Gene Symbol | FRMD4A |
Entrez Gene ID | 55691 |
Full Name | FERM domain containing 4A |
Synonyms | CCAFCA,FRMD4,bA295P9.4 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. |
Disorder MIM: | |
Disorder Html: | ?Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia, 616819 (3) |