MTMR8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTMR8
Entrez Gene ID	55613
Full Name	myotubularin related protein 8
General protein information	Preferred Names myotubularin related protein 8 Names myotubularin-related protein 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq11.2
Summary	This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases. [provided by RefSeq, Mar 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017677.3	NP_060147.2	myotubularin-related protein 8
NM_017677.4	NP_060147.2	myotubularin-related protein 8

Pathways from BioSystems

Homologies

	MTMR8	XP_001097351.1
Danio rerio (zebrafish)	mtmr8	NP_956688.1
Gallus gallus (chicken)	MTMR8	NP_001012717.1
Caenorhabditis elegans (roundworm)	mtm-6	NP_001022602.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005341	XP_001688643.1
Homo sapiens (human)	MTMR8	NP_060147.2
Pan troglodytes (chimpanzee)	MTMR8	XP_521093.2
Drosophila melanogaster (fruit fly)	CG3530	NP_611791.2
Xenopus tropicalis (tropical clawed frog)	mtmr8	XP_002931842.2

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation.
Yoo KY, Son JY, Lee JU, Shin W, Im DW, Kim SJ, Ryu SE, Heo YS
Acta crystallographica. Section D, Biological crystallography71(Pt 7)1528-39(2015 Jul)

X-linked MTMR8 diversity and evolutionary history of sub-Saharan populations.
Labuda D, Yotova V, Lefebvre JF, Moreau C, Utermann G, Williams SM
PloS one8(11)e80710(2013)

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.
Lorenzo O, Urb? S, Clague MJ
Journal of cell science119(Pt 14)2953-9(2006 Jul)

The myotubularin family: from genetic disease to phosphoinositide metabolism.
Laporte J, Blondeau F, Buj-Bello A, Mandel JL
Trends in genetics : TIG17(4)221-8(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, the crystal structure of the phosphatase domain of MTMR8 is reported.
Title: Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation.

East African population that gave rise to non-Africans underwent a selective sweep affecting the subcentromeric region where MTMR8 is located
Title: X-linked MTMR8 diversity and evolutionary history of sub-Saharan populations.

The following MTMR8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTMR8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22519	NM_017677.4 Latest version!	Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu22519	NM_017677.3	Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTMR8 ( NM_017677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060147.2 Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.

