HAUS7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HAUS7
Entrez Gene ID	55559
Full Name	HAUS augmin like complex subunit 7
Synonyms	UCHL5IP,UIP1
General protein information	Preferred Names HAUS augmin like complex subunit 7 Names HAUS augmin-like complex subunit 7 26S proteasome-associated UCH37-interacting protein 1 UCHL5 interacting protein X-linked protein STS1769
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].
Disorder MIM:	300540

mRNA and Protein(s)

mRNA	Protein	Name
NM_017518.7	NP_059988.3	HAUS augmin-like complex subunit 7

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HAUS7	NP_001095747.1
Rattus norvegicus (Norway rat)	Haus7	NP_001264201.1
Pan troglodytes (chimpanzee)	HAUS7	XP_003317816.2
Mus musculus (house mouse)	Haus7	NP_082909.1
Xenopus tropicalis (tropical clawed frog)	haus7	NP_001120080.1
Homo sapiens (human)	HAUS7	NP_059988.3
	HAUS7	XP_001083074.1
Canis lupus familiaris (dog)	HAUS7	XP_005642047.1
Danio rerio (zebrafish)	haus7	XP_005162196.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel mutation in HAUS7 results in severe oligozoospermia in two brothers.
Li L, Sha YW, Su ZY, Mei LB, Ji ZY, Zhang Q, Lin SB, Wang X, Qiu PP, Li P, Yin C
Gene639106-110(2018 Jan)

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS
The EMBO journal30(8)1520-35(2011 Apr)

Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, H?rich? JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science (New York, N.Y.)328(5978)593-9(2010 Apr)

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.
Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L
Current biology : CB19(10)816-26(2009 May)

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.
Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G
Proceedings of the National Academy of Sciences of the United States of America106(17)6998-7003(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Discusses transcript evidence for TREX1 and TREX2, as well as readthrough transcripts with upstream loci ATRIP and HAUS7.
Title: Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.

The following HAUS7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HAUS7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20161	NM_017518.7 Latest version!	Homo sapiens HAUS augmin like complex subunit 7 (HAUS7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HAUS7 ( NM_017518.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_059988.3 Homo sapiens HAUS augmin like complex subunit 7 (HAUS7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20161
Clone ID Related Accession (Same CDS sequence)	NM_017518.7
Accession Version	NM_017518.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	HAUS augmin-like complex subunit 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008141.1. This sequence is a reference standard in the RefSeqGene project. On Sep 14, 2012 this sequence version replaced NM_017518.6. Transcript Variant: This variant (1) encodes the protein. CCDS Note: The translation initiation codon selected for this CCDS representation has a strong Kozak signal, but it appears to be human-specific. A much better-conserved alternate start codon, which also has a strong Kozak signal, exists further downstream. Use of the downstream start codon would result in a protein that is 10 aa shorter at the N-terminus. No experimental evidence exists to indicate which start codon is used in vivo. ##Evidence-Data-START## Transcript exon combination :: BC008141.1, SRR1163658.418290.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGGG CGCGGCTCGG AGCGCGAAAC ATGGCGGGGC AGGACGCTGG CTGCGGCCGT 
GGCGGCGACG ACTACTCAGA GGACGAGGGC GACAGCAGCG TGTCCAGGGC GGCTGTGGAG 
GTGTTCGGGA AGCTGAAGGA CCTAAACTGC CCCTTCCTCG AGGGTCTGTA TATCACAGAG 
CCAAAGACAA TTCAGGAACT GCTGTGCAGC CCCTCAGAGT ACCGCTTGGA GATCCTAGAG 
TGGATGTGTA CCCGGGTCTG GCCCTCACTG CAGGACAGGT TCAGCTCACT GAAAGGGGTC 
CCAACAGAGG TGAAGATCCA AGAAATGACG AAGCTGGGCC ACGAGCTGAT GCTGTGTGCG 
CCAGATGACC AGGAGCTCCT CAAGGGCTGT GCCTGCGCCC AGAAGCAGCT ACACTTCATG 
GACCAGTTGC TCGATACCAT CCGGAGCCTG ACCATTGGGT GCTCCAGTTG CTCGAGCCTG 
ATGGAGCACT TCGAGGACAC CAGGGAGAAG AACGAGGCCT TGCTGGGGGA GCTCTTCTCT 
AGCCCCCACC TGCAGATGCT CCTGAATCCA GAGTGCGACC CGTGGCCCCT GGACATGCAG 
CCCCTCCTCA ACAAGCAGAG TGATGACTGG CAGTGGGCCA GTGCCTCTGC CAAGTCCGAG 
GAGGAGGAGA AGCTGGCGGA GCTTGCCAGG CAGCTGCAGG AGAGTGCTGC CAAGTTGCAC 
GCGCTTAGAA CGGAGTACTT TGCACAGCAT GAGCAAGGGG CTGCTGCGGG CGCAGCCGAC 
ATCAGCACCC TAGACCAGAA GCTGCGTCTG GTCACTTCCG ACTTCCACCA GCTAATCTTG 
GCTTTTCTCC AAGTCTACGA CGACGAGCTG GGCGAGTGCT GCCAGCGCCC AGGCCCTGAC 
CTCCACCCGT GCGGCCCCAT CATCCAGGCC ACGCACCAGA ATCTGACTTC CTACAGCCAA 
CTGCTGCAAG TGGTCATGGC AGTTGCTGAC ACCTCTGCGA AGGCCGTGGA GACCGTGAAG 
AAGCAGCAAG GCGAGCAGAT CTGCTGGGGT GGCAGCAGCT CCGTCATGAG TCTAGCTACC 
AAGATGAATG AACTAATGGA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059988.3
CDS	45..1151
Translation	MGGARLGARNMAGQDAGCGRGGDDYSEDEGDSSVSRAAVEVFGKLKDLNCPFLEGLYITEPKTIQELLCSPSEYRLEILEWMCTRVWPSLQDRFSSLKGVPTEVKIQEMTKLGHELMLCAPDDQELLKGCACAQKQLHFMDQLLDTIRSLTIGCSSCSSLMEHFEDTREKNEALLGELFSSPHLQMLLNPECDPWPLDMQPLLNKQSDDWQWASASAKSEEEEKLAELARQLQESAAKLHALRTEYFAQHEQGAAAGAADISTLDQKLRLVTSDFHQLILAFLQVYDDELGECCQRPGPDLHPCGPIIQATHQNLTSYSQLLQVVMAVADTSAKAVETVKKQQGEQICWGGSSSVMSLATKMNELMEK

