RNPC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNPC3
Entrez Gene ID	55599
Full Name	RNA binding region (RNP1, RRM) containing 3
Synonyms	RBM40,RNP,SNRNP65
General protein information	Preferred Names RNA binding region (RNP1, RRM) containing 3 Names RNA-binding protein 40 RNA-binding motif protein 40 RNA-binding region-containing protein 3 U11/U12 small nuclear ribonucleoprotein 65 kDa protein U11/U12 snRNP 65 kDa protein U11/U12 snRNP 65K U11/U12-65K
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p21.1
Summary	Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017619.3	NP_060089.1	RNA-binding protein 40
NM_017619.4	NP_060089.1	RNA-binding region-containing protein 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rnpc3	NP_001094280.1
Xenopus tropicalis (tropical clawed frog)	rnpc3	NP_001016017.1
Danio rerio (zebrafish)	rnpc3	NP_001035019.1
Homo sapiens (human)	RNPC3	NP_060089.1
Canis lupus familiaris (dog)	RNPC3	XP_005621908.1
Mus musculus (house mouse)	Rnpc3	NP_001033785.1
Pan troglodytes (chimpanzee)	RNPC3	XP_003308296.1
Bos taurus (cattle)	RNPC3	NP_001070585.1
	RNPC3	XP_001108341.2
Gallus gallus (chicken)	RNPC3	XP_422302.3

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.
Norppa AJ, Kauppala TM, Heikkinen HA, Verma B, Iwai H, Frilander MJ
RNA (New York, N.Y.)(2017 Dec)

U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.
Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC
Scientific reports631393(2016 Aug)

Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.
Argente J, Flores R, Guti?rrez-Arum? A, Verma B, Martos-Moreno G?, Cusc? I, Oghabian A, Chowen JA, Frilander MJ, P?rez-Jurado LA
EMBO molecular medicine6(3)299-306(2014 03)

Protein microarray analysis identifies human cellular prion protein interactors.
Satoh J, Obayashi S, Misawa T, Sumiyoshi K, Oosumi K, Tabunoki H
Neuropathology and applied neurobiology35(1)16-35(2009 Feb)

Minor spliceosome components are predominantly localized in the nucleus.
Pessa HK, Will CL, Meng X, Schneider C, Watkins NJ, Per?l? N, Nymark M, Turunen JJ, L?hrmann R, Frilander MJ
Proceedings of the National Academy of Sciences of the United States of America105(25)8655-60(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Exome analysis of one proband revealed missense (c.1320C>A, p.P474T) and nonsense (c.1504C>T, p.R502X) mutations in the RNPC3 gene.
Title: Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.

U11/U12-65K contribute to di-snRNP formation and intron bridging in the minor prespliceosome
Title: The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein.

The following RNPC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNPC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02872	NM_017619.4 Latest version!	Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu02872	NM_017619.3	Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNPC3 ( NM_017619.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060089.1 Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.