Price & Availability↑

CloneID	OHu22519
Clone ID Related Accession (Same CDS sequence)	NM_017677.3 , NM_017677.4
Accession Version	NM_017677.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	myotubularin-related protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA691850.1, BC012399.1 and AL356317.8. This sequence is a reference standard in the RefSeqGene project. On Jan 20, 2010 this sequence version replaced NM_017677.2. ##Evidence-Data-START## Transcript exon combination :: BC012399.1, SRR1660803.207601.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCATA TTACGGTACC CAAGGTAGAA AACGTGAAAT TGGTGGATCG TTATGTGAGT 
AAGAAACCAG CTAATGGGAT TCTTTATCTT ACTGCAACCC ACCTGATCTA TGTGGAGGCT 
TCAGGTGCAG CCCGGAAAGA AACATGGATT GCACTCCATC ACATTGCCAC TGTGGAGAAG 
TTACCCATCA CTAGCCTGGG TTGTCCCCTG ACCCTCCGCT GCAAGAATTT CCGGGTGGCC 
CACTTTGTTT TAGATTCTGA CCTTGTGTGC CATGAGGTTT ATATTTCACT GCTCAAGCTT 
TCTCAGCCAG CATTACCTGA AGATCTTTAT GCTTTTTCTT ATAATCCCAA ATCCTCAAAA 
GAGATGAGGG AAAGTGGATG GAAACTGATT GACCCAATAT CAGACTTTGG GCGTATGGGA 
ATACCCAACA GAAACTGGAC CATAACAGAT GCCAACAGAA ACTATGAGAT ATGCAGCACC 
TACCCTCCTG AAATAGTGGT TCCTAAATCT GTTACCTTGG GAACGGTGGT TGGAAGTTCA 
AAGTTCAGAA GTAAAGAACG TGTCCCTGTG CTCTCCTACC TCTACAAAGA GAACAATGCT 
GCCATTTGCC GCTGTAGCCA GCCTCTCTCT GGATTTTACA CTCGCTGTGT AGATGATGAG 
CTCTTGTTGG AGGCCATTAG CCAAACAAAC CCAGGGAGCC AGTTTATGTA TGTTGTAGAC 
ACAAGACCAA AGTTGAATGC CATGGCCAAC CGAGCAGCTG GGAAGGGGTA TGAAAATGAA 
GACAACTATG CCAACATTCG CTTCAGATTC ATGGGCATTG AGAACATCCA TGTAATGCGG 
AGCAGTCTGC AGAAACTCTT GGAAGTTTGT GAATTGAAAA CTCCAACAAT GAGTGAATTT 
CTTAGCGGCC TGGAGAGCTC AGGGTGGTTA AGACACATTA AAGCTATTAT GGATGCTGGA 
ATTTTCATTA CAAAGGCAGT GAAGGTAGAA AAGGCCAGTG TCTTAGTCCA TTGTTCTGAT 
GGATGGGACC GCACAGCACA AGTCTGCTCA GTGGCTAGCA TCCTCCTAGA TCCATTTTAT 
AGGACATTCA AAGGACTCAT GATCTTGATA GAGAAGGAAT GGATATCCAT GGGCCACAAG 
TTTTCCCAAA GGTGTGGCCA CCTCGATGGG GACTCTAAAG AAGTGTCCCC TATCTTCACC 
CAGTTCCTAG ACTGTATCTG GCAATTAATG GAACAGTTTC CCTGTGCCTT TGAGTTTAAT 
GAAAACTTCC TGCTGGAGAT TCATGACCAT GTTTTCTCCT GCCAGTTTGG AAACTTCCTT 
GGTAACTGCC AGAAGGATCG GGAAGATCTA AGAGTCTATG AGAAAACACA TTCTGTGTGG 
CCTTTCTTGG TTCAGAGGAA ACCAGACTTC AGGAACCCTC TCTATAAAGG CTTCACTATG 
TATGGGGTAC TCAATCCTAG TACTGTGCCC TACAACATTC AGTTCTGGTG TGGGATGTAT 
AACCGCTTTG ACAAAGGGCT GCAGCCCAAG CAGAGTATGC TAGAGAGCCT CCTGGAAATT 
AAGAAACAGA GAGCAATGCT GGAGACAGAT GTGCATGAAC TAGAAAAGAA ACTAAAAGTC 
CGTGATGAGC CACCAGAAGA GATCTGTACC TGCTCTCAAT TAGGAAACAT ATTATCCCAG 
CATCTGGGAA GTCCTTTGAC CAATCCTCTT GGCTTTATGG GTATCAATGG AGACCTGAAT 
ACCCTGATGG AGAATGGCAC CCTATCCAGG GAAGGAGGCC TCCGAGCTCA GATGGATCAA 
GTAAAAAGCC AGGGTGCAGA CCTCCACCAT AACTGTTGTG AGATTGTGGG CAGCCTTAGG 
GCCATAAATA TCTCTGGGGA TGTGGGCATC TCTGAGGCCA TGGGCATCTC TGGAGACATG 
TGCACCTTTG AGGCTACGGG CTTCTCCAAA GACTTAGGAA TCTGTGGGGC CATGGACATC 
TCTGAGGCCA CTGGCATCTC TGGAAACTTG GGTATTTCTG AGGCCAGGGG TTTCTCTGGG 
GACATGGGCA TCTTGGGGGA CACAGGCATC TCCAAGGCCA GCACCAAGGA GGCAGACTAC 
TCCAAGCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060147.2
CDS	91..2205
Translation	MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ

Target ORF information:

RefSeq Version	NM_017677.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017677.3

ORF Insert Sequence:

ATGGATCATA TTACGGTACC CAAGGTAGAA AACGTGAAAT TGGTGGATCG TTATGTGAGT 
AAGAAACCAG CTAATGGGAT TCTTTATCTT ACTGCAACCC ACCTGATCTA TGTGGAGGCT 
TCAGGTGCAG CCCGGAAAGA AACATGGATT GCACTCCATC ACATTGCCAC TGTGGAGAAG 
TTACCCATCA CTAGCCTGGG TTGTCCCCTG ACCCTCCGCT GCAAGAATTT CCGGGTGGCC 
CACTTTGTTT TAGATTCTGA CCTTGTGTGC CATGAGGTTT ATATTTCACT GCTCAAGCTT 
TCTCAGCCAG CATTACCTGA AGATCTTTAT GCTTTTTCTT ATAATCCCAA ATCCTCAAAA 
GAGATGAGGG AAAGTGGATG GAAACTGATT GACCCAATAT CAGACTTTGG GCGTATGGGA 
ATACCCAACA GAAACTGGAC CATAACAGAT GCCAACAGAA ACTATGAGAT ATGCAGCACC 
TACCCTCCTG AAATAGTGGT TCCTAAATCT GTTACCTTGG GAACGGTGGT TGGAAGTTCA 
AAGTTCAGAA GTAAAGAACG TGTCCCTGTG CTCTCCTACC TCTACAAAGA GAACAATGCT 
GCCATTTGCC GCTGTAGCCA GCCTCTCTCT GGATTTTACA CTCGCTGTGT AGATGATGAG 
CTCTTGTTGG AGGCCATTAG CCAAACAAAC CCAGGGAGCC AGTTTATGTA TGTTGTAGAC 
ACAAGACCAA AGTTGAATGC CATGGCCAAC CGAGCAGCTG GGAAGGGGTA TGAAAATGAA 
GACAACTATG CCAACATTCG CTTCAGATTC ATGGGCATTG AGAACATCCA TGTAATGCGG 
AGCAGTCTGC AGAAACTCTT GGAAGTTTGT GAATTGAAAA CTCCAACAAT GAGTGAATTT 
CTTAGCGGCC TGGAGAGCTC AGGGTGGTTA AGACACATTA AAGCTATTAT GGATGCTGGA 
ATTTTCATTA CAAAGGCAGT GAAGGTAGAA AAGGCCAGTG TCTTAGTCCA TTGTTCTGAT 
GGATGGGACC GCACAGCACA AGTCTGCTCA GTGGCTAGCA TCCTCCTAGA TCCATTTTAT 
AGGACATTCA AAGGACTCAT GATCTTGATA GAGAAGGAAT GGATATCCAT GGGCCACAAG 
TTTTCCCAAA GGTGTGGCCA CCTCGATGGG GACTCTAAAG AAGTGTCCCC TATCTTCACC 
CAGTTCCTAG ACTGTATCTG GCAATTAATG GAACAGTTTC CCTGTGCCTT TGAGTTTAAT 
GAAAACTTCC TGCTGGAGAT TCATGACCAT GTTTTCTCCT GCCAGTTTGG AAACTTCCTT 
GGTAACTGCC AGAAGGATCG GGAAGATCTA AGAGTCTATG AGAAAACACA TTCTGTGTGG 
CCTTTCTTGG TTCAGAGGAA ACCAGACTTC AGGAACCCTC TCTATAAAGG CTTCACTATG 
TATGGGGTAC TCAATCCTAG TACTGTGCCC TACAACATTC AGTTCTGGTG TGGGATGTAT 
AACCGCTTTG ACAAAGGGCT GCAGCCCAAG CAGAGTATGC TAGAGAGCCT CCTGGAAATT 
AAGAAACAGA GAGCAATGCT GGAGACAGAT GTGCATGAAC TAGAAAAGAA ACTAAAAGTC 
CGTGATGAGC CACCAGAAGA GATCTGTACC TGCTCTCAAT TAGGAAACAT ATTATCCCAG 
CATCTGGGAA GTCCTTTGAC CAATCCTCTT GGCTTTATGG GTATCAATGG AGACCTGAAT 
ACCCTGATGG AGAATGGCAC CCTATCCAGG GAAGGAGGCC TCCGAGCTCA GATGGATCAA 
GTAAAAAGCC AGGGTGCAGA CCTCCACCAT AACTGTTGTG AGATTGTGGG CAGCCTTAGG 
GCCATAAATA TCTCTGGGGA TGTGGGCATC TCTGAGGCCA TGGGCATCTC TGGAGACATG 
TGCACCTTTG AGGCTACGGG CTTCTCCAAA GACTTAGGAA TCTGTGGGGC CATGGACATC 
TCTGAGGCCA CTGGCATCTC TGGAAACTTG GGTATTTCTG AGGCCAGGGG TTTCTCTGGG 
GACATGGGCA TCTTGGGGGA CACAGGCATC TCCAAGGCCA GCACCAAGGA GGCAGACTAC 
TCCAAGCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTMR8 ( NM_017677.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060147.2 Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.