Target ORF information:

RefSeq Version	NM_017518.7
Organism	Homo sapiens(human)
Definition	Homo sapiens HAUS augmin like complex subunit 7 (HAUS7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017518.7

ORF Insert Sequence:

ATGGGCGGGG CGCGGCTCGG AGCGCGAAAC ATGGCGGGGC AGGACGCTGG CTGCGGCCGT 
GGCGGCGACG ACTACTCAGA GGACGAGGGC GACAGCAGCG TGTCCAGGGC GGCTGTGGAG 
GTGTTCGGGA AGCTGAAGGA CCTAAACTGC CCCTTCCTCG AGGGTCTGTA TATCACAGAG 
CCAAAGACAA TTCAGGAACT GCTGTGCAGC CCCTCAGAGT ACCGCTTGGA GATCCTAGAG 
TGGATGTGTA CCCGGGTCTG GCCCTCACTG CAGGACAGGT TCAGCTCACT GAAAGGGGTC 
CCAACAGAGG TGAAGATCCA AGAAATGACG AAGCTGGGCC ACGAGCTGAT GCTGTGTGCG 
CCAGATGACC AGGAGCTCCT CAAGGGCTGT GCCTGCGCCC AGAAGCAGCT ACACTTCATG 
GACCAGTTGC TCGATACCAT CCGGAGCCTG ACCATTGGGT GCTCCAGTTG CTCGAGCCTG 
ATGGAGCACT TCGAGGACAC CAGGGAGAAG AACGAGGCCT TGCTGGGGGA GCTCTTCTCT 
AGCCCCCACC TGCAGATGCT CCTGAATCCA GAGTGCGACC CGTGGCCCCT GGACATGCAG 
CCCCTCCTCA ACAAGCAGAG TGATGACTGG CAGTGGGCCA GTGCCTCTGC CAAGTCCGAG 
GAGGAGGAGA AGCTGGCGGA GCTTGCCAGG CAGCTGCAGG AGAGTGCTGC CAAGTTGCAC 
GCGCTTAGAA CGGAGTACTT TGCACAGCAT GAGCAAGGGG CTGCTGCGGG CGCAGCCGAC 
ATCAGCACCC TAGACCAGAA GCTGCGTCTG GTCACTTCCG ACTTCCACCA GCTAATCTTG 
GCTTTTCTCC AAGTCTACGA CGACGAGCTG GGCGAGTGCT GCCAGCGCCC AGGCCCTGAC 
CTCCACCCGT GCGGCCCCAT CATCCAGGCC ACGCACCAGA ATCTGACTTC CTACAGCCAA 
CTGCTGCAAG TGGTCATGGC AGTTGCTGAC ACCTCTGCGA AGGCCGTGGA GACCGTGAAG 
AAGCAGCAAG GCGAGCAGAT CTGCTGGGGT GGCAGCAGCT CCGTCATGAG TCTAGCTACC 
AAGATGAATG AACTAATGGA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel mutation in HAUS7 results in severe oligozoospermia in two brothers.
Gene639106-110(2018 Jan)
Li L,Sha YW,Su ZY,Mei LB,Ji ZY,Zhang Q,Lin SB,Wang X,Qiu PP,Li P,Yin C

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
The EMBO journal30(8)1520-35(2011 Apr)
Jakobsen L,Vanselow K,Skogs M,Toyoda Y,Lundberg E,Poser I,Falkenby LG,Bennetzen M,Westendorf J,Nigg EA,Uhlen M,Hyman AA,Andersen JS

Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science (New York, N.Y.)328(5978)593-9(2010 Apr)
Hutchins JR,Toyoda Y,Hegemann B,Poser I,H?rich? JK,Sykora MM,Augsburg M,Hudecz O,Buschhorn BA,Bulkescher J,Conrad C,Comartin D,Schleiffer A,Sarov M,Pozniakovsky A,Slabicki MM,Schloissnig S,Steinmacher I,Leuschner M,Ssykor A,Lawo S,Pelletier L,Stark H,Nasmyth K,Ellenberg J,Durbin R,Buchholz F,Mechtler K,Hyman AA,Peters JM

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.
Current biology : CB19(10)816-26(2009 May)
Lawo S,Bashkurov M,Mullin M,Ferreria MG,Kittler R,Habermann B,Tagliaferro A,Poser I,Hutchins JR,Hegemann B,Pinchev D,Buchholz F,Peters JM,Hyman AA,Gingras AC,Pelletier L

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.
Proceedings of the National Academy of Sciences of the United States of America106(17)6998-7003(2009 Apr)
Uehara R,Nozawa RS,Tomioka A,Petry S,Vale RD,Obuse C,Goshima G

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HAUS7 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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