Price & Availability↑

CloneID	OHu02872
Clone ID Related Accession (Same CDS sequence)	NM_017619.3 , NM_017619.4
Accession Version	NM_017619.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	RNA-binding protein 40
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN386195.1, AY099329.1 and BC010697.1. On Dec 10, 2004 this sequence version replaced NM_017619.2. ##Evidence-Data-START## Transcript exon combination :: BC010697.1, AY099329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC CCGAGCAGCC GCTTGCGATA TCAAGGGGAT GCACGAGCTC CTCCTCGCTT 
TCCCCGCCTC GGGGCGACCG AACCCTTCTG GTCAGGCACC TGCCGGCTGA GCTTACTGCT 
GAGGAGAAAG AGGACTTGCT GAAGTACTTC GGGGCTCAGT CTGTGCGGGT CCTGTCAGAT 
AAGGGGCGAC TGAAACATAC AGCTTTTGCC ACATTCCCTA ATGAAAAAGC AGCTATAAAG 
GCATTGACAA GACTCCATCA ACTGAAACTT TTAGGTCATA CTTTAGTCGT TGAATTTGCA 
AAAGAGCAAG ATCGAGTTCA CTCCCCATGT CCCACTTCAG GCTCTGAAAA AAAAAAAAGG 
TCTGATGACC CTGTCGAAGA TGATAAAGAA AAAAAAGAAC TTGGTTATTT AACAGTAGAA 
AATGGAATTG CACCAAACCA TGGGCTGACT TTTCCTTTAA ATTCATGCCT CAAGTATATG 
TACCCACCAC CTTCCAGCAC AATCCTAGCA AACATTGTAA ATGCCTTGGC AAGCGTGCCT 
AAGTTCTATG TACAGGTCCT TCATCTTATG AATAAAATGA ATTTGCCCAC ACCTTTTGGA 
CCAATTACTG CGCGACCTCC CATGTATGAA GACTATATGC CATTGCATGC ACCTCTTCCA 
CCCACATCTC CTCAGCCACC TGAGGAACCT CCTTTGCCAG ACGAGGATGA GGAATTATCT 
AGTGAAGAAT CAGAATATGA AAGCACTGAT GATGAGGACC GACAGAGAAT GAACAAATTA 
ATGGAACTAG CAAATCTTCA GCCCAAAAGA CCTAAAACAA TAAAGCAGCG CCATGTGAGA 
AAAAAGAGAA AAATAAAGGA TATGTTGAAT ACACCTTTGT GTCCTTCACA CAGCAGTTTA 
CATCCAGTGC TGTTACCTTC AGATGTATTT GACCAACCAC AACCTGTAGG TAACAAAAGA 
ATTGAATTCC ATATATCTAC CGACATGCCA GCTGCATTTA AGAAAGATTT AGAAAAGGAA 
CAAAATTGTG AGGAAAAAAA TCATGATTTA CCTGCTACTG AAGTTGATGC ATCCAATATA 
GGATTTGGAA AAATCTTCCC CAAACCTAAT TTGGACATCA CAGAGGAGAT TAAAGAAGAC 
TCTGATGAAA TGCCTTCAGA ATGTATTTCT AGAAGGGAAT TGGAAAAGGG CAGAATTTCT 
AGAGAAGAAA TGGAAACACT TTCAGTTTTC AGAAGTTATG AACCGGGTGA ACCAAACTGT 
AGAATTTATG TAAAGAATTT AGCTAAACAT GTTCAAGAAA AGGACCTTAA ATATATTTTT 
GGAAGATATG TTGACTTTTC ATCAGAAACA CAGCGGATCA TGTTTGATAT ACGTTTGATG 
AAAGAAGGTC GTATGAAAGG ACAAGCTTTC ATTGGACTTC CTAATGAAAA AGCAGCAGCA 
AAAGCCTTAA AGGAAGCTAA TGGATATGTG CTTTTTGGAA AACCCATGGT GGTTCAGTTT 
GCTCGATCTG CTAGACCAAA ACAAGATCCT AAGGAAGGAA AAAGAAAGTG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060089.1
CDS	116..1669
Translation	MAAPEQPLAISRGCTSSSSLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAIKALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPTSGSEKKKRSDDPVEDDKEKKELGYLTVENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITARPPMYEDYMPLHAPLPPTSPQPPEEPPLPDEDEELSSEESEYESTDDEDRQRMNKLMELANLQPKRPKTIKQRHVRKKRKIKDMLNTPLCPSHSSLHPVLLPSDVFDQPQPVGNKRIEFHISTDMPAAFKKDLEKEQNCEEKNHDLPATEVDASNIGFGKIFPKPNLDITEEIKEDSDEMPSECISRRELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLAKHVQEKDLKYIFGRYVDFSSETQRIMFDIRLMKEGRMKGQAFIGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDPKEGKRKC

Target ORF information:

RefSeq Version	NM_017619.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017619.3

ORF Insert Sequence:

ATGGCAGCTC CCGAGCAGCC GCTTGCGATA TCAAGGGGAT GCACGAGCTC CTCCTCGCTT 
TCCCCGCCTC GGGGCGACCG AACCCTTCTG GTCAGGCACC TGCCGGCTGA GCTTACTGCT 
GAGGAGAAAG AGGACTTGCT GAAGTACTTC GGGGCTCAGT CTGTGCGGGT CCTGTCAGAT 
AAGGGGCGAC TGAAACATAC AGCTTTTGCC ACATTCCCTA ATGAAAAAGC AGCTATAAAG 
GCATTGACAA GACTCCATCA ACTGAAACTT TTAGGTCATA CTTTAGTCGT TGAATTTGCA 
AAAGAGCAAG ATCGAGTTCA CTCCCCATGT CCCACTTCAG GCTCTGAAAA AAAAAAAAGG 
TCTGATGACC CTGTCGAAGA TGATAAAGAA AAAAAAGAAC TTGGTTATTT AACAGTAGAA 
AATGGAATTG CACCAAACCA TGGGCTGACT TTTCCTTTAA ATTCATGCCT CAAGTATATG 
TACCCACCAC CTTCCAGCAC AATCCTAGCA AACATTGTAA ATGCCTTGGC AAGCGTGCCT 
AAGTTCTATG TACAGGTCCT TCATCTTATG AATAAAATGA ATTTGCCCAC ACCTTTTGGA 
CCAATTACTG CGCGACCTCC CATGTATGAA GACTATATGC CATTGCATGC ACCTCTTCCA 
CCCACATCTC CTCAGCCACC TGAGGAACCT CCTTTGCCAG ACGAGGATGA GGAATTATCT 
AGTGAAGAAT CAGAATATGA AAGCACTGAT GATGAGGACC GACAGAGAAT GAACAAATTA 
ATGGAACTAG CAAATCTTCA GCCCAAAAGA CCTAAAACAA TAAAGCAGCG CCATGTGAGA 
AAAAAGAGAA AAATAAAGGA TATGTTGAAT ACACCTTTGT GTCCTTCACA CAGCAGTTTA 
CATCCAGTGC TGTTACCTTC AGATGTATTT GACCAACCAC AACCTGTAGG TAACAAAAGA 
ATTGAATTCC ATATATCTAC CGACATGCCA GCTGCATTTA AGAAAGATTT AGAAAAGGAA 
CAAAATTGTG AGGAAAAAAA TCATGATTTA CCTGCTACTG AAGTTGATGC ATCCAATATA 
GGATTTGGAA AAATCTTCCC CAAACCTAAT TTGGACATCA CAGAGGAGAT TAAAGAAGAC 
TCTGATGAAA TGCCTTCAGA ATGTATTTCT AGAAGGGAAT TGGAAAAGGG CAGAATTTCT 
AGAGAAGAAA TGGAAACACT TTCAGTTTTC AGAAGTTATG AACCGGGTGA ACCAAACTGT 
AGAATTTATG TAAAGAATTT AGCTAAACAT GTTCAAGAAA AGGACCTTAA ATATATTTTT 
GGAAGATATG TTGACTTTTC ATCAGAAACA CAGCGGATCA TGTTTGATAT ACGTTTGATG 
AAAGAAGGTC GTATGAAAGG ACAAGCTTTC ATTGGACTTC CTAATGAAAA AGCAGCAGCA 
AAAGCCTTAA AGGAAGCTAA TGGATATGTG CTTTTTGGAA AACCCATGGT GGTTCAGTTT 
GCTCGATCTG CTAGACCAAA ACAAGATCCT AAGGAAGGAA AAAGAAAGTG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNPC3 ( NM_017619.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060089.1 Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.

