PRG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRG2
Entrez Gene ID	5553
Full Name	proteoglycan 2, pro eosinophil major basic protein
Synonyms	BMPG,MBP,MBP1,proMBP
General protein information	Preferred Names proteoglycan 2, pro eosinophil major basic protein Names bone marrow proteoglycan eosinophil granule major basic protein eosinophil major basic protein natural killer cell activator proteoglycan 2 preproprotein proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Summary	The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].
Disorder MIM:	605601

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302927.2	NP_001289856.1	bone marrow proteoglycan isoform 1 preproprotein
NM_001243245.3	NP_001230174.1	bone marrow proteoglycan isoform 2 preproprotein
NM_002728.5	NP_002719.3	bone marrow proteoglycan isoform 1 preproprotein
NM_001302926.1	NP_001289855.1	bone marrow proteoglycan isoform 1 preproprotein
NM_002728.6	NP_002719.3	bone marrow proteoglycan isoform 1 preproprotein
NM_001302926.2	NP_001289855.1	bone marrow proteoglycan isoform 1 preproprotein
NM_001243245.2	NP_001230174.1	bone marrow proteoglycan isoform 2 preproprotein
NM_001302927.1	NP_001289856.1	bone marrow proteoglycan isoform 1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRG2	XP_003318023.1
	LOC100423556	XP_002799599.1
Rattus norvegicus (Norway rat)	Prg2	NP_113807.2
Homo sapiens (human)	PRG2	NP_002719.3
Mus musculus (house mouse)	Prg2	NP_032946.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM
Leukemia31(11)2426-2434(2017 Nov)

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU
Molecular cell57(6)1011-21(2015 Mar)

An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.
Ponikau JU, Winter LA, Kephart GM, Squillace DL, Hershcovitch MD, Moon S, Sherris DA, Kern EB, Gleich GJ, Kita H
International forum of allergy & rhinology5(1)28-35(2015 Jan)

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO
BMC cancer14518(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

free protein in nasal mucus can be used as a biomarker to diagnose chronic rhinosinusitis
Title: An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.

mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.
Title: Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.

Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1.
Title: Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-?1.

During pregnancy, the proform of eosinophil major basic protein-angiotensinogen constitutes the major form in late pregnancy.
Title: Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the proform of eosinophil major basic protein.

Combinations of respiratory syncytial virus and MBP synergistically induced cell death in pulmonary alveolar epithelial cells (A549).
Title: Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549).

The following PRG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27030	NM_001302927.1 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27030	NM_001302926.1 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27030	NM_002728.5 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26687	NM_001243245.2 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu107307	NM_001302926.2 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107307	NM_001302927.2 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107307	NM_002728.6 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu108205	NM_001243245.3 Latest version!	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRG2 ( NM_002728.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002719.3 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27030
Clone ID Related Accession (Same CDS sequence)	NM_002728.5 , NM_001302926.1 , NM_001302927.1
Accession Version	NM_002728.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65787.1, BC005929.1, AP000781.6, BX397850.2 and BX454677.2. On Nov 27, 2014 this sequence version replaced NM_002728.4. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X65787.1, AL540731.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002719.3
CDS	75..743
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_002728.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002728.5

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001302926.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289855.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu27030
Clone ID Related Accession (Same CDS sequence)	NM_002728.5 , NM_001302926.1 , NM_001302927.1
Accession Version	NM_001302926.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65787.1, DA841825.1, BC005929.1, AP000781.6, BX397850.2 and BX454677.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX381087.2, BX381122.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289855.1
CDS	71..739
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001302926.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302926.1

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001302927.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289856.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu27030
Clone ID Related Accession (Same CDS sequence)	NM_002728.5 , NM_001302926.1 , NM_001302927.1
Accession Version	NM_001302927.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65787.1, AU135652.1, BC005929.1, AP000781.6, BX397850.2 and BX454677.2. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX335104.2, BX336480.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289856.1
CDS	188..856
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001302927.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302927.1

