MREG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MREG
Entrez Gene ID	55686
Full Name	melanoregulin
Synonyms	DSU,WDT2
General protein information	Preferred Names melanoregulin Names melanoregulin dilute suppressor protein homolog whn-dependent transcript 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Disorder MIM:	609207

mRNA and Protein(s)

mRNA	Protein	Name
NM_018000.2	NP_060470.2	melanoregulin
NM_001372188.1	NP_001359117.1	melanoregulin isoform 1
NM_001372189.1	NP_001359118.1	melanoregulin isoform 3
XM_017004475.1	XP_016859964.1	melanoregulin isoform X2
NM_018000.3	NP_060470.2	melanoregulin isoform 2
XM_011511468.2	XP_011509770.1	melanoregulin isoform X1
NM_001372190.1	NP_001359119.1	melanoregulin isoform 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MREG	XP_003309510.1
Homo sapiens (human)	MREG	NP_060470.2
Bos taurus (cattle)	MREG	NP_001179882.1
Gallus gallus (chicken)	MREG	XP_421870.3
Xenopus tropicalis (tropical clawed frog)	mreg	NP_001016432.1
Canis lupus familiaris (dog)	MREG	XP_852765.2
Mus musculus (house mouse)	Mreg	NP_001005423.1
	MREG	XP_001085687.1
Rattus norvegicus (Norway rat)	Mreg	NP_001178931.1

Gene Ontology
Bibliography

Related articles in PubMed

MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling.
Meng X, Dong Y, Yu X, Wang D, Wang S, Chen S, Pang S
Biochemical and biophysical research communications491(1)72-78(2017 09)

The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium.
Frost LS, Lopes VS, Bragin A, Reyes-Reveles J, Brancato J, Cohen A, Mitchell CH, Williams DS, Boesze-Battaglia K
Molecular neurobiology52(3)1135-1151(2015 Dec)

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Evans DM, Zhu G, Dy V, Heath AC, Madden PA, Kemp JP, McMahon G, St Pourcain B, Timpson NJ, Golding J, Lawlor DA, Steer C, Montgomery GW, Martin NG, Smith GD, Whitfield JB
Human molecular genetics22(19)3998-4006(2013 Oct)

Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Ohbayashi N, Maruta Y, Ishida M, Fukuda M
Journal of cell science125(Pt 6)1508-18(2012 Mar)

Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
Hersh CP, Pillai SG, Zhu G, Lomas DA, Bakke P, Gulsvik A, DeMeo DL, Klanderman BJ, Lazarus R, Litonjua AA, Sparrow D, Reilly JJ, Agusti A, Calverley PM, Donner CF, Levy RD, Make BJ, Par? PD, Rennard SI, Vestbo J, Wouters EF, Scholand MB, Coon H, Hoidal J, Silverman EK
American journal of respiratory and critical care medicine182(5)605-13(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, MREG regulates thyroid cancer cell invasion and proliferation through PI3K/Akt-mTOR signaling pathway. MREG may serve as a promising therapeutic strategy for thyroid cancer.
Title: MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling.

MREG-dependent processing links both autophagic and phagocytic processes in LC3-associated phagocytosis. MREG participates in coordinating the association of phagosomes with LC3 for content degradation with the MREG loss leading to phagosome accumulation.
Title: The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium.

Observational study of gene-disease association. (HuGE Navigator)
Title: Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.

The following MREG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MREG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13295	NM_018000.3 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu69626	XM_011511468.2 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu108805	NM_001372189.1 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu108805	NM_001372190.1 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu69626	NM_001372188.1 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu89663	XM_017004475.1 Latest version!	Homo sapiens melanoregulin (MREG), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu13295	NM_018000.2	Homo sapiens melanoregulin (MREG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MREG ( NM_018000.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060470.2 Homo sapiens melanoregulin (MREG), mRNA.