Price & Availability↑

CloneID	OHu02872
Clone ID Related Accession (Same CDS sequence)	NM_017619.3 , NM_017619.4
Accession Version	NM_017619.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	RNA-binding region-containing protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC095032.3, CN386195.1, AY099329.1 and BC010697.1. On Nov 23, 2018 this sequence version replaced NM_017619.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.224208.1, SRR3476690.855281.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000423855.7/ ENSP00000391432.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCTC CCGAGCAGCC GCTTGCGATA TCAAGGGGAT GCACGAGCTC CTCCTCGCTT 
TCCCCGCCTC GGGGCGACCG AACCCTTCTG GTCAGGCACC TGCCGGCTGA GCTTACTGCT 
GAGGAGAAAG AGGACTTGCT GAAGTACTTC GGGGCTCAGT CTGTGCGGGT CCTGTCAGAT 
AAGGGGCGAC TGAAACATAC AGCTTTTGCC ACATTCCCTA ATGAAAAAGC AGCTATAAAG 
GCATTGACAA GACTCCATCA ACTGAAACTT TTAGGTCATA CTTTAGTCGT TGAATTTGCA 
AAAGAGCAAG ATCGAGTTCA CTCCCCATGT CCCACTTCAG GCTCTGAAAA AAAAAAAAGG 
TCTGATGACC CTGTCGAAGA TGATAAAGAA AAAAAAGAAC TTGGTTATTT AACAGTAGAA 
AATGGAATTG CACCAAACCA TGGGCTGACT TTTCCTTTAA ATTCATGCCT CAAGTATATG 
TACCCACCAC CTTCCAGCAC AATCCTAGCA AACATTGTAA ATGCCTTGGC AAGCGTGCCT 
AAGTTCTATG TACAGGTCCT TCATCTTATG AATAAAATGA ATTTGCCCAC ACCTTTTGGA 
CCAATTACTG CGCGACCTCC CATGTATGAA GACTATATGC CATTGCATGC ACCTCTTCCA 
CCCACATCTC CTCAGCCACC TGAGGAACCT CCTTTGCCAG ACGAGGATGA GGAATTATCT 
AGTGAAGAAT CAGAATATGA AAGCACTGAT GATGAGGACC GACAGAGAAT GAACAAATTA 
ATGGAACTAG CAAATCTTCA GCCCAAAAGA CCTAAAACAA TAAAGCAGCG CCATGTGAGA 
AAAAAGAGAA AAATAAAGGA TATGTTGAAT ACACCTTTGT GTCCTTCACA CAGCAGTTTA 
CATCCAGTGC TGTTACCTTC AGATGTATTT GACCAACCAC AACCTGTAGG TAACAAAAGA 
ATTGAATTCC ATATATCTAC CGACATGCCA GCTGCATTTA AGAAAGATTT AGAAAAGGAA 
CAAAATTGTG AGGAAAAAAA TCATGATTTA CCTGCTACTG AAGTTGATGC ATCCAATATA 
GGATTTGGAA AAATCTTCCC CAAACCTAAT TTGGACATCA CAGAGGAGAT TAAAGAAGAC 
TCTGATGAAA TGCCTTCAGA ATGTATTTCT AGAAGGGAAT TGGAAAAGGG CAGAATTTCT 
AGAGAAGAAA TGGAAACACT TTCAGTTTTC AGAAGTTATG AACCGGGTGA ACCAAACTGT 
AGAATTTATG TAAAGAATTT AGCTAAACAT GTTCAAGAAA AGGACCTTAA ATATATTTTT 
GGAAGATATG TTGACTTTTC ATCAGAAACA CAGCGGATCA TGTTTGATAT ACGTTTGATG 
AAAGAAGGTC GTATGAAAGG ACAAGCTTTC ATTGGACTTC CTAATGAAAA AGCAGCAGCA 
AAAGCCTTAA AGGAAGCTAA TGGATATGTG CTTTTTGGAA AACCCATGGT GGTTCAGTTT 
GCTCGATCTG CTAGACCAAA ACAAGATCCT AAGGAAGGAA AAAGAAAGTG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060089.1
CDS	373..1926
Translation	MAAPEQPLAISRGCTSSSSLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAIKALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPTSGSEKKKRSDDPVEDDKEKKELGYLTVENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITARPPMYEDYMPLHAPLPPTSPQPPEEPPLPDEDEELSSEESEYESTDDEDRQRMNKLMELANLQPKRPKTIKQRHVRKKRKIKDMLNTPLCPSHSSLHPVLLPSDVFDQPQPVGNKRIEFHISTDMPAAFKKDLEKEQNCEEKNHDLPATEVDASNIGFGKIFPKPNLDITEEIKEDSDEMPSECISRRELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLAKHVQEKDLKYIFGRYVDFSSETQRIMFDIRLMKEGRMKGQAFIGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDPKEGKRKC

Target ORF information:

RefSeq Version	NM_017619.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding region (RNP1, RRM) containing 3 (RNPC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017619.4

ORF Insert Sequence:

ATGGCAGCTC CCGAGCAGCC GCTTGCGATA TCAAGGGGAT GCACGAGCTC CTCCTCGCTT 
TCCCCGCCTC GGGGCGACCG AACCCTTCTG GTCAGGCACC TGCCGGCTGA GCTTACTGCT 
GAGGAGAAAG AGGACTTGCT GAAGTACTTC GGGGCTCAGT CTGTGCGGGT CCTGTCAGAT 
AAGGGGCGAC TGAAACATAC AGCTTTTGCC ACATTCCCTA ATGAAAAAGC AGCTATAAAG 
GCATTGACAA GACTCCATCA ACTGAAACTT TTAGGTCATA CTTTAGTCGT TGAATTTGCA 
AAAGAGCAAG ATCGAGTTCA CTCCCCATGT CCCACTTCAG GCTCTGAAAA AAAAAAAAGG 
TCTGATGACC CTGTCGAAGA TGATAAAGAA AAAAAAGAAC TTGGTTATTT AACAGTAGAA 
AATGGAATTG CACCAAACCA TGGGCTGACT TTTCCTTTAA ATTCATGCCT CAAGTATATG 
TACCCACCAC CTTCCAGCAC AATCCTAGCA AACATTGTAA ATGCCTTGGC AAGCGTGCCT 
AAGTTCTATG TACAGGTCCT TCATCTTATG AATAAAATGA ATTTGCCCAC ACCTTTTGGA 
CCAATTACTG CGCGACCTCC CATGTATGAA GACTATATGC CATTGCATGC ACCTCTTCCA 
CCCACATCTC CTCAGCCACC TGAGGAACCT CCTTTGCCAG ACGAGGATGA GGAATTATCT 
AGTGAAGAAT CAGAATATGA AAGCACTGAT GATGAGGACC GACAGAGAAT GAACAAATTA 
ATGGAACTAG CAAATCTTCA GCCCAAAAGA CCTAAAACAA TAAAGCAGCG CCATGTGAGA 
AAAAAGAGAA AAATAAAGGA TATGTTGAAT ACACCTTTGT GTCCTTCACA CAGCAGTTTA 
CATCCAGTGC TGTTACCTTC AGATGTATTT GACCAACCAC AACCTGTAGG TAACAAAAGA 
ATTGAATTCC ATATATCTAC CGACATGCCA GCTGCATTTA AGAAAGATTT AGAAAAGGAA 
CAAAATTGTG AGGAAAAAAA TCATGATTTA CCTGCTACTG AAGTTGATGC ATCCAATATA 
GGATTTGGAA AAATCTTCCC CAAACCTAAT TTGGACATCA CAGAGGAGAT TAAAGAAGAC 
TCTGATGAAA TGCCTTCAGA ATGTATTTCT AGAAGGGAAT TGGAAAAGGG CAGAATTTCT 
AGAGAAGAAA TGGAAACACT TTCAGTTTTC AGAAGTTATG AACCGGGTGA ACCAAACTGT 
AGAATTTATG TAAAGAATTT AGCTAAACAT GTTCAAGAAA AGGACCTTAA ATATATTTTT 
GGAAGATATG TTGACTTTTC ATCAGAAACA CAGCGGATCA TGTTTGATAT ACGTTTGATG 
AAAGAAGGTC GTATGAAAGG ACAAGCTTTC ATTGGACTTC CTAATGAAAA AGCAGCAGCA 
AAAGCCTTAA AGGAAGCTAA TGGATATGTG CTTTTTGGAA AACCCATGGT GGTTCAGTTT 
GCTCGATCTG CTAGACCAAA ACAAGATCCT AAGGAAGGAA AAAGAAAGTG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.
RNA (New York, N.Y.)(2017 Dec)
Norppa AJ,Kauppala TM,Heikkinen HA,Verma B,Iwai H,Frilander MJ

U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.
Scientific reports631393(2016 Aug)
Singh J,Sikand K,Conrad H,Will CL,Komar AA,Shukla GC

Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.
EMBO molecular medicine6(3)299-306(2014 03)
Argente J,Flores R,Guti?rrez-Arum? A,Verma B,Martos-Moreno G?,Cusc? I,Oghabian A,Chowen JA,Frilander MJ,P?rez-Jurado LA

Protein microarray analysis identifies human cellular prion protein interactors.
Neuropathology and applied neurobiology35(1)16-35(2009 Feb)
Satoh J,Obayashi S,Misawa T,Sumiyoshi K,Oosumi K,Tabunoki H

Minor spliceosome components are predominantly localized in the nucleus.
Proceedings of the National Academy of Sciences of the United States of America105(25)8655-60(2008 Jun)
Pessa HK,Will CL,Meng X,Schneider C,Watkins NJ,Per?l? N,Nymark M,Turunen JJ,L?hrmann R,Frilander MJ

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RNPC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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