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCGT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001243245.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230174.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26687
Clone ID Related Accession (Same CDS sequence)	NM_001243245.2
Accession Version	NM_001243245.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65787.1, CB997424.1, AP000781.6, BC005929.1, BX397850.2 and BX454677.2. On Nov 27, 2014 this sequence version replaced NM_001243245.1. Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX343940.2, BX379838.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGTTTACTT GCCGGAGGTG CTACAGGGGC 
AACCTGGTTT CCATCCACAA CTTCAATATT AATTATCGAA TCCAGTGTTC TGTCAGCGCG 
CTCAACCAGG GTCAAGTCTG GATTGGAGGC AGGATCACAG GCTCGGGTCG CTGCAGACGC 
TTTCAGTGGG TTGACGGCAG CCGCTGGAAC TTTGCGTACT GGGCTGCTCA CCAGCCCTGG 
TCCCGCGGTG GTCACTGCGT GGCCCTGTGT ACCCGAGGAG GCCACTGGCG TCGAGCCCAC 
TGCCTCAGAA GACTTCCTTT CATCTGTTCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230174.1
CDS	75..710
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001243245.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243245.2

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGTTTACTT GCCGGAGGTG CTACAGGGGC 
AACCTGGTTT CCATCCACAA CTTCAATATT AATTATCGAA TCCAGTGTTC TGTCAGCGCG 
CTCAACCAGG GTCAAGTCTG GATTGGAGGC AGGATCACAG GCTCGGGTCG CTGCAGACGC 
TTTCAGTGGG TTGACGGCAG CCGCTGGAAC TTTGCGTACT GGGCTGCTCA CCAGCCCTGG 
TCCCGCGGTG GTCACTGCGT GGCCCTGTGT ACCCGAGGAG GCCACTGGCG TCGAGCCCAC 
TGCCTCAGAA GACTTCCTTT CATCTGTTCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001302927.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289856.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu107307
Clone ID Related Accession (Same CDS sequence)	NM_001302927.2 , NM_002728.6 , NM_001302926.2
Accession Version	NM_001302927.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000781.6. On May 31, 2019 this sequence version replaced NM_001302927.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX336480.2, BX335104.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289856.1
CDS	181..849
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001302927.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302927.2

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_002728.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002719.3 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107307
Clone ID Related Accession (Same CDS sequence)	NM_001302927.2 , NM_002728.6 , NM_001302926.2
Accession Version	NM_002728.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000781.6. On Nov 23, 2018 this sequence version replaced NM_002728.5. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005929.1, AL540731.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311862.10/ ENSP00000312134.5 Protein has antimicrobial activity :: PMID: 3199069 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002719.3
CDS	68..736
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_002728.6
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002728.6

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001302926.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289855.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu107307
Clone ID Related Accession (Same CDS sequence)	NM_001302927.2 , NM_002728.6 , NM_001302926.2
Accession Version	NM_001302926.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000781.6. On Jun 1, 2019 this sequence version replaced NM_001302926.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX439088.2, BX381122.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289855.1
CDS	64..732
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001302926.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302926.2