Price & Availability↑

CloneID	OHu13295
Clone ID Related Accession (Same CDS sequence)	NM_018000.2 , NM_018000.3
Accession Version	NM_018000.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	melanoregulin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ928130.1, CX781801.1, AC093382.3 and CA843296.1. On Feb 6, 2007 this sequence version replaced NM_018000.1. ##Evidence-Data-START## Transcript exon combination :: BQ958428.1, SRR1163655.396674.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGAGTG GCAGAAGCTC AACTATGATA TCCATACCCT GCGGCAGGTT 
CGAAGGGAAG TAAGAAACAG ATGGAAGTGC ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA 
GCTGACTCTT TGTTGTCAGT GACTAAACTC AGCACCATCA GTGATTCTAA AAACACAAGG 
AAAGCTCGAG AGATGTTGTT AAAACTGGCT GAAGAAACCA ATATTTTCCC AACAAGTTGG 
GAGCTCTCAG AGAGATATCT CTTTGTTGTG GACCGTCTCA TTGCACTTGA TGCTGCAGAA 
GAGTTCTTTA AGCTTGCTCG TCGAACTTAC CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA 
GATGGCCAGA AAGAACTGCA CTACCTTCCG TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060470.2
CDS	297..941
Translation	MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	NM_018000.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018000.2

ORF Insert Sequence:

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGAGTG GCAGAAGCTC AACTATGATA TCCATACCCT GCGGCAGGTT 
CGAAGGGAAG TAAGAAACAG ATGGAAGTGC ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA 
GCTGACTCTT TGTTGTCAGT GACTAAACTC AGCACCATCA GTGATTCTAA AAACACAAGG 
AAAGCTCGAG AGATGTTGTT AAAACTGGCT GAAGAAACCA ATATTTTCCC AACAAGTTGG 
GAGCTCTCAG AGAGATATCT CTTTGTTGTG GACCGTCTCA TTGCACTTGA TGCTGCAGAA 
GAGTTCTTTA AGCTTGCTCG TCGAACTTAC CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA 
GATGGCCAGA AAGAACTGCA CTACCTTCCG TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( NM_018000.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060470.2 Homo sapiens melanoregulin (MREG), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13295
Clone ID Related Accession (Same CDS sequence)	NM_018000.2 , NM_018000.3
Accession Version	NM_018000.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	melanoregulin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX781801.1, AC093382.3 and CA843296.1. On Nov 22, 2018 this sequence version replaced NM_018000.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.396674.1, SRR1163657.464487.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263268.11/ ENSP00000263268.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGAGTG GCAGAAGCTC AACTATGATA TCCATACCCT GCGGCAGGTT 
CGAAGGGAAG TAAGAAACAG ATGGAAGTGC ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA 
GCTGACTCTT TGTTGTCAGT GACTAAACTC AGCACCATCA GTGATTCTAA AAACACAAGG 
AAAGCTCGAG AGATGTTGTT AAAACTGGCT GAAGAAACCA ATATTTTCCC AACAAGTTGG 
GAGCTCTCAG AGAGATATCT CTTTGTTGTG GACCGTCTCA TTGCACTTGA TGCTGCAGAA 
GAGTTCTTTA AGCTTGCTCG TCGAACTTAC CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA 
GATGGCCAGA AAGAACTGCA CTACCTTCCG TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060470.2
CDS	225..869
Translation	MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	NM_018000.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018000.3

ORF Insert Sequence:

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGAGTG GCAGAAGCTC AACTATGATA TCCATACCCT GCGGCAGGTT 
CGAAGGGAAG TAAGAAACAG ATGGAAGTGC ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA 
GCTGACTCTT TGTTGTCAGT GACTAAACTC AGCACCATCA GTGATTCTAA AAACACAAGG 
AAAGCTCGAG AGATGTTGTT AAAACTGGCT GAAGAAACCA ATATTTTCCC AACAAGTTGG 
GAGCTCTCAG AGAGATATCT CTTTGTTGTG GACCGTCTCA TTGCACTTGA TGCTGCAGAA 
GAGTTCTTTA AGCTTGCTCG TCGAACTTAC CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA 
GATGGCCAGA AAGAACTGCA CTACCTTCCG TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( XM_011511468.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509770.1 Homo sapiens melanoregulin (MREG), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu69626
Clone ID Related Accession (Same CDS sequence)	NM_001372188.1 , XM_011511468.2
Accession Version	XM_011511468.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	melanoregulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011511468.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGGAGTG GCAGAAGCTC 
AACTATGATA TCCATACCCT GCGGCAGGTT CGAAGGGAAG TAAGAAACAG ATGGAAGTGC 
ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA GCTGACTCTT TGTTGTCAGT GACTAAACTC 
AGCACCATCA GTGATTCTAA AAACACAAGG AAAGCTCGAG AGATGTTGTT AAAACTGGCT 
GAAGAAACCA ATATTTTCCC AACAAGTTGG GAGCTCTCAG AGAGATATCT CTTTGTTGTG 
GACCGTCTCA TTGCACTTGA TGCTGCAGAA GAGTTCTTTA AGCTTGCTCG TCGAACTTAC 
CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA GATGGCCAGA AAGAACTGCA CTACCTTCCG 
TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509770.1
CDS	147..941
Translation	MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGVLQSGETSKLKHKANHCWELLTAPLSLEGARPLGTGLSWPPPPANRYSKEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	XM_011511468.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511468.2