Price & Availability↑

CloneID	OHu22519
Clone ID Related Accession (Same CDS sequence)	NM_017677.3 , NM_017677.4
Accession Version	NM_017677.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	myotubularin-related protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA691850.1, BC012399.1 and AL356317.8. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_017677.3. ##Evidence-Data-START## Transcript exon combination :: BC012399.1, SRR1660803.207601.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374852.4/ ENSP00000363985.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCATA TTACGGTACC CAAGGTAGAA AACGTGAAAT TGGTGGATCG TTATGTGAGT 
AAGAAACCAG CTAATGGGAT TCTTTATCTT ACTGCAACCC ACCTGATCTA TGTGGAGGCT 
TCAGGTGCAG CCCGGAAAGA AACATGGATT GCACTCCATC ACATTGCCAC TGTGGAGAAG 
TTACCCATCA CTAGCCTGGG TTGTCCCCTG ACCCTCCGCT GCAAGAATTT CCGGGTGGCC 
CACTTTGTTT TAGATTCTGA CCTTGTGTGC CATGAGGTTT ATATTTCACT GCTCAAGCTT 
TCTCAGCCAG CATTACCTGA AGATCTTTAT GCTTTTTCTT ATAATCCCAA ATCCTCAAAA 
GAGATGAGGG AAAGTGGATG GAAACTGATT GACCCAATAT CAGACTTTGG GCGTATGGGA 
ATACCCAACA GAAACTGGAC CATAACAGAT GCCAACAGAA ACTATGAGAT ATGCAGCACC 
TACCCTCCTG AAATAGTGGT TCCTAAATCT GTTACCTTGG GAACGGTGGT TGGAAGTTCA 
AAGTTCAGAA GTAAAGAACG TGTCCCTGTG CTCTCCTACC TCTACAAAGA GAACAATGCT 
GCCATTTGCC GCTGTAGCCA GCCTCTCTCT GGATTTTACA CTCGCTGTGT AGATGATGAG 
CTCTTGTTGG AGGCCATTAG CCAAACAAAC CCAGGGAGCC AGTTTATGTA TGTTGTAGAC 
ACAAGACCAA AGTTGAATGC CATGGCCAAC CGAGCAGCTG GGAAGGGGTA TGAAAATGAA 
GACAACTATG CCAACATTCG CTTCAGATTC ATGGGCATTG AGAACATCCA TGTAATGCGG 
AGCAGTCTGC AGAAACTCTT GGAAGTTTGT GAATTGAAAA CTCCAACAAT GAGTGAATTT 
CTTAGCGGCC TGGAGAGCTC AGGGTGGTTA AGACACATTA AAGCTATTAT GGATGCTGGA 
ATTTTCATTA CAAAGGCAGT GAAGGTAGAA AAGGCCAGTG TCTTAGTCCA TTGTTCTGAT 
GGATGGGACC GCACAGCACA AGTCTGCTCA GTGGCTAGCA TCCTCCTAGA TCCATTTTAT 
AGGACATTCA AAGGACTCAT GATCTTGATA GAGAAGGAAT GGATATCCAT GGGCCACAAG 
TTTTCCCAAA GGTGTGGCCA CCTCGATGGG GACTCTAAAG AAGTGTCCCC TATCTTCACC 
CAGTTCCTAG ACTGTATCTG GCAATTAATG GAACAGTTTC CCTGTGCCTT TGAGTTTAAT 
GAAAACTTCC TGCTGGAGAT TCATGACCAT GTTTTCTCCT GCCAGTTTGG AAACTTCCTT 
GGTAACTGCC AGAAGGATCG GGAAGATCTA AGAGTCTATG AGAAAACACA TTCTGTGTGG 
CCTTTCTTGG TTCAGAGGAA ACCAGACTTC AGGAACCCTC TCTATAAAGG CTTCACTATG 
TATGGGGTAC TCAATCCTAG TACTGTGCCC TACAACATTC AGTTCTGGTG TGGGATGTAT 
AACCGCTTTG ACAAAGGGCT GCAGCCCAAG CAGAGTATGC TAGAGAGCCT CCTGGAAATT 
AAGAAACAGA GAGCAATGCT GGAGACAGAT GTGCATGAAC TAGAAAAGAA ACTAAAAGTC 
CGTGATGAGC CACCAGAAGA GATCTGTACC TGCTCTCAAT TAGGAAACAT ATTATCCCAG 
CATCTGGGAA GTCCTTTGAC CAATCCTCTT GGCTTTATGG GTATCAATGG AGACCTGAAT 
ACCCTGATGG AGAATGGCAC CCTATCCAGG GAAGGAGGCC TCCGAGCTCA GATGGATCAA 
GTAAAAAGCC AGGGTGCAGA CCTCCACCAT AACTGTTGTG AGATTGTGGG CAGCCTTAGG 
GCCATAAATA TCTCTGGGGA TGTGGGCATC TCTGAGGCCA TGGGCATCTC TGGAGACATG 
TGCACCTTTG AGGCTACGGG CTTCTCCAAA GACTTAGGAA TCTGTGGGGC CATGGACATC 
TCTGAGGCCA CTGGCATCTC TGGAAACTTG GGTATTTCTG AGGCCAGGGG TTTCTCTGGG 
GACATGGGCA TCTTGGGGGA CACAGGCATC TCCAAGGCCA GCACCAAGGA GGCAGACTAC 
TCCAAGCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060147.2
CDS	90..2204
Translation	MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ

Target ORF information:

RefSeq Version	NM_017677.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myotubularin related protein 8 (MTMR8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017677.4

ORF Insert Sequence:

ATGGATCATA TTACGGTACC CAAGGTAGAA AACGTGAAAT TGGTGGATCG TTATGTGAGT 
AAGAAACCAG CTAATGGGAT TCTTTATCTT ACTGCAACCC ACCTGATCTA TGTGGAGGCT 
TCAGGTGCAG CCCGGAAAGA AACATGGATT GCACTCCATC ACATTGCCAC TGTGGAGAAG 
TTACCCATCA CTAGCCTGGG TTGTCCCCTG ACCCTCCGCT GCAAGAATTT CCGGGTGGCC 
CACTTTGTTT TAGATTCTGA CCTTGTGTGC CATGAGGTTT ATATTTCACT GCTCAAGCTT 
TCTCAGCCAG CATTACCTGA AGATCTTTAT GCTTTTTCTT ATAATCCCAA ATCCTCAAAA 
GAGATGAGGG AAAGTGGATG GAAACTGATT GACCCAATAT CAGACTTTGG GCGTATGGGA 
ATACCCAACA GAAACTGGAC CATAACAGAT GCCAACAGAA ACTATGAGAT ATGCAGCACC 
TACCCTCCTG AAATAGTGGT TCCTAAATCT GTTACCTTGG GAACGGTGGT TGGAAGTTCA 
AAGTTCAGAA GTAAAGAACG TGTCCCTGTG CTCTCCTACC TCTACAAAGA GAACAATGCT 
GCCATTTGCC GCTGTAGCCA GCCTCTCTCT GGATTTTACA CTCGCTGTGT AGATGATGAG 
CTCTTGTTGG AGGCCATTAG CCAAACAAAC CCAGGGAGCC AGTTTATGTA TGTTGTAGAC 
ACAAGACCAA AGTTGAATGC CATGGCCAAC CGAGCAGCTG GGAAGGGGTA TGAAAATGAA 
GACAACTATG CCAACATTCG CTTCAGATTC ATGGGCATTG AGAACATCCA TGTAATGCGG 
AGCAGTCTGC AGAAACTCTT GGAAGTTTGT GAATTGAAAA CTCCAACAAT GAGTGAATTT 
CTTAGCGGCC TGGAGAGCTC AGGGTGGTTA AGACACATTA AAGCTATTAT GGATGCTGGA 
ATTTTCATTA CAAAGGCAGT GAAGGTAGAA AAGGCCAGTG TCTTAGTCCA TTGTTCTGAT 
GGATGGGACC GCACAGCACA AGTCTGCTCA GTGGCTAGCA TCCTCCTAGA TCCATTTTAT 
AGGACATTCA AAGGACTCAT GATCTTGATA GAGAAGGAAT GGATATCCAT GGGCCACAAG 
TTTTCCCAAA GGTGTGGCCA CCTCGATGGG GACTCTAAAG AAGTGTCCCC TATCTTCACC 
CAGTTCCTAG ACTGTATCTG GCAATTAATG GAACAGTTTC CCTGTGCCTT TGAGTTTAAT 
GAAAACTTCC TGCTGGAGAT TCATGACCAT GTTTTCTCCT GCCAGTTTGG AAACTTCCTT 
