGCTACCTG 
AGAGCTGTGG ACCTGATCCG TCATGGCGGG AAGAAGATGC GGTTCCTGGT CGCGAAGTCC 
GACGTGGAAA CAGCCAAGAA GATCCATTTC CGCACGCCCC CTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity.
eLife5e11394(2016 Jan)
de Kreuk BJ,Gingras AR,Knight JD,Liu JJ,Gingras AC,Ginsberg MH

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

Radil controls neutrophil adhesion and motility through ?2-integrin activation.
Molecular biology of the cell23(24)4751-65(2012 Dec)
Liu L,Aerbajinai W,Ahmed SM,Rodgers GP,Angers S,Parent CA

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.
The Journal of biological chemistry285(9)6538-51(2010 Feb)
Ahmed SM,Daulat AM,Meunier A,Angers S

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

RADIL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報