ORF Insert Sequence:

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGGAGTG GCAGAAGCTC 
AACTATGATA TCCATACCCT GCGGCAGGTT CGAAGGGAAG TAAGAAACAG ATGGAAGTGC 
ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA GCTGACTCTT TGTTGTCAGT GACTAAACTC 
AGCACCATCA GTGATTCTAA AAACACAAGG AAAGCTCGAG AGATGTTGTT AAAACTGGCT 
GAAGAAACCA ATATTTTCCC AACAAGTTGG GAGCTCTCAG AGAGATATCT CTTTGTTGTG 
GACCGTCTCA TTGCACTTGA TGCTGCAGAA GAGTTCTTTA AGCTTGCTCG TCGAACTTAC 
CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA GATGGCCAGA AAGAACTGCA CTACCTTCCG 
TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( NM_001372189.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001359118.1 Homo sapiens melanoregulin (MREG), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu108805
Clone ID Related Accession (Same CDS sequence)	NM_001372189.1 , NM_001372190.1
Accession Version	NM_001372189.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-22
Organism	Homo sapiens(human)
Product	melanoregulin isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010686.9 and AC093382.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DA265590.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCCCATG ATGTGTCCCA CACAGAGGCA GACGACGACA GAACCCTGTA CAATTTGATA 
GTCATTCGTA ATCAGCAGGC CAAAGACTCA GAGGAGTGGC AGAAGCTCAA CTATGATATC 
CATACCCTGC GGCAGGTTCG AAGGGAAGTA AGAAACAGAT GGAAGTGCAT CTTAGAAGAT 
TTAGGTTTTC AAAAGGAAGC TGACTCTTTG TTGTCAGTGA CTAAACTCAG CACCATCAGT 
GATTCTAAAA ACACAAGGAA AGCTCGAGAG ATGTTGTTAA AACTGGCTGA AGAAACCAAT 
ATTTTCCCAA CAAGTTGGGA GCTCTCAGAG AGATATCTCT TTGTTGTGGA CCGTCTCATT 
GCACTTGATG CTGCAGAAGA GTTCTTTAAG CTTGCTCGTC GAACTTACCC CAAGAAGCCT 
GGGGTTCCAT GCCTGGCAGA TGGCCAGAAA GAACTGCACT ACCTTCCGTT TCCAAGTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001359118.1
CDS	203..685
Translation	MPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	NM_001372189.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001372189.1

ORF Insert Sequence:

ATGCCCCATG ATGTGTCCCA CACAGAGGCA GACGACGACA GAACCCTGTA CAATTTGATA 
GTCATTCGTA ATCAGCAGGC CAAAGACTCA GAGGAGTGGC AGAAGCTCAA CTATGATATC 
CATACCCTGC GGCAGGTTCG AAGGGAAGTA AGAAACAGAT GGAAGTGCAT CTTAGAAGAT 
TTAGGTTTTC AAAAGGAAGC TGACTCTTTG TTGTCAGTGA CTAAACTCAG CACCATCAGT 
GATTCTAAAA ACACAAGGAA AGCTCGAGAG ATGTTGTTAA AACTGGCTGA AGAAACCAAT 
ATTTTCCCAA CAAGTTGGGA GCTCTCAGAG AGATATCTCT TTGTTGTGGA CCGTCTCATT 
GCACTTGATG CTGCAGAAGA GTTCTTTAAG CTTGCTCGTC GAACTTACCC CAAGAAGCCT 
GGGGTTCCAT GCCTGGCAGA TGGCCAGAAA GAACTGCACT ACCTTCCGTT TCCAAGTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( NM_001372190.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001359119.1 Homo sapiens melanoregulin (MREG), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu108805
Clone ID Related Accession (Same CDS sequence)	NM_001372189.1 , NM_001372190.1
Accession Version	NM_001372190.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-22
Organism	Homo sapiens(human)
Product	melanoregulin isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010686.9 and AC093382.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DA208539.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCCCATG ATGTGTCCCA CACAGAGGCA GACGACGACA GAACCCTGTA CAATTTGATA 
GTCATTCGTA ATCAGCAGGC CAAAGACTCA GAGGAGTGGC AGAAGCTCAA CTATGATATC 
CATACCCTGC GGCAGGTTCG AAGGGAAGTA AGAAACAGAT GGAAGTGCAT CTTAGAAGAT 
TTAGGTTTTC AAAAGGAAGC TGACTCTTTG TTGTCAGTGA CTAAACTCAG CACCATCAGT 
GATTCTAAAA ACACAAGGAA AGCTCGAGAG ATGTTGTTAA AACTGGCTGA AGAAACCAAT 
ATTTTCCCAA CAAGTTGGGA GCTCTCAGAG AGATATCTCT TTGTTGTGGA CCGTCTCATT 
GCACTTGATG CTGCAGAAGA GTTCTTTAAG CTTGCTCGTC GAACTTACCC CAAGAAGCCT 
GGGGTTCCAT GCCTGGCAGA TGGCCAGAAA GAACTGCACT ACCTTCCGTT TCCAAGTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001359119.1
CDS	190..672
Translation	MPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	NM_001372190.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001372190.1

ORF Insert Sequence:

ATGCCCCATG ATGTGTCCCA CACAGAGGCA GACGACGACA GAACCCTGTA CAATTTGATA 
GTCATTCGTA ATCAGCAGGC CAAAGACTCA GAGGAGTGGC AGAAGCTCAA CTATGATATC 
CATACCCTGC GGCAGGTTCG AAGGGAAGTA AGAAACAGAT GGAAGTGCAT CTTAGAAGAT 
TTAGGTTTTC AAAAGGAAGC TGACTCTTTG TTGTCAGTGA CTAAACTCAG CACCATCAGT 
GATTCTAAAA ACACAAGGAA AGCTCGAGAG ATGTTGTTAA AACTGGCTGA AGAAACCAAT 
ATTTTCCCAA CAAGTTGGGA GCTCTCAGAG AGATATCTCT TTGTTGTGGA CCGTCTCATT 
GCACTTGATG CTGCAGAAGA GTTCTTTAAG CTTGCTCGTC GAACTTACCC CAAGAAGCCT 
GGGGTTCCAT GCCTGGCAGA TGGCCAGAAA GAACTGCACT ACCTTCCGTT TCCAAGTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( NM_001372188.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001359117.1 Homo sapiens melanoregulin (MREG), transcript variant 1, mRNA.

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CloneID	OHu69626
Clone ID Related Accession (Same CDS sequence)	NM_001372188.1 , XM_011511468.2
Accession Version	NM_001372188.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-22
Organism	Homo sapiens(human)
Product	melanoregulin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010686.9 and AC093382.3. On Aug 23, 2019 this sequence version replaced XM_011511468.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.574340.1 [ECO:0000332] ##Evidence-Data-END##

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGGAGTG GCAGAAGCTC 
AACTATGATA TCCATACCCT GCGGCAGGTT CGAAGGGAAG TAAGAAACAG ATGGAAGTGC 
ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA GCTGACTCTT TGTTGTCAGT GACTAAACTC 
AGCACCATCA GTGATTCTAA AAACACAAGG AAAGCTCGAG AGATGTTGTT AAAACTGGCT 
GAAGAAACCA ATATTTTCCC AACAAGTTGG GAGCTCTCAG AGAGATATCT CTTTGTTGTG 
GACCGTCTCA TTGCACTTGA TGCTGCAGAA GAGTTCTTTA AGCTTGCTCG TCGAACTTAC 
CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA GATGGCCAGA AAGAACTGCA CTACCTTCCG 
TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001359117.1
CDS	225..1019
Translation	MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGVLQSGETSKLKHKANHCWELLTAPLSLEGARPLGTGLSWPPPPANRYSKEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP

Target ORF information:

RefSeq Version	NM_001372188.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001372188.1

ORF Insert Sequence:

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGGAGTG GCAGAAGCTC 
AACTATGATA TCCATACCCT GCGGCAGGTT CGAAGGGAAG TAAGAAACAG ATGGAAGTGC 
ATCTTAGAAG ATTTAGGTTT TCAAAAGGAA GCTGACTCTT TGTTGTCAGT GACTAAACTC 
AGCACCATCA GTGATTCTAA AAACACAAGG AAAGCTCGAG AGATGTTGTT AAAACTGGCT 
GAAGAAACCA ATATTTTCCC AACAAGTTGG GAGCTCTCAG AGAGATATCT CTTTGTTGTG 
GACCGTCTCA TTGCACTTGA TGCTGCAGAA GAGTTCTTTA AGCTTGCTCG TCGAACTTAC 
CCCAAGAAGC CTGGGGTTCC ATGCCTGGCA GATGGCCAGA AAGAACTGCA CTACCTTCCG 
TTTCCAAGTC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MREG ( XM_017004475.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859964.1 Homo sapiens melanoregulin (MREG), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu89663
Clone ID Related Accession (Same CDS sequence)	XM_017004475.1
Accession Version	XM_017004475.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	melanoregulin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGATAAT CCCTCTTCAT 
TTTAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859964.1
CDS	147..575
Translation	MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGVLQSGETSKLKHKANHCWELLTAPLSLEGARPLGTGLSWPPPPANRYSKIIPLHFK

Target ORF information:

RefSeq Version	XM_017004475.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanoregulin (MREG), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017004475.1

ORF Insert Sequence:

ATGGGGCTGA GGGACTGGCT GAGAACCGTG TGCTGCTGCT GCGGGTGCGA GTGCTTGGAG 
GAGCGCGCCC TGCCTGAGAA GGAGCCCCTC GTCAGTGATA ACAATCCATA TTCCTCATTT 
GGAGCAACTC TGGTGAGGGA TGATGAGAAG AATTTATGGA GTATGCCCCA TGATGTGTCC 
CACACAGAGG CAGACGACGA CAGAACCCTG TACAATTTGA TAGTCATTCG TAATCAGCAG 
GCCAAAGACT CAGAGGGAGT GCTCCAGAGT GGTGAGACAT CCAAGCTAAA GCATAAAGCC 
AACCATTGTT GGGAGTTATT GACGGCCCCT CTAAGTCTTG AAGGTGCCAG ACCGCTGGGC 
ACAGGCCTCT CCTGGCCTCC ACCCCCTGCC AACCGCTACT CCAAGATAAT CCCTCTTCAT 
TTTAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling.
Biochemical and biophysical research communications491(1)72-78(2017 09)
Meng X,Dong Y,Yu X,Wang D,Wang S,Chen S,Pang S

The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium.
Molecular neurobiology52(3)1135-1151(2015 Dec)
Frost LS,Lopes VS,Bragin A,Reyes-Reveles J,Brancato J,Cohen A,Mitchell CH,Williams DS,Boesze-Battaglia K

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Human molecular genetics22(19)3998-4006(2013 Oct)
Evans DM,Zhu G,Dy V,Heath AC,Madden PA,Kemp JP,McMahon G,St Pourcain B,Timpson NJ,Golding J,Lawlor DA,Steer C,Montgomery GW,Martin NG,Smith GD,Whitfield JB

Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Journal of cell science125(Pt 6)1508-18(2012 Mar)
Ohbayashi N,Maruta Y,Ishida M,Fukuda M

Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
American journal of respiratory and critical care medicine182(5)605-13(2010 Sep)
Hersh CP,Pillai SG,Zhu G,Lomas DA,Bakke P,Gulsvik A,DeMeo DL,Klanderman BJ,Lazarus R,Litonjua AA,Sparrow D,Reilly JJ,Agusti A,Calverley PM,Donner CF,Levy RD,Make BJ,Par? PD,Rennard SI,Vestbo J,Wouters EF,Scholand MB,Coon H,Hoidal J,Silverman EK

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MREG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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