GGTAACTGCC AGAAGGATCG GGAAGATCTA AGAGTCTATG AGAAAACACA TTCTGTGTGG 
CCTTTCTTGG TTCAGAGGAA ACCAGACTTC AGGAACCCTC TCTATAAAGG CTTCACTATG 
TATGGGGTAC TCAATCCTAG TACTGTGCCC TACAACATTC AGTTCTGGTG TGGGATGTAT 
AACCGCTTTG ACAAAGGGCT GCAGCCCAAG CAGAGTATGC TAGAGAGCCT CCTGGAAATT 
AAGAAACAGA GAGCAATGCT GGAGACAGAT GTGCATGAAC TAGAAAAGAA ACTAAAAGTC 
CGTGATGAGC CACCAGAAGA GATCTGTACC TGCTCTCAAT TAGGAAACAT ATTATCCCAG 
CATCTGGGAA GTCCTTTGAC CAATCCTCTT GGCTTTATGG GTATCAATGG AGACCTGAAT 
ACCCTGATGG AGAATGGCAC CCTATCCAGG GAAGGAGGCC TCCGAGCTCA GATGGATCAA 
GTAAAAAGCC AGGGTGCAGA CCTCCACCAT AACTGTTGTG AGATTGTGGG CAGCCTTAGG 
GCCATAAATA TCTCTGGGGA TGTGGGCATC TCTGAGGCCA TGGGCATCTC TGGAGACATG 
TGCACCTTTG AGGCTACGGG CTTCTCCAAA GACTTAGGAA TCTGTGGGGC CATGGACATC 
TCTGAGGCCA CTGGCATCTC TGGAAACTTG GGTATTTCTG AGGCCAGGGG TTTCTCTGGG 
GACATGGGCA TCTTGGGGGA CACAGGCATC TCCAAGGCCA GCACCAAGGA GGCAGACTAC 
TCCAAGCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation.
Acta crystallographica. Section D, Biological crystallography71(Pt 7)1528-39(2015 Jul)
Yoo KY,Son JY,Lee JU,Shin W,Im DW,Kim SJ,Ryu SE,Heo YS

X-linked MTMR8 diversity and evolutionary history of sub-Saharan populations.
PloS one8(11)e80710(2013)
Labuda D,Yotova V,Lefebvre JF,Moreau C,Utermann G,Williams SM

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.
Journal of cell science119(Pt 14)2953-9(2006 Jul)
Lorenzo O,Urb? S,Clague MJ

The myotubularin family: from genetic disease to phosphoinositide metabolism.
Trends in genetics : TIG17(4)221-8(2001 Apr)
Laporte J,Blondeau F,Buj-Bello A,Mandel JL

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MTMR8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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