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGGTGAGAA GTCTTCAGAC GTTTAGTCAA 
GCTTGGTTTA CTTGCCGGAG GTGCTACAGG GGCAACCTGG TTTCCATCCA CAACTTCAAT 
ATTAATTATC GAATCCAGTG TTCTGTCAGC GCGCTCAACC AGGGTCAAGT CTGGATTGGA 
GGCAGGATCA CAGGCTCGGG TCGCTGCAGA CGCTTTCAGT GGGTTGACGG CAGCCGCTGG 
AACTTTGCAT ACTGGGCTGC TCACCAGCCC TGGTCCCGCG GTGGTCACTG CGTGGCCCTG 
TGTACCCGAG GAGGCCACTG GCGTCGAGCC CACTGCCTCA GAAGACTTCC TTTCATCTGT 
TCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG2 ( NM_001243245.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230174.1 Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu108205
Clone ID Related Accession (Same CDS sequence)	NM_001243245.3
Accession Version	NM_001243245.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	bone marrow proteoglycan isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000781.6. On May 31, 2019 this sequence version replaced NM_001243245.2. Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB997424.1, BX379838.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 3199069 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGTTTACTT GCCGGAGGTG CTACAGGGGC 
AACCTGGTTT CCATCCACAA CTTCAATATT AATTATCGAA TCCAGTGTTC TGTCAGCGCG 
CTCAACCAGG GTCAAGTCTG GATTGGAGGC AGGATCACAG GCTCGGGTCG CTGCAGACGC 
TTTCAGTGGG TTGACGGCAG CCGCTGGAAC TTTGCATACT GGGCTGCTCA CCAGCCCTGG 
TCCCGCGGTG GTCACTGCGT GGCCCTGTGT ACCCGAGGAG GCCACTGGCG TCGAGCCCAC 
TGCCTCAGAA GACTTCCTTT CATCTGTTCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230174.1
CDS	68..703
Translation	MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Target ORF information:

RefSeq Version	NM_001243245.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 2, pro eosinophil major basic protein (PRG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243245.3

ORF Insert Sequence:

ATGAAACTCC CCTTACTTCT GGCTCTTCTA TTTGGGGCAG TTTCTGCTCT TCATCTAAGG 
TCTGAGACTT CCACCTTTGA GACCCCTTTG GGTGCTAAGA CGCTGCCTGA GGATGAGGAG 
ACACCAGAGC AGGAGATGGA GGAGACCCCT TGCAGGGAGC TGGAGGAAGA GGAGGAGTGG 
GGCTCTGGAA GTGAAGATGC CTCCAAGAAA GATGGGGCTG TTGAGTCTAT CTCAGTGCCA 
GATATGGTGG ACAAAAACCT TACGTGTCCT GAGGAAGAGG ACACAGTAAA AGTGGTGGGC 
ATCCCTGGGT GCCAGACCTG CCGCTACCTC CTGTTTACTT GCCGGAGGTG CTACAGGGGC 
AACCTGGTTT CCATCCACAA CTTCAATATT AATTATCGAA TCCAGTGTTC TGTCAGCGCG 
CTCAACCAGG GTCAAGTCTG GATTGGAGGC AGGATCACAG GCTCGGGTCG CTGCAGACGC 
TTTCAGTGGG TTGACGGCAG CCGCTGGAAC TTTGCATACT GGGCTGCTCA CCAGCCCTGG 
TCCCGCGGTG GTCACTGCGT GGCCCTGTGT ACCCGAGGAG GCCACTGGCG TCGAGCCCAC 
TGCCTCAGAA GACTTCCTTT CATCTGTTCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Leukemia31(11)2426-2434(2017 Nov)
Glavey SV,Naba A,Manier S,Clauser K,Tahri S,Park J,Reagan MR,Moschetta M,Mishima Y,Gambella M,Rocci A,Sacco A,O'Dwyer ME,Asara JM,Palumbo A,Roccaro AM,Hynes RO,Ghobrial IM

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Molecular cell57(6)1011-21(2015 Mar)
Soragni A,Yousefi S,Stoeckle C,Soriaga AB,Sawaya MR,Kozlowski E,Schmid I,Radonjic-Hoesli S,Boutet S,Williams GJ,Messerschmidt M,Seibert MM,Cascio D,Zatsepin NA,Burghammer M,Riekel C,Colletier JP,Riek R,Eisenberg DS,Simon HU

An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.
International forum of allergy & rhinology5(1)28-35(2015 Jan)
Ponikau JU,Winter LA,Kephart GM,Squillace DL,Hershcovitch MD,Moon S,Sherris DA,Kern EB,Gleich GJ,Kita H

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
BMC cancer14518(2014 Jul)
Naba A,Clauser KR,Whittaker CA,Carr SA,Tanabe KK,Hynes RO

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